ZA841122B - N,n-disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkylamides - Google Patents

N,n-disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkylamides

Info

Publication number: ZA841122B
Authority: ZA; South Africa
Prior art keywords: sub; alkyl; carbon atoms; lower alkyl; hydrogen
Prior art date: 1983-02-16

Application number

ZA841122A

Other languages

English (en)

Inventor

Gordon Henry Jones

Michael Charles Venuti

Robert Alvarez

John Joseph Bruno

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-02-16

Filing date

1984-02-15

Publication date

1985-09-25

1984-02-15 Application filed by Syntex Inc filed Critical Syntex Inc

1985-09-25 Publication of ZA841122B publication Critical patent/ZA841122B/xx

Links

125000000217 alkyl group Chemical group 0.000 abstract 13
125000004432 carbon atom Chemical group C* 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
125000001475 halogen functional group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
-1 (±)-decahydroquinolinyl Chemical group 0.000 abstract 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000002001 anti-metastasis Effects 0.000 abstract 1
239000003146 anticoagulant agent Substances 0.000 abstract 1
229960004676 antithrombotic agent Drugs 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000005242 carbamoyl alkyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 abstract 1
230000000297 inotrophic effect Effects 0.000 abstract 1
125000002757 morpholinyl group Chemical group 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000002571 phosphodiesterase inhibitor Substances 0.000 abstract 1
125000003386 piperidinyl group Chemical group 0.000 abstract 1
125000000719 pyrrolidinyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 abstract 1
125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
- C07D215/08—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms with acylated ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)

ZA841122A 1983-02-16 1984-02-15 N,n-disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkylamides ZA841122B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/467,125 US4490371A (en)	1983-02-16	1983-02-16	N,N-Disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-B]quinazolinyl)oxyalkylamides

Publications (1)

Publication Number	Publication Date
ZA841122B true ZA841122B (en)	1985-09-25

Family

ID=23854465

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA841122A ZA841122B (en)	1983-02-16	1984-02-15	N,n-disubstituted-(2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkylamides

Country Status (20)

