ATE89281T1 - Morpholin-derivate, deren verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen. - Google Patents

Morpholin-derivate, deren verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Info

Publication number: ATE89281T1
Authority: AT; Austria
Prior art keywords: production; pharmaceutical compositions; compositions containing; morpholine derivatives; aralkyl
Prior art date: 1987-03-24

Application number

AT88400693T

Other languages

English (en)

Inventor

Gilbert Regnier

Claude Guillonneau

Jean Lepagnol

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-24

Filing date

1988-03-23

Publication date

1993-05-15

1988-03-23 Application filed by Adir filed Critical Adir

1993-05-15 Application granted granted Critical

1993-05-15 Publication of ATE89281T1 publication Critical patent/ATE89281T1/de

Links

YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical class C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000032683 aging Effects 0.000 abstract 1
230000002490 cerebral effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000302 ischemic effect Effects 0.000 abstract 1
150000002780 morpholines Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Cardiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Hospice & Palliative Care (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Control For Baths (AREA)
Earth Drilling (AREA)

AT88400693T 1987-03-24 1988-03-23 Morpholin-derivate, deren verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen. ATE89281T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR8704047A FR2612926B1 (fr)	1987-03-24	1987-03-24	Nouveaux derives de la morpholine, leur procede de preparation et les compositions pharmaceutiques les renfermant
EP88400693A EP0286495B1 (de)	1987-03-24	1988-03-23	Morpholin-Derivate, deren Verfahren zur Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Publications (1)

Publication Number	Publication Date
ATE89281T1 true ATE89281T1 (de)	1993-05-15

Family

ID=9349348

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT88400693T ATE89281T1 (de)	1987-03-24	1988-03-23	Morpholin-derivate, deren verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.

Country Status (17)

Country	Link
US (1)	US4782054A (de)
EP (1)	EP0286495B1 (de)
JP (1)	JPH0657709B2 (de)
AT (1)	ATE89281T1 (de)
AU (1)	AU600209B2 (de)
CA (1)	CA1313870C (de)
DE (1)	DE3880874T2 (de)
DK (1)	DK171580B1 (de)
ES (1)	ES2006390A6 (de)
FR (1)	FR2612926B1 (de)
GR (1)	GR1000241B (de)
HK (1)	HK57297A (de)
IE (1)	IE61882B1 (de)
NZ (1)	NZ223984A (de)
OA (1)	OA08822A (de)
PT (1)	PT87061B (de)
ZA (1)	ZA882107B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2653999A1 (fr) *	1989-11-06	1991-05-10	Adir	Nouveaux derives de la morpholine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
US5637699A (en) *	1992-06-29	1997-06-10	Merck & Co., Inc.	Process for preparing morpholine tachykinin receptor antagonists
US5719147A (en) *	1992-06-29	1998-02-17	Merck & Co., Inc.	Morpholine and thiomorpholine tachykinin receptor antagonists
US6048859A (en)	1992-06-29	2000-04-11	Merck & Co., Inc.	Morpholine and thiomorpholine tachykinin receptor antagonists
TW385308B (en) *	1994-03-04	2000-03-21	Merck & Co Inc	Prodrugs of morpholine tachykinin receptor antagonists
GB0409744D0 (en) *	2004-04-30	2004-06-09	Pfizer Ltd	Novel compounds
AP2006003771A0 (en)	2004-04-30	2006-10-31	Warner Lambert Co	Substituted morpholine compounds for the treatmentof central nervous system disorders

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1138405A (en) *	1966-12-28	1969-01-01	Ici Ltd	Morpholine derivatives
BE758766A (fr) *	1969-11-17	1971-05-10	Ici Ltd	Nouveaux derives de la morpholine et de la

