ZA839231B - Molecular cloning and characterization of a further gene sequence coding for human relaxin - Google Patents

Molecular cloning and characterization of a further gene sequence coding for human relaxin

Info

Publication number: ZA839231B
Authority: ZA; South Africa
Prior art keywords: characterization; molecular cloning; gene sequence; sequence coding; human relaxin
Prior art date: 1982-12-13

Application number

ZA839231A

Other languages

English (en)

Inventor

Peter John Hudson

Hugh David Niall

Geoffrey William Tregear

Original Assignee

Florey Howard Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-13

Filing date

1983-12-12

Publication date

1984-08-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3769889&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA839231(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1983-12-12 Application filed by Florey Howard Inst filed Critical Florey Howard Inst

1984-08-29 Publication of ZA839231B publication Critical patent/ZA839231B/xx

Links

BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title 1
238000012512 characterization method Methods 0.000 title 1
238000010369 molecular cloning Methods 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
101001091088 Homo sapiens Prorelaxin H2 Proteins 0.000 abstract 2
102000049116 human RLN2 Human genes 0.000 abstract 2
238000000034 method Methods 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
General Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Reproductive Health (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

ZA839231A 1982-12-13 1983-12-12 Molecular cloning and characterization of a further gene sequence coding for human relaxin ZA839231B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AUPF724782		1982-12-13

Publications (1)

Publication Number	Publication Date
ZA839231B true ZA839231B (en)	1984-08-29

Family

ID=3769889

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA839231A ZA839231B (en)	1982-12-13	1983-12-12	Molecular cloning and characterization of a further gene sequence coding for human relaxin

Country Status (14)

Country	Link
US (1)	US4758516A (da)
EP (2)	EP0303033B1 (da)
JP (3)	JP2545055B2 (da)
KR (1)	KR940002536B1 (da)
AT (2)	ATE62507T1 (da)
CA (1)	CA1220735A (da)
DE (1)	DE3382249D1 (da)
DK (2)	DK171684B1 (da)
ES (6)	ES8602133A1 (da)
HU (1)	HU197767B (da)
IE (1)	IE63902B1 (da)
IL (1)	IL70414A (da)
NZ (1)	NZ206534A (da)
ZA (1)	ZA839231B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0101309B1 (en) *	1982-08-12	1991-01-16	Howard Florey Institute Of Experimental Physiology And Medicine	Molecular cloning and characterization of a gene sequence coding for human relaxin
US5179195A (en) *	1982-12-13	1993-01-12	Howard Florey Institute Of Experimental Physiology And Medicine	Human relaxin polypeptides
US4835251A (en) *	1986-06-23	1989-05-30	Genetech, Inc.	Method of chain combination
EP0260149A1 (en) *	1986-09-12	1988-03-16	Howard Florey Institute Of Experimental Physiology And Medicine	Human prorelaxin for therapeutic use
WO1989007945A1 (en) *	1988-02-26	1989-09-08	Genentech, Inc.	Human relaxin formulation
CA2051375C (en) *	1989-05-04	2000-09-12	Dennis J. Henner	Process and compositions for the isolation of human relaxin
US5089419A (en) *	1989-08-07	1992-02-18	International Canine Genetics	Detection of pregnancy by identification of the c peptide of relaxin in the urine of animals
US5166191A (en) *	1991-08-19	1992-11-24	Genentech, Inc.	Use of relaxin in cardiovascular therapy
US5478807A (en) *	1991-08-19	1995-12-26	Genentech, Inc.	Use of relaxin in the treatment of bradycardia
AU3123393A (en) *	1991-10-28	1993-06-07	Board Of Regents, The University Of Texas System	A method for detecting a differentiation marker in normal and carcinoma cells and in biological samples and body fluid
US6348327B1 (en)	1991-12-06	2002-02-19	Genentech, Inc.	Non-endocrine animal host cells capable of expressing variant proinsulin and processing the same to form active, mature insulin and methods of culturing such cells
CA2165781C (en) *	1993-06-21	2007-02-13	Tim Breece	Process for producing relaxin
US20050032683A1 (en)	2000-10-04	2005-02-10	Amento Edward P.	Methods of modulating apoptosis by administration of relaxin agonists or antagonists
US20040006205A1 (en) *	2001-04-03	2004-01-08	Li Li	Therapeutic polypeptides, nucleic acids encoding same, and methods of use
CA2456753A1 (en) *	2001-08-17	2003-02-27	The Board Of Trustees Of The Leland Stanford Junior University	Mammalian relaxin receptors
AU2003903124A0 (en) *	2003-06-20	2003-07-10	Mark Del Borgo	Analogues of heteromeric proteins
WO2005115435A2 (en) *	2004-04-30	2005-12-08	Bas Medical, Inc.	Methods and compositions for control of fetal growth via modulation of relaxin
US20060052304A1 (en) *	2004-09-02	2006-03-09	Bas Medical, Inc.	Method for remodeling bone and related sutures
CN102026650A (zh) *	2008-05-16	2011-04-20	科尔泰拉公司	预防早产的方法
GR1006941B (el)	2009-06-01	2010-08-27	Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras),	Πεπτιδικη συνθεση (peptide synthesis)
US8389475B2 (en)	2009-08-10	2013-03-05	The Board Of Trustees Of The Leland Stanford Junior University	Relaxin analogs
PE20140160A1 (es)	2010-08-17	2014-02-08	Ambrx Inc	Polipeptidos de relaxina modificados y sus usos
AU2012280474A1 (en)	2011-07-01	2014-01-16	Bayer Intellectual Property Gmbh	Relaxin fusion polypeptides and uses thereof
EP2630964A1 (en)	2012-02-22	2013-08-28	Immundiagnostik AG	Method and medicament for treating patients in risk of prediabetes and type-2 diabetes
WO2015073727A1 (en)	2013-11-13	2015-05-21	Aequus Biopharma, Inc.	Engineered glycoproteins and uses thereof
EP2946788A1 (en)	2014-05-23	2015-11-25	Immundiagnostik AG	Method and composition for treating heart failure with preserved ejection fraction
CN115837014A (zh)	2016-05-18	2023-03-24	摩登纳特斯有限公司	编码松弛素的多核苷酸
SG10201912034UA (en)	2017-02-08	2020-02-27	Bristol Myers Squibb Co	Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4468464A (en) *	1974-11-04	1984-08-28	The Board Of Trustees Of The Leland Stanford Junior University	Biologically functional molecular chimeras
GR70279B (da) *	1979-09-12	1982-09-03	Univ California
US4267101A (en) *	1980-02-01	1981-05-12	Serono Laboratories Inc.	Process for obtaining human relaxin from fetal membranes
EP0068375A3 (en) *	1981-06-22	1983-04-13	G.D. Searle & Co.	Recombinant dna techniques for the production of relaxin
IE55479B1 (en) *	1982-02-12	1990-09-26	Florey Howard Inst	Molecular cloning and characterization of the gene sequence coding for porcine relaxin
EP0101309B1 (en) *	1982-08-12	1991-01-16	Howard Florey Institute Of Experimental Physiology And Medicine	Molecular cloning and characterization of a gene sequence coding for human relaxin

