ZA93423B - 3'derivatized oligonucleotide analogs with nonnucleotidic groupings, their preparation and use - Google Patents

3'derivatized oligonucleotide analogs with nonnucleotidic groupings, their preparation and use

Info

Publication number: ZA93423B
Authority: ZA; South Africa
Prior art keywords: oxy; alpha; sulfandiyl; alkyl; formula
Prior art date: 1992-01-22

Application number

ZA93423A

Other languages

English (en)

Inventor

Eugen Uhlmann

Gerard O'malley

Irvin Winkler

Anuschirwan Peyman

Matthias Helsberg

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-22

Filing date

1993-01-21

Publication date

1993-09-09

1993-01-21 Application filed by Hoechst Ag filed Critical Hoechst Ag

1993-09-09 Publication of ZA93423B publication Critical patent/ZA93423B/xx

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 3
-1 oxy, sulfandiyl Chemical group 0.000 abstract 6
125000000217 alkyl group Chemical group 0.000 abstract 5
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 4
125000001841 imino group Chemical group [H]N=* 0.000 abstract 3
125000001424 substituent group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 abstract 1
239000013543 active substance Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000000732 arylene group Chemical group 0.000 abstract 1
125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
150000001875 compounds Chemical group 0.000 abstract 1
125000000524 functional group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000002777 nucleoside Substances 0.000 abstract 1
150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000005731 phosphitylation reaction Methods 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
125000000464 thioxo group Chemical group S=* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Graft Or Block Polymers (AREA)
Macromonomer-Based Addition Polymer (AREA)

ZA93423A 1992-01-22 1993-01-21 3'derivatized oligonucleotide analogs with nonnucleotidic groupings, their preparation and use ZA93423B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4201663		1992-01-22

Publications (1)

Publication Number	Publication Date
ZA93423B true ZA93423B (en)	1993-09-09

Family

ID=6450031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA93423A ZA93423B (en)	1992-01-22	1993-01-21	3'derivatized oligonucleotide analogs with nonnucleotidic groupings, their preparation and use

Country Status (18)

Country	Link
US (1)	US5646261A (fr)
EP (2)	EP1142902B1 (fr)
JP (1)	JP3676388B2 (fr)
KR (1)	KR100273824B1 (fr)
AT (2)	ATE217881T1 (fr)
AU (1)	AU657191B2 (fr)
CA (1)	CA2087817C (fr)
DE (2)	DE59310380D1 (fr)
DK (2)	DK0552767T3 (fr)
ES (2)	ES2250268T3 (fr)
FI (1)	FI115215B (fr)
HU (1)	HUT63172A (fr)
IL (1)	IL104460A (fr)
NO (1)	NO308609B1 (fr)
NZ (1)	NZ245721A (fr)
PL (1)	PL172245B1 (fr)
PT (1)	PT552767E (fr)
ZA (1)	ZA93423B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2966849B2 (ja) *	1987-12-03	1999-10-25	三井化学株式会社	黄色系昇華転写用色材
EP0593901B2 (fr) *	1992-09-24	2008-04-09	Sanofi-Aventis Deutschland GmbH	Analogues des oligoribonucleotide et ribozymer avec 3'-3'-et 5'-5' liasons terminaler
EP0602524A1 (fr) *	1992-12-15	1994-06-22	Hoechst Aktiengesellschaft	Sondes marqués par chemiluminescence et leur utilisation dans épreuves des sondes
CA2114355A1 (fr) *	1993-01-29	1994-07-30	Hidehiko Furukawa	Oligodesoxyribonucleotides modifies, leur preparation et leur utilisation therapeutique
US5532130A (en) *	1993-07-20	1996-07-02	Dyad Pharmaceutical Corporation	Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides
US6919441B2 (en)	1994-03-14	2005-07-19	Aventis Pharma Deutschland Gmbh	Polyamide-oligonucleotide derivatives, their preparation and use
DE4408528A1 (de) *	1994-03-14	1995-09-28	Hoechst Ag	Peptid-Oligonucleotid-Derivate, deren Herstellung und Verwendung
US6358689B1 (en) *	1994-05-11	2002-03-19	Boston University	Detection of markers in nascent proteins
DE4418691A1 (de) *	1994-05-28	1996-02-22	Boehringer Mannheim Gmbh	3'-(4'-) nicht-radioaktiv markierte Nukleoside und Nukleotide mit Aminocarbonsäure-, Peptid- oder Carbonsäure-Spacer
EP0763050B1 (fr) *	1994-06-01	2000-01-05	Hybridon, Inc.	Oligonucleotides ramifiés inhibiteurs des agents pathogènes
US5696248A (en) *	1994-06-15	1997-12-09	Hoechst Aktiengesellschaft	3'-modified oligonucleotide derivatives
US6326487B1 (en)	1995-06-05	2001-12-04	Aventis Pharma Deutschland Gmbh	3 modified oligonucleotide derivatives
US6331617B1 (en)	1996-03-21	2001-12-18	University Of Iowa Research Foundation	Positively charged oligonucleotides as regulators of gene expression
US6274313B1 (en)	1996-03-21	2001-08-14	Pioneer-Hybrid International, Inc.	Oligonucleotides with cationic phosphoramidate internucleoside linkages and methods of use
US20040082774A1 (en) *	1999-03-16	2004-04-29	Guzaev Andrei P.	Novel phosphate and thiophosphate protecting groups
US6121437A (en) *	1999-03-16	2000-09-19	Isis Pharmaceuticals, Inc.	Phosphate and thiophosphate protecting groups
US20040023367A1 (en) *	2002-07-31	2004-02-05	Affymetrix, Inc.	Method of photolithographic production of polymer arrays
US8084589B2 (en) *	2007-08-31	2011-12-27	University Of Massachusetts	Phosphoramidite nucleoside analogs
EP2618846A1 (fr) *	2010-09-24	2013-07-31	Mallinckrodt LLC	Conjugués d'aptamères pour ciblage de nanovecteurs thérapeutiques et/ou diagnostiques

