ZA806342B - Benzodiazepine compounds and their use as pharamceuticals - Google Patents

Benzodiazepine compounds and their use as pharamceuticals

Info

Publication number: ZA806342B
Authority: ZA; South Africa
Prior art keywords: pharamceuticals; benzodiazepine compounds; benzodiazepine; compounds
Prior art date: 1979-10-16

Application number

ZA00806342A

Other languages

English (en)

Inventor

J Chakrabarti

T Hotten

Original Assignee

Lilly Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-10-16

Filing date

1980-10-15

Publication date

1982-05-26

1980-10-15 Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd

1982-05-26 Publication of ZA806342B publication Critical patent/ZA806342B/xx

Links

125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA00806342A 1979-10-16 1980-10-15 Benzodiazepine compounds and their use as pharamceuticals ZA806342B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB7935846		1979-10-16

Publications (1)

Publication Number	Publication Date
ZA806342B true ZA806342B (en)	1982-05-26

Family

ID=10508540

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA00806342A ZA806342B (en)	1979-10-16	1980-10-15	Benzodiazepine compounds and their use as pharamceuticals

Country Status (33)

Country	Link
US (3)	US4404137A (da)
EP (1)	EP0027390B1 (da)
JP (1)	JPS5663987A (da)
KR (2)	KR850000471B1 (da)
AR (2)	AR228041A1 (da)
AT (1)	AT373889B (da)
AU (1)	AU538500B2 (da)
BE (1)	BE885729A (da)
BG (2)	BG34907A3 (da)
CA (1)	CA1159056A (da)
CH (1)	CH646700A5 (da)
CS (1)	CS244409B2 (da)
DD (1)	DD153692A5 (da)
DE (1)	DE3068706D1 (da)
DK (1)	DK437480A (da)
ES (1)	ES495948A0 (da)
FI (1)	FI67550C (da)
FR (1)	FR2467851A1 (da)
GB (1)	GB8327127D0 (da)
GR (1)	GR70720B (da)
HU (1)	HU182213B (da)
IE (1)	IE50358B1 (da)
IL (1)	IL61264A (da)
IT (1)	IT1143047B (da)
LU (1)	LU82853A1 (da)
MX (1)	MX6233E (da)
NZ (1)	NZ195248A (da)
PH (2)	PH16288A (da)
PL (2)	PL126824B1 (da)
PT (1)	PT71913B (da)
RO (2)	RO81351B (da)
YU (1)	YU261580A (da)
ZA (1)	ZA806342B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4404137A (en) *	1979-10-16	1983-09-13	Lilly Industries Limited	Pyrazolo [3,4-b][1,5]benzodiazepine compounds
US4431589A (en) *	1980-12-11	1984-02-14	Lilly House	Benzodiazepine compounds and their use as pharmaceuticals
US4596799A (en) *	1985-01-29	1986-06-24	Ciba-Geigy Corporation	9H-pyrrolo[2,1-c]-1,2,4-triazolo[4,3-a][1,4]benzodiazepines
TW219896B (da) *	1988-07-07	1994-02-01	Duphar Int Res
GB8819059D0 (en) *	1988-08-11	1988-09-14	Lilly Industries Ltd	Benzodiazepine compounds & their use as pharmaceuticals
US5631250A (en) *	1995-03-24	1997-05-20	Eli Lilly And Company	Process and solvate of 2-methyl-thieno-benzodiazepine
US5637584A (en) *	1995-03-24	1997-06-10	Eli Lilly And Company	Solvate of olanzapine
US20050250767A1 (en) *	2003-01-23	2005-11-10	Weiner David M	Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050085463A1 (en) *	2003-01-23	2005-04-21	Weiner David M.	Use of N-desmethylclozapine to treat human neuropsychiatric disease
CN1741803A (zh) *	2003-01-23	2006-03-01	阿卡蒂亚药品公司	N－脱甲基氯氮平在治疗人神经精神疾病中的用途
SG133606A1 (en) *	2003-12-22	2007-07-30	Acadia Pharm Inc	Amino substituted diaryl [a,d] cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
JP2007536216A (ja) *	2004-04-01	2007-12-13	アカディアファーマシューティカルズ，インコーポレーテッド	固体ｎ−デスメチルクロザピンおよびその結晶形を合成および単離する方法
WO2007053618A1 (en) *	2005-10-31	2007-05-10	Acadia Pharmaceuticals Inc.	Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
JP5438482B2 (ja) *	2009-12-03	2014-03-12	Ｊｕｋｉ株式会社	ミシン、ミシンの縫製データ編集装置及びミシンの縫製データ編集プログラム

