ZA903343B - Fluoro-amide derivatives - Google Patents

Fluoro-amide derivatives

Info

Publication number: ZA903343B
Authority: ZA; South Africa
Prior art keywords: fluoro; amide derivatives; hle; diseases; treatment
Prior art date: 1989-05-08

Application number

ZA903343A

Other languages

English (en)

Inventor

Donald John Wolanin

John Wolanin Donald

Original Assignee

Ici America Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-08

Filing date

1990-05-02

Publication date

1991-01-30

1990-05-02 Application filed by Ici America Inc filed Critical Ici America Inc

1991-01-30 Publication of ZA903343B publication Critical patent/ZA903343B/xx

Links

MDQRDWAGHRLBPA-UHFFFAOYSA-N fluoroamine Chemical class FN MDQRDWAGHRLBPA-UHFFFAOYSA-N 0.000 title abstract 3
101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 abstract 3
102100033174 Neutrophil elastase Human genes 0.000 abstract 3
238000000034 method Methods 0.000 abstract 2
206010014561 Emphysema Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Crystallography & Structural Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

ZA903343A 1989-05-08 1990-05-02 Fluoro-amide derivatives ZA903343B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898910547A GB8910547D0 (en)	1989-05-08	1989-05-08	Substituted ketones

Publications (1)

Publication Number	Publication Date
ZA903343B true ZA903343B (en)	1991-01-30

Family

ID=10656399

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA903343A ZA903343B (en)	1989-05-08	1990-05-02	Fluoro-amide derivatives

Country Status (13)

Country	Link
US (1)	US5270301A (fr)
EP (1)	EP0397427B1 (fr)
JP (1)	JP2872748B2 (fr)
AT (1)	ATE105302T1 (fr)
AU (1)	AU622316B2 (fr)
CA (1)	CA2016209A1 (fr)
DE (1)	DE69008615T2 (fr)
DK (1)	DK0397427T3 (fr)
ES (1)	ES2053107T3 (fr)
GB (1)	GB8910547D0 (fr)
IE (1)	IE63573B1 (fr)
NZ (1)	NZ233514A (fr)
ZA (1)	ZA903343B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8809316D0 (en) *	1987-05-11	1988-05-25	Ici America Inc	Heterocyclic ketones
GB8910550D0 (en) *	1989-05-08	1989-06-21	Ici America Inc	Substituted amides
ZA905737B (en) *	1989-07-26	1991-05-29	Merrell Dow Pharma	Novel peptidase inhibitors
US5486529A (en) *	1992-04-16	1996-01-23	Zeneca Limited	Certain pyridyl ketones for treating diseases involving leukocyte elastase
US5441960A (en) *	1992-04-16	1995-08-15	Zeneca Limited	1-pyrimidinylacetamide human leukocyte elastate inhibitors
GB9211783D0 (en) *	1992-06-04	1992-07-15	Ici Plc	Amide derivatives
IL108031A0 (en) *	1992-12-22	1994-04-12	Procter & Gamble	Difluoro pentapeptide derivatives and pharmaceutical compositions containing them
US5885967A (en) *	1994-03-04	1999-03-23	Eli Lilly And Company	Antithrombotic agents
CN1759113A (zh) *	2003-01-16	2006-04-12	特瓦制药工业有限公司	伊贝沙坦的新合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4256761A (en) *	1979-07-13	1981-03-17	Usv Pharmaceutical Corporation	Antihypertensive amides
GB8600263D0 (en) *	1985-01-22	1986-02-12	Ici America Inc	Peptide derivatives
ATE71934T1 (de) *	1985-06-07	1992-02-15	Ici America Inc	Selektionierte difluorverbindungen.
GB8613704D0 (en) *	1986-06-05	1986-07-09	Ici America Inc	Difluoro keto compounds
DE3782191T2 (de) *	1986-06-05	1993-02-25	Ici America Inc	Difluorketoverbindungen.
EP0276101A3 (fr) *	1987-01-19	1989-11-23	Ici Americas Inc.	Dérivés de peptides substitués
GB8809316D0 (en) *	1987-05-11	1988-05-25	Ici America Inc	Heterocyclic ketones
EP0369391A3 (fr) *	1988-11-15	1991-09-25	Boehringer Ingelheim Pharmaceuticals Inc.	Amides N-substitués
GB8910550D0 (en) *	1989-05-08	1989-06-21	Ici America Inc	Substituted amides

1989
- 1989-05-08 GB GB898910547A patent/GB8910547D0/en active Pending
1990
- 1990-05-01 NZ NZ233514A patent/NZ233514A/en unknown
- 1990-05-01 AU AU54565/90A patent/AU622316B2/en not_active Ceased
- 1990-05-02 ZA ZA903343A patent/ZA903343B/xx unknown
- 1990-05-04 EP EP90304903A patent/EP0397427B1/fr not_active Expired - Lifetime
- 1990-05-04 DK DK90304903.9T patent/DK0397427T3/da active
- 1990-05-04 ES ES90304903T patent/ES2053107T3/es not_active Expired - Lifetime
- 1990-05-04 DE DE69008615T patent/DE69008615T2/de not_active Expired - Fee Related
- 1990-05-04 AT AT9090304903T patent/ATE105302T1/de not_active IP Right Cessation
- 1990-05-07 CA CA002016209A patent/CA2016209A1/fr not_active Abandoned
- 1990-05-07 US US07/519,618 patent/US5270301A/en not_active Expired - Fee Related
- 1990-05-07 IE IE165390A patent/IE63573B1/en not_active IP Right Cessation
- 1990-05-08 JP JP2118526A patent/JP2872748B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2016209A1 (fr)	1990-11-08
JPH0356496A (ja)	1991-03-12
ES2053107T3 (es)	1994-07-16
DK0397427T3 (da)	1994-06-06
NZ233514A (en)	1993-01-27
IE901653L (en)	1990-11-08
DE69008615D1 (de)	1994-06-09
AU622316B2 (en)	1992-04-02
JP2872748B2 (ja)	1999-03-24
EP0397427B1 (fr)	1994-05-04
AU5456590A (en)	1990-11-15
GB8910547D0 (en)	1989-06-21
EP0397427A1 (fr)	1990-11-14
US5270301A (en)	1993-12-14
DE69008615T2 (de)	1994-08-18
IE63573B1 (en)	1995-05-17
ATE105302T1 (de)	1994-05-15

Publication	Publication Date	Title
TW262475B (en)	1995-11-11	Heterocyclic amides, intermediates and process for their preparation and pharmaceutical compositions containing them
AU3959693A (en)	1993-11-18	Alpha-aminoboronic acid peptides and their use as elastase inhibitors
IL105425A0 (en)	1993-08-18	Heterocyclic ketones
IL102805A0 (en)	1993-01-31	Substituted heterocycles
IL105424A0 (en)	1993-08-18	Heterocyclic compounds
AU622316B2 (en)	1992-04-02	Fluoro-amide derivatives
FI946202A0 (fi)	1994-12-30	Fluoria sisältäviä dipeptidejä inhibiittoreina ihmisen lenkosyyttielastaasi-inhibiittoreita vastaan
GB9211783D0 (en)	1992-07-15	Amide derivatives
GB8910550D0 (en)	1989-06-21	Substituted amides