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3239888A1 (de) *	1982-10-28	1984-05-03	Hubert Prof. Dr. 2000 Hamburg Köster	Verfahren zur herstellung von oligonucleosidphosphonaten
US4739044A (en) *	1985-06-13	1988-04-19	Amgen	Method for derivitization of polynucleotides
DE3751468T2 (de) *	1986-10-30	1996-02-29	Daicel Chem	Verfahren zur herstellung von oligonukleotiden und verbindungen zur bildung hochmolekularer schutzgruppen.
US4816571A (en) *	1987-06-04	1989-03-28	Applied Biosystems, Inc.	Chemical capping by phosphitylation during oligonucleotide synthesis
US5216141A (en) *	1988-06-06	1993-06-01	Benner Steven A	Oligonucleotide analogs containing sulfur linkages
US5399676A (en) *	1989-10-23	1995-03-21	Gilead Sciences	Oligonucleotides with inverted polarity
DE69034150T2 (de) *	1989-10-24	2005-08-25	Isis Pharmaceuticals, Inc., Carlsbad	2'-Modifizierte Oligonukleotide
US5210015A (en) *	1990-08-06	1993-05-11	Hoffman-La Roche Inc.	Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
GB9021625D0 (en) *	1990-10-04	1990-11-21	Ici Plc	Synthesis of oligonucleotides
KR930016437A (ko) *	1992-01-22	1993-08-26	귀틀라인, 슈미트	올리고뉴클레오티드 유사체, 이의 제조방법 및 용도

1993
- 1993-01-19 US US08/005,283 patent/US5646261A/en not_active Expired - Lifetime
- 1993-01-20 FI FI930221A patent/FI115215B/fi not_active IP Right Cessation
- 1993-01-20 KR KR1019930000676A patent/KR100273824B1/ko not_active Expired - Lifetime
- 1993-01-20 IL IL10446093A patent/IL104460A/xx not_active IP Right Cessation
- 1993-01-20 NZ NZ245721A patent/NZ245721A/en not_active IP Right Cessation
- 1993-01-21 DK DK93100893T patent/DK0552767T3/da active
- 1993-01-21 DE DE59310380T patent/DE59310380D1/de not_active Expired - Lifetime
- 1993-01-21 AT AT93100893T patent/ATE217881T1/de active
- 1993-01-21 CA CA2087817A patent/CA2087817C/fr not_active Expired - Lifetime
- 1993-01-21 AT AT01116471T patent/ATE307821T1/de active
- 1993-01-21 ZA ZA93423A patent/ZA93423B/xx unknown
- 1993-01-21 ES ES01116471T patent/ES2250268T3/es not_active Expired - Lifetime
- 1993-01-21 PT PT93100893T patent/PT552767E/pt unknown
- 1993-01-21 ES ES93100893T patent/ES2177533T3/es not_active Expired - Lifetime
- 1993-01-21 DE DE59310287T patent/DE59310287D1/de not_active Expired - Lifetime
- 1993-01-21 JP JP00825693A patent/JP3676388B2/ja not_active Expired - Lifetime
- 1993-01-21 HU HU9300161A patent/HUT63172A/hu unknown
- 1993-01-21 EP EP01116471A patent/EP1142902B1/fr not_active Expired - Lifetime
- 1993-01-21 AU AU31911/93A patent/AU657191B2/en not_active Expired
- 1993-01-21 NO NO930200A patent/NO308609B1/no not_active IP Right Cessation
- 1993-01-21 DK DK01116471T patent/DK1142902T3/da active
- 1993-01-21 EP EP93100893A patent/EP0552767B1/fr not_active Expired - Lifetime
- 1993-01-22 PL PL93297516A patent/PL172245B1/pl unknown

