ZA893140B - Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides - Google Patents

Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides

Info

Publication number: ZA893140B
Authority: ZA; South Africa
Prior art keywords: alkyl; imidazol; hydrogen; compounds; benzamides
Prior art date: 1988-04-28

Application number

ZA893140A

Other languages

English (en)

Inventor

Eric Cossement

Cossement Eric

Jean-Pierre Geerts

Geerts Jean-Pierre

Jean Gobert

Gobert Jean

Philippe Michel

Michel Philippe

Ernst Wuelfert

Wuelfert Ernst

Original Assignee

Ucb Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-28

Filing date

1989-04-27

Publication date

1990-01-31

1989-04-27 Application filed by Ucb Sa filed Critical Ucb Sa

1990-01-31 Publication of ZA893140B publication Critical patent/ZA893140B/xx

Links

229940054066 benzamide antipsychotics Drugs 0.000 title abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
239000005711 Benzoic acid Substances 0.000 abstract 1
125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 abstract 1
-1 amino, hydroxyl Chemical group 0.000 abstract 1
230000002253 anti-ischaemic effect Effects 0.000 abstract 1
JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Substances N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 abstract 1
DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
229910017464 nitrogen compound Inorganic materials 0.000 abstract 1
150000002830 nitrogen compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Adhesives Or Adhesive Processes (AREA)
Lubricants (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)

ZA893140A 1988-04-28 1989-04-27 Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides ZA893140B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888810067A GB8810067D0 (en)	1988-04-28	1988-04-28	Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides

Publications (1)

Publication Number	Publication Date
ZA893140B true ZA893140B (en)	1990-01-31

Family

ID=10636026

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA893140A ZA893140B (en)	1988-04-28	1989-04-27	Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides

Country Status (30)

Country	Link
US (1)	US4923865A (de)
EP (1)	EP0341231B1 (de)
JP (1)	JP2840288B2 (de)
KR (1)	KR970011275B1 (de)
AT (1)	ATE82571T1 (de)
AU (1)	AU610796B2 (de)
BR (2)	BR1100052A (de)
CA (1)	CA1310966C (de)
CY (1)	CY1758A (de)
DE (1)	DE68903531T2 (de)
DK (1)	DK205589A (de)
ES (1)	ES2052969T3 (de)
FI (1)	FI101791B1 (de)
GB (1)	GB8810067D0 (de)
GR (1)	GR3006836T3 (de)
HK (1)	HK9494A (de)
HU (1)	HU203877B (de)
IE (1)	IE63698B1 (de)
IL (1)	IL90087A0 (de)
LT (1)	LT3671B (de)
LV (1)	LV10437B (de)
MY (1)	MY104084A (de)
NO (1)	NO173331C (de)
NZ (1)	NZ228897A (de)
PH (1)	PH25461A (de)
PL (2)	PL156250B1 (de)
PT (1)	PT90368B (de)
RU (3)	RU1830063C (de)
UA (1)	UA12835A1 (de)
ZA (1)	ZA893140B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9310965D0 (en) *	1993-05-27	1993-07-14	Ucb Sa	2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
JPH09505298A (ja) *	1993-11-15	1997-05-27	シェーリングコーポレイション	Ｈ▲下３▼‐レセプターアンタゴニストとしてのフェニル‐アルキルイミダゾール
JP3294961B2 (ja) *	1993-12-10	2002-06-24	杏林製薬株式会社	新規イミダゾール誘導体及びその製造法
GB9521680D0 (en) *	1995-10-23	1996-01-03	Orion Yhtymo Oy	New use of imidazole derivatives
DE10161818A1 (de) *	2001-12-14	2003-06-26	Gruenenthal Gmbh	Substituierte 1,5-Diaminopentan-3-ol-Verbindungen
BRPI0516132A (pt) *	2004-10-07	2007-12-04	Vitae Pharmaceuticals Inc	compostos, composição destes, método de antagonização de uma ou mais proteases aspárticas e método para tratar ou melhorar um distúrbio mediado por protease aspártica
TWI411607B (zh) *	2005-11-14	2013-10-11	Vitae Pharmaceuticals Inc	天門冬胺酸蛋白酶抑制劑
CL2007002689A1 (es) *	2006-09-18	2008-04-18	Vitae Pharmaceuticals Inc	Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
WO2009096996A1 (en) *	2007-06-20	2009-08-06	Smithkline Beecham Corporation	Renin inhibitors
EP2170815A2 (de) *	2007-06-20	2010-04-07	Vitae Pharmaceuticals, Inc.	Renininhibitoren
US20090226549A1 (en) *	2008-03-06	2009-09-10	Kenneth John Hughes	Herbal extracts and flavor systems for oral products and methods of making the same
EP2307396A1 (de) *	2008-06-20	2011-04-13	Vitae Pharmaceuticals, Inc.	Renininhibitoren und verfahren zu deren anwendung
CA2729052A1 (en) *	2008-06-26	2009-12-30	Vitae Pharmaceuticals, Inc.	Salts of methyl 2-((r)-(3-chlorophenyl)((r)-1-((s)-2-(methylamino)-3((r)-tetrahydro-2h-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate
AR077692A1 (es) *	2009-08-06	2011-09-14	Vitae Pharmaceuticals Inc	Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
AU2012212323A1 (en) *	2011-02-01	2013-09-12	The Board Of Trustees Of The University Of Illinois	HDAC inhibitors and therapeutic methods using the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives
US4303485A (en)	1979-08-20	1981-12-01	Minnesota Mining And Manufacturing Company	Ultraviolet polymerization of acrylate monomers using oxidizable tin compounds
GB2092569B (en) *	1981-02-05	1984-09-19	Farmos Oy	Substituted imidazole derivatives and their preparation and use
GB2101114B (en) *	1981-07-10	1985-05-22	Farmos Group Ltd	Substituted imidazole derivatives and their preparation and use
DE3635700A1 (de)	1986-10-21	1988-04-28	Michael Schmeller	Hubeinrichtung
GB8626287D0 (en) *	1986-11-04	1986-12-03	Ucb Sa	Substituted 1h-imidazoles
GB8714013D0 (en) *	1987-06-16	1987-07-22	Ici Plc	(substituted-aralkyl)heterocyclic compounds

