ZA902397B - (3h)-pteridinones,preparation processes and drugs containing them - Google Patents

(3h)-pteridinones,preparation processes and drugs containing them

Info

Publication number: ZA902397B
Authority: ZA; South Africa
Prior art keywords: pteridinones; preparation processes; drugs containing; drugs; processes
Prior art date: 1989-03-30

Application number

ZA902397A

Other languages

English (en)

Inventor

Gerard Ferrand

Ferrand Gerard

Herve Dumas

Dumas Herve

Jean-Claude Depin

Depin Jean-Claude

Yvette Quentin

Quentin Yvette

Original Assignee

Lipha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-30

Filing date

1990-03-28

Publication date

1991-01-30

1990-03-28 Application filed by Lipha filed Critical Lipha

1991-01-30 Publication of ZA902397B publication Critical patent/ZA902397B/xx

Links

239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
238000002360 preparation method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Pulmonology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA902397A 1989-03-30 1990-03-28 (3h)-pteridinones,preparation processes and drugs containing them ZA902397B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8904193A FR2645152B1 (fr)	1989-03-30	1989-03-30	3h-pteridinones-4, procedes de preparation et medicaments les contenant

Publications (1)

Publication Number	Publication Date
ZA902397B true ZA902397B (en)	1991-01-30

Family

ID=9380213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA902397A ZA902397B (en)	1989-03-30	1990-03-28	(3h)-pteridinones,preparation processes and drugs containing them

Country Status (30)

Country	Link
US (1)	US5167949A (de)
EP (1)	EP0399856B1 (de)
JP (1)	JPH0725761B2 (de)
AR (1)	AR248278A1 (de)
AT (1)	ATE126229T1 (de)
AU (1)	AU630178B2 (de)
CA (1)	CA2013324C (de)
CZ (1)	CZ284679B6 (de)
DD (1)	DD296927A5 (de)
DE (1)	DE69021444T2 (de)
DK (1)	DK0399856T3 (de)
ES (1)	ES2078324T3 (de)
FR (1)	FR2645152B1 (de)
GE (1)	GEP19971023B (de)
GR (1)	GR3017245T3 (de)
HR (1)	HRP920759B1 (de)
HU (1)	HU208826B (de)
IE (1)	IE68689B1 (de)
IL (1)	IL93914A (de)
LV (1)	LV5821B4 (de)
MA (1)	MA21786A1 (de)
NO (1)	NO175100C (de)
NZ (1)	NZ233130A (de)
OA (1)	OA09441A (de)
PT (1)	PT93600B (de)
RU (1)	RU1836344C (de)
SI (1)	SI9010633B (de)
TN (1)	TNSN90040A1 (de)
YU (1)	YU47346B (de)
ZA (1)	ZA902397B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5270465A (en) *	1989-03-30	1993-12-14	Lipha, Lyonnaise Industrille Pharmaceutique	4(3H)-pteridinone compounds
FR2772615B1 (fr)	1997-12-23	2002-06-14	Lipha	Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
US6806272B2 (en)	2001-09-04	2004-10-19	Boehringer Ingelheim Pharma Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
UY27427A1 (es) *	2001-09-04	2003-03-31	Boehringer Ingelheim Pharma	Nuevas dihidro-pteridinonas, procedimientos para su preparación y su utilización como medicamentos
FR2831789B1 (fr)	2001-11-07	2004-01-23	Oreal	Procede et dispositif pour l'evaluation de la secheresse cutanee notamment
US6861422B2 (en)	2003-02-26	2005-03-01	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
DE102004029784A1 (de)	2004-06-21	2006-01-05	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel
DE102004033670A1 (de)	2004-07-09	2006-02-02	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel
US20060074088A1 (en)	2004-08-14	2006-04-06	Boehringer Ingelheim International Gmbh	Dihydropteridinones for the treatment of cancer diseases
US20060035903A1 (en) *	2004-08-14	2006-02-16	Boehringer Ingelheim International Gmbh	Storage stable perfusion solution for dihydropteridinones
US7728134B2 (en)	2004-08-14	2010-06-01	Boehringer Ingelheim International Gmbh	Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament
US20060058311A1 (en)	2004-08-14	2006-03-16	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation
US7759485B2 (en)	2004-08-14	2010-07-20	Boehringer Ingelheim International Gmbh	Process for the manufacture of dihydropteridinones
EP1630163A1 (de)	2004-08-25	2006-03-01	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1632493A1 (de)	2004-08-25	2006-03-08	Boehringer Ingelheim Pharma GmbH & Co.KG	Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102004058337A1 (de) *	2004-12-02	2006-06-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US7439358B2 (en)	2006-02-08	2008-10-21	Boehringer Ingelheim International Gmbh	Specific salt, anhydrous and crystalline form of a dihydropteridione derivative
EP2139895A1 (de) *	2007-03-23	2010-01-06	F. Hoffmann-Roche AG	Azapyridopyrimidinonderivate
EP2185559A1 (de)	2007-08-03	2010-05-19	Boehringer Ingelheim International GmbH	Kristalline form eines dihydropteridionderivats
US8546566B2 (en)	2010-10-12	2013-10-01	Boehringer Ingelheim International Gmbh	Process for manufacturing dihydropteridinones and intermediates thereof
US9358233B2 (en)	2010-11-29	2016-06-07	Boehringer Ingelheim International Gmbh	Method for treating acute myeloid leukemia
US9370535B2 (en)	2011-05-17	2016-06-21	Boehringer Ingelheim International Gmbh	Method for treatment of advanced solid tumors
JP2016525532A (ja)	2013-07-26	2016-08-25	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	骨髄異形成症候群の処置
US9867831B2 (en)	2014-10-01	2018-01-16	Boehringer Ingelheim International Gmbh	Combination treatment of acute myeloid leukemia and myelodysplastic syndrome