Country	Link
US (1)	US4490371A (pl)
EP (1)	EP0116948B1 (pl)
JP (1)	JPS59155383A (pl)
KR (1)	KR840007727A (pl)
AT (1)	ATE49210T1 (pl)
AU (1)	AU572118B2 (pl)
CA (1)	CA1253862A (pl)
DE (1)	DE3480925D1 (pl)
DK (1)	DK70784A (pl)
ES (3)	ES8604226A1 (pl)
FI (1)	FI78097C (pl)
GR (1)	GR79543B (pl)
HU (1)	HU189886B (pl)
IL (1)	IL70964A (pl)
NO (1)	NO164476C (pl)
NZ (1)	NZ207156A (pl)
PL (3)	PL142959B1 (pl)
PT (1)	PT78106B (pl)
SU (2)	SU1349700A3 (pl)
ZA (1)	ZA841122B (pl)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES8607299A1 (es) *	1984-02-15	1986-06-01	Syntex Inc	Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas
US4593029A (en) *	1984-02-15	1986-06-03	Syntex (U.S.A.) Inc.	Novel ω-(N-imidazolyl)alkyl ethers of 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
GB8514207D0 (en) *	1985-06-05	1985-07-10	Pfizer Ltd	Cardiac stimulants
US4837239A (en) *	1985-08-23	1989-06-06	Syntex (U.S.A.) Inc.	Cardiotonic phosphodiesterase inhibitors complexed with water soluble vitamins
US4670434A (en) *	1985-11-14	1987-06-02	Syntex (U.S.A.) Inc.	(2-oxo-3-methylene-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolinyl)oxyalkylamides useful as cyclic AMP phosphodiesterase inhibitors
US4775674A (en) *	1986-05-23	1988-10-04	Bristol-Myers Company	Imidazoquinolinylether derivatives useful as phosphodiesterase and blood aggregation inhibitors
US4701459A (en) *	1986-07-08	1987-10-20	Bristol-Myers Company	7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
US4761416A (en) *	1986-07-25	1988-08-02	Syntex (U.S.A.) Inc.	N-N-disubstituted-ω-[2-amino-3-(carbonylmethyl)-3, 4-dihydroquinazolinyl]oxyalkylamides and related compounds
US4739056A (en) *	1986-11-26	1988-04-19	Syntex (U.S.A.) Inc.	N-N-disubstituted-omega-(2-amino-3-(carbonylmethyl)-3,4-dihydroquinazolinyl)oxy-alkylamides and related compounds
NZ234186A (en) *	1989-07-07	1991-10-25	Janssen Pharmaceutica Nv	Imidazo quinazolin-one derivatives and pharmaceutical compositions
US4943573A (en) *	1989-11-01	1990-07-24	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
ATE141791T1 (de)	1991-07-05	1996-09-15	Byk Gulden Lomberg Chem Fab	Verwendung substituierter pyridazine gegen dermatosen
US5196428A (en) *	1992-04-03	1993-03-23	Bristol-Myers Squibb Company	Imidazo[4,5-b]qinolinyl oxy alkyl ureas
US5348960A (en) *	1992-04-03	1994-09-20	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl tetrazolyl piperidine derivatives
US5158958A (en) *	1992-04-03	1992-10-27	Bristol-Myers Squibb Company	Imidazo[4,5-b]quinolinyl oxy alkyl sulfonyl piperidine derivatives
US5208237A (en) *	1992-04-03	1993-05-04	Bristol-Meyers Squibb Company	7-oxypropylsulfonamido-imidazo[4,5-b]quinolin-2-ones
EP1216037A2 (en) *	1999-09-21	2002-06-26	Emory University	Methods and compositions for treating platelet-related disorders using mpl pathway inhibitory agents
AU2003297562A1 (en) *	2002-11-27	2004-06-23	Artesian Therapeutics, Inc.	COMPOUNDS WITH MIXED PDE-INHIBITORY AND Beta-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
US7985756B2 (en)	2005-10-21	2011-07-26	Braincells Inc.	Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
WO2007134077A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
EP2068872A1 (en) *	2006-09-08	2009-06-17	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
FR2910001B1 (fr) *	2006-12-18	2009-03-20	Sod Conseils Rech Applic	Derives d'imidazo, pyrimido et diazepine pyrimidine-dione et leur utilisation comme medicament
MX2009013293A (es)	2007-06-04	2010-02-15	Synergy Pharmaceuticals Inc	Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
GB0808944D0 (en) *	2008-05-16	2008-06-25	Shire Llc	Substituted quinazolines
GB0808950D0 (en) *	2008-05-16	2008-06-25	Shire Llc	Substituted quinazolines
GB0808953D0 (en) *	2008-05-16	2008-06-25	Shire Llc	substituted quinazolines
EP2810951B1 (en)	2008-06-04	2017-03-15	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en)	2008-07-16	2019-09-24	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
JP6074142B2 (ja)	2009-02-26	2017-02-01	タールファーマシューティカルズ，インコーポレイテッド	医薬化合物の結晶化
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CA3100941C (en)	2011-03-01	2024-03-05	Synergy Pharmaceuticals Inc.	Process of preparing guanylate cyclase c agonists
EP2804603A1 (en)	2012-01-10	2014-11-26	President and Fellows of Harvard College	Beta-cell replication promoting compounds and methods of their use
EP3718557A3 (en)	2013-02-25	2020-10-21	Bausch Health Ireland Limited	Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
JP2016514671A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	グアニル酸シクラーゼのアゴニストおよびその使用
JP2016514670A (ja)	2013-03-15	2016-05-23	シナジーファーマシューティカルズインコーポレイテッド	他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
EA201592263A1 (ru)	2013-06-05	2016-05-31	Синерджи Фармасьютикалз, Инк.	Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
KR20160042039A (ko)	2013-08-09	2016-04-18	알데릭스, 인코포레이티드	인산염 수송을 억제하기 위한 화합물 및 방법
WO2020237096A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Combination for lowering serum phosphate in a patient