1988
- 1988-04-28 GB GB888810067A patent/GB8810067D0/en active Pending
1989
- 1989-03-31 CA CA000595384A patent/CA1310966C/en not_active Expired - Lifetime
- 1989-04-06 US US07/334,854 patent/US4923865A/en not_active Expired - Fee Related
- 1989-04-20 EP EP89870054A patent/EP0341231B1/de not_active Expired - Lifetime
- 1989-04-20 DE DE8989870054T patent/DE68903531T2/de not_active Expired - Fee Related
- 1989-04-20 AT AT89870054T patent/ATE82571T1/de active
- 1989-04-20 ES ES89870054T patent/ES2052969T3/es not_active Expired - Lifetime
- 1989-04-25 IL IL90087A patent/IL90087A0/xx not_active IP Right Cessation
- 1989-04-25 PL PL1989279104A patent/PL156250B1/pl unknown
- 1989-04-25 PH PH38563A patent/PH25461A/en unknown
- 1989-04-25 PL PL1989283865A patent/PL161362B1/pl unknown
- 1989-04-25 MY MYPI89000528A patent/MY104084A/en unknown
- 1989-04-26 FI FI891975A patent/FI101791B1/fi not_active IP Right Cessation
- 1989-04-26 IE IE136089A patent/IE63698B1/en not_active IP Right Cessation
- 1989-04-26 PT PT90368A patent/PT90368B/pt not_active IP Right Cessation
- 1989-04-26 NZ NZ228897A patent/NZ228897A/xx unknown
- 1989-04-27 ZA ZA893140A patent/ZA893140B/xx unknown
- 1989-04-27 JP JP1109030A patent/JP2840288B2/ja not_active Expired - Lifetime
- 1989-04-27 AU AU33730/89A patent/AU610796B2/en not_active Ceased
- 1989-04-27 NO NO891760A patent/NO173331C/no not_active IP Right Cessation
- 1989-04-27 DK DK205589A patent/DK205589A/da unknown
- 1989-04-27 RU SU894613927A patent/RU1830063C/ru active
- 1989-04-28 KR KR1019890005825A patent/KR970011275B1/ko not_active Expired - Fee Related
- 1989-04-28 HU HU892041A patent/HU203877B/hu not_active IP Right Cessation
- 1989-10-04 RU SU894742030A patent/RU1814647C/ru active
- 1989-10-04 UA UA4613927A patent/UA12835A1/uk unknown
1990
- 1990-04-05 RU SU904743506A patent/RU1836353C/ru active
1993
- 1993-01-21 GR GR930400087T patent/GR3006836T3/el unknown
- 1993-06-11 LV LVP-93-548A patent/LV10437B/lv unknown
- 1993-08-03 LT LTIP827A patent/LT3671B/lt not_active IP Right Cessation
1994
- 1994-02-02 HK HK94/94A patent/HK9494A/xx not_active IP Right Cessation
- 1994-07-15 CY CY175894A patent/CY1758A/xx unknown
1996
- 1996-09-23 BR BR1100052-0A patent/BR1100052A/pt active IP Right Grant
- 1996-10-17 BR BR1100064-3A patent/BR1100064A/pt active IP Right Grant