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3159628A (en) *	1962-05-28	1964-12-01	Smith Kline French Lab	Pteridine-5-oxide derivatives
US3426019A (en) *	1962-06-29	1969-02-04	Smithkline Corp	Derivatives of pteridine and a method for their preparation
SE307365B (de) *	1966-05-28	1969-01-07	Yoshitomi Pharmaceutical
US3732224A (en) *	1969-10-20	1973-05-08	Sherwin Williams Co	Method of controlling plant growth and 3-substituted lumazines used in such method
US3819631A (en) *	1970-12-15	1974-06-25	May & Baker Ltd	Azapurinones
US3859287A (en) *	1971-05-05	1975-01-07	Walter Wesley Parish	Thiopteridines and process for producing same
DE2232098A1 (de) *	1972-06-30	1974-01-17	Boehringer Mannheim Gmbh	2-alkyl-4(3h)-pteridinone und verfahren zu ihrer herstellung
US4183934A (en) *	1978-10-16	1980-01-15	Abbott Laboratories	4-Hydroxy-7-(substituted)phenylpteridines
US4361700A (en) *	1980-05-20	1982-11-30	James S. Waldron	Pyridopyrimidinone derivatives

1989
- 1989-03-30 FR FR8904193A patent/FR2645152B1/fr not_active Expired - Lifetime
1990
- 1990-03-26 AU AU52218/90A patent/AU630178B2/en not_active Ceased
- 1990-03-27 ES ES90400827T patent/ES2078324T3/es not_active Expired - Lifetime
- 1990-03-27 IL IL9391490A patent/IL93914A/en not_active IP Right Cessation
- 1990-03-27 EP EP90400827A patent/EP0399856B1/de not_active Expired - Lifetime
- 1990-03-27 DE DE69021444T patent/DE69021444T2/de not_active Expired - Fee Related
- 1990-03-27 OA OA59755A patent/OA09441A/xx unknown
- 1990-03-27 MA MA22052A patent/MA21786A1/fr unknown
- 1990-03-27 AT AT90400827T patent/ATE126229T1/de not_active IP Right Cessation
- 1990-03-27 DK DK90400827.3T patent/DK0399856T3/da active
- 1990-03-28 CA CA002013324A patent/CA2013324C/fr not_active Expired - Fee Related
- 1990-03-28 ZA ZA902397A patent/ZA902397B/xx unknown
- 1990-03-28 CZ CS901520A patent/CZ284679B6/cs not_active IP Right Cessation
- 1990-03-29 HU HU901898A patent/HU208826B/hu not_active IP Right Cessation
- 1990-03-29 RU SU904743545A patent/RU1836344C/ru active
- 1990-03-29 SI SI9010633A patent/SI9010633B/sl not_active IP Right Cessation
- 1990-03-29 YU YU63390A patent/YU47346B/sh unknown
- 1990-03-29 PT PT93600A patent/PT93600B/pt not_active IP Right Cessation
- 1990-03-29 DD DD90339197A patent/DD296927A5/de unknown
- 1990-03-29 US US07/501,104 patent/US5167949A/en not_active Expired - Fee Related
- 1990-03-29 AR AR90316504A patent/AR248278A1/es active
- 1990-03-29 NO NO901430A patent/NO175100C/no not_active IP Right Cessation
- 1990-03-29 IE IE115790A patent/IE68689B1/en not_active IP Right Cessation
- 1990-03-29 NZ NZ233130A patent/NZ233130A/en unknown
- 1990-03-30 JP JP2081429A patent/JPH0725761B2/ja not_active Expired - Fee Related
- 1990-03-30 TN TNTNSN90040A patent/TNSN90040A1/fr unknown
1992
- 1992-10-01 HR HRP-633/90A patent/HRP920759B1/xx not_active IP Right Cessation
1993
- 1993-03-11 GE GEAP1993603A patent/GEP19971023B/en unknown
1995
- 1995-08-30 GR GR950402356T patent/GR3017245T3/el unknown
1996
- 1996-07-18 LV LV960271A patent/LV5821B4/xx unknown

