ZA853296B - Stable sulpho-adenosyl-l-methionine(same)salts,particularly suitable for oral pharmaceutical use - Google Patents

Stable sulpho-adenosyl-l-methionine(same)salts,particularly suitable for oral pharmaceutical use

Info

Publication number: ZA853296B
Authority: ZA; South Africa
Prior art keywords: same; salts; adenosyl; methionine; particularly suitable
Prior art date: 1984-05-16

Application number

ZA853296A

Other languages

English (en)

Inventor

Federico Gennari

Original Assignee

Bioresearch Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-16

Filing date

1985-05-02

Publication date

1985-12-24

1985-05-02 Application filed by Bioresearch Spa filed Critical Bioresearch Spa

1985-12-24 Publication of ZA853296B publication Critical patent/ZA853296B/xx

Links

150000003839 salts Chemical class 0.000 title abstract 6
239000002253 acid Substances 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
CTTJWXVQRJUJQW-UHFFFAOYSA-N 2,2-dioctyl-3-sulfobutanedioic acid Chemical compound CCCCCCCCC(C(O)=O)(C(C(O)=O)S(O)(=O)=O)CCCCCCCC CTTJWXVQRJUJQW-UHFFFAOYSA-N 0.000 abstract 1
229910006069 SO3H Inorganic materials 0.000 abstract 1
240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
239000013592 cell lysate Substances 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000006166 lysate Substances 0.000 abstract 1
230000002934 lysing effect Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229960004452 methionine Drugs 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000003884 phenylalkyl group Chemical group 0.000 abstract 1
230000001376 precipitating effect Effects 0.000 abstract 1
238000000108 ultra-filtration Methods 0.000 abstract 1
238000005406 washing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/94—Saccharomyces
- Y10S435/942—Saccharomyces cerevisiae

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cosmetics (AREA)
Cephalosporin Compounds (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Detergent Compositions (AREA)

ZA853296A 1984-05-16 1985-05-02 Stable sulpho-adenosyl-l-methionine(same)salts,particularly suitable for oral pharmaceutical use ZA853296B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT20940/84A IT1173992B (it)	1984-05-16	1984-05-16	Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale

Publications (1)

Publication Number	Publication Date
ZA853296B true ZA853296B (en)	1985-12-24

Family

ID=11174364

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA853296A ZA853296B (en)	1984-05-16	1985-05-02	Stable sulpho-adenosyl-l-methionine(same)salts,particularly suitable for oral pharmaceutical use

Country Status (21)

