ZA876434B - Dihydropyridine compounds,processes for their preparation and their use - Google Patents

Dihydropyridine compounds,processes for their preparation and their use

Info

Publication number: ZA876434B
Authority: ZA; South Africa
Prior art keywords: carbon atoms; alkyl; chain; halogen; hydroxyl
Prior art date: 1986-08-30

Application number

ZA876434A

Other languages

English (en)

Inventor

Siegfried Goldmann

Goldmann Siegfried

Hans-Juergen Ahr

Ahr Hans-Juergen

Walter Puls

Puls Walter

Hilmar Bischoff

Bischoff Hilmar

Dieter Petzinna

Petzinna Dieter

Klaus Schlossmann

Schlossmann Klaus

Joachim Bender

Bender Joachim

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-30

Filing date

1987-08-28

Publication date

1988-05-25

1987-08-28 Application filed by Bayer Ag filed Critical Bayer Ag

1988-05-25 Publication of ZA876434B publication Critical patent/ZA876434B/xx

Links

125000004925 dihydropyridyl group Chemical class N1(CC=CC=C1)* 0.000 title abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 4
-1 cyano, hydroxyl Chemical group 0.000 abstract 4
229910052736 halogen Inorganic materials 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004230 chromenyl group Chemical group O1C(C=CC2=CC=CC=C12)* 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000004428 fluoroalkoxy group Chemical group 0.000 abstract 1
125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Investigating Or Analysing Biological Materials (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ZA876434A 1986-08-30 1987-08-28 Dihydropyridine compounds,processes for their preparation and their use ZA876434B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19863629545 DE3629545A1 (de)	1986-08-30	1986-08-30	Dihydropyridinverbindungen, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number	Publication Date
ZA876434B true ZA876434B (en)	1988-05-25

Family

ID=6308550

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA876434A ZA876434B (en)	1986-08-30	1987-08-28	Dihydropyridine compounds,processes for their preparation and their use

Country Status (18)

Country	Link
US (1)	US4786641A (fr)
EP (1)	EP0258729B1 (fr)
JP (1)	JPH0832685B2 (fr)
KR (1)	KR880002874A (fr)
CN (1)	CN87105876A (fr)
AT (1)	ATE52250T1 (fr)
AU (1)	AU602529B2 (fr)
CA (1)	CA1300626C (fr)
DD (1)	DD263985A5 (fr)
DE (2)	DE3629545A1 (fr)
DK (1)	DK452687A (fr)
ES (1)	ES2014456B3 (fr)
FI (1)	FI873726A7 (fr)
GR (1)	GR3000447T3 (fr)
HU (1)	HU199120B (fr)
IL (1)	IL83661A0 (fr)
PT (1)	PT85622B (fr)
ZA (1)	ZA876434B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE59410255D1 (de)	1993-12-10	2003-04-17	Bayer Ag	Phenyl-substituierte 1,4-Dihydropyridine mit cerebraler Aktivität
DE4430092A1 (de) *	1994-08-25	1996-02-29	Bayer Ag	2,3-Cyclisch kondensierte 1,4-Dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JPH11106375A (ja) *	1997-08-18	1999-04-20	Pfizer Pharmaceut Inc	ブラジキニンアンタゴニストとしての光学的に活性な１，４−ジヒドロピリジン化合物
US6711297B1 (en) *	1998-07-03	2004-03-23	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	Methods and apparatus for dynamic transfer of image data
CO5271699A1 (es)	2000-01-24	2003-04-30	Pfizer Prod Inc	Procedimiento para el tratamiento de cardiomiopatia utilizando inhibidores de la glucogeno fosforilasa
GB0021831D0 (en) *	2000-09-06	2000-10-18	Astrazeneca Ab	Chemical compounds
GB0205162D0 (en) *	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205166D0 (en)	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205175D0 (en) *	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205165D0 (en) *	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205170D0 (en)	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0205176D0 (en) *	2002-03-06	2002-04-17	Astrazeneca Ab	Chemical compounds
GB0318463D0 (en) *	2003-08-07	2003-09-10	Astrazeneca Ab	Chemical compounds
GB0318464D0 (en) *	2003-08-07	2003-09-10	Astrazeneca Ab	Chemical compounds
GB0319690D0 (en) *	2003-08-22	2003-09-24	Astrazeneca Ab	Chemical compounds
GB0319759D0 (en) *	2003-08-22	2003-09-24	Astrazeneca Ab	Chemical compounds
EP1663227A2 (fr) *	2003-09-10	2006-06-07	Synta Pharmaceuticals Corporation	Composes de dihydropyridine permettant de traiter ou de prevenir des troubles metaboliques

