ZA852349B - Method for selective methylation of erythromycin a derivatives - Google Patents

Method for selective methylation of erythromycin a derivatives

Info

Publication number: ZA852349B
Authority: ZA; South Africa
Prior art keywords: erythromycin; derivatives; selective methylation; methylation; selective
Prior art date: 1984-04-06

Application number

ZA852349A

Other languages

English (en)

Inventor

Yoshiaki Watanabe

Shigeo Morimoto

Masami Goi

Morihiro Mitsukuchi

Takashi Adachi

Jozi Nakagami

Toshifumi Asaka

Tadashi Eguchi

Kaoru Sota

Original Assignee

Taisho Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-04-06

Filing date

1985-03-28

Publication date

1985-11-27

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13375748&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA852349(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1985-03-28 Application filed by Taisho Pharmaceutical Co Ltd filed Critical Taisho Pharmaceutical Co Ltd

1985-11-27 Publication of ZA852349B publication Critical patent/ZA852349B/xx

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
238000011935 selective methylation Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA852349A 1984-04-06 1985-03-28 Method for selective methylation of erythromycin a derivatives ZA852349B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP59068509A JPS60214796A (ja)	1984-04-06	1984-04-06	６−０−メチルエリスロマイシン類の製法

Publications (1)

Publication Number	Publication Date
ZA852349B true ZA852349B (en)	1985-11-27

Family

ID=13375748

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA852349A ZA852349B (en)	1984-04-06	1985-03-28	Method for selective methylation of erythromycin a derivatives

Country Status (17)