Country	Link
US (1)	US5128249A (mo)
EP (1)	EP0162324B1 (mo)
JP (1)	JPH0630606B2 (mo)
AT (1)	ATE36541T1 (mo)
AU (1)	AU568435B2 (mo)
CA (1)	CA1241611A (mo)
DE (1)	DE3564436D1 (mo)
DK (1)	DK161971C (mo)
EG (1)	EG17393A (mo)
ES (1)	ES543198A0 (mo)
FI (1)	FI85288C (mo)
GR (1)	GR851183B (mo)
IE (1)	IE58694B1 (mo)
IN (1)	IN162826B (mo)
IT (1)	IT1173992B (mo)
MX (1)	MX7438E (mo)
NO (1)	NO163744C (mo)
PT (1)	PT80453B (mo)
SU (1)	SU1487816A3 (mo)
YU (1)	YU44498B (mo)
ZA (1)	ZA853296B (mo)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1173990B (it) *	1984-05-16	1987-06-24	Bioresearch Spa	Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1177373B (it) *	1984-12-06	1987-08-26	Bioresearch Spa	Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica
IT1200589B (it) *	1985-02-14	1989-01-27	Gibipharma Spa	Derivati naturali attivita farmagologica
WO1989003389A1 (en) *	1987-10-09	1989-04-20	Vincenzo Zappia	Lipophilic salts of s-adenosyl-l-methionine (sam) with acylated taurine derivatives
GB9211779D0 (en) *	1992-06-03	1992-07-15	Ciba Geigy Ag	Amine salts
JPH06192109A (ja) *	1992-09-04	1994-07-12	Fuji Kagaku Kogyo Kk	抗腫瘍効果増強剤
US6492349B1 (en)	1993-03-31	2002-12-10	Nutramax Laboratories, Inc.	Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue
US6255295B1 (en)	1996-12-23	2001-07-03	Nutramax Laboratories, Inc.	Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
IT1317920B1 (it) *	2000-10-20	2003-07-15	Univ Roma	S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer.
US6759395B2 (en)	2000-12-18	2004-07-06	Orchid Chemicals & Pharmaceuticals, Ltd.	Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
AU2002228321A1 (en) *	2000-12-18	2002-07-01	Orchid Chemicals And Pharmaceuticals Limited	A novel soft-gelatin capsule comprising s-adenosylmethionine and a method for producing the same
US6649753B2 (en)	2001-06-07	2003-11-18	Orchid Chemicals & Pharmaceuticals Ltd.	Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
WO2002102823A1 (en) *	2001-06-14	2002-12-27	Orchid Chemicals & Pharmaceuticals Limited	Stable salts of s-adenosyl-l-methionine (same) and the process for their preparation
DK1325740T3 (da)	2001-12-12	2004-08-16	Chemistry & Health Int Bv	Stabile granulater indeholdende s-adenosylmethionin og fremgangsmåde til fremstilling deraf
US20050272687A1 (en) *	2004-06-08	2005-12-08	Hebert Rolland F	Stable S-adenosyl-l-methionine
US20090012036A1 (en) *	2005-05-24	2009-01-08	Hebert Rolland F	Stable S-adenosyl-L-methionine
WO2007083631A1 (ja) *	2006-01-17	2007-07-26	Mitsubishi Gas Chemical Company, Inc.	Ｓ－アデノシル－ｌ－メチオニンの安定化法及び安定化された組成物
US20080206333A1 (en) *	2007-01-31	2008-08-28	Methylation Sciences International Srl	Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
US20090197824A1 (en) *	2008-01-31	2009-08-06	Methylation Sciences International Srl	Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
US20090088404A1 (en) *	2007-01-31	2009-04-02	Methylation Sciences International Srl	Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
US20100004191A1 (en) *	2008-07-01	2010-01-07	Rolland F Hebert	Compositions of S-adenosyl-L-methionine.
US20110027342A1 (en)	2009-07-28	2011-02-03	Msi Methylation Sciences, Inc.	S-adenosylmethionine formulations with enhanced bioavailability
US8329208B2 (en) *	2009-07-28	2012-12-11	Methylation Sciences International Srl	Pharmacokinetics of S-adenosylmethionine formulations
EP2949331A1 (en)	2012-10-17	2015-12-02	Methylation Sciences International SRL	Compositions comprising s-adenosylmethionine and a gallic acid ester
EP2945959B1 (en)	2013-01-16	2020-05-13	Hebert Sam-E LLC	Stable indole-3-propionate salts of s-adenosyl-l-methionine
CN103265595B (zh) *	2013-05-21	2015-12-23	南京基准生物科技有限公司	一种酿酒酵母发酵液中提取s-腺苷甲硫氨酸的方法
EP4712796A2 (en)	2023-05-15	2026-03-25	Bonafide Health, LLC	Sleep-improving compositions and methods of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE37913B1 (en) *	1972-08-02	1977-11-09	Bioresearch Sas	Salt of s-adenosyl-l-methionine
IE39517B1 (en) *	1973-06-27	1978-10-25	Bioresearch Sas	Double salts of s-adenosyl-l-methhionine
AR221676A1 (es) *	1974-07-12	1981-03-13	Bioresearch Sas	Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
JPS53107485A (en) *	1977-02-28	1978-09-19	Yamasa Shoyu Co Ltd	Preparation of s-adenosyl-l-methionine salt
GB2064523B (en) *	1979-12-04	1983-06-29	Kanegafuchi Chemical Ind	Stable composition of s-adenosyl-l-methionine
GB2116172B (en) *	1982-02-25	1986-07-09	Nippon Zeon Co	Microbial cells containing s-adenosyl methionine in high concentrations and process for production of s adenosyl methionine
IT1169773B (it) *	1983-08-24	1987-06-03	Bioresearch Spa	Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
JPS60102796A (ja) *	1983-11-09	1985-06-06	三洋電機株式会社	リ−ドレス部品の端子接続方法
IT1173990B (it) *	1984-05-16	1987-06-24	Bioresearch Spa	Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale

