ZA901148B - Avermectin ketal derivatives useful as antiparasitic agents - Google Patents
Avermectin ketal derivatives useful as antiparasitic agentsInfo
- Publication number
- ZA901148B ZA901148B ZA901148A ZA901148A ZA901148B ZA 901148 B ZA901148 B ZA 901148B ZA 901148 A ZA901148 A ZA 901148A ZA 901148 A ZA901148 A ZA 901148A ZA 901148 B ZA901148 B ZA 901148B
- Authority
- ZA
- South Africa
- Prior art keywords
- avermectin
- antiparasitic agents
- derivatives useful
- ketal
- ketal derivatives
- Prior art date
Links
- 239000005660 Abamectin Substances 0.000 title abstract 3
- 239000003096 antiparasitic agent Substances 0.000 title abstract 2
- 229940125687 antiparasitic agent Drugs 0.000 title abstract 2
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract 2
- TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 abstract 1
- PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 abstract 1
- 238000007385 chemical modification Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Veterinary Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31126889A | 1989-02-16 | 1989-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA901148B true ZA901148B (en) | 1990-10-31 |
Family
ID=23206158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA901148A ZA901148B (en) | 1989-02-16 | 1990-02-15 | Avermectin ketal derivatives useful as antiparasitic agents |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5077308A (de) |
| EP (1) | EP0388019B1 (de) |
| JP (1) | JPH02270880A (de) |
| AT (1) | ATE104983T1 (de) |
| AU (1) | AU623744B2 (de) |
| CA (1) | CA2010078A1 (de) |
| DE (1) | DE69008399T2 (de) |
| DK (1) | DK0388019T3 (de) |
| ES (1) | ES2063256T3 (de) |
| NZ (1) | NZ232422A (de) |
| ZA (1) | ZA901148B (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL119649A (en) * | 1995-11-30 | 2002-03-10 | Akzo Nobel Nv | Preparation of Cyclic Kills of History - 3 keto- (5) 10, (-9) 11 steroidadians |
| KR100499438B1 (ko) * | 1997-12-03 | 2005-07-07 | 머크 앤드 캄파니 인코포레이티드 | 수소화 피마자유를 함유하는 지속성 주사제 |
| ES2359973T3 (es) | 1998-03-19 | 2011-05-30 | MERCK SHARP & DOHME CORP. | Composiciones poliméricas líquidas para la liberación controlada de sustancias bioactivas. |
| US6787342B2 (en) | 2000-02-16 | 2004-09-07 | Merial Limited | Paste formulations |
| US7001889B2 (en) * | 2002-06-21 | 2006-02-21 | Merial Limited | Anthelmintic oral homogeneous veterinary pastes |
| US20060205681A1 (en) * | 2002-06-21 | 2006-09-14 | Maryam Moaddeb | Homogenous paste formulations |
| US20040077703A1 (en) * | 2002-10-02 | 2004-04-22 | Soll Mark D. | Nodulisporic acid derivative spot-on formulations for combating parasites |
| US7531186B2 (en) | 2003-12-17 | 2009-05-12 | Merial Limited | Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz |
| US8362086B2 (en) | 2005-08-19 | 2013-01-29 | Merial Limited | Long acting injectable formulations |
| US20080027011A1 (en) * | 2005-12-20 | 2008-01-31 | Hassan Nached | Homogeneous paste and gel formulations |
| EP2465851A1 (de) | 2006-07-05 | 2012-06-20 | Aventis Agriculture | Derivate von 1-Aryl-5-alkyl-pyrazol-Verbindungen, Verfahren zu ihrer Herstellung und Methoden ihrer Verwendung |
| US8901163B2 (en) | 2007-01-03 | 2014-12-02 | Galderma S.A. | Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound |
| RS55271B1 (sr) | 2007-05-15 | 2017-02-28 | Merial Sas | Ariloazol-2-il cijanoetilamino jedinjenja, postupci dobijanja i postupci njihove primene |