Country	Link
US (1)	US4672109A (fr)
EP (1)	EP0158467B1 (fr)
JP (1)	JPS60214796A (fr)
KR (1)	KR910007572B1 (fr)
AR (1)	AR240833A1 (fr)
AT (1)	ATE44384T1 (fr)
AU (1)	AU567803B2 (fr)
CA (1)	CA1225637A (fr)
DE (1)	DE3571323D1 (fr)
DK (1)	DK172481B1 (fr)
ES (1)	ES541898A0 (fr)
FI (1)	FI77250C (fr)
GE (1)	GEP19960318B (fr)
HK (1)	HK99694A (fr)
PT (1)	PT80237B (fr)
SU (1)	SU1577700A3 (fr)
ZA (1)	ZA852349B (fr)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS61103890A (ja) *	1984-10-26	1986-05-22	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシンａ誘導体
GB8506380D0 (en) *	1985-03-12	1985-04-11	Beecham Group Plc	Chemical compounds
DK109886A (da)	1985-03-12	1986-09-13	Beecham Group Plc	Erythromycinderivater
US4670549A (en) *	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
US4833236A (en) *	1986-05-02	1989-05-23	Taisho Pharmaceutical Co., Ltd.	Erythromycin derivatives
EP0260938B1 (fr) *	1986-09-18	1992-12-09	Taisho Pharmaceutical Co. Ltd	Dérivés de l'érythromycine A et leur méthode de préparation
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
JP2751385B2 (ja) *	1988-05-19	1998-05-18	大正製薬株式会社	エリスロマイシンａオキシム及びその塩の製造方法
US5302705A (en) *	1989-10-07	1994-04-12	Taisho Pharmaceutical Co., Ltd.	6-O-methylerythromycin a oxime derivatives
IT1276901B1 (it) *	1994-12-13	1997-11-03	Zambon Spa	Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
ZA966601B (en) *	1995-08-03	1997-02-19	Chugai Pharmaceutical Co Ltd	Process for producing erythromycin derivatives.
US5872229A (en) *	1995-11-21	1999-02-16	Abbott Laboratories	Process for 6-O-alkylation of erythromycin derivatives
US5756473A (en) *	1995-11-21	1998-05-26	Abbott Laboratories	6-O-methyl erythromycin D and process for making
US5719272A (en) *	1996-04-02	1998-02-17	Abbott Laboratories	2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5808017A (en) *	1996-04-10	1998-09-15	Abbott Laboratories	Process for preparing erythromycin A oxime
DE69730138T2 (de)	1996-07-29	2005-03-03	Abbott Laboratories, Abbott Park	Herstellung von kristallinen form ii von clarithromycin
US5858986A (en) *	1996-07-29	1999-01-12	Abbott Laboratories	Crystal form I of clarithromycin
US5945405A (en) *	1997-01-17	1999-08-31	Abbott Laboratories	Crystal form O of clarithromycin
US5864023A (en) *	1997-02-13	1999-01-26	Abbott Laboratories	3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) *	1997-09-10	1999-07-27	Abbott Laboratories	9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
US5852180A (en) *	1997-11-17	1998-12-22	Abbott Laboratories	Chemical synthesis of 6-O-alkyl erythromycin A
US5932710A (en)	1997-12-01	1999-08-03	Abbott Laboratories	Process for preparing 6-O-alkyl-9-oxime erythromycin B
IL135792A0 (en) *	1997-12-01	2001-05-20	Abbott Lab	6-o-alkyl derivatives of erythronolide b
IL124084A0 (en) *	1998-04-14	1999-04-11	Chemagis Ltd	Erythromycin a derivatives and methods for the preparation thereof
IL125372A0 (en) *	1998-07-15	1999-03-12	Chemagis Ltd	Erythromycin derivatives and methods for the preparation thereof
KR100283990B1 (ko) *	1998-12-29	2001-03-02	민경윤	에리스로마이신 a 유도체 및 그의 제조방법
SI20150A (sl) *	1999-02-19	2000-08-31	Lek, Tovarna Farmacevtskih In	Direktno stisljivi matriks za nadzorovano sproščanje celodnevne doze klaritromicina
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
KR20010008496A (ko) *	1999-07-01	2001-02-05	유충식	6-오-메틸 에리트로마이신의 제조방법
US6627743B1 (en)	1999-12-03	2003-09-30	Abbott Laboratories	6-O-methylerythromycin A crystal form III
WO2001044262A1 (fr)	1999-12-16	2001-06-21	Teva Pharmaceutical Industries Ltd.	Procedes de preparation de polymorphes de clarithromycine et nouveau polymorphe iv
AU2261901A (en)	2000-01-11	2001-07-24	Teva Pharma	Processes for preparing clarithromycin polymorphs
US6544555B2 (en)	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
US6565882B2 (en)	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
KR20030047873A (ko) *	2000-02-29	2003-06-18	테바 파마슈티컬 인더스트리즈 리미티드	클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
RU2230748C2 (ru) *	2000-03-15	2004-06-20	Ханми Фарм. Ко., Лтд.	Способ получения кларитромицина в виде кристаллов формы ii
PT1283821E (pt)	2000-05-15	2004-06-30	Ranbaxy Lab Ltd	Metodo rentavel para metilacao selectiva de derivados de eritromicina a
JP2004506664A (ja) *	2000-08-23	2004-03-04	ウォックハート・リミテッド	無水アジトロマイシンの製造法
US20020068078A1 (en)	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6541014B2 (en)	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20050163857A1 (en) *	2002-04-03	2005-07-28	Ashok Rampal	Clarithromycin formulations having improved bioavailability
US6843854B2 (en)	2002-05-31	2005-01-18	Purdue Research Foundation	Method and apparatus for separating a component from a mixture
ES2221807B1 (es) *	2003-06-24	2005-12-16	Ercros Industrial, S.A.	Un procedimiento para la obtencion de claritromicina.
AU2004258949B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528185A (ja)	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
AU2004258953B2 (en)	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2535177A1 (fr)	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Pastille robuste
US8062672B2 (en)	2003-08-12	2011-11-22	Shionogi Inc.	Antibiotic product, use and formulation thereof
AU2004270170B2 (en)	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2538064C (fr)	2003-09-15	2013-12-17	Advancis Pharmaceutical Corporation	Antibiotique, son utilisation et sa formulation
CA2572292A1 (fr)	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Comprime pour distribution par impulsion
US20060111560A1 (en) *	2004-11-01	2006-05-25	Glenmark Pharmaceuticals Limited	Process for the preparation of crystalline form II of clarithromycin
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US8778924B2 (en)	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
RU2455308C2 (ru)	2006-05-01	2012-07-10	Тайсо Фармасьютикал Ко., Лтд.	Макролидные производные
US8299052B2 (en) *	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1100504A (en) *	1967-08-16	1968-01-24	Pliva Pharm & Chem Works	Erythromycin oxime and 9-amino-3-o-cladinosyl-5-o-desosaminyl-6,11,12-trihydroxy-2,4,6,8,10,12-hexamethylpentadecane-13-olide
US4166901A (en) *	1978-01-03	1979-09-04	Pfizer Inc.	4"-Deoxy-4"-arylglyoxamido- and aroylthioformamido derivatives of oleandomycin and its esters
FR2473525A1 (fr) *	1980-01-11	1981-07-17	Roussel Uclaf	Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4331803A (en) *	1980-06-04	1982-05-25	Taisho Pharmaceutical Co., Ltd.	Novel erythromycin compounds
JPS5896095A (ja) *	1981-11-30	1983-06-07	Taisho Pharmaceut Co Ltd	１１−ｏ−アルキルエリスロマイシンａ誘導体
JPS5896097A (ja) *	1981-12-01	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンｂ誘導体
JPS5896098A (ja) *	1981-12-03	1983-06-07	Taisho Pharmaceut Co Ltd	エリスロマイシンａ誘導体
US4382085A (en) *	1982-03-01	1983-05-03	Pfizer Inc.	4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents
IL75908A0 (en) *	1984-08-31	1985-12-31	Abbott Lab	Macrolide alkylation process

