ZA895567B - Process for the preparation of purine derivatives - Google Patents

Process for the preparation of purine derivatives

Info

Publication number: ZA895567B
Authority: ZA; South Africa
Prior art keywords: acyloxymethyl; hydroxymethyl; hydrogen; converting; group
Prior art date: 1988-07-23

Application number

ZA895567A

Other languages

English (en)

Inventor

Trevor John Grinter

John Grinter Trevor

Peter Markham Kincey

Markham Kincey Peter

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-23

Filing date

1989-07-21

Publication date

1990-07-25

1989-07-21 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1990-07-25 Publication of ZA895567B publication Critical patent/ZA895567B/xx

Links

238000000034 method Methods 0.000 title abstract 3
229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
125000000561 purinyl group Chemical class N1=C(N=C2N=CNC2=C1)* 0.000 title 1
125000005042 acyloxymethyl group Chemical group 0.000 abstract 5
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
-1 benzylthio Chemical group 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002346 iodo group Chemical group I* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/14—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with two methyl radicals in positions 1 and 3 and two methyl radicals in positions 7, 8, or 9

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Catalysts (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Mechanical Operated Clutches (AREA)

ZA895567A 1988-07-23 1989-07-21 Process for the preparation of purine derivatives ZA895567B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB888817607A GB8817607D0 (en)	1988-07-23	1988-07-23	Novel process

Publications (1)

Publication Number	Publication Date
ZA895567B true ZA895567B (en)	1990-07-25

Family

ID=10641009

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA895567A ZA895567B (en)	1988-07-23	1989-07-21	Process for the preparation of purine derivatives

Country Status (18)

Country	Link
US (1)	US5017701A (fr)
EP (1)	EP0352953B1 (fr)
JP (1)	JP2856773B2 (fr)
KR (1)	KR0137468B1 (fr)
AT (1)	ATE198479T1 (fr)
AU (1)	AU623667B2 (fr)
DE (1)	DE68929277T2 (fr)
DK (1)	DK171991B1 (fr)
ES (1)	ES2153343T3 (fr)
FI (1)	FI893535A7 (fr)
GB (1)	GB8817607D0 (fr)
HU (1)	HU204829B (fr)
MA (1)	MA21601A1 (fr)
NO (1)	NO169008C (fr)
NZ (1)	NZ230026A (fr)
PL (1)	PL161207B1 (fr)
PT (1)	PT91247B (fr)
ZA (1)	ZA895567B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5684153A (en)	1984-08-16	1997-11-04	Beecham Group Plc	Process for the preparation of purine derivatives
US5175288A (en) *	1987-08-01	1992-12-29	Beecham Group P.L.C.	Process for preparing purine derivatives and intermediates thereof
GB8822236D0 (en) *	1988-09-21	1988-10-26	Beecham Group Plc	Chemical process
GB8829571D0 (en) *	1988-12-19	1989-02-08	Wellcome Found	Antiviral compounds
GB8922076D0 (en) *	1989-09-28	1989-11-15	Beecham Group Plc	Novel process
DE4020481A1 (de) *	1990-06-27	1992-01-02	Hoechst Ag	Verfahren zur herstellung von substituierten acyclischen nukleosiden und dabei auftretende zwischenprodukte
CA2076886C (fr) *	1991-11-22	2002-06-11	Masami Igi	Methode d'obtention de 2-amino-6-halogenopurine et intermediaires de synthese
US5874578A (en) *	1992-07-13	1999-02-23	Bristol-Myers Squibb	Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
GB9407698D0 (en) *	1994-04-19	1994-06-15	Smithkline Beecham Plc	Pharmaceuticals
JP3241994B2 (ja) *	1995-07-03	2001-12-25	株式会社荏原製作所	水中モータ及び防水コネクタ
GB9615275D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
GB9615276D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
AT412211B (de) *	1996-07-20	2004-11-25	Novartis Int Pharm Ltd	Verfahren zur herstellung von penciclovir und famciclovir
GB9615253D0 (en) *	1996-07-20	1996-09-04	Smithkline Beecham Plc	Pharmaceuticals
EP0827960A1 (fr)	1996-09-10	1998-03-11	Ajinomoto Co., Inc.	Procédé pour la préparation de dérivés de purine
GB9807116D0 (en) *	1998-04-02	1998-06-03	Smithkline Beecham Plc	Novel process
GB9807114D0 (en) *	1998-04-02	1998-06-03	Smithkline Beecham Plc	Novel process
EP1352910A1 (fr) *	2002-04-10	2003-10-15	Grünenthal GmbH	Nouveaux derives d'analogues de nitrobenzylthioinosine
CA2496684A1 (fr) *	2002-08-26	2004-03-04	Teva Pharmaceutical Industries Ltd	Formes i, ii, iii cristallines solides de famciclovir et preparation de celles-ci
JP4800216B2 (ja) *	2003-10-24	2011-10-26	エグゼリクシス，インコーポレイテッド	ｐ７０Ｓ６キナーゼモジュレーターおよび使用方法
EP1747223A1 (fr) *	2004-05-18	2007-01-31	Teva Pharmaceutical Industries Ltd.	Processus de séchage pour préparer un famciclovir solide cristallin
DE602004009166T2 (de) *	2004-06-29	2008-08-21	Grünenthal GmbH	Neue Analoga von Nitrobenzylthioinosin
KR100618232B1 (ko) *	2004-09-22	2006-09-04	한미약품 주식회사	팜시클로버의 제조방법
GB2426247A (en)	2005-05-20	2006-11-22	Arrow Int Ltd	Methods of preparing purine derivatives such as famciclovir