| WO2009070687A1 (en) | 2007-11-26 | 2009-06-04 | Merial Limited | Solvent systems for pour-on formulations for combating parasites |
| WO2009080546A1 (en) | 2007-12-21 | 2009-07-02 | Basf Se | The use of 6-halogeno-[1,2,4]-triazolo-[1,5-a]-pyrimidine compounds for combating pests in and on animals |
| NZ590141A (en) * | 2008-06-24 | 2012-05-25 | Merial Ltd | Anthelminthic formulations including castor oil and another vegetable oil |
| AR074024A1 (es) | 2008-11-14 | 2010-12-15 | Merial Ltd | Compuesto de arilazol-2-il-cianoetilamino enantiomericamente enriquecidos, composicion plaguicida y su uso para prevenir la infeccion parasitaria |
| US9173728B2 (en) | 2008-11-19 | 2015-11-03 | Merial Inc. | Multi-cavity container having offset indentures for dispensing fluids |
| MY155497A (en) * | 2008-11-19 | 2015-10-30 | Merial Inc | Compositions comprising an aryl pyrazole and/or a formamidine, methods and use thereof |
| JP5595412B2 (ja) | 2008-12-04 | 2014-09-24 | メリアル リミテッド | 二量体アベルメクチン及びミルベマイシン誘導体 |
| CN102596968B (zh) | 2009-07-30 | 2015-05-06 | 梅里亚有限公司 | 杀虫的4-氨基-噻吩并[2,3-d]-嘧啶化合物及其使用方法 |
| CN102712583B (zh) | 2009-12-04 | 2015-04-08 | 梅里亚有限公司 | 农药用双-有机硫化合物 |
| RS54772B1 (sr) | 2009-12-17 | 2016-10-31 | Merial Sas | Antiparazitska jedinjenja dihidroazola i kompozicije koje ih sadrže |
| BR112012014933B1 (pt) | 2009-12-17 | 2020-10-27 | Merial, Inc. | composições que compreendem compostos lactonas macrocíclicas e spirodioxepinoindóis |
| UA108641C2 (uk) | 2010-04-02 | 2015-05-25 | Паразитицидна композиція, яка містить чотири активних агенти, та спосіб її застосування | |
| EP2568980B1 (de) | 2010-05-12 | 2015-11-11 | Merial, Inc. | Injizierbare parasitizide formulierungen aus levamisol und makrocyclischen lactonen |
| US8901090B2 (en) | 2010-10-20 | 2014-12-02 | Galderma S.A. | Method of treating otitis externa using macrocyclic lactone compound |
| EP2629772B1 (de) | 2010-10-20 | 2016-05-18 | Galderma S.A. | Ivermectin zur behandlung von hämorrhoiden |
| US8822528B2 (en) | 2010-11-16 | 2014-09-02 | Merial Limited | Monensin derivatives for the treatment and prevention of protozoal infections |
| WO2012078605A1 (en) | 2010-12-07 | 2012-06-14 | Merial Limited | Topical combination formulations of macrocyclic lactones with synthetic pyrethroids |
| US20120329832A1 (en) | 2011-06-27 | 2012-12-27 | Jean Delaveau | Novel Insect-Repellent Coumarin Derivatives, Syntheses, and Methods of Use |
| ES2618813T3 (es) | 2011-06-27 | 2017-06-22 | Merial, Inc. | Compuestos y composiciones de éter amido-piridílico y uso contra los parásitos |
| RS58417B1 (sr) | 2011-09-12 | 2019-04-30 | Merial Inc | Paraziticidne kompozicije koje sadrže izoksazolinsko aktivno sredstvo, postupci i upotrebe povezane sa njima |
| WO2013044118A2 (en) | 2011-09-23 | 2013-03-28 | Merial Limited | Indirect modeling of new repellent molecules active against insects, acarids, and other arthropods |
| AU2012340351B2 (en) | 2011-11-17 | 2017-06-15 | Boehringer Ingelheim Animal Health USA Inc. | Compositions comprising an aryl pyrazole and a substituted imidazole, methods and uses thereof |
| BR112014013371B1 (pt) | 2011-12-02 | 2020-04-07 | Merial Ltd | formulações de moxidectina injetável de ação prolongada e novas formas de cristal de moxidectina |
| EP3216448B8 (de) | 2012-02-06 | 2019-06-05 | Boehringer Ingelheim Animal Health USA Inc. | Parasitizide orale tiermedizinische zusammensetzungen mit systemisch wirkenden wirkstoffen, verfahren und verwendungen davon |
