ZA906810B - Heterogeneous synthesis of azepinones from esters - Google Patents

Heterogeneous synthesis of azepinones from esters

Info

Publication number: ZA906810B
Authority: ZA; South Africa
Prior art keywords: cyclized; methoxyphenyl; hydroxy; amino; acid
Prior art date: 1989-08-31

Application number

ZA906810A

Other languages

English (en)

Inventor

Daniel Eugene Martin

Eugene Martin Daniel

Original Assignee

Marion Merrell Dow Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-31

Filing date

1990-08-27

Publication date

1991-10-30

1990-08-27 Application filed by Marion Merrell Dow Inc filed Critical Marion Merrell Dow Inc

1991-10-30 Publication of ZA906810B publication Critical patent/ZA906810B/xx

Links

DXZDEAJXVCLRLE-UHFFFAOYSA-N azepin-2-one Chemical class O=C1C=CC=CC=N1 DXZDEAJXVCLRLE-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
150000002148 esters Chemical class 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
-1 amino-acid ester compound Chemical class 0.000 abstract 3
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 abstract 1
FEDJGPQLLNQAIY-UHFFFAOYSA-N 2-[(6-oxo-1h-pyridazin-3-yl)oxy]acetic acid Chemical compound OC(=O)COC=1C=CC(=O)NN=1 FEDJGPQLLNQAIY-UHFFFAOYSA-N 0.000 abstract 1
KHQWPNQLSKDWAR-UHFFFAOYSA-N 3-(2-aminophenyl)sulfanyl-2-hydroxy-3-(4-methoxyphenyl)propanoic acid Chemical compound C1=CC(OC)=CC=C1C(C(O)C(O)=O)SC1=CC=CC=C1N KHQWPNQLSKDWAR-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
229960005316 diltiazem hydrochloride Drugs 0.000 abstract 1
238000005342 ion exchange Methods 0.000 abstract 1
239000003456 ion exchange resin Substances 0.000 abstract 1
229920003303 ion-exchange polymer Polymers 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229920001467 poly(styrenesulfonates) Polymers 0.000 abstract 1
229920003053 polystyrene-divinylbenzene Polymers 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
GIZSHQYTTBQKOQ-UHFFFAOYSA-N threo-Syringoylglycerol Chemical compound COC1=CC(C(O)C(O)CO)=CC(OC)=C1O GIZSHQYTTBQKOQ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA906810A 1989-08-31 1990-08-27 Heterogeneous synthesis of azepinones from esters ZA906810B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US40065889A	1989-08-31	1989-08-31

Publications (1)

Publication Number	Publication Date
ZA906810B true ZA906810B (en)	1991-10-30

Family

ID=23584491

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA906810A ZA906810B (en)	1989-08-31	1990-08-27	Heterogeneous synthesis of azepinones from esters

Country Status (13)

Country	Link
EP (1)	EP0415384B1 (fr)
JP (1)	JP3090212B2 (fr)
KR (1)	KR0163585B1 (fr)
AT (1)	ATE150459T1 (fr)
AU (1)	AU628217B2 (fr)
CA (1)	CA2024124C (fr)
DD (1)	DD295367A5 (fr)
DE (1)	DE69030222T2 (fr)
ES (1)	ES2101682T3 (fr)
HU (1)	HU206103B (fr)
IE (1)	IE903151A1 (fr)
IL (1)	IL95509A (fr)
ZA (1)	ZA906810B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1249318B (it) *	1991-05-23	1995-02-22	Zambon Spa	Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici
DE4313413A1 (de) *	1993-04-23	1994-10-27	Basf Ag	3-(Het)aryloxy(thio)-Carbonsäurederivate, Verfahren und Zwischenprodukte zu ihrer Herstellung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4567175A (en) *	1983-06-03	1986-01-28	Tanabe Seiyaku Co., Ltd.	8-Chloro-1,5-benzothiazepine derivatives
ZA893392B (en) *	1988-05-24	1990-01-31	Hoffmann La Roche	Process for the manufacture of optically active naphthothiazepinones
ATE116643T1 (de) *	1989-04-28	1995-01-15	Tanabe Seiyaku Co	Verfahren zur herstellung von 1,5- benzothiazepinderivaten.
JPH0798813B2 (ja) *	1989-04-28	1995-10-25	田辺製薬株式会社	１，５―ベンゾチアゼピン誘導体の製法

1990
- 1990-08-27 ZA ZA906810A patent/ZA906810B/xx unknown
- 1990-08-27 AU AU61382/90A patent/AU628217B2/en not_active Expired
- 1990-08-28 JP JP02224560A patent/JP3090212B2/ja not_active Expired - Lifetime
- 1990-08-28 CA CA002024124A patent/CA2024124C/fr not_active Expired - Lifetime
- 1990-08-28 HU HU905508A patent/HU206103B/hu not_active IP Right Cessation
- 1990-08-28 IL IL9550990A patent/IL95509A/en not_active IP Right Cessation
- 1990-08-29 DE DE69030222T patent/DE69030222T2/de not_active Expired - Lifetime
- 1990-08-29 AT AT90116565T patent/ATE150459T1/de not_active IP Right Cessation
- 1990-08-29 KR KR1019900013352A patent/KR0163585B1/ko not_active Expired - Fee Related
- 1990-08-29 EP EP90116565A patent/EP0415384B1/fr not_active Expired - Lifetime
- 1990-08-29 ES ES90116565T patent/ES2101682T3/es not_active Expired - Lifetime
- 1990-08-30 DD DD90343730A patent/DD295367A5/de unknown
- 1990-08-30 IE IE315190A patent/IE903151A1/en unknown

Also Published As

Publication number	Publication date
IL95509A0 (en)	1991-06-30
AU6138290A (en)	1991-03-07
JPH0393778A (ja)	1991-04-18
EP0415384A3 (en)	1992-04-15
IE903151A1 (en)	1991-03-27
HUT59118A (en)	1992-04-28
DE69030222D1 (de)	1997-04-24
KR910004584A (ko)	1991-03-29
IL95509A (en)	1994-10-07
DE69030222T2 (de)	1997-10-16
HU206103B (en)	1992-08-28
KR0163585B1 (ko)	1998-12-01
EP0415384B1 (fr)	1997-03-19
ES2101682T3 (es)	1997-07-16
JP3090212B2 (ja)	2000-09-18
ATE150459T1 (de)	1997-04-15
HU905508D0 (en)	1991-02-28
AU628217B2 (en)	1992-09-10
CA2024124A1 (fr)	1991-03-01
CA2024124C (fr)	2003-04-15
EP0415384A2 (fr)	1991-03-06
DD295367A5 (de)	1991-10-31

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