ZA89232B - Acylated uridine and cytidine and use thereof - Google Patents

Acylated uridine and cytidine and use thereof

Info

Publication number: ZA89232B
Authority: ZA; South Africa
Prior art keywords: cytidine; acylated; uridine; acylated uridine; administration
Prior art date: 1987-10-28

Application number

ZA89232A

Other languages

English (en)

Inventor

Reid Von Borstel

Von Borstel Reid

Michael Kevin Bamat

Kevin Bamat Michael

Original Assignee

Pro Neuron Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-28

Filing date

1989-01-11

Publication date

1990-06-27

1989-01-11 Application filed by Pro Neuron Inc filed Critical Pro Neuron Inc

1990-06-27 Publication of ZA89232B publication Critical patent/ZA89232B/xx

Links

DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical class O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 title abstract 5
UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 title abstract 4
UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 title abstract 2
UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 title abstract 2
206010019280 Heart failures Diseases 0.000 abstract 1
DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 abstract 1
238000007429 general method Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 abstract 1
229940045145 uridine Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Biotechnology (AREA)
Orthopedic Medicine & Surgery (AREA)
Psychology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)

ZA89232A 1987-10-28 1989-01-11 Acylated uridine and cytidine and use thereof ZA89232B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US11592987A	1987-10-28	1987-10-28

Publications (1)

Publication Number	Publication Date
ZA89232B true ZA89232B (en)	1990-06-27

Family

ID=22364208

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA89232A ZA89232B (en)	1987-10-28	1989-01-11	Acylated uridine and cytidine and use thereof

Country Status (11)

Country	Link
US (1)	US5583117A (de)
EP (1)	EP0339075B1 (de)
JP (6)	JP2894610B2 (de)
AT (1)	ATE93236T1 (de)
AU (1)	AU2789989A (de)
CA (1)	CA1321994C (de)
DE (1)	DE3883374T2 (de)
IL (1)	IL88208A (de)
IN (1)	IN167680B (de)
WO (1)	WO1989003837A1 (de)
ZA (1)	ZA89232B (de)

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US3975367A (en) *	1971-06-08	1976-08-17	The Upjohn Company	Arabinofuranosyl N4 -aminoacyl cytosine containing compounds
DE2147094A1 (de) *	1971-09-21	1973-04-05	Robugen Gmbh	Virostatisch wirksames arzneimittel
US4022963A (en) *	1972-06-08	1977-05-10	Deutsch Daniel Harold	Acetylation process for nucleoside compounds
US3991045A (en) *	1973-05-30	1976-11-09	Asahi Kasei Kogyo Kabushiki Kaisha	N4 -acylarabinonucleosides
JPS5119779A (en) *	1974-08-12	1976-02-17	Asahi Chemical Ind	N44 ashiru shichijinno seizoho
JPS5223085A (en) *	1975-08-12	1977-02-21	Ajinomoto Co Inc	Selective n-deacylation of n4- - acylcytidine derivatives
JPS5524150A (en) *	1978-08-09	1980-02-21	Taiho Yakuhin Kogyo Kk	Anti-malignant-tumor agent
JPS5635196A (en) *	1979-08-29	1981-04-07	Sanyo Electric Co	Sound identification system
JPS5791994A (en) *	1980-11-26	1982-06-08	Fuji Kagaku Kogyo Kk	5'-o-(n-alkylcarbamoylalanyl)-5-fluorouridine and its preparation
DE3100478A1 (de) *	1981-01-09	1982-08-12	Dr. Thilo & Co GmbH, 8021 Sauerlach	5'ester von pyrimidinnucleosiden mit antiviraler wirksamkeit, verfahren zur herstellung und daraus hergestellte arzneimittel
JPS5849315A (ja) *	1981-09-18	1983-03-23	Mitsui Pharmaceut Inc	抗腫瘍剤
JPS60174797A (ja) *	1984-02-21	1985-09-09	Funai Corp	Ν−アロイルチミジン誘導体ならびに抗腫瘍活性物質の毒性低下剤
FR2571201B1 (fr) *	1984-10-02	1987-01-02	Valeo	Procede de chauffage dans la masse d'une substance par exemple en vue d'une vulcanisation ou d'une polymerisation
IT1178044B (it) *	1984-10-09	1987-09-03	Polifarma Spa	Agente attivo farmaceutico per il trattamento di patologie cerebrali a base di uridina
AU593271B2 (en) *	1985-07-22	1990-02-08	Teijin Limited	Antiviral treatments
US4762823A (en) *	1985-10-16	1988-08-09	Sloan-Kettering Institute For Cancer Research	Nucleosides of 5-monofluoromethyluracil and 5-difluoromethyluracil
FR2594022B1 (fr) *	1986-02-07	1988-05-27	Cousin Cie Ets A & M Freres	Articulation pour dossier de siege a grain composite.
JPH05223085A (ja) *	1992-02-07	1993-08-31	Daikin Ind Ltd	密閉形圧縮機