| JO3626B1 (ar) | 2012-02-23 | 2020-08-27 | Merial Inc | تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها |
| BR122015032741B1 (pt) | 2012-04-20 | 2019-11-26 | Merial Ltd | composições parasiticídicas compreendendo derivados de benzimidazol, métodos e seus usos |
| NZ723198A (en) | 2012-11-20 | 2018-11-30 | Boehringer Ingelheim Animal Health Usa Inc | Anthelmintic compounds and compositions and methods of using thereof |
| EP2950795B1 (de) | 2013-01-31 | 2018-04-25 | Merial, Inc. | Verfahren zur behandlung und heilung von leishmaniose mit fexinindazol |
| WO2015066277A1 (en) | 2013-11-01 | 2015-05-07 | Merial Limited | Antiparisitic and pesticidal isoxazoline compounds |
| EP3131398B1 (de) | 2014-04-17 | 2019-10-23 | Boehringer Ingelheim Animal Health USA Inc. | Verwendung von malonsäuredinitrilverbindungen für den schutz von tieren gegen parasiten |
| ES2842592T3 (es) | 2014-05-19 | 2021-07-14 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos antihelmínticos |
| EP3157912B1 (de) | 2014-06-19 | 2019-02-20 | Merial, Inc. | Parasitizide zusammensetzungen mit indolderivaten, verfahren und verwendungen davon |
| US10864193B2 (en) | 2014-10-31 | 2020-12-15 | Boehringer Ingelheim Animal Health USA Inc. | Parasiticidal compositions comprising fipronil at high concentrations |
| UY36570A (es) | 2015-02-26 | 2016-10-31 | Merial Inc | Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas |
| SG11201708068PA (en) | 2015-04-08 | 2017-10-30 | Merial Inc | Extended release injectable formulations comprising an isoxazoline active agent, methods and uses thereof |
| LT3298027T (lt) | 2015-05-20 | 2021-08-10 | Boehringer Ingelheim Animal Health USA Inc. | Antihelmintiniai depsipeptido junginiai |
| WO2016191389A2 (en) | 2015-05-27 | 2016-12-01 | Merial, Inc. | Compositions containing antimicrobial igy antibodies, for treatment and prevention of disorders and diseases caused by oral health compromising (ohc) microorganisms |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| WO2018039508A1 (en) | 2016-08-25 | 2018-03-01 | Merial, Inc. | Method for reducing unwanted effects in parasiticidal treatments |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| CA3044038A1 (en) | 2016-11-16 | 2018-05-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic depsipeptide compounds |
| WO2019005700A1 (en) | 2017-06-26 | 2019-01-03 | Merial, Inc. | DOUBLE-ACTING PARASITICIDE GRANULATE COMPOSITIONS, METHODS AND USES THEREOF |
| BR112020003217A2 (pt) | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| EP3749096A1 (de) | 2018-02-08 | 2020-12-16 | Boehringer Ingelheim Animal Health USA Inc. | Parasitizide zusammensetzungen mit eprinomectin und praziquantel, verfahren und verwendungen davon |
| AU2019301510B2 (en) | 2018-07-09 | 2024-06-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Anthelminthic heterocyclic compounds |
| CN113260419A (zh) | 2018-11-20 | 2021-08-13 | 勃林格殷格翰动物保健美国公司 | 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法 |
| NZ776819A (en) | 2019-01-16 | 2023-04-28 | Boehringer Ingelheim Animal Health Usa Inc | Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof |
| AU2020231319A1 (en) | 2019-03-01 | 2021-10-21 | Boehringer Ingelheim Animal Health USA Inc. | Injectable clorsulon compositions, methods and uses thereof |
| CA3133100A1 (en) | 2019-03-19 | 2020-09-24 | Boehringer Ingelheim Animal Health USA Inc. | Anthelmintic aza-benzothiophene and aza-benzofuran compounds |