Also Published As

Publication number	Publication date
CA2013324C (fr)	2001-08-21
YU47346B (sh)	1995-01-31
NO901430D0 (no)	1990-03-29
HRP920759B1 (en)	1998-08-31
LV5821A4 (lv)	1997-04-20
LV5821B4 (lv)	1997-10-20
MA21786A1 (fr)	1990-10-01
CZ284679B6 (cs)	1999-02-17
NZ233130A (en)	1992-01-29
GEP19971023B (en)	1997-06-13
GR3017245T3 (en)	1995-11-30
PT93600A (pt)	1990-11-20
YU63390A (en)	1991-10-31
DK0399856T3 (da)	1995-09-18
HUT53646A (en)	1990-11-28
EP0399856A1 (de)	1990-11-28
IE68689B1 (en)	1996-07-10
JPH02304089A (ja)	1990-12-17
FR2645152B1 (fr)	1991-05-31
IE901157L (en)	1990-09-30
NO175100C (no)	1994-08-31
IL93914A0 (en)	1990-12-23
AU5221890A (en)	1990-10-04
HRP920759A2 (en)	1995-06-30
CA2013324A1 (fr)	1990-09-30
JPH0725761B2 (ja)	1995-03-22
ATE126229T1 (de)	1995-08-15
SI9010633A (en)	1997-02-28
SI9010633B (sl)	1999-06-30
US5167949A (en)	1992-12-01
NO175100B (no)	1994-05-24
RU1836344C (ru)	1993-08-23
NO901430L (no)	1990-10-01
TNSN90040A1 (fr)	1991-03-05
EP0399856B1 (de)	1995-08-09
DD296927A5 (de)	1991-12-19
HU208826B (en)	1994-01-28
IL93914A (en)	1994-02-27
DE69021444T2 (de)	1996-03-14
FR2645152A1 (fr)	1990-10-05
HU901898D0 (en)	1990-08-28
PT93600B (pt)	1996-03-29
AR248278A1 (es)	1995-07-12
CZ152090A3 (cs)	1998-11-11
AU630178B2 (en)	1992-10-22
OA09441A (fr)	1992-10-15
DE69021444D1 (de)	1995-09-14
ES2078324T3 (es)	1995-12-16

Publication	Publication Date	Title
AU5221890A (en)	1990-10-04	4(3h)-pteridinones, preparation processes and drugs containing them
ZA87107B (en)	1987-08-26	Diarylalkyl-substituted alkylamines,processes for their preparation,their use,and medicaments containing them
OA08707A (en)	1989-03-31	Tertiary hydroxyalkylxanthines, processes for their preparation, medicaments containing them and their use.
IL83198A0 (en)	1987-12-31	Benzenesulphonamidoindanyl derivatives,their preparation and medicaments containing them
IL93954A0 (en)	1990-12-23	5-alkylquinolonecarboxylic acids,their preparation and medicaments containing them
HU903281D0 (en)	1990-10-28	Process for producing 2-hydroxy-n-propyl-amines and containing them pharmaceutical preparatives
AU629602B2 (en)	1992-10-08	Derivatives of benzocycloalkenyldihydroxyalkanoic, processes of preparation and medications containing them
ZA879166B (en)	1988-06-14	Pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them
IL81676A0 (en)	1987-09-16	Naphthothiazepinones,their manufacture and medicaments containing them
GR3002516T3 (en)	1993-01-25	(s)-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate, process for its preparation and pharmaceutical preparation containing it
LTIP1406A (en)	1995-05-25	Edulcorant and its preparation process
EP0543263A3 (en)	1993-08-25	Benziimidazoles, pharmaceuticals containing them and process for their preparation
IL94639A0 (en)	1991-04-15	Renin-inhibiting peptides,their preparation and medicaments containing them
ZA871756B (en)	1987-09-01	Arylazolylmethylbenzocycloalkene derivatives,processes for the preparation thereof,and the use thereof
AR242193A1 (es)	1993-03-31	Procedimiento para la preparacion de 4-/4,5-dihidro-2-imidazolil(o 2-oxazolil o 2-tiazolil)7-amino-5(o 3,5)-halogeno benzamida e intermediarios de sintesis utilizados segun dicho procedimiento.
EP0488009A3 (en)	1992-08-19	Piperidinoalkyl-benzoxazine-and-thiazine-compounds, processes for their preparation and drugs containing them
EP0413999A3 (en)	1992-01-08	N,n-bis-1,3,5-triazine-6-yl-piperazines and processes for their preparation
ZA886915B (en)	1989-05-30	4-azasaccharines,4-aza-dihydro-or-tetrahydro-saccharines and processes for the preparation thereof
IL84509A0 (en)	1988-04-29	Pyrrolo-benzimidazoles,their preparation and pharmaceutical composition containing them
IL88673A0 (en)	1989-07-31	N-hydroxy-5-phenyl-2-furancarboxi-midamides,and pharmaceutical compositions containing them
CS343490A3 (en)	1992-01-15	Pharmaceutical
IL93589A0 (en)	1990-12-23	Bisphenethanolamine,its preparation and preparations containing it
EP0344112A3 (en)	1990-04-11	Substituted bisacyloxynaphthacenes, and process for the preparation of tetrathiotetracenes
EP0240352A3 (en)	1988-11-23	5-fluorouracil derivatives and processes for producing thereof
HU900122D0 (en)	1990-03-28	Process for desallylasation of n-allyl-anilines and n,n-diallyl-anilines