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4347187A (en) *	1980-10-20	1982-08-31	Syntex (U.S.A.) Inc.	Process for preparing 5-aroyl 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein
US4347185A (en) *	1980-10-20	1982-08-31	Syntex (U.S.A.) Inc.	Processes for preparing 5-benzoyl-7-halo-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids
AU577303B2 (en) *	1983-08-18	1988-09-22	Novartis International Pharmaceutical Ltd	9-substituted-2-amino purines
EP0141927B1 (fr) *	1983-08-18	1991-10-30	Beecham Group Plc	Dérivés de guanine antiviraux
IL73682A (en) *	1983-12-20	1991-08-16	Medivir Ab	Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4845084A (en) *	1984-01-26	1989-07-04	Merck & Co., Inc.	Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
DE3582399D1 (de) *	1984-09-20	1991-05-08	Beecham Group Plc	Purin-derivate und ihre pharmazeutische verwendung.
EP0302644B1 (fr) *	1987-08-01	1997-01-29	Beecham Group Plc	Dérivés de purine et leur préparation
GB8922076D0 (en) *	1989-09-28	1989-11-15	Beecham Group Plc	Novel process

1988
- 1988-07-23 GB GB888817607A patent/GB8817607D0/en active Pending
1989
- 1989-07-18 AT AT89307271T patent/ATE198479T1/de not_active IP Right Cessation
- 1989-07-18 ES ES89307271T patent/ES2153343T3/es not_active Expired - Lifetime
- 1989-07-18 EP EP89307271A patent/EP0352953B1/fr not_active Expired - Lifetime
- 1989-07-18 DE DE68929277T patent/DE68929277T2/de not_active Expired - Lifetime
- 1989-07-21 US US07/383,859 patent/US5017701A/en not_active Expired - Lifetime
- 1989-07-21 PL PL1989280709A patent/PL161207B1/pl unknown
- 1989-07-21 NZ NZ230026A patent/NZ230026A/xx unknown
- 1989-07-21 DK DK362689A patent/DK171991B1/da not_active IP Right Cessation
- 1989-07-21 MA MA21853A patent/MA21601A1/fr unknown
- 1989-07-21 PT PT91247A patent/PT91247B/pt not_active IP Right Cessation
- 1989-07-21 AU AU38822/89A patent/AU623667B2/en not_active Expired
- 1989-07-21 JP JP1190386A patent/JP2856773B2/ja not_active Expired - Lifetime
- 1989-07-21 FI FI893535A patent/FI893535A7/fi not_active Application Discontinuation
- 1989-07-21 NO NO892998A patent/NO169008C/no not_active IP Right Cessation
- 1989-07-21 ZA ZA895567A patent/ZA895567B/xx unknown
- 1989-07-21 HU HU893709A patent/HU204829B/hu unknown
- 1989-07-22 KR KR1019890010404A patent/KR0137468B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5017701A (en)	1991-05-21
HK1012355A1 (en)	1999-07-30
NO169008B (no)	1992-01-20
EP0352953A3 (fr)	1991-10-23
AU3882289A (en)	1990-01-25
KR0137468B1 (ko)	1998-06-01
AU623667B2 (en)	1992-05-21
ATE198479T1 (de)	2001-01-15
NZ230026A (en)	1992-11-25
PT91247A (pt)	1990-02-08
JP2856773B2 (ja)	1999-02-10
FI893535A0 (fi)	1989-07-21
EP0352953B1 (fr)	2001-01-03
GB8817607D0 (en)	1988-09-01
HU204829B (en)	1992-02-28
HUT50820A (en)	1990-03-28
JPH0259583A (ja)	1990-02-28
EP0352953A2 (fr)	1990-01-31
DK171991B1 (da)	1997-09-08
DK362689D0 (da)	1989-07-21
NO169008C (no)	1992-04-29
NO892998D0 (no)	1989-07-21
DK362689A (da)	1990-01-24
PL161207B1 (en)	1993-06-30
ES2153343T3 (es)	2001-03-01
NO892998L (no)	1990-01-24
FI893535A7 (fi)	1990-01-24
PT91247B (pt)	1995-05-04
DE68929277T2 (de)	2001-08-23
DE68929277D1 (de)	2001-02-08
MA21601A1 (fr)	1990-04-01
KR910002856A (ko)	1991-02-26