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB125803A (en) *	1918-05-29	1919-05-01	Joseph Ernest Barrows	Improvements in Sparking Plugs for use with Internal Combustion Engines.
GB161221A (en) *	1919-11-21	1921-03-21	Edwin William Nick	Improved method of feed-water regulation for marine boilers and means therefor
GB158138A (en) *	1919-11-25	1921-02-03	Herman Schoener	Improvements in weed cutters or hoes
DE2248150A1 (de) *	1972-09-30	1974-04-04	Bayer Ag	Dihydropyridinpolyester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US3970662A (en) *	1975-06-19	1976-07-20	Sterling Drug Inc.	4-(3-Nitrophenyl)-2,3,5,6-pyridinetetracarboxylic acid and intermediates
EP0125803A3 (fr) *	1983-04-27	1987-01-21	FISONS plc	Dihydropyridines pharmaceutiquement actives
DE3445356A1 (de) *	1983-12-15	1985-06-27	Ciba-Geigy Ag, Basel	Halogenierte thiophen-verbindungen
DE3410645A1 (de) *	1984-03-23	1985-09-26	Bayer Ag, 5090 Leverkusen	L-alkylsubstituierte 1,4-dihydropyridinlactone, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4748244A (en) *	1984-05-11	1988-05-31	Ciba-Geigy Corporation	Process for the preparation of pyridine-2-3-dicarboxylic acid derivatives, and novel 1-amino-1,4-dihydropyridine-2-3-diarboxylic acid derivatives

1986
- 1986-08-30 DE DE19863629545 patent/DE3629545A1/de not_active Withdrawn
1987
- 1987-08-18 AT AT87111924T patent/ATE52250T1/de not_active IP Right Cessation
- 1987-08-18 DE DE8787111924T patent/DE3762416D1/de not_active Expired - Lifetime
- 1987-08-18 EP EP87111924A patent/EP0258729B1/fr not_active Expired - Lifetime
- 1987-08-18 ES ES87111924T patent/ES2014456B3/es not_active Expired - Lifetime
- 1987-08-20 US US07/087,491 patent/US4786641A/en not_active Expired - Fee Related
- 1987-08-27 IL IL83661A patent/IL83661A0/xx not_active IP Right Cessation
- 1987-08-27 FI FI873726A patent/FI873726A7/fi not_active Application Discontinuation
- 1987-08-28 JP JP62213163A patent/JPH0832685B2/ja not_active Expired - Lifetime
- 1987-08-28 CA CA000545604A patent/CA1300626C/fr not_active Expired - Lifetime
- 1987-08-28 DD DD87306465A patent/DD263985A5/de not_active IP Right Cessation
- 1987-08-28 AU AU77695/87A patent/AU602529B2/en not_active Ceased
- 1987-08-28 CN CN198787105876A patent/CN87105876A/zh active Pending
- 1987-08-28 ZA ZA876434A patent/ZA876434B/xx unknown
- 1987-08-28 PT PT85622A patent/PT85622B/pt not_active IP Right Cessation
- 1987-08-28 HU HU873794A patent/HU199120B/hu not_active IP Right Cessation
- 1987-08-28 DK DK452687A patent/DK452687A/da not_active Application Discontinuation
- 1987-08-29 KR KR1019870009512A patent/KR880002874A/ko not_active Withdrawn
1990
- 1990-04-26 GR GR90400152T patent/GR3000447T3/el unknown

Also Published As

Publication number	Publication date
DE3629545A1 (de)	1988-03-10
DE3762416D1 (de)	1990-05-31
DK452687D0 (da)	1987-08-28
PT85622B (pt)	1990-05-31
AU602529B2 (en)	1990-10-18
HU199120B (en)	1990-01-29
US4786641A (en)	1988-11-22
CN87105876A (zh)	1988-03-23
ATE52250T1 (de)	1990-05-15
JPS6372674A (ja)	1988-04-02
ES2014456B3 (es)	1990-07-16
IL83661A0 (en)	1988-01-31
FI873726A7 (fi)	1988-03-01
EP0258729A2 (fr)	1988-03-09
AU7769587A (en)	1988-03-03
DD263985A5 (de)	1989-01-18
JPH0832685B2 (ja)	1996-03-29
CA1300626C (fr)	1992-05-12
HUT45014A (en)	1988-05-30
KR880002874A (ko)	1988-05-12
EP0258729B1 (fr)	1990-04-25
PT85622A (en)	1987-09-01
EP0258729A3 (en)	1988-06-15
FI873726A0 (fi)	1987-08-27
GR3000447T3 (en)	1991-06-28
DK452687A (da)	1988-03-01

Publication	Publication Date	Title
ZA876434B (en)	1988-05-25	Dihydropyridine compounds,processes for their preparation and their use
AU4929690A (en)	1990-08-16	Phenyl pyradazine-3(2H)one, thiadizin-2(3H)one, triazin-3(2H) one and oxadiazin-5(4H)one derivatives for the treatment of congestive heart failure
RU1833371C (ru)	1993-08-07	Cпocoб пoлучehия amидoпpoизboдhыx 4-фehил-3-буtehoboй kиcлotы
GR860090B (en)	1986-05-16	Methods for the preparation of 1- aryl - 4- nitropyrazole and their use as herbicide
DK153398C (da)	1988-12-12	Analogifremgangsmaade til fremstilling af substituerede 4-aminopyridiner
MY101938A (en)	1992-02-15	Benzothiazoline fungicides
TW330147B (en)	1998-04-21	Halogenobenzimidazoles, their preparation processes and their use
DE3681913D1 (de)	1991-11-14	Dihydropyridinlactole, verfahren zur herstellung und ihre verwendung in arzneimitteln.
ES554054A0 (es)	1987-04-01	Procedimiento para preparar piridin-1-oxidos varias veces substituidos
EP0197533A3 (en)	1988-01-13	Dioxolobenzisoxazole derivatives and process for preparing the same
MY104164A (en)	1994-02-28	Heterocyclic compounds.