Also Published As

Publication number	Publication date
NO891760L (no)	1989-10-30
BR1100052A (pt)	1999-12-07
UA12835A1 (uk)	1997-02-28
PL161362B1 (pl)	1993-06-30
LT3671B (en)	1996-01-25
NO173331C (no)	1993-12-08
GB8810067D0 (en)	1988-06-02
US4923865A (en)	1990-05-08
ATE82571T1 (de)	1992-12-15
EP0341231B1 (de)	1992-11-19
LTIP827A (en)	1995-02-27
JPH01313467A (ja)	1989-12-18
PT90368B (pt)	1994-08-31
PT90368A (pt)	1989-11-10
IE891360L (en)	1989-10-28
DE68903531T2 (de)	1993-04-29
FI891975A0 (fi)	1989-04-26
BR1100064A (pt)	1999-12-07
HK9494A (en)	1994-02-09
AU610796B2 (en)	1991-05-23
NO173331B (no)	1993-08-23
JP2840288B2 (ja)	1998-12-24
DK205589A (da)	1989-10-29
AU3373089A (en)	1989-11-02
ES2052969T3 (es)	1994-07-16
PH25461A (en)	1991-07-01
IL90087A0 (en)	1989-12-15
EP0341231A1 (de)	1989-11-08
FI101791B (fi)	1998-08-31
HUT51257A (en)	1990-04-28
DK205589D0 (da)	1989-04-27
IE63698B1 (en)	1995-05-31
RU1830063C (ru)	1993-07-23
MY104084A (en)	1993-11-30
NO891760D0 (no)	1989-04-27
RU1814647C (ru)	1993-05-07
FI101791B1 (fi)	1998-08-31
CY1758A (en)	1994-07-15
KR970011275B1 (ko)	1997-07-09
PL156250B1 (pl)	1992-02-28
NZ228897A (en)	1990-08-28
FI891975A7 (fi)	1989-10-29
DE68903531D1 (de)	1992-12-24
KR890016017A (ko)	1989-11-28
LV10437B (en)	1996-04-20
RU1836353C (ru)	1993-08-23
LV10437A (lv)	1995-02-20
CA1310966C (en)	1992-12-01
GR3006836T3 (de)	1993-06-30
HU203877B (en)	1991-10-28

Publication	Publication Date	Title
GB8810067D0 (en)	1988-06-02	Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides
IL126969A (en)	2003-01-12	2,4-diaminopyrimidine derivatives, a process for their preparation, their use for the preparation of dopamine d4 antagonist pharmaceutical compositions and their use in labeling dopamine d4 receptor
ES8402559A1 (es)	1984-02-01	Un procedimiento para preparar nuevos compuestos peptidicos.
HUT40790A (en)	1987-02-27	Process for producing 2-/4-benzoyl-1-piperidinyl/-1-phenyl-alkanol derivatives and pharmaceutical compositions containing them
AU601452B2 (en)	1990-09-13	Novel aminoalkylthio derivatives of triazolopyridine or triazoloquinoline, the processes for their preparation, and drugs, useful especially as analgesics, in which they are present
HU9202143D0 (en)	1992-10-28	2-amino-pyrimidine-4-carboxamide derivatives, method for producing them pharmaceutical preparatives containing said compounds
IL63381A0 (en)	1981-10-30	5-substituted 5,10-dihydro-11h-dibenzo(b,e)(1,4)diazepin-11-one derivatives,their preparation and pharmaceutical compositions containing them
MY102578A (en)	1992-07-31	Substituted 1h-imidazoles
AU648924B2 (en)	1994-05-05	New 1-(alkoxybenzyl)piperazine amide compounds, processes for preparing them and pharmaceutical compositions containing them
ES2000907A6 (es)	1988-03-16	Procedimiento de preparar compuestos 2-oxaisocefen microbiologicamente activos
AU3265989A (en)	1989-12-21	New heteroarotinoid derivatives, processes for preparing them and pharmaceutical compositions containing them
CA2093510A1 (en)	1992-05-01	Oxysulfonyl carbamates
ES8403866A1 (es)	1984-02-01	Un metodo de producir un derivado de 4-ciano-2-azetidinona.
ES8706156A1 (es)	1987-06-01	Un procedimiento para la preparacion de compuestos de cefa- losporina
TW336224B (en)	1998-07-11	Compound useful as adhesion receptor antagonists, their preparation processes, and pharmaceutical compositions containing same
AU1012988A (en)	1988-07-14	New N-(1H-indol-4-yl)benzamide derivatives and also their salts, their application by way of medicinal products and the compositions containing them
IL71430A (en)	1987-12-31	2-imino-n-phenylsulfonyl-imidazolidine derivatives,process for the manufacture thereof and pharmaceutical preparations containing such compounds
MY106270A (en)	1995-04-29	Novel antimicrobial fluoroquinolonyl cephems.