ZA882107B - Morpholine derivatives,the process for their preparation and the pharmaceutical compositions containing them - Google Patents

Morpholine derivatives,the process for their preparation and the pharmaceutical compositions containing them

Info

Publication number: ZA882107B
Authority: ZA; South Africa
Prior art keywords: preparation; pharmaceutical compositions; compositions containing; morpholine derivatives; aralkyl
Prior art date: 1987-03-24

Application number

ZA882107A

Other languages

English (en)

Inventor

Gilbert Regnier

Regnier Gilbert

Claude Guillonneau

Guillonneau Claude

Jean Lepagnol

Lepagnol Jean

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-24

Filing date

1988-03-24

Publication date

1989-06-28

1988-03-24 Application filed by Adir filed Critical Adir

1989-06-28 Publication of ZA882107B publication Critical patent/ZA882107B/xx

Links

150000002780 morpholines Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000032683 aging Effects 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biomedical Technology (AREA)
Hospice & Palliative Care (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Control For Baths (AREA)
Earth Drilling (AREA)

ZA882107A 1987-03-24 1988-03-24 Morpholine derivatives,the process for their preparation and the pharmaceutical compositions containing them ZA882107B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8704047A FR2612926B1 (fr)	1987-03-24	1987-03-24	Nouveaux derives de la morpholine, leur procede de preparation et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number	Publication Date
ZA882107B true ZA882107B (en)	1989-06-28

Family

ID=9349348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA882107A ZA882107B (en)	1987-03-24	1988-03-24	Morpholine derivatives,the process for their preparation and the pharmaceutical compositions containing them

Country Status (17)

Country	Link
US (1)	US4782054A (de)
EP (1)	EP0286495B1 (de)
JP (1)	JPH0657709B2 (de)
AT (1)	ATE89281T1 (de)
AU (1)	AU600209B2 (de)
CA (1)	CA1313870C (de)
DE (1)	DE3880874T2 (de)
DK (1)	DK171580B1 (de)
ES (1)	ES2006390A6 (de)
FR (1)	FR2612926B1 (de)
GR (1)	GR1000241B (de)
HK (1)	HK57297A (de)
IE (1)	IE61882B1 (de)
NZ (1)	NZ223984A (de)
OA (1)	OA08822A (de)
PT (1)	PT87061B (de)
ZA (1)	ZA882107B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2653999A1 (fr) *	1989-11-06	1991-05-10	Adir	Nouveaux derives de la morpholine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US6048859A (en)	1992-06-29	2000-04-11	Merck & Co., Inc.	Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) *	1992-06-29	1997-06-10	Merck & Co., Inc.	Process for preparing morpholine tachykinin receptor antagonists
US5719147A (en) *	1992-06-29	1998-02-17	Merck & Co., Inc.	Morpholine and thiomorpholine tachykinin receptor antagonists
IL112778A0 (en) *	1994-03-04	1995-05-26	Merck & Co Inc	Substituted heterocycles, their preparation and pharmaceutical compositions containing them
BRPI0510453A (pt)	2004-04-30	2007-10-30	Warner Lambert Co	composto substituìdos com morfolina para o tratamento de distúrbios do sistema nervoso central
GB0409744D0 (en) *	2004-04-30	2004-06-09	Pfizer Ltd	Novel compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1138405A (en) *	1966-12-28	1969-01-01	Ici Ltd	Morpholine derivatives
BE758766A (fr) *	1969-11-17	1971-05-10	Ici Ltd	Nouveaux derives de la morpholine et de la