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3450694A (en) *	1966-02-23	1969-06-17	Abbott Lab	Substituted benzoxazepines and benzothiazepines
US3758479A (en) *	1967-03-22	1973-09-11	Sandoz Ag	Nitro and sulphamoyl substituted dibenzodiazepines
DE1795183B1 (de) *	1968-08-20	1972-07-20	Thomae Gmbh Dr K	5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
CA918659A (en) *	1969-07-31	1973-01-09	Yoshitomi Pharmaceutical Industries	11-(4-substituted-1-piperazinyl)-dibenzo (b,f) (1,4) thiazepines
US4172831A (en) *	1974-11-26	1979-10-30	Lilly Industries Limited	Thieno-benzodiazepines
US4115568A (en) *	1974-11-26	1978-09-19	Lilly Industries Limited	Thieno[3,2-b]-[1,5]benzodiazepines
US3953430A (en) *	1975-02-24	1976-04-27	American Cyanamid Company	Substituted benzodiazepin-10-ones and method of use
US3951981A (en) *	1975-02-24	1976-04-20	American Cyanamid Company	Substituted benzodiazepines and method of use
DE2707269A1 (de) *	1977-02-19	1978-08-24	Hoechst Ag	Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung
DE2707270A1 (de) *	1977-02-19	1978-08-24	Hoechst Ag	Pyrazolo-diazepine und verfahren zu ihrer herstellung
US4097597A (en) *	1977-02-23	1978-06-27	Abbott Laboratories	Dibenzo b,e! 1,4!diazepines
IT7851496A0 (it) *	1977-10-31	1978-10-13	Sandoz Ag	Menti pirazinobenzossazepine loro preparazione e loro impiego quali medica
CH643263A5 (de) *	1979-05-11	1984-05-30	Sandoz Ag	Benzodiazepine, ihre herstellung und verwendung.
AU529934B2 (en) *	1979-08-03	1983-06-23	Byk Gulden Lomberg Chemische Fabrik Gmbh	Substituted tetraazatricyclic compounds
US4404137A (en) *	1979-10-16	1983-09-13	Lilly Industries Limited	Pyrazolo [3,4-b][1,5]benzodiazepine compounds

1980
- 1980-10-02 US US06/193,200 patent/US4404137A/en not_active Expired - Lifetime
- 1980-10-11 GR GR63138A patent/GR70720B/el unknown
- 1980-10-13 RO RO102349A patent/RO81351B/ro unknown
- 1980-10-13 IL IL61264A patent/IL61264A/xx unknown
- 1980-10-13 MX MX809093U patent/MX6233E/es unknown
- 1980-10-13 PH PH24717A patent/PH16288A/en unknown
- 1980-10-13 NZ NZ195248A patent/NZ195248A/xx unknown
- 1980-10-13 FR FR8021823A patent/FR2467851A1/fr active Granted
- 1980-10-13 YU YU02615/80A patent/YU261580A/xx unknown
- 1980-10-13 CS CS806938A patent/CS244409B2/cs unknown
- 1980-10-13 RO RO108967A patent/RO85822B/ro unknown
- 1980-10-14 AT AT0510180A patent/AT373889B/de not_active IP Right Cessation
- 1980-10-14 PT PT71913A patent/PT71913B/pt unknown
- 1980-10-14 IT IT49899/80A patent/IT1143047B/it active
- 1980-10-14 AU AU63252/80A patent/AU538500B2/en not_active Ceased
- 1980-10-14 CH CH763980A patent/CH646700A5/fr not_active IP Right Cessation
- 1980-10-14 CA CA000362328A patent/CA1159056A/en not_active Expired
- 1980-10-15 HU HU802502A patent/HU182213B/hu not_active IP Right Cessation
- 1980-10-15 DD DD80224618A patent/DD153692A5/de unknown
- 1980-10-15 LU LU82853A patent/LU82853A1/fr unknown
- 1980-10-15 IE IE2135/80A patent/IE50358B1/en unknown
- 1980-10-15 DE DE8080303649T patent/DE3068706D1/de not_active Expired
- 1980-10-15 DK DK437480A patent/DK437480A/da not_active Application Discontinuation
- 1980-10-15 BE BE6/47291A patent/BE885729A/fr not_active IP Right Cessation
- 1980-10-15 KR KR1019800003960A patent/KR850000471B1/ko not_active Expired
- 1980-10-15 PL PL1980227306A patent/PL126824B1/pl unknown
- 1980-10-15 BG BG049366A patent/BG34907A3/xx unknown
- 1980-10-15 FI FI803253A patent/FI67550C/fi not_active IP Right Cessation
- 1980-10-15 JP JP14423180A patent/JPS5663987A/ja active Pending
- 1980-10-15 BG BG057344A patent/BG35042A3/xx unknown
- 1980-10-15 EP EP80303649A patent/EP0027390B1/en not_active Expired
- 1980-10-15 ES ES495948A patent/ES495948A0/es active Granted
- 1980-10-15 PL PL1980231270A patent/PL135044B1/pl unknown
- 1980-10-15 ZA ZA00806342A patent/ZA806342B/xx unknown
- 1980-10-16 AR AR282893A patent/AR228041A1/es active
1982
- 1982-07-21 AR AR290034A patent/AR228101A1/es active
- 1982-07-28 PH PH27643A patent/PH17759A/en unknown
- 1982-09-29 US US06/426,580 patent/US4486591A/en not_active Expired - Fee Related
1983
- 1983-10-11 GB GB838327127A patent/GB8327127D0/en active Pending
1984
- 1984-07-24 KR KR1019840004388A patent/KR850000472B1/ko not_active Expired
- 1984-08-06 US US06/638,181 patent/US4542131A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATA510180A (de)	1983-07-15
PL231270A1 (da)	1981-12-23
IE50358B1 (en)	1986-04-02
AU538500B2 (en)	1984-08-16
AR228101A1 (es)	1983-01-14
FI67550C (fi)	1985-04-10
PH17759A (en)	1984-12-05
AT373889B (de)	1984-02-27
EP0027390B1 (en)	1984-07-25
DK437480A (da)	1981-04-17
ES8106905A1 (es)	1981-09-16
GB8327127D0 (en)	1983-11-09
ES495948A0 (es)	1981-09-16
US4404137A (en)	1983-09-13
AU6325280A (en)	1981-04-30
DD153692A5 (de)	1982-01-27
PT71913B (en)	1981-08-31
HU182213B (en)	1983-12-28
IT8049899A0 (it)	1980-10-14
NZ195248A (en)	1983-11-18
IT1143047B (it)	1986-10-22
DE3068706D1 (en)	1984-08-30
US4486591A (en)	1984-12-04
PT71913A (en)	1980-11-01
BG35042A3 (en)	1983-01-16
AR228041A1 (es)	1983-01-14
PL126824B1 (en)	1983-09-30
IE802135L (en)	1981-04-16
US4542131A (en)	1985-09-17
PL135044B1 (en)	1985-09-30
RO85822A (ro)	1984-11-25
FR2467851B1 (da)	1985-04-05
KR850000471B1 (ko)	1985-04-08
FI803253L (fi)	1981-04-17
FI67550B (fi)	1984-12-31
EP0027390A1 (en)	1981-04-22
RO81351A (ro)	1983-02-15
BG34907A3 (en)	1983-12-15
JPS5663987A (en)	1981-05-30
CS244409B2 (en)	1986-07-17
KR850001463A (ko)	1985-03-18
RO85822B (ro)	1984-11-30
MX6233E (es)	1985-01-14
KR830004300A (ko)	1983-07-09
YU261580A (en)	1983-12-31
PL227306A1 (da)	1981-09-18
IL61264A (en)	1985-08-30
PH16288A (en)	1983-09-05
GR70720B (da)	1983-01-18
CA1159056A (en)	1983-12-20
BE885729A (fr)	1981-04-15
CH646700A5 (fr)	1984-12-14
FR2467851A1 (fr)	1981-04-30
RO81351B (ro)	1983-02-28
LU82853A1 (fr)	1982-05-10
IL61264A0 (en)	1980-12-31
KR850000472B1 (ko)	1985-04-08