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3932407A (en) *	1973-11-19	1976-01-13	Bristol-Myers Company	Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones
FI59246C (fi) *	1974-06-24	1981-07-10	Otsuka Pharma Co Ltd	Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
US4313947A (en) *	1974-06-24	1982-02-02	Otsuka Pharmaceutical Co., Ltd.	Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use
NZ187452A (en) *	1977-06-10	1980-05-27	Otsuka Pharma Co Ltd	N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation
NL7807507A (nl) *	1977-07-25	1979-01-29	Hoffmann La Roche	Tricyclische verbindingen.
FR2512674B1 (fr) *	1981-09-16	1986-01-10	Sandoz Sa	Nouveaux derives tricycliques de la quinazolinone, leur preparation et medicaments contenant ces derives
ES8607299A1 (es) *	1984-02-15	1986-06-01	Syntex Inc	Procedimiento para preparar (2-oxo-1,2,3,5-tetrahidroimida- zo(2,1-b)quinazolinil)-oxialquilamidas

1983
- 1983-02-16 US US06/467,125 patent/US4490371A/en not_active Expired - Fee Related
1984
- 1984-02-15 ES ES529749A patent/ES8604226A1/es not_active Expired
- 1984-02-15 EP EP84101551A patent/EP0116948B1/en not_active Expired - Lifetime
- 1984-02-15 AU AU24605/84A patent/AU572118B2/en not_active Ceased
- 1984-02-15 ZA ZA841122A patent/ZA841122B/xx unknown
- 1984-02-15 DE DE8484101551T patent/DE3480925D1/de not_active Expired - Lifetime
- 1984-02-15 PL PL1984253009A patent/PL142959B1/pl unknown
- 1984-02-15 DK DK70784A patent/DK70784A/da not_active Application Discontinuation
- 1984-02-15 AT AT84101551T patent/ATE49210T1/de not_active IP Right Cessation
- 1984-02-15 NO NO840551A patent/NO164476C/no unknown
- 1984-02-15 JP JP59027991A patent/JPS59155383A/ja active Pending
- 1984-02-15 NZ NZ207156A patent/NZ207156A/en unknown
- 1984-02-15 IL IL70964A patent/IL70964A/xx unknown
- 1984-02-15 PT PT78106A patent/PT78106B/pt not_active IP Right Cessation
- 1984-02-15 SU SU843706049A patent/SU1349700A3/ru active
- 1984-02-15 PL PL1984246224A patent/PL143010B1/pl unknown
- 1984-02-15 CA CA000447497A patent/CA1253862A/en not_active Expired
- 1984-02-15 PL PL1984253010A patent/PL142960B1/pl unknown
- 1984-02-15 FI FI840603A patent/FI78097C/fi not_active IP Right Cessation
- 1984-02-15 GR GR73806A patent/GR79543B/el unknown
- 1984-02-15 HU HU84593A patent/HU189886B/hu not_active IP Right Cessation
- 1984-02-15 KR KR1019840000702A patent/KR840007727A/ko not_active Ceased
1985
- 1985-06-14 ES ES544202A patent/ES8603878A1/es not_active Expired
- 1985-06-14 ES ES544203A patent/ES8603879A1/es not_active Expired
1986
- 1986-10-08 SU SU864028265A patent/SU1493109A3/ru active