1988
- 1988-10-27 CA CA000581429A patent/CA1321994C/en not_active Expired - Lifetime
- 1988-10-27 JP JP63509176A patent/JP2894610B2/ja not_active Expired - Lifetime
- 1988-10-27 WO PCT/US1988/003823 patent/WO1989003837A1/en not_active Ceased
- 1988-10-27 EP EP88909932A patent/EP0339075B1/de not_active Expired - Lifetime
- 1988-10-27 DE DE88909932T patent/DE3883374T2/de not_active Expired - Lifetime
- 1988-10-27 AU AU27899/89A patent/AU2789989A/en not_active Abandoned
- 1988-10-27 AT AT88909932T patent/ATE93236T1/de not_active IP Right Cessation
- 1988-10-28 IN IN755/MAS/88A patent/IN167680B/en unknown
- 1988-10-28 IL IL8820888A patent/IL88208A/en not_active IP Right Cessation
1989
- 1989-01-11 ZA ZA89232A patent/ZA89232B/xx unknown
1993
- 1993-10-25 US US08/140,475 patent/US5583117A/en not_active Expired - Lifetime
1994
- 1994-12-07 JP JP6303877A patent/JPH07228535A/ja active Pending
1997
- 1997-02-20 JP JP03673497A patent/JP3474073B2/ja not_active Expired - Lifetime
2000
- 2000-12-13 JP JP2000379524A patent/JP2001192335A/ja not_active Withdrawn
2005
- 2005-12-28 JP JP2005380457A patent/JP2006137772A/ja not_active Withdrawn
2007
- 2007-09-07 JP JP2007233452A patent/JP2008019268A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
EP0339075A1 (de)	1989-11-02
JP2894610B2 (ja)	1999-05-24
EP0339075B1 (de)	1993-08-18
ATE93236T1 (de)	1993-09-15
JP2001192335A (ja)	2001-07-17
JP3474073B2 (ja)	2003-12-08
JP2008019268A (ja)	2008-01-31
JPH07228535A (ja)	1995-08-29
JPH02500372A (ja)	1990-02-08
AU2789989A (en)	1989-05-23
CA1321994C (en)	1993-09-07
IL88208A0 (en)	1989-06-30
HK1005740A1 (en)	1999-01-22
JP2006137772A (ja)	2006-06-01
IN167680B (de)	1990-12-08
EP0339075A4 (de)	1990-04-10
IL88208A (en)	1996-10-16
DE3883374T2 (de)	1993-12-09
JPH101436A (ja)	1998-01-06
US5583117A (en)	1996-12-10
WO1989003837A1 (en)	1989-05-05
DE3883374D1 (de)	1993-09-23

Publication	Publication Date	Title
ZA89232B (en)	1990-06-27	Acylated uridine and cytidine and use thereof
EP0151989A3 (en)	1986-10-08	Means for the treatment of cardiac diseases
HU9008407D0 (en)	1991-07-29	Process for the production of purine nucleoside derivatives and medical preparations containing them as active agents
ES8606289A1 (es)	1986-04-16	Un procedimiento para la preparacion de piridazinaminas.
IL87885A (en)	1993-06-10	Pharmaceutical compositions having antiprogestational and anti-estrogenic activities for the treatment of hormone- dependent tumors
AU3065989A (en)	1989-08-25	Polypeptide compounds having growth hormone releasing activity
FR2629715B1 (fr)	1993-09-03	Derives de l'adenosine, leur procede de preparation et leur utilisation en therapeutique
GR3017686T3 (en)	1996-01-31	Fluorocytidine derivatives, their preparation and medical preparations containing them.
ES8801303A1 (es)	1987-12-16	Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido.
UA39158C2 (uk)	2001-06-15	Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
MX9101913A (es)	1992-07-08	Derivados de quinazolinas para potenciar la actividad antitumoral
NO165843C (no)	1991-04-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-6 -substituerte adenosiner.
EP0222330A3 (de)	1988-07-06	N6-Substituierte-5'-oxydierte Adenosinanaloga
IE800102L (en)	1980-07-19	N-benzylimidazoles
PL268927A1 (en)	1989-01-23	Method of obtaining novel derivatives of benzimidazole
IT8567279A1 (it)	1986-09-22	Apparecchio per l'applicazione controllata, sul tessuto umano, di sostanze riducenti per realizzare microabrasioni.
FI886019A7 (fi)	1988-12-28	Laastari vaikuttavien aineiden valvotusti jakamiseksi iholle
GR3002377T3 (en)	1992-12-30	Ifosfamide-mesna-lyophilized composition and process to prepare it
AU2062288A (en)	1989-02-16	Combination of pyrimidine derivatives and retinoids, as separate components, for inducing and stimulating hair growth and reducing its loss
GR3005481T3 (de)	1993-05-24
ES8704962A1 (es)	1987-04-16	Un procedimiento para preparar 1b-d-ribofuranosil, 1-2-4-triazol-3-carboxamida.
ES2154290T3 (es)	2001-04-01	Estimulacion de la diferenciacion celular por sindecano.
GB2194887B (en)	1991-01-30	Composition for inducing and stimulating hair growth or for decreasing hair loss, based on pyrimidine derivatives
ATE111158T1 (de)	1994-09-15	Humaner papillomvirus typ 41.
DE3686472D1 (de)	1992-09-24	Cardiotonische phenyloxazolone.