ZA873896B - Novel triazine salt - Google Patents

Novel triazine salt

Info

Publication number: ZA873896B
Authority: ZA; South Africa
Prior art keywords: novel triazine; triazine salt; salt; novel; dichlorophenyl
Prior art date: 1986-05-30

Application number

ZA873896A

Other languages

English (en)

Inventor

David Alan Sawyer

Alan Sawyer David

Frederick Charles Copp

Charles Copp Frederick

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-05-30

Filing date

1987-05-29

Publication date

1989-01-25

1987-05-29 Application filed by Wellcome Found filed Critical Wellcome Found

1989-01-25 Publication of ZA873896B publication Critical patent/ZA873896B/xx

Links

150000003918 triazines Chemical class 0.000 title 1
CJIDZLNMKONKAD-UHFFFAOYSA-N 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine;2-hydroxyethanesulfonic acid Chemical compound OCCS(O)(=O)=O.NC1=NC(N)=NN=C1C1=CC=CC(Cl)=C1Cl CJIDZLNMKONKAD-UHFFFAOYSA-N 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
238000002347 injection Methods 0.000 abstract 1
239000007924 injection Substances 0.000 abstract 1
238000007911 parenteral administration Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA873896A 1986-05-30 1987-05-29 Novel triazine salt ZA873896B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB868613183A GB8613183D0 (en)	1986-05-30	1986-05-30	Triazine salt

Publications (1)

Publication Number	Publication Date
ZA873896B true ZA873896B (en)	1989-01-25

Family

ID=10598692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA873896A ZA873896B (en)	1986-05-30	1987-05-29	Novel triazine salt

Country Status (18)

Country	Link
US (1)	US4847249A (fr)
EP (1)	EP0247892B1 (fr)
JP (1)	JPH0751571B2 (fr)
KR (1)	KR910002254B1 (fr)
AT (1)	ATE62902T1 (fr)
AU (1)	AU597982B2 (fr)
CA (1)	CA1286670C (fr)
DE (1)	DE3769516D1 (fr)
DK (1)	DK166278C (fr)
ES (1)	ES2021709B3 (fr)
FI (1)	FI90770C (fr)
GB (1)	GB8613183D0 (fr)
GR (1)	GR3001942T3 (fr)
HU (1)	HU196769B (fr)
IE (1)	IE60626B1 (fr)
IL (1)	IL82710A (fr)
NZ (1)	NZ220497A (fr)
ZA (1)	ZA873896B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9012312D0 (en) *	1990-06-01	1990-07-18	Wellcome Found	Pharmacologically active cns compounds
US5629016A (en) *	1991-01-30	1997-05-13	Glaxo Wellcome Inc.	Water-dispersible tablets
FI20021701L (fi) *	1991-01-30	2002-09-24	Wellcome Found	Veteen dispergoituvia tabletteja
GB9124807D0 (en) *	1991-11-22	1992-01-15	Wellcome Found	Pharmaceutical formulations
GB9203483D0 (en) *	1992-02-19	1992-04-08	Wellcome Found	Anti-inflammatory compounds
AU688729B2 (en) *	1992-06-12	1998-03-19	Wellcome Foundation Limited, The	Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine isethionate for the treatment and prevention of dependence, tolerance and sensitization of drugs
GB9215908D0 (en) *	1992-07-27	1992-09-09	Wellcome Found	Water dispersible tablets
FR2699077B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
FR2699078B1 (fr) *	1992-12-16	1995-01-13	Rhone Poulenc Rorer Sa	Application de la lamotrigine dans le traitement de lésions neurologiques liées à des traumatismes.
FR2700117B1 (fr) *	1993-01-07	1995-02-03	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement de la maladie de Parkinson et des syndromes parkinsoniens.
FR2702148B1 (fr) *	1993-03-05	1995-04-07	Rhone Poulenc Rorer Sa	Application d'anticonvulsivants dans le traitement du neuro-sida.
GB9305693D0 (en) *	1993-03-19	1993-05-05	Wellcome Found	Therapeutic triazine compounds and use
US5866597A (en) *	1993-03-19	1999-02-02	Glaxo Wellcome Inc.	Use of triazine compounds for the treatment of memory and learning disorders
GB9306639D0 (en) *	1993-03-30	1993-05-26	Tocris Neuramin Limited	Organic compounds
FR2702149B1 (fr) *	1993-06-03	1995-04-07	Rhone Poulenc Rorer Sa	Application de la lamotrigine dans le traitement du neuro-sida.
US5698226A (en) *	1993-07-13	1997-12-16	Glaxo Wellcome Inc.	Water-dispersible tablets
WO1996020934A1 (fr) *	1994-12-30	1996-07-11	The Wellcome Foundation Limited	Procede de preparation de lamotrigine
GB9426448D0 (en) *	1994-12-30	1995-03-01	Wellcome Found	Process
GB9512854D0 (en) *	1995-06-23	1995-08-23	Wellcome Found	Novel formulation
GB9812413D0 (en)	1998-06-10	1998-08-05	Glaxo Group Ltd	Compound and its use
CZ20011949A3 (cs) *	1998-12-14	2001-09-12	Torrent Pharmacauticals Ltd	Zlepšený způsob výroby 3,5-diamino-6-(2,3-dichlorfenyl)-1,2,4-triazinu
WO2001049669A1 (fr) *	2000-01-03	2001-07-12	Rpg Life Sciences Limited	Procede de preparation de 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, plus connue sous le nom de lamotrigine
IL134730A (en) *	2000-02-25	2003-10-31	Chemagis Ltd	Process for preparing substituted benzoyl cyanide amidinohydrazones
IL157608A0 (en) *	2001-02-27	2004-03-28	Teva Pharma	New crystal forms of lamotrigine and processes for their preparations
AU2003234240A1 (en) *	2002-04-23	2003-11-10	Teva Pharmaceutical Industries Ltd.	Pharmaceutical composition containing lamotrigine particles of defined morphology
HU225667B1 (en)	2002-09-20	2007-05-29	Richter Gedeon Nyrt	Method for producing high-purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine
ES2209639B1 (es)	2002-10-31	2005-08-01	Vita Cientifica, S.L.	Procedimiento para la obtencion de un compuesto farmaceuticamente activo y obtencion de su intermedio.
GB2395483A (en) *	2003-07-03	2004-05-26	Jubilant Organosys Ltd	Crystalline lamotrigine and its monohydrate
US8486927B2 (en)	2007-11-09	2013-07-16	Thar Pharmaceuticals	Crystalline forms of lamotrigine
US12605388B2 (en)	2024-09-25	2026-04-21	Azurity Pharmaceuticals Ireland Limited	Lamotrigine salts, co-crystals, and compositions