Also Published As

Publication number	Publication date
ES544202A0 (es)	1986-01-16
DK70784D0 (da)	1984-02-15
ES8603879A1 (es)	1986-01-16
IL70964A (en)	1987-08-31
DK70784A (da)	1984-08-17
FI840603A7 (fi)	1984-08-17
SU1349700A3 (ru)	1987-10-30
NZ207156A (en)	1987-07-31
NO164476B (no)	1990-07-02
ES544203A0 (es)	1986-01-16
FI840603A0 (fi)	1984-02-15
NO164476C (no)	1990-10-10
AU2460584A (en)	1984-08-23
NO840551L (no)	1984-08-17
PL246224A1 (en)	1985-08-27
PT78106A (en)	1984-03-01
JPS59155383A (ja)	1984-09-04
FI78097C (fi)	1989-06-12
PT78106B (en)	1986-06-02
ES8604226A1 (es)	1986-02-01
PL142959B1 (en)	1987-12-31
ATE49210T1 (de)	1990-01-15
GR79543B (pl)	1984-10-30
CA1253862A (en)	1989-05-09
HU189886B (en)	1986-08-28
ES529749A0 (es)	1986-02-01
PL253010A1 (en)	1985-09-10
EP0116948A3 (en)	1984-12-19
DE3480925D1 (de)	1990-02-08
US4490371A (en)	1984-12-25
ES8603878A1 (es)	1986-01-16
EP0116948B1 (en)	1990-01-03
KR840007727A (ko)	1984-12-10
EP0116948A2 (en)	1984-08-29
SU1493109A3 (ru)	1989-07-07
PL143010B1 (en)	1987-12-31
PL142960B1 (en)	1987-12-31
PL253009A1 (en)	1985-09-10
IL70964A0 (en)	1984-05-31
AU572118B2 (en)	1988-05-05
FI78097B (fi)	1989-02-28

Publication	Publication Date	Title
EP0116948A3 (en)	1984-12-19	(2-oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkyl-amides
CA2078790A1 (en)	1992-07-22	3-benzylidene-1-carbamoyl-2-pyrrolidone analogues
CA2047848A1 (en)	1992-02-01	Azabicyclo derivatives
IE811830L (en)	1982-02-12	Indoles.
EP0614661A3 (en)	1994-11-02	Benzylidene and cinnamylidene malononitrile derivatives to inhibit proliferative processes in mammalian cells.
CA2057786A1 (en)	1992-06-22	Amino and nitro containing tricyclic compounds useful as inhibitors or ace
SE8204817L (sv)	1983-02-25	Tetrazinderivat
IE812859L (en)	1982-06-05	Azetidinones.
ZM3785A1 (en)	1988-12-30	Bis-(4 aminopheny-l)-sulfones
ES8505942A1 (es)	1985-06-01	Un procedimiento para la preparacion de derivados de urea
TW249804B (pl)	1995-06-21
ES8205808A1 (es)	1982-08-01	Un procedimiento para la preparacion de nuevos derivados del acido 2-penem-3-carboxilico.
IE832503L (en)	1984-04-27	1,2,3,4-tetrasubstituted naphthalenes
GR3023558T3 (en)	1997-08-29	Analogues of vpa used as anti-epileptica.
ES8604219A1 (es)	1986-01-16	Un procedimiento para la preparacion de benzoquinolicinas
ES2003086A6 (es)	1988-10-16	Procedimiento de obtencion de tienoquinolicinsulfonamidas
ES8607235A1 (es)	1986-06-01	"4-(nitrofenil)-tetrahidropiridinas,procedimiento para su obtencion y su empleo como medicamento"
PH27293A (en)	1993-05-04	Aryloxy arlthip heteroaryloxy heteroarylthio-alkenylene derivatives of amine and a method of use thereof
GB1184538A (en)	1970-03-18	alpha-Alkyl-5-Hydroxytryptophan Esters
CA2053705A1 (en)	1992-04-20	Piperazine derivatives
KR880012545A (ko)	1988-11-28	피롤알데히드 이의 제조방법 및 용도
EP0386044A4 (en)	1992-04-15	Hypoglycaemic peptides
GB1269404A (en)	1972-04-06	0-substituted-2,5-diphenylpyrroles
GB1167605A (en)	1969-10-15	Improvements in or relating to Nucleosides and the Manufacture Thereof
IE832550L (en)	1984-05-02	Semicarbazides.