| BR112022000982A2 (pt) | 2019-07-22 | 2022-03-08 | Intervet Int Bv | Forma de dosagem veterinária mastigável macia |
| KR20230028268A (ko) | 2020-05-29 | 2023-02-28 | 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 | 구충성 헤테로시클릭 화합물 |
| WO2022140728A1 (en) | 2020-12-21 | 2022-06-30 | Boehringer Ingelheim Animam Health Usa Inc. | Parasiticidal collar comprising isoxazoline compounds |
| WO2025257633A1 (en) | 2024-06-12 | 2025-12-18 | Boehringer Ingelheim Vetmedica Gmbh | Long-acting castor oil-containing injectable formulations and methods of use thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950360A (en) * | 1972-06-08 | 1976-04-13 | Sankyo Company Limited | Antibiotic substances |
| SE434277B (sv) * | 1976-04-19 | 1984-07-16 | Merck & Co Inc | Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis |
| USRE32006E (en) * | 1977-12-19 | 1985-10-15 | Merck & Co., Inc. | 13-Halo and 13-deoxy C-076 compounds |
| USRE32032E (en) * | 1978-02-10 | 1985-11-19 | Foam Cutting Engineers, Inc. | Method of densifying open-celled polyurethane material |
| US4200581A (en) * | 1978-08-04 | 1980-04-29 | Merck & Co., Inc. | Alkyl derivatives of C-076 compounds |
| JPS59108785A (ja) * | 1982-11-25 | 1984-06-23 | Sankyo Co Ltd | ミルベマイシン類の5−オキシム誘導体 |
| EP0170006B1 (de) * | 1984-06-05 | 1992-07-08 | American Cyanamid Company | Wirkstoffe und deren Herstellungsverfahren, Verfahren und Zusamensetzungen, die diese Wirkstoffe enthalten zur Bekämpfung von helmintischen, arthropodischen, ectoparasitischen und acaridischen Infektionen |
| FR2570390B1 (fr) * | 1984-09-14 | 1987-11-27 | Glaxo Group Ltd | Nouveaux composes antibiotiques et procede de preparation |
| HUT39739A (en) * | 1984-12-04 | 1986-10-29 | Ciba Geigy Ag | Process for production of derivatives of 13,3-milbemycin and medical preparatives containing thereof |
| EP0254583B1 (de) * | 1986-07-24 | 1994-09-07 | Beecham Group Plc | Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen |
| DE3889676D1 (de) * | 1987-02-04 | 1994-06-30 | Ciba Geigy | Mikrobielles Verfahren zur Herstellung von Milbemycin-Derivaten. |
| US4871719A (en) * | 1987-03-24 | 1989-10-03 | Ciba-Geigy Corporation | Composition for controlling parasites in productive livestock |
-
1990
- 1990-02-08 NZ NZ232422A patent/NZ232422A/xx unknown
- 1990-02-14 CA CA002010078A patent/CA2010078A1/en not_active Abandoned
- 1990-02-15 ZA ZA901148A patent/ZA901148B/xx unknown
- 1990-02-15 DK DK90301638.4T patent/DK0388019T3/da active
- 1990-02-15 AU AU49830/90A patent/AU623744B2/en not_active Ceased
- 1990-02-15 EP EP90301638A patent/EP0388019B1/de not_active Expired - Lifetime
- 1990-02-15 DE DE69008399T patent/DE69008399T2/de not_active Expired - Fee Related
- 1990-02-15 AT AT9090301638T patent/ATE104983T1/de active
- 1990-02-15 ES ES90301638T patent/ES2063256T3/es not_active Expired - Lifetime
- 1990-02-16 JP JP2034038A patent/JPH02270880A/ja active Pending
- 1990-07-23 US US07/556,044 patent/US5077308A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2063256T3 (es) | 1995-01-01 |
| AU4983090A (en) | 1991-08-29 |
| EP0388019A1 (de) | 1990-09-19 |
| JPH02270880A (ja) | 1990-11-05 |
| US5077308A (en) | 1991-12-31 |
| AU623744B2 (en) | 1992-05-21 |
| CA2010078A1 (en) | 1990-08-16 |
| DK0388019T3 (da) | 1994-05-24 |
| DE69008399T2 (de) | 1994-10-27 |
| NZ232422A (en) | 1992-11-25 |
| EP0388019B1 (de) | 1994-04-27 |
| ATE104983T1 (de) | 1994-05-15 |
| DE69008399D1 (de) | 1994-06-01 |
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