ZA882880B - - Google Patents
Info
- Publication number
- ZA882880B ZA882880B ZA882880A ZA882880A ZA882880B ZA 882880 B ZA882880 B ZA 882880B ZA 882880 A ZA882880 A ZA 882880A ZA 882880 A ZA882880 A ZA 882880A ZA 882880 B ZA882880 B ZA 882880B
- Authority
- ZA
- South Africa
- Prior art keywords
- cephem
- derivatives
- carbocyclic
- conjugated
- alkenyl
- Prior art date
Links
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- -1 dibenzylideneacetonyl Chemical group 0.000 abstract 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 150000001782 cephems Chemical class 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 229910001507 metal halide Inorganic materials 0.000 abstract 1
- 150000005309 metal halides Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/019,395 US4847373A (en) | 1987-02-26 | 1987-02-26 | Production of 3-allyl- and 3-butenyl-3-cephems |
| US07/019,396 US4870168A (en) | 1987-02-26 | 1987-02-26 | 3-Unsaturated alkyl cephems from 3-triflyl cephems |
| IE117988A IE64885B1 (en) | 1987-02-26 | 1988-04-19 | A process for the production of 3-hydrocarbyl-3-cephems |
| AU14758/88A AU602395B2 (en) | 1987-02-26 | 1988-04-19 | 3-unsaturated alkyl cephems from 3-triflyl cephems |
| FI881872A FI91760C (fi) | 1987-02-26 | 1988-04-21 | Menetelmä terapeuttisesti käyttökelpoisten 7-substituoitujen asetamido-3-alkenyyli-3-kefeemijohdannaisten valmistamiseksi |
| FI881904A FI94253C (fi) | 1987-02-26 | 1988-04-22 | Menetelmä 3-kefeemijohdannaisten valmistamiseksi |
| HU882083A HU207521B (en) | 1987-02-26 | 1988-04-25 | Process for producing 3-substituted 3-cepheme-derivatives |
| CS882885A CS272234B2 (en) | 1987-02-26 | 1988-04-28 | Method of 3-hydrocarbyl-3-cephaem derivative production |
| PT87367A PT87367B (pt) | 1987-02-26 | 1988-04-29 | Processo para a preparacao de derivados de alquil-cefem insaturados em posicao 3 a partir de novos compostos intermedios derivados de 3-triflil-cefem |
| CA000564614A CA1338644C (en) | 1987-02-26 | 1988-05-18 | Production of 3-allyl- and 3-butenyl-3-cephems |
| CN88102961A CN1035181C (zh) | 1987-02-26 | 1988-05-20 | 从3－三氟甲磺酰氧基头孢烯制备3－不饱和烃基头孢烯的方法 |
| EP88108505A EP0343277B1 (en) | 1987-02-26 | 1988-05-27 | A process for the production of 3-hydrocarbyl-3-cephems |
| JP63130057A JP2650716B2 (ja) | 1987-02-26 | 1988-05-27 | ３−アリル及び３−ブテニル−３−セフェムの製造 |
| JP63134270A JP2706090B2 (ja) | 1987-02-26 | 1988-05-31 | ３−トリフリルセフェムからの３−不飽和アルキルセフェム |
| DD88327653A DD280533A5 (de) | 1987-02-26 | 1988-06-07 | Verfahren zur herstellung von 3-trifluormethan-sulfonyloxy-3-cephem-zwischenverbindungen |
| DD88316493A DD270712A5 (de) | 1987-02-26 | 1988-06-07 | Verfahren zur herstellung von (hydrocarbyl)-3-cephem-derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA882880B true ZA882880B (cs) | 1988-10-27 |
Family
ID=39688793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA882880A ZA882880B (cs) | 1987-02-26 | 1988-04-22 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US4870168A (cs) |
| EP (2) | EP0342252A1 (cs) |
| JP (2) | JP2650716B2 (cs) |
| CN (1) | CN1035181C (cs) |
| AT (1) | ATE112571T1 (cs) |
| AU (2) | AU602395B2 (cs) |
| CA (1) | CA1338644C (cs) |
| CS (1) | CS272234B2 (cs) |
| DD (2) | DD270712A5 (cs) |
| DE (1) | DE3851749T2 (cs) |
| ES (1) | ES2060619T3 (cs) |