1984
- 1984-04-06 JP JP59068509A patent/JPS60214796A/ja active Granted
1985
- 1985-03-22 EP EP85301997A patent/EP0158467B1/fr not_active Expired
- 1985-03-22 AT AT85301997T patent/ATE44384T1/de not_active IP Right Cessation
- 1985-03-22 DE DE8585301997T patent/DE3571323D1/de not_active Expired
- 1985-03-26 AU AU40378/85A patent/AU567803B2/en not_active Expired
- 1985-03-26 CA CA000477464A patent/CA1225637A/fr not_active Expired
- 1985-03-28 ZA ZA852349A patent/ZA852349B/xx unknown
- 1985-04-02 ES ES541898A patent/ES541898A0/es active Granted
- 1985-04-03 DK DK198501523A patent/DK172481B1/da not_active IP Right Cessation
- 1985-04-03 AR AR299984A patent/AR240833A1/es active
- 1985-04-04 PT PT80237A patent/PT80237B/pt unknown
- 1985-04-04 FI FI851376A patent/FI77250C/fi not_active IP Right Cessation
- 1985-04-05 US US06/720,383 patent/US4672109A/en not_active Expired - Lifetime
- 1985-04-05 SU SU853878949A patent/SU1577700A3/ru active
- 1985-04-06 KR KR1019850002325A patent/KR910007572B1/ko not_active Expired
1993
- 1993-07-28 GE GEAP19931269A patent/GEP19960318B/en unknown
1994
- 1994-09-15 HK HK99694A patent/HK99694A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
US4672109A (en)	1987-06-09
EP0158467B1 (fr)	1989-07-05
ATE44384T1 (de)	1989-07-15
DK152385D0 (da)	1985-04-03
FI77250B (fi)	1988-10-31
AU4037885A (en)	1985-10-10
JPH053475B2 (fr)	1993-01-14
FI851376L (fi)	1985-10-07
GEP19960318B (en)	1996-06-24
FI77250C (fi)	1989-02-10
AR240833A1 (es)	1991-02-28
PT80237B (pt)	1987-06-17
AU567803B2 (en)	1987-12-03
DK172481B1 (da)	1998-11-23
DE3571323D1 (en)	1989-08-10
EP0158467A3 (en)	1986-03-19
EP0158467A2 (fr)	1985-10-16
ES8602839A1 (es)	1985-12-01
HK99694A (en)	1994-09-23
SU1577700A3 (ru)	1990-07-07
KR850007434A (ko)	1985-12-04
CA1225637A (fr)	1987-08-18
FI851376A0 (fi)	1985-04-04
DK152385A (da)	1985-10-07
ES541898A0 (es)	1985-12-01
PT80237A (en)	1985-05-01
KR910007572B1 (ko)	1991-09-28
JPS60214796A (ja)	1985-10-28

Publication	Publication Date	Title
DE3571323D1 (en)	1989-08-10	Method for selective methylation of erythromycin a derivatives
DE3661420D1 (en)	1989-01-19	Method for selective methylation of erythromycin a derivatives
DE3575729D1 (en)	1990-03-08	6-o-methylerythromycin a derivative
ZA866443B (en)	1987-07-29	Erythromycin derivatives
EG17459A (en)	1992-12-30	Method for preparation 9a-aza-9a-homoerythromycin derivatives
GB8512158D0 (en)	1985-06-19	Synchronization method
ZA841592B (en)	1985-05-29	Macrolide derivatives
EP0222186A3 (en)	1987-10-07	Erythromycin a derivatives
DE3474831D1 (en)	1988-12-01	C-20- and c-23-modified macrolide derivatives
YU42841B (en)	1988-12-31	Process for obtaining 9-dihydro-11,12-ketal derivatives of erythromycin a and api-erythromycin a
GB2190616B (en)	1989-10-11	Method for making drill rods
HUT41404A (en)	1987-04-28	Process for preparing dihydro-pyridine derivatives
GB2168353B (en)	1988-06-22	Process for preparing nucleoside derivatives
HUT42896A (en)	1987-08-28	Process for producing antibiotic derivatives
DE3263301D1 (en)	1985-05-30	Erythromycin a derivatives
EP0196167A3 (en)	1987-10-21	Method for adjusting a time delay
DE3468883D1 (en)	1988-02-25	Macrolide derivatives
ZA841277B (en)	1985-09-25	C-20-and c-23-modified macrolide derivatives
GB2154606B (en)	1987-03-25	Selective agent for group a streptococci
ZA861646B (en)	1987-11-25	Method for selective mythylation of erythromycin a derivatives
DE3565268D1 (en)	1988-11-03	Novel tylosin derivatives
GR862415B (en)	1987-01-22	Method for preparing chinolin derivatives
PL242694A1 (en)	1985-01-16	Method of preparation of erythromycin a
IE840490L (en)	1984-09-03	Macrolide derivatives
PL241664A1 (en)	1984-11-08	Method of isolation of cyclic 11,12-carbonate of a erythromycin