1983
- 1983-12-09 IL IL70414A patent/IL70414A/xx not_active IP Right Cessation
- 1983-12-09 NZ NZ206534A patent/NZ206534A/en unknown
- 1983-12-12 EP EP88110103A patent/EP0303033B1/en not_active Expired - Lifetime
- 1983-12-12 IE IE290883A patent/IE63902B1/en not_active IP Right Cessation
- 1983-12-12 DE DE8383307553T patent/DE3382249D1/de not_active Expired - Lifetime
- 1983-12-12 EP EP83307553A patent/EP0112149B1/en not_active Expired - Lifetime
- 1983-12-12 ES ES527964A patent/ES8602133A1/es not_active Expired
- 1983-12-12 ZA ZA839231A patent/ZA839231B/xx unknown
- 1983-12-12 AT AT83307553T patent/ATE62507T1/de not_active IP Right Cessation
- 1983-12-12 CA CA000443049A patent/CA1220735A/en not_active Expired
- 1983-12-12 AT AT88110103T patent/ATE90360T1/de not_active IP Right Cessation
- 1983-12-13 JP JP58233744A patent/JP2545055B2/ja not_active Expired - Lifetime
- 1983-12-13 KR KR1019830005905A patent/KR940002536B1/ko not_active Expired - Lifetime
- 1983-12-13 HU HU834243A patent/HU197767B/hu unknown
- 1983-12-13 US US06/560,790 patent/US4758516A/en not_active Expired - Lifetime
- 1983-12-13 DK DK573783A patent/DK171684B1/da not_active IP Right Cessation
1985
- 1985-06-17 ES ES544293A patent/ES8802249A1/es not_active Expired
1986
- 1986-02-17 ES ES552095A patent/ES8801373A1/es not_active Expired
- 1986-02-17 ES ES552094A patent/ES8708015A1/es not_active Expired
- 1986-02-17 ES ES552093A patent/ES8708016A1/es not_active Expired
1987
- 1987-05-11 ES ES557531A patent/ES8801675A1/es not_active Expired
1992
- 1992-11-30 DK DK143492A patent/DK172012B1/da not_active IP Right Cessation
1993
- 1993-03-22 JP JP5061747A patent/JP2677332B2/ja not_active Expired - Lifetime
1994
- 1994-10-26 JP JP6262254A patent/JP2891882B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK171684B1 (da)	1997-03-10
ES527964A0 (es)	1985-11-16
ES544293A0 (es)	1988-04-16
IL70414A0 (en)	1984-03-30
EP0303033A3 (en)	1989-10-25
ES8708015A1 (es)	1987-09-01
JP2677332B2 (ja)	1997-11-17
EP0303033B1 (en)	1993-06-09
ATE62507T1 (de)	1991-04-15
ES552095A0 (es)	1987-12-16
ES552093A0 (es)	1987-09-01
JPH07173198A (ja)	1995-07-11
DK573783A (da)	1984-06-14
ES8708016A1 (es)	1987-09-01
US4758516A (en)	1988-07-19
NZ206534A (en)	1988-05-30
CA1220735A (en)	1987-04-21
DK143492D0 (da)	1992-11-30
EP0303033A2 (en)	1989-02-15
ES552094A0 (es)	1987-09-01
ES8801373A1 (es)	1987-12-16
HU197767B (en)	1989-05-29
JP2891882B2 (ja)	1999-05-17
DK172012B1 (da)	1997-09-15
KR940002536B1 (ko)	1994-03-25
ATE90360T1 (de)	1993-06-15
JPS59156284A (ja)	1984-09-05
EP0112149A3 (en)	1985-05-22
JPH06100585A (ja)	1994-04-12
ES8801675A1 (es)	1988-02-16
DK573783D0 (da)	1983-12-13
DK143492A (da)	1992-11-30
EP0112149A2 (en)	1984-06-27
ES557531A0 (es)	1988-02-16
IE832908L (en)	1984-06-13
EP0112149B1 (en)	1991-04-10
IE63902B1 (en)	1995-06-14
JP2545055B2 (ja)	1996-10-16
KR840007024A (ko)	1984-12-04
ES8802249A1 (es)	1988-04-16
DE3382249D1 (de)	1991-05-16
ES8602133A1 (es)	1985-11-16
IL70414A (en)	1991-06-10