| FI (2) | FI91760C (cs) |
| HU (1) | HU207521B (cs) |
| IE (1) | IE64885B1 (cs) |
| PT (1) | PT87367B (cs) |
| ZA (1) | ZA882880B (cs) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4874856A (en) * | 1985-06-24 | 1989-10-17 | Bristol-Myers Company | 3-(substituted)propenyl-7-(aminothiazolylacetamido) ceph-3-em-4-carboxylic acids and esters thereof |
| GB8821797D0 (en) * | 1988-09-16 | 1988-10-19 | Beecham Group Plc | Novel compounds |
| US5245027A (en) * | 1989-11-21 | 1993-09-14 | Bristol-Myers Squibb Company | 3-fluorosulfonyloxyceph-3-em compounds |
| US5043439A (en) * | 1990-03-08 | 1991-08-27 | Bristol-Myers Squibb Company | Process for production of cephalosporins |
| DE4030706A1 (de) * | 1990-09-28 | 1992-04-02 | Bayer Ag | Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US5106842A (en) * | 1990-10-22 | 1992-04-21 | Bristol-Myers Squibb Co. | Antibiotic c-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof |
| DE4037841A1 (de) * | 1990-11-28 | 1992-06-04 | Bayer Ag | Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| AT396106B (de) * | 1991-03-08 | 1993-06-25 | Biochemie Gmbh | Neues verfahren zur herstellung von 3-vinylcephalosporinverbindungen |
| DE69233249T2 (de) | 1992-02-05 | 2004-08-19 | Biochemie Ges.M.B.H., Kundl | Verfahren zur Herstellung von einem 3-Cephem-4-Carbonsäurederivat |
| JP3224279B2 (ja) * | 1992-07-27 | 2001-10-29 | 大塚化学株式会社 | セフエム化合物の製造法 |
| US5688786A (en) * | 1994-04-01 | 1997-11-18 | Microcide Pharmaceuticals, Inc. | β-lactam antibiotics |
| US5604218A (en) * | 1994-04-01 | 1997-02-18 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
| US5698547A (en) * | 1994-04-01 | 1997-12-16 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
| MY127641A (en) * | 1995-10-12 | 2006-12-29 | Essential Therapeutics Inc | Cephalosporin antibiotics |
| US6025352A (en) * | 1997-09-29 | 2000-02-15 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
| US6030965A (en) * | 1997-09-30 | 2000-02-29 | Microcide Pharmaceuticals, Inc. | Cephalosporin antibiotics |
| JP4535530B2 (ja) * | 1999-09-20 | 2010-09-01 | 大塚化学株式会社 | ３−スルホニルオキシ−３−セフェム化合物の製造方法 |
| TW500724B (en) | 1999-10-05 | 2002-09-01 | Pharmacia & Amp Upjohn Company | Oxazinoquinolones useful for the treatment of viral infections |
| US6821969B2 (en) * | 2001-02-13 | 2004-11-23 | Pharmacia & Upjohn Company | Thioxazinoquinolones as antiviral agents |
| JP2005516011A (ja) * | 2001-12-13 | 2005-06-02 | ランバクシー ラボラトリーズ リミテッド | 結晶二水化セフニディールカリウム |
| JP2008526782A (ja) * | 2005-10-31 | 2008-07-24 | テバ ファーマシューティカル インダストリーズ リミティド | セフジニルセシウム塩結晶 |
| EP1848724A2 (en) * | 2005-10-31 | 2007-10-31 | Teva Pharmaceutical Industries Ltd | Process for the preparation of cefdinir |
| CA2702257C (en) | 2007-10-09 | 2016-07-12 | Sopharmia, Inc. | Broad spectrum beta-lactamase inhibitors |
| US9975905B2 (en) | 2013-03-12 | 2018-05-22 | Gladius Pharmaceuticals Corporation | Derivatized 3-styryl-cephalosporins |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3769277A (en) * | 1970-01-23 | 1973-10-30 | Glaxo Lab Ltd | Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group |
| US3959324A (en) * | 1972-04-26 | 1976-05-25 | The Procter & Gamble Company | Alkyltin cyclopropylcarbinylsulfonate |
