ZA878504B - Keto-reduction of carbacyclin intermediates - Google Patents

Keto-reduction of carbacyclin intermediates

Info

Publication number: ZA878504B
Authority: ZA; South Africa
Prior art keywords: atoms; residue; coor; keto; reduction
Prior art date: 1986-11-13

Application number

ZA878504A

Other languages

English (en)

Inventor

Dahl Helmut

Buettner Gabriela

Perschel Dieter

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-13

Filing date

1987-11-12

Publication date

1988-05-04

1987-11-12 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

1988-05-04 Publication of ZA878504B publication Critical patent/ZA878504B/xx

Links

XZFRIPGNUQRGPI-WLPVIMDJSA-N Carbacyclin Chemical compound C1\C(=C\CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 XZFRIPGNUQRGPI-WLPVIMDJSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
NZTVVUIIJPWANB-UHFFFAOYSA-N 3,3a,4,5,6,6a-hexahydro-2h-pentalen-1-one Chemical class C1CCC2C(=O)CCC21 NZTVVUIIJPWANB-UHFFFAOYSA-N 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000006193 alkinyl group Chemical group 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Pyrane Compounds (AREA)

ZA878504A 1986-11-13 1987-11-12 Keto-reduction of carbacyclin intermediates ZA878504B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19863638761 DE3638761A1 (de)	1986-11-13	1986-11-13	Verbesserte ketoreduktion von carbacyclinzwischenprodukten

Publications (1)

Publication Number	Publication Date
ZA878504B true ZA878504B (en)	1988-05-04

Family

ID=6313861

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA878504A ZA878504B (en)	1986-11-13	1987-11-12	Keto-reduction of carbacyclin intermediates

Country Status (15)

Country	Link
US (1)	US5200530A (cs)
EP (1)	EP0268548B1 (cs)
JP (1)	JP2596575B2 (cs)
AT (1)	ATE66472T1 (cs)
AU (1)	AU610101B2 (cs)
CA (1)	CA1326238C (cs)
CS (1)	CS271479B2 (cs)
DD (1)	DD265623A5 (cs)
DE (2)	DE3638761A1 (cs)
ES (1)	ES2038205T3 (cs)
GR (1)	GR3002974T3 (cs)
HU (1)	HU199447B (cs)
IE (1)	IE59349B1 (cs)
WO (1)	WO1988003527A1 (cs)
ZA (1)	ZA878504B (cs)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3638757A1 (de) *	1986-11-13	1988-05-26	Schering Ag	Neues verfahren zur herstellung von optisch aktiven carbacyclin-zwischenstufen
DE3835162A1 (de) *	1988-10-13	1990-04-19	Schering Ag	(1s,2s,3r,5r)-2-((3s)-2-halogen-3-hydroxy-1-alken(inyl))-3-trialkylsilyloxy-7,7-(2,2-dimethyl-trimethylendioxy)-bicyclo-(3.3.0)-octan-verbindungen und verfahren zu deren herstellung
FR2763777B1 (fr)	1997-05-22	1999-08-13	Sgs Thomson Microelectronics	Circuit de commande d'une membrane vibrante
US7232920B2 (en) *	2003-04-22	2007-06-19	Biocon	Process for stereoselective reduction of β-ketoesters

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3225288A1 (de) *	1982-07-02	1984-01-19	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA1252780A (en) *	1983-07-26	1989-04-18	Kazuo Koyama	Carbacyclin derivatives, process for their preparation and compositions containing them
JPS60172941A (ja) *	1984-02-16	1985-09-06	Sankyo Co Ltd	カルバサイクリン類
US4522949A (en) *	1983-10-20	1985-06-11	E. R. Squibb & Sons, Inc.	7-Oxabicycloheptane substituted prostaglandin interphenylene analogs useful as cardiovascular agents
DE3405181A1 (de) *	1984-02-10	1985-08-22	Schering AG, 1000 Berlin und 4709 Bergkamen	Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