Publication	Publication Date	Title
EP0303033A3 (en)	1989-10-25	Molecular cloning and characterization of a further gene sequence coding for human relaxin
ZA835963B (en)	1984-04-25	Molecular cloning and characterization of a gene sequence coding for human relaxin
ZA859437B (en)	1987-08-26	Dna sequence encoding a hirudin-like protein and process for preparing such protein
GR3024379T3 (en)	1997-11-28	Peptides with organo-protective activity, the process for preparing them and their use in therapy
NZ243594A (en)	1994-08-26	Modifying polyphenol oxidase activity in fruit and vegetables and the dna sequences used
CS8708732A2 (en)	1991-07-16	Method of hv1, hv2, hv3 hirodin forms' one variant production
DK0919621T3 (da)	2009-01-19	Human TAK1 og DNA der koder derfor
EP0367641A3 (en)	1990-08-29	Lymphokines, dna sequences encoding these lymphokines and pharmaceutical compositions containing these lymphokines
AU562962B2 (en)	1987-06-25	Molecular cloning and characterisation of the gene sequence coding for human relaxin
EP0288901A3 (en)	1989-11-15	Recombinant human glutathione peroxidase, process for preparing the same and dna coding the same
ES2008391A6 (es)	1989-07-16	Un metodo para producir isopenicilina n sintetasa.
EP0320698A3 (en)	1990-07-18	Process for making shaped belts, in particular toothed belts, from rubber or the like
IE862937L (en)	1987-05-08	Bacillus regulatory region cloning.
ATE75255T1 (de)	1992-05-15	Peptid und dafuer kodierendes gen.
ATE60089T1 (de)	1991-02-15	Molekulare klonierung und charakterisierung der das menschliche relaxin kodierenden gen-sequenz.
IE872928L (en)	1988-04-30	Relatively low molecular weight polypeptide reinin¹inhibitors.