| GB1377624A (en) * | 1972-07-07 | 1974-12-18 | Glaxo Lab Ltd | Cephalosporin compounds |
| JPS543087A (en) * | 1977-06-03 | 1979-01-11 | Fujisawa Pharmaceut Co Ltd | Preparation of cephalosporin compound |
| US4255423A (en) * | 1977-07-27 | 1981-03-10 | Merck & Co., Inc. | Cephalosporin compounds |
| JPS5758689A (en) * | 1980-09-25 | 1982-04-08 | Toyama Chem Co Ltd | Novel preparation of 7-substituted or unsubstituted amino-3-substituted methylcephem carboxylic acids |
| NZ198350A (en) * | 1980-09-25 | 1985-02-28 | Toyama Chemical Co Ltd | Cephalosporins and intermediates;pharmaceutical compositions |
| NZ203734A (en) * | 1982-03-31 | 1986-03-14 | Beecham Group Plc | Beta-lactam derivatives and pharmaceutical compositions |
| US4609730A (en) * | 1982-11-22 | 1986-09-02 | Fujisawa Pharmaceutical Co., Ltd. | 7-[substituted imino-2-(2-aminothiazol-4-yl)-acetamido]-3(2,2-dihalovinyl or ethynyl)-3-cephem-4-carboxylic acid (syn isomers), having antimicrobial activities |
| US4520022A (en) * | 1983-01-28 | 1985-05-28 | Bristol-Myers Company | Substituted vinyl cephalosporins |
| FR2580652B1 (fr) * | 1985-04-22 | 1989-01-06 | Bristol Myers Co | Acide 7-amino-3-propenylcephalosporanique et ses esters |
| US4708955A (en) * | 1985-06-24 | 1987-11-24 | Bristol-Myers Company | 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof |
| US4619925A (en) * | 1985-11-08 | 1986-10-28 | Bristol-Myers Company | 3-Propenyl cephalosporin derivatives |
| US4727070A (en) * | 1985-11-25 | 1988-02-23 | Bristol-Myers Company | 3-Propenzl cephalosporin isomer separation process and derivative |
-
1987
- 1987-02-26 US US07/019,396 patent/US4870168A/en not_active Expired - Lifetime
- 1987-02-26 US US07/019,395 patent/US4847373A/en not_active Expired - Lifetime
-
1988
- 1988-04-19 AU AU14758/88A patent/AU602395B2/en not_active Expired
- 1988-04-19 IE IE117988A patent/IE64885B1/en not_active IP Right Cessation
- 1988-04-21 FI FI881872A patent/FI91760C/fi not_active IP Right Cessation
- 1988-04-22 ZA ZA882880A patent/ZA882880B/xx unknown
- 1988-04-22 FI FI881904A patent/FI94253C/fi not_active IP Right Cessation
- 1988-04-25 HU HU882083A patent/HU207521B/hu unknown
- 1988-04-28 CS CS882885A patent/CS272234B2/cs not_active IP Right Cessation
- 1988-04-29 PT PT87367A patent/PT87367B/pt not_active IP Right Cessation
- 1988-05-17 EP EP88107887A patent/EP0342252A1/en not_active Withdrawn
- 1988-05-18 CA CA000564614A patent/CA1338644C/en not_active Expired - Fee Related
- 1988-05-20 AU AU16515/88A patent/AU617669B2/en not_active Expired
- 1988-05-20 CN CN88102961A patent/CN1035181C/zh not_active Expired - Lifetime
- 1988-05-27 JP JP63130057A patent/JP2650716B2/ja not_active Expired - Fee Related
- 1988-05-27 DE DE3851749T patent/DE3851749T2/de not_active Expired - Lifetime
- 1988-05-27 AT AT88108505T patent/ATE112571T1/de not_active IP Right Cessation
- 1988-05-27 EP EP88108505A patent/EP0343277B1/en not_active Expired - Lifetime
- 1988-05-27 ES ES88108505T patent/ES2060619T3/es not_active Expired - Lifetime
- 1988-05-31 JP JP63134270A patent/JP2706090B2/ja not_active Expired - Lifetime
- 1988-06-07 DD DD88316493A patent/DD270712A5/de unknown
- 1988-06-07 DD DD88327653A patent/DD280533A5/de unknown
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