Publication	Publication Date	Title
AU3882289A (en)	1990-01-25	A process for the preparation of 2-amino purine derivatives
HUT47128A (en)	1989-01-30	Process for producing oxetanocins and pharmaceutical compositions comprising such compounds
AU7473791A (en)	1991-10-10	Process for producing 2,2'-o-cyclonucleosides, nucleosides, and analogs thereof
AU3603989A (en)	1989-12-14	Diethylenetriamine pentaacetic acid derivatives
IE820240L (en)	1982-08-04	Carbapenem derivatives
EP0266182A3 (fr)	1988-11-02	Dérivés d'acidé gamma-lactone-carboxylique et leur préparation
PL249964A1 (en)	1985-05-07	Process for preparing novel derivatives of 7-//z/-2-/2-aminothiazolyl-4/-2-oxyiminoacetamide/-3-cephemo-4-carboxylic acid
IE830166L (en)	1983-08-01	Process for preparing an azetidinone derivative
IE883550L (en)	1989-05-30	Novel compounds
EP0331080A3 (fr)	1990-11-22	Dérivés d'imidazole, procédé pour leur préparation et leur utilisation
MX9803887A (es)	1998-09-30	Produccion de una sal de acido clavulanico.
ES8307235A1 (es)	1983-02-01	Un procedimiento para la preparacion de ranitidina.
CA2046293A1 (fr)	1990-10-06	Preparation d'ethenes a substitution
EP0147181A3 (fr)	1986-09-17	Dérivés de l'acide thiazolylacétique et leur préparation
Hood et al.	1983	Identification of 7α-hydroxycephalosporin C as an intermediate in the methoxylation of cephalosporin C by a cell free extract of Streptomyces clavuligerus
YU44630B (en)	1990-10-31	Process for preparing 6-/d(-)-alpha(4-ethyl-2,3-dioxo-1-piperazincarboxamido)-phenylacetamido/phenicilanic acid
AU2181592A (en)	1993-01-25	Novel anti-viral compounds and processes for production of anti-viral compounds
WO1994026724A3 (fr)	1995-01-19	Preparation de n-cyanodithioimino-carbonates et 3-mercapto-5-amino-1h-1,2,4-triazole
EP0529081A4 (en)	1993-06-02	Halogenated -g(b)-lactam compound and production of 3-hydroxycephem derivative therefrom
ES2060187T3 (es)	1994-11-16	Derivados de fenilglicina.
SG43092A1 (en)	1997-10-17	Process for preparing 5-arylhydantoin
ES2138535A1 (es)	2000-01-01	Procedimiento para la preparacion de los compuestos antivirales penciclovir y famciclovir.
NZ220308A (en)	1989-01-06	Process for preparing 7-amino-3-acetoxymethyl- ceph-3-em-4-carboxylic acid derivatives and analogues
JPS6419091A (en)	1989-01-23	Production of (2"r)-4'-o-tetrahydropyranyladriamycin
KR960031464A (ko)	1996-09-17	세팔로스포린 유도체의 신규한 제조방법