Publication	Publication Date	Title
ZW21580A1 (en)	1981-04-29	Imidazodiazepine derivatives
IL61143A0 (en)	1980-11-30	6-n-propyl-8alpha-methoxymethyl or methylmercaptomethylergolines and related compounds
ZA806342B (en)	1982-05-26	Benzodiazepine compounds and their use as pharamceuticals
JPS5686153A (en)	1981-07-13	Mercaptoacylldisubstituteddproline derivative and relative compounds
ZA804462B (en)	1981-07-29	Tricyclic compounds, their preparation and use
DE3165712D1 (en)	1984-09-27	Benzodiazepine compounds and their use as pharmaceuticals
ZA805920B (en)	1981-09-30	Quinazoline derivatives
JPS5649758A (en)	1981-05-06	Disazo compound* its manufacture and use
JPS5620064A (en)	1981-02-25	Anthraquinoneeazo compounds* their manufacture and their use as pigment
ZM8080A1 (en)	1981-07-21	Imidazodiazepine derivatives
JPS5683479A (en)	1981-07-08	Novel oxybenztriazole derivatives* their manufacture and their use
JPS55122770A (en)	1980-09-20	Benzodiazepine derivative
JPS5629556A (en)	1981-03-24	Substituted trichloropropylureas and their use
JPS5675475A (en)	1981-06-22	Imidazole derivative* its manufacture and its use
JPS5697289A (en)	1981-08-05	Benzazepine derivative
JPS55100362A (en)	1980-07-31	Tetrahydroo2hhbenzocpyrroles
JPS55153784A (en)	1980-11-29	Benzodiazepin compound
ZA80583B (en)	1981-01-28	Benzazepine derivatives
PH16300A (en)	1983-09-05	Notrothiazoline derivatives and their use as schistosonicidal agents
GB2061260B (en)	1983-08-10	Amoxycillin preparation
JPS5692865A (en)	1981-07-27	Substituted 22aminoo344dihydropyridine derivatives their manufacture and their pharmaceutic use
JPS5675483A (en)	1981-06-22	Alkynylacylanilide derivative* its manufacture and use
IE800285L (en)	1980-08-16	Sedative
GB2056981B (en)	1983-11-23	Benzodiazepines
AU5567980A (en)	1980-08-28	Pyrazolo diazepines