ZA902747B - Modification of plasminogen activators - Google Patents

Modification of plasminogen activators

Info

Publication number
ZA902747B
ZA902747B ZA902747A ZA902747A ZA902747B ZA 902747 B ZA902747 B ZA 902747B ZA 902747 A ZA902747 A ZA 902747A ZA 902747 A ZA902747 A ZA 902747A ZA 902747 B ZA902747 B ZA 902747B
Authority
ZA
South Africa
Prior art keywords
phosphorylated
plasminogen activator
pro
unphosphorylated
modification
Prior art date
Application number
ZA902747A
Other languages
English (en)
Inventor
Francesco Blasi
Blasi Francesco
Maria Patrizia Stoppelli
Patrizia Stoppelli Maria
Maria Rosaria Mastronicola
Rosaria Mastronicola Maria
Karen Gjersing Welinder
Gjersing Welinder Karen
Isabel Correas
Correas Isabel
Original Assignee
Blasi Francesco
Patrizia Stoppelli Maria
Rosaria Mastronicola Maria
Gjersing Welinder Karen
Correas Isabel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Blasi Francesco, Patrizia Stoppelli Maria, Rosaria Mastronicola Maria, Gjersing Welinder Karen, Correas Isabel filed Critical Blasi Francesco
Publication of ZA902747B publication Critical patent/ZA902747B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
ZA902747A 1989-04-14 1990-04-10 Modification of plasminogen activators ZA902747B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK182289A DK182289D0 (da) 1989-04-14 1989-04-14 Modifikation af proteiner

Publications (1)

Publication Number Publication Date
ZA902747B true ZA902747B (en) 1991-01-30

Family

ID=8108312

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA902747A ZA902747B (en) 1989-04-14 1990-04-10 Modification of plasminogen activators

Country Status (16)

Country Link
US (2) US5416006A (de)
EP (1) EP0422198B1 (de)
JP (1) JPH03505530A (de)
KR (1) KR920700285A (de)
AT (1) ATE120797T1 (de)
AU (1) AU623522B2 (de)
CA (1) CA2031210A1 (de)
DE (1) DE69018361T2 (de)
DK (1) DK182289D0 (de)
ES (1) ES2072432T3 (de)
HU (1) HUT56130A (de)
IL (1) IL94070A0 (de)
NZ (1) NZ233321A (de)
PT (1) PT93755A (de)
WO (1) WO1990012872A1 (de)
ZA (1) ZA902747B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ267291A (en) * 1993-05-28 1997-09-22 Chiron Corp Peptide inhibitors of urokinase receptor activity
JPH08508172A (ja) 1993-06-01 1996-09-03 カイロン コーポレイション ウロキナーゼプラスミノーゲン活性化因子インヒビターの発現
US6248715B1 (en) * 1993-06-01 2001-06-19 Chiron Corporation Method of treating a urokinase-type plasminogen activator-mediated disorder
US6936587B1 (en) * 1997-07-25 2005-08-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions
US5994309A (en) 1997-07-25 1999-11-30 Angstrom Pharmaceuticals, Inc. Anti-invasive and anti-angiogenic compositions and methods
JP4187106B2 (ja) * 2002-01-31 2008-11-26 ジーエルサイエンス株式会社 アミノ酸、ペプチド、タンパク質、糖又は脂質分析方法及び装置
RU2216348C1 (ru) * 2002-11-14 2003-11-20 Общество с ограниченной ответственностью "Научно-производственное предприятие "Техноген" Фармацевтическая композиция, обладающая тромболитическим и фибринолитическим действием

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0190711B1 (de) * 1985-02-07 1989-04-26 Kowa Company, Ltd. Monoklonale Antikörper gegen den Gewebeplasminogenaktivator von normalen menschlichen Zellen
GB8623823D0 (en) * 1986-10-03 1986-11-05 Sandoz Ltd Therapeutic lysis of fibrin blood clots

Also Published As

Publication number Publication date
EP0422198B1 (de) 1995-04-05
AU5541190A (en) 1990-11-16
ES2072432T3 (es) 1995-07-16
DE69018361D1 (de) 1995-05-11
AU623522B2 (en) 1992-05-14
WO1990012872A1 (en) 1990-11-01
US5416006A (en) 1995-05-16
CA2031210A1 (en) 1990-10-15
ATE120797T1 (de) 1995-04-15
KR920700285A (ko) 1992-02-19
PT93755A (pt) 1990-11-20
DK182289D0 (da) 1989-04-14
NZ233321A (en) 1991-09-25
EP0422198A1 (de) 1991-04-17
JPH03505530A (ja) 1991-12-05
IL94070A0 (en) 1991-01-31
HUT56130A (en) 1991-07-29
US5688503A (en) 1997-11-18
DE69018361T2 (de) 1995-08-31

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