Also Published As

Publication number	Publication date
NO308609B1 (no)	2000-10-02
KR100273824B1 (ko)	2000-12-15
DE59310287D1 (de)	2002-06-27
FI930221L (fi)	1993-07-23
EP1142902A3 (fr)	2001-10-17
ATE307821T1 (de)	2005-11-15
AU3191193A (en)	1993-07-29
CA2087817A1 (fr)	1993-07-23
FI115215B (fi)	2005-03-31
ES2250268T3 (es)	2006-04-16
EP0552767A3 (en)	1994-09-07
ES2177533T3 (es)	2002-12-16
US5646261A (en)	1997-07-08
PL172245B1 (pl)	1997-08-29
IL104460A (en)	2003-03-12
PT552767E (pt)	2002-10-31
EP0552767A2 (fr)	1993-07-28
EP1142902A2 (fr)	2001-10-10
NO930200L (no)	1993-07-23
HUT63172A (en)	1993-07-28
EP1142902B1 (fr)	2005-10-26
FI930221A0 (fi)	1993-01-20
NZ245721A (en)	1995-09-26
KR930016438A (ko)	1993-08-26
JP3676388B2 (ja)	2005-07-27
HU9300161D0 (en)	1993-04-28
JPH05310778A (ja)	1993-11-22
PL297516A1 (en)	1993-09-06
DK1142902T3 (da)	2006-03-06
AU657191B2 (en)	1995-03-02
IL104460A0 (en)	1993-05-13
DE59310380D1 (de)	2005-12-01
DK0552767T3 (da)	2002-08-19
NO930200D0 (no)	1993-01-21
EP0552767B1 (fr)	2002-05-22
CA2087817C (fr)	2010-03-16
ATE217881T1 (de)	2002-06-15

Publication	Publication Date	Title
ZA93423B (en)	1993-09-09	3'derivatized oligonucleotide analogs with nonnucleotidic groupings, their preparation and use
KR930016437A (ko)	1993-08-26	올리고뉴클레오티드 유사체, 이의 제조방법 및 용도
NZ243153A (en)	1994-08-26	4a-substituted avermectin derivatives and anti-parasitic compositions thereof
WO2001026629A3 (fr)	2002-05-10	Lipide cationique-neutre destine a l'apport d'acides nucleiques et de medicaments
IL96643A0 (en)	1991-09-16	Morpholinyl derivatives of doxorubicin,their preparation and pharmaceutical compositions containing them
ZA905246B (en)	1991-03-27	Diaryl ether cyclic ethers
IL100218A0 (en)	1992-09-06	Anthracycline conjugates,their preparation and pharmaceutical compositions containing them
IE831349L (en)	1983-12-10	4-aminopiperidine derivatives
IE55974B1 (en)	1991-03-13	Anthracycline glycosides,their manufacture and medicaments containing them
SI1010698T1 (en)	2002-06-30	1,2-dithiolane derivatives, their process of preparation and pharmaceutical compositions containing them
IL94980A0 (en)	1991-06-10	Antiherpes pentapeptide derivatives having a substituted aspartic acid side chain,their preparation and pharmaceutical compositions containing them
DE69019786D1 (de)	1995-07-06	Antiherpes-Tetrapeptid-Derivate mit einer substituierten Seitenkette aus Asparaginsäure.
HU9401399D0 (en)	1994-08-29	Nitroxyalkylamide derivatives, process for producing them and pharmaceutical compositions containing them
PT76834A (en)	1983-07-01	Process for the preparation of a pesticidal namely insecticidal acaricidal and/or nematocidal composition containing organophosphate pesticides
ZA905407B (en)	1991-04-24	Pyrrolo(2,1-b)thiozle derivatives
FR2699536B1 (fr)	1995-03-03	Nouveaux dérivés de p-[di(2-chloroéthyl)amino]phénylalanine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
JPS6442499A (en)	1989-02-14	Cytosine derivative of racemic type
CA2019006A1 (fr)	1991-12-14	Derives tetrapeptidiques ayant une chaine laterale d'acide aspartique substitue par un groupement cycloalkyl