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0021121B1 (fr) *	1979-06-01	1983-05-11	The Wellcome Foundation Limited	Dérivés de la triazine-1,2,4, procédé pour la préparation de tels composés et compositions pharmaceutiques les contenant
IT1145308B (it) *	1979-08-16	1986-11-05	Wellcome Found	Composti aromatici sostituiti
DE3271930D1 (en) *	1982-05-03	1986-08-14	Richardson Vicks Ltd	Pharmaceutical preparation for the topical treatment of acne
GB8328757D0 (en) *	1983-10-27	1983-11-30	Wellcome Found	Chemical compounds

1986
- 1986-05-30 GB GB868613183A patent/GB8613183D0/en active Pending
1987
- 1987-05-29 ES ES87304776T patent/ES2021709B3/es not_active Expired - Lifetime
- 1987-05-29 IL IL82710A patent/IL82710A/xx unknown
- 1987-05-29 KR KR1019870005364A patent/KR910002254B1/ko not_active Expired
- 1987-05-29 CA CA000538395A patent/CA1286670C/fr not_active Expired - Fee Related
- 1987-05-29 ZA ZA873896A patent/ZA873896B/xx unknown
- 1987-05-29 FI FI872406A patent/FI90770C/fi not_active IP Right Cessation
- 1987-05-29 EP EP87304776A patent/EP0247892B1/fr not_active Expired - Lifetime
- 1987-05-29 JP JP62134772A patent/JPH0751571B2/ja not_active Expired - Fee Related
- 1987-05-29 IE IE141587A patent/IE60626B1/en not_active IP Right Cessation
- 1987-05-29 HU HU872487A patent/HU196769B/hu not_active IP Right Cessation
- 1987-05-29 AU AU73684/87A patent/AU597982B2/en not_active Ceased
- 1987-05-29 DK DK275987A patent/DK166278C/da active
- 1987-05-29 US US07/056,136 patent/US4847249A/en not_active Expired - Lifetime
- 1987-05-29 DE DE8787304776T patent/DE3769516D1/de not_active Expired - Fee Related
- 1987-05-29 NZ NZ220497A patent/NZ220497A/xx unknown
- 1987-05-29 AT AT87304776T patent/ATE62902T1/de not_active IP Right Cessation
1991
- 1991-05-13 GR GR91400613T patent/GR3001942T3/el unknown