1987
- 1987-03-24 FR FR8704047A patent/FR2612926B1/fr not_active Expired
1988
- 1988-03-04 US US07/164,103 patent/US4782054A/en not_active Expired - Lifetime
- 1988-03-09 CA CA000561016A patent/CA1313870C/fr not_active Expired - Fee Related
- 1988-03-18 DK DK150088A patent/DK171580B1/da not_active IP Right Cessation
- 1988-03-23 AT AT88400693T patent/ATE89281T1/de active
- 1988-03-23 NZ NZ223984A patent/NZ223984A/xx unknown
- 1988-03-23 AU AU13520/88A patent/AU600209B2/en not_active Ceased
- 1988-03-23 PT PT87061A patent/PT87061B/pt not_active IP Right Cessation
- 1988-03-23 GR GR880100179A patent/GR1000241B/el not_active IP Right Cessation
- 1988-03-23 DE DE88400693T patent/DE3880874T2/de not_active Expired - Fee Related
- 1988-03-23 IE IE85188A patent/IE61882B1/en not_active IP Right Cessation
- 1988-03-23 EP EP88400693A patent/EP0286495B1/de not_active Expired - Lifetime
- 1988-03-23 JP JP63069198A patent/JPH0657709B2/ja not_active Expired - Lifetime
- 1988-03-24 ZA ZA882107A patent/ZA882107B/xx unknown
- 1988-03-24 ES ES8800903A patent/ES2006390A6/es not_active Expired
- 1988-03-24 OA OA59308A patent/OA08822A/xx unknown
1997
- 1997-05-01 HK HK57297A patent/HK57297A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK57297A (en)	1997-05-09
GR880100179A (en)	1989-01-31
GR1000241B (el)	1992-05-12
PT87061B (pt)	1992-07-31
JPH0657709B2 (ja)	1994-08-03
AU1352088A (en)	1988-09-22
US4782054A (en)	1988-11-01
FR2612926B1 (fr)	1989-06-09
EP0286495A1 (de)	1988-10-12
DE3880874T2 (de)	1993-12-23
DK171580B1 (da)	1997-02-03
OA08822A (fr)	1989-03-31
PT87061A (pt)	1988-04-01
JPS63255279A (ja)	1988-10-21
DK150088A (da)	1988-09-25
ZA882107B (en)	1989-06-28
EP0286495B1 (de)	1993-05-12
IE880851L (en)	1988-09-24
DK150088D0 (da)	1988-03-18
CA1313870C (fr)	1993-02-23
IE61882B1 (en)	1994-11-30
DE3880874D1 (de)	1993-06-17
ES2006390A6 (es)	1989-04-16
AU600209B2 (en)	1990-08-02
NZ223984A (en)	1990-05-28
FR2612926A1 (fr)	1988-09-30

Publication	Publication Date	Title
DE3775882D1 (de)	1992-02-20	Substituierte 6-fluor-4-oxo-1,4-dihydrochinolin-3-carbonsaeuren ; deren derivate; diese verbindung enthaltende pharmazeutische zubereitungen und verfahren zur herstellung dieser verbindungen.
IL87034A (en)	1993-02-21	3-demethylmevalonic acid derivatives, a process for their preparation and pharmaceutical compositions containing them
ATE89281T1 (de)	1993-05-15	Morpholin-derivate, deren verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE9472T1 (de)	1984-10-15	Amino-desoxy-1.4; 3.6-dianhydro-hexit-nitrate, verfahren zu ihrer herstellung und pharmazeutische zubereitung.
ATE3429T1 (de)	1983-06-15	Paromomycin-derivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammenzetzung.
ATE104976T1 (de)	1994-05-15	Morpholinderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
AU610173B2 (en)	1991-05-16	New spiro (4,5) decane derivatives, process for the preparation thereof, and pharmaceutical compositions containing them
FR2703048B1 (fr)	1996-01-05	Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
HUT48464A (en)	1989-06-28	Process for producing pharmaceutical composition for treating hypertonia and cardiac failure
GR860679B (en)	1986-07-14	Novel 3-pyridylmethylnaphthyl derivatives method for their preparation and their use as medicine
HUT46909A (en)	1988-12-28	Process for production of substituated quinoxanileimidasoline-2,4-dions and medical preparatives containing such compositions
IL85229A0 (en)	1988-07-31	Novel imidazo-and triazolothiadiazines,a process for the preparation thereof,pharmaceutical compositions containing same,and the use thereof
DE3680893D1 (de)	1991-09-19	Pyrimido(5,4-b)(1,4)oxazinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel sowie zwischenprodukte darstellende pyrimido(5,4-b)(1,4)oxazinderivate.
DE3466877D1 (en)	1987-11-26	Crystalline salts of l or (s)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters and process
ZA948515B (en)	1995-06-20	Cyclised analogues of fatty acid metabolites,a process for their preparation and pharmaceutical compositions containing them
DE3377415D1 (en)	1988-08-25	Novel phenylpiperazine derivatives, process for preparing them and therapeutic compositions containing them