1987
- 1987-03-24 FR FR8704047A patent/FR2612926B1/fr not_active Expired
1988
- 1988-03-04 US US07/164,103 patent/US4782054A/en not_active Expired - Lifetime
- 1988-03-09 CA CA000561016A patent/CA1313870C/fr not_active Expired - Fee Related
- 1988-03-18 DK DK150088A patent/DK171580B1/da not_active IP Right Cessation
- 1988-03-23 JP JP63069198A patent/JPH0657709B2/ja not_active Expired - Lifetime
- 1988-03-23 PT PT87061A patent/PT87061B/pt not_active IP Right Cessation
- 1988-03-23 NZ NZ223984A patent/NZ223984A/xx unknown
- 1988-03-23 IE IE85188A patent/IE61882B1/en not_active IP Right Cessation
- 1988-03-23 GR GR880100179A patent/GR1000241B/el not_active IP Right Cessation
- 1988-03-23 EP EP88400693A patent/EP0286495B1/de not_active Expired - Lifetime
- 1988-03-23 AT AT88400693T patent/ATE89281T1/de active
- 1988-03-23 AU AU13520/88A patent/AU600209B2/en not_active Ceased
- 1988-03-23 DE DE88400693T patent/DE3880874T2/de not_active Expired - Fee Related
- 1988-03-24 ZA ZA882107A patent/ZA882107B/xx unknown
- 1988-03-24 ES ES8800903A patent/ES2006390A6/es not_active Expired
- 1988-03-24 OA OA59308A patent/OA08822A/xx unknown
1997
- 1997-05-01 HK HK57297A patent/HK57297A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE3880874T2 (de)	1993-12-23
ES2006390A6 (es)	1989-04-16
EP0286495A1 (de)	1988-10-12
OA08822A (fr)	1989-03-31
JPH0657709B2 (ja)	1994-08-03
DK150088A (da)	1988-09-25
GR1000241B (el)	1992-05-12
EP0286495B1 (de)	1993-05-12
PT87061B (pt)	1992-07-31
US4782054A (en)	1988-11-01
GR880100179A (en)	1989-01-31
AU1352088A (en)	1988-09-22
IE61882B1 (en)	1994-11-30
DK171580B1 (da)	1997-02-03
CA1313870C (fr)	1993-02-23
NZ223984A (en)	1990-05-28
PT87061A (pt)	1988-04-01
IE880851L (en)	1988-09-24
FR2612926A1 (fr)	1988-09-30
DK150088D0 (da)	1988-03-18
HK57297A (en)	1997-05-09
AU600209B2 (en)	1990-08-02
JPS63255279A (ja)	1988-10-21
FR2612926B1 (fr)	1989-06-09
ATE89281T1 (de)	1993-05-15
DE3880874D1 (de)	1993-06-17

Publication	Publication Date	Title
PT80661B (en)	1987-05-04	Process for preparing substituted imidazopyridines
ZA882107B (en)	1989-06-28	Morpholine derivatives,the process for their preparation and the pharmaceutical compositions containing them
DE3063288D1 (en)	1983-07-07	Paromomycin derivatives, a process for the preparation thereof and therapeutical composition containing them
HU901570D0 (en)	1990-06-28	Process for the preparation of azetidinyl-pyridonecarboxylic acid derivatives and pharmaceutical compositions containing such compounds
AU610173B2 (en)	1991-05-16	New spiro (4,5) decane derivatives, process for the preparation thereof, and pharmaceutical compositions containing them
HUT48464A (en)	1989-06-28	Process for producing pharmaceutical composition for treating hypertonia and cardiac failure
AU631465B2 (en)	1992-11-26	New morpholine derivatives, the process for the preparation thereof and the pharmaceutical compositions containing them
GR860679B (en)	1986-07-14	Novel 3-pyridylmethylnaphthyl derivatives method for their preparation and their use as medicine
AU5608790A (en)	1990-12-06	New pyrrolidone derivatives, the process for their preparation and the pharmaceutical compositions containing them
IL86169A (en)	1992-08-18	Substituted quinoxalyl-imidazolidine-2,4-diones,processes for their preparation and pharmaceutical compositions containing them
IL85229A0 (en)	1988-07-31	Novel imidazo-and triazolothiadiazines,a process for the preparation thereof,pharmaceutical compositions containing same,and the use thereof
DE3680893D1 (de)	1991-09-19	Pyrimido(5,4-b)(1,4)oxazinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel sowie zwischenprodukte darstellende pyrimido(5,4-b)(1,4)oxazinderivate.
DE3466877D1 (en)	1987-11-26	Crystalline salts of l or (s)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters and process
ZA948515B (en)	1995-06-20	Cyclised analogues of fatty acid metabolites,a process for their preparation and pharmaceutical compositions containing them
FR2592653A1 (fr)	1987-07-10	Derives de chromene, procede d'obtention et compositions pharmaceutiques.