1986
- 1986-11-13 DE DE19863638761 patent/DE3638761A1/de not_active Withdrawn
1987
- 1987-11-05 DD DD87308710A patent/DD265623A5/de not_active IP Right Cessation
- 1987-11-06 CS CS877982A patent/CS271479B2/cs not_active IP Right Cessation
- 1987-11-12 AU AU82363/87A patent/AU610101B2/en not_active Ceased
- 1987-11-12 US US07/772,762 patent/US5200530A/en not_active Expired - Lifetime
- 1987-11-12 HU HU875805A patent/HU199447B/hu unknown
- 1987-11-12 WO PCT/DE1987/000519 patent/WO1988003527A1/de not_active Ceased
- 1987-11-12 IE IE304887A patent/IE59349B1/en not_active IP Right Cessation
- 1987-11-12 DE DE8787730147T patent/DE3772332D1/de not_active Expired - Lifetime
- 1987-11-12 ZA ZA878504A patent/ZA878504B/xx unknown
- 1987-11-12 AT AT87730147T patent/ATE66472T1/de not_active IP Right Cessation
- 1987-11-12 JP JP62506740A patent/JP2596575B2/ja not_active Expired - Lifetime
- 1987-11-12 EP EP87730147A patent/EP0268548B1/de not_active Expired - Lifetime
- 1987-11-12 CA CA000551617A patent/CA1326238C/en not_active Expired - Lifetime
- 1987-11-12 ES ES198787730147T patent/ES2038205T3/es not_active Expired - Lifetime
1991
- 1991-10-23 GR GR91401608T patent/GR3002974T3/el unknown

Also Published As

Publication number	Publication date
CA1326238C (en)	1994-01-18
IE59349B1 (en)	1994-02-09
DE3638761A1 (de)	1988-05-26
IE873048L (en)	1988-05-13
ATE66472T1 (de)	1991-09-15
EP0268548A3 (en)	1988-06-22
GR3002974T3 (en)	1993-01-25
WO1988003527A1 (fr)	1988-05-19
EP0268548B1 (de)	1991-08-21
AU610101B2 (en)	1991-05-16
HU199447B (en)	1990-02-28
CS798287A2 (en)	1989-09-12
DE3772332D1 (de)	1991-09-26
US5200530A (en)	1993-04-06
JP2596575B2 (ja)	1997-04-02
JPH01501390A (ja)	1989-05-18
ES2038205T3 (es)	1993-07-16
AU8236387A (en)	1988-06-01
EP0268548A2 (de)	1988-05-25
DD265623A5 (de)	1989-03-08
CS271479B2 (en)	1990-10-12
HUT46901A (en)	1988-12-28

Publication	Publication Date	Title
PH17786A (en)	1984-12-13	New methyl substituted 4-methoxy-pyridine-n-oxides to be used as intermediate in the preparation of the new intermediate
HUT44041A (en)	1988-01-28	Process for producing new diamino-androstane derivatives
DK198291D0 (da)	1991-12-09	Azidosulfat
DE3372364D1 (en)	1987-08-13	1-carboxyalkanoylperhydroindole-2-carboxylic acids and derivatives
ATE50773T1 (de)	1990-03-15	Alkylresorcinolphosphite.
HUT46901A (en)	1988-12-28	Process for keto-reduction of carbacyclin intermediers
ES8801619A1 (es)	1988-02-16	Procedimiento para la obtencion de n-6-metoxi-5(perfluoroal-quil)-1-naftoil-n-metilglicinas y sus analogos tionaftoili- cos
DE3464619D1 (en)	1987-08-13	Pentaerythritol-spiro-bis-phosphite compositions having improved hydrolytic stability
MX170732B (es)	1993-09-10	Composicion de derivados de succinimida y su uso
HUT37137A (en)	1985-11-28	Process for producing intermediates of prosteglandine analogues
CA1273946C (en)	1990-09-11	ANTICONVULSANT GAMMA-THIOBUTYROLACTONE DERIVATIVES
ES8401008A1 (es)	1983-12-16	Procedimiento para la preparacion de derivados de carbaciclina.
PL255694A1 (en)	1986-12-02	Process for preparing novel derivatives of cyclopentylbutyn-2-one
IL67839A0 (en)	1983-06-15	Novel carbacyclins,process for the preparation thereof,and pharmaceutical compositions containing the same
DE3477003D1 (en)	1989-04-13	Process for the preparation of 17-alpha-acyloxy-6-chloro-1-alpha,2-alpha-methylene-4,6-pregnadiene-3-20-diones
IE821015L (en)	1982-10-29	Aminocyclopentanol acids and esters.
RO92582B (ro)	1987-12-01	Procedeu pentru prepararea unor 5,6-dialcoxi-4-alchil-2 (1h)-chinazoline