Also Published As

Publication number	Publication date
DE3769516D1 (de)	1991-05-29
ATE62902T1 (de)	1991-05-15
HUT45978A (en)	1988-09-28
US4847249A (en)	1989-07-11
GR3001942T3 (en)	1992-11-23
IL82710A0 (en)	1987-11-30
FI90770B (fi)	1993-12-15
FI872406L (fi)	1987-12-01
EP0247892A1 (fr)	1987-12-02
DK275987D0 (da)	1987-05-29
IE871415L (en)	1987-11-30
IE60626B1 (en)	1994-07-27
NZ220497A (en)	1990-05-28
EP0247892B1 (fr)	1991-04-24
GB8613183D0 (en)	1986-07-02
HU196769B (en)	1989-01-30
DK166278C (da)	1993-08-23
AU7368487A (en)	1987-12-03
JPH0751571B2 (ja)	1995-06-05
FI872406A0 (fi)	1987-05-29
AU597982B2 (en)	1990-06-14
FI90770C (fi)	1994-03-25
IL82710A (en)	1992-01-15
KR910002254B1 (ko)	1991-04-08
DK275987A (da)	1987-12-01
ES2021709B3 (es)	1991-11-16
DK166278B (da)	1993-03-29
JPS62289570A (ja)	1987-12-16
CA1286670C (fr)	1991-07-23
KR870011112A (ko)	1987-12-21

Publication	Publication Date	Title
GB8613183D0 (en)	1986-07-02	Triazine salt
KR0156747B1 (en)	1998-11-16	Use of 1,3-oxathiolan nucleoside analogues in the treatment of hepatitis-b
FI870421A7 (fi)	1987-07-31	Analogiamenetelmä alkueläintenvastaisesti vaikuttavien 5,6-dihydro-2-(substituoitu fenyyli)-1,2,4-triatsiini-3,5(2H,4H)-dionijohdannaisten valmistamiseksi
DE3466668D1 (en)	1987-11-12	Process for the decomposition of s-triazine derivatives in aqueous solutions
PH24055A (en)	1990-03-05	Triazine derivatives
GB2277265A (en)	1994-10-26	Use of 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine for the treatment of pain and oedema
EG19154A (en)	1994-09-29	Antiviral highly water soluble, stable, cujstaline salts of 2,3 dideoxyinosine monohydrate,2,3 dideoxy 2,3 didehydrothumidine monohydrate and 2,3 - dideoxy-2- fluoroinosine hemilydrate
GR861229B (en)	1986-09-10	Process for preparing 6- amino-3-hydrazinopyridazine derivatives
YU48589A (en)	1990-06-30	Process for improved preparation of4,4'-dinitro-stilbene-2,2'-disulphonic acid and it's salts
PT86006A (en)	1987-11-01	Process for the preparation of 2-aminomethyl-5-(2-biphenylyl)-1,3,4-thiadiazole
DE3363560D1 (en)	1986-06-26	Finely pulverized 2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine and pharmaceutically acceptable acid addition salts thereof
DE3269727D1 (en)	1986-04-10	Crystalline human leukocyte interferon
GR871510B (en)	1987-10-08	Paracetamole stable aqueous solutions for injection
GB2246792B (en)	1994-10-05	Electrochemical process for preparing 4,4'-dinitrostilbene-2,2'-disulfonic acid and the salts thereof
ZA879143B (en)	1988-06-13	Triazine derivatives
RO102375A2 (ro)	1991-12-02	Procedeu de alchilare a 2-cian-2-hidroxiiminoacetamidei (cianacetamidoximei)
IT8522214V0 (it)	1985-06-19	Bottone del tipo detto "automatico" avente anche una funzione di gancio per un bloccaggio stabile delle due parti del bottone.
CS170786A1 (en)	1987-02-12	Prumyslovy kmen houby claviceps purpurea (fr.) tul. 59 cc 5 86
IT1182606B (it)	1987-10-05	Metodo e dispositivo per effettuare mediante laser trattamenti termici con distribuzione uniforme di potenza