1984
- 1984-05-16 IT IT20940/84A patent/IT1173992B/it active
1985
- 1985-04-25 AT AT85105001T patent/ATE36541T1/de not_active IP Right Cessation
- 1985-04-25 EP EP85105001A patent/EP0162324B1/en not_active Expired
- 1985-04-25 DE DE8585105001T patent/DE3564436D1/de not_active Expired
- 1985-05-02 ZA ZA853296A patent/ZA853296B/xx unknown
- 1985-05-06 IN IN346/CAL/85A patent/IN162826B/en unknown
- 1985-05-08 US US06/731,722 patent/US5128249A/en not_active Expired - Fee Related
- 1985-05-08 MX MX8511549U patent/MX7438E/es unknown
- 1985-05-13 IE IE118885A patent/IE58694B1/en not_active IP Right Cessation
- 1985-05-13 PT PT80453A patent/PT80453B/pt not_active IP Right Cessation
- 1985-05-13 CA CA000481420A patent/CA1241611A/en not_active Expired
- 1985-05-14 YU YU801/85A patent/YU44498B/xx unknown
- 1985-05-15 DK DK215685A patent/DK161971C/da not_active IP Right Cessation
- 1985-05-15 SU SU85A patent/SU1487816A3/ru active
- 1985-05-15 NO NO851963A patent/NO163744C/no unknown
- 1985-05-15 AU AU42517/85A patent/AU568435B2/en not_active Ceased
- 1985-05-15 GR GR851183A patent/GR851183B/el unknown
- 1985-05-16 EG EG305/85A patent/EG17393A/xx active
- 1985-05-16 JP JP60102795A patent/JPH0630606B2/ja not_active Expired - Lifetime
- 1985-05-16 ES ES543198A patent/ES543198A0/es active Granted
- 1985-05-16 FI FI851953A patent/FI85288C/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI851953A0 (fi)	1985-05-16
CA1241611A (en)	1988-09-06
AU568435B2 (en)	1987-12-24
FI85288C (fi)	1992-03-25
IT1173992B (it)	1987-06-24
JPH0630606B2 (ja)	1994-04-27
ES8602939A1 (es)	1985-12-16
EG17393A (en)	1989-06-30
YU44498B (en)	1990-08-31
YU80185A (en)	1988-02-29
NO851963L (no)	1985-11-18
IT8420940A0 (it)	1984-05-16
NO163744B (no)	1990-04-02
PT80453B (pt)	1987-08-19
FI851953L (fi)	1985-11-17
AU4251785A (en)	1985-11-21
SU1487816A3 (ru)	1989-06-15
IE851188L (en)	1985-11-16
PT80453A (en)	1985-06-01
DK215685A (da)	1985-11-17
IT8420940A1 (it)	1985-11-16
MX7438E (es)	1988-11-15
EP0162324B1 (en)	1988-08-17
DK161971C (da)	1992-02-10
DK161971B (da)	1991-09-02
DK215685D0 (da)	1985-05-15
ATE36541T1 (de)	1988-09-15
DE3564436D1 (en)	1988-09-22
NO163744C (no)	1990-07-11
IE58694B1 (en)	1993-11-03
EP0162324A1 (en)	1985-11-27
IN162826B (mo)	1988-07-16
ES543198A0 (es)	1985-12-16
GR851183B (mo)	1985-11-25
FI85288B (fi)	1991-12-13
JPS60255799A (ja)	1985-12-17
US5128249A (en)	1992-07-07

Publication	Publication Date	Title
EG17393A (en)	1989-06-30	Stable sulpho-adenosyl-l-methionine(same)salts,particularly suitable for oral pharmaceutical use
AU4251985A (en)	1985-11-21	Stable salts of sulpho-adenosyl-methionine with disulphonic acids
ATE11057T1 (de)	1985-01-15	Verfahren zur herstellung von d-glucoson und dfructose.
AU590852B2 (en)	1989-11-16	Effluent treatment
ES2187483T3 (es)	2003-06-16	Procedimiento para la preparacion de acido a-lipoico esento de disolvente.
GB1479880A (en)	1977-07-13	Process for the purification of aqueous solutions of glycerol
JPS6428207A (en)	1989-01-30	Sodium sulfide anhydrous single crystal and production thereof
ES434309A1 (es)	1976-11-16	Procedimiento para preparar soluciones fosforicas muy pu- ras.
SU751840A1 (ru)	1980-07-30	Электролит дл электрохимического получени пероксодикарбоната кали
ES8308518A1 (es)	1983-10-01	Procedimiento para la eliminacion de molibdeno a partir de soluciones acuosas de sales de manganeso-ii.
JPS6460391A (en)	1989-03-07	Production of gamma-halo-beta(r)-hydroxybutyric acid ester
JPS6422848A (en)	1989-01-25	Separation and purification of amino acid
JPS557095A (en)	1980-01-18	Production of itaconic acid
EP0111569A4 (en)	1984-10-11	Hydroxyalkanesulfonic acids and their derivatives, and process for their preparation.
ES2019018A6 (es)	1991-05-16	Procedimiento para el aislamiento y purificacion de acidos libres a partir de sus sales por electrodialisis.