ZA9610769B - Pharmaceutical composition comprising l-carnitine or an alkanoyl l-carnitine in combination with a polyunsaturated fatty acid - Google Patents

Pharmaceutical composition comprising l-carnitine or an alkanoyl l-carnitine in combination with a polyunsaturated fatty acid

Info

Publication number
ZA9610769B
ZA9610769B ZA9610769A ZA9610769A ZA9610769B ZA 9610769 B ZA9610769 B ZA 9610769B ZA 9610769 A ZA9610769 A ZA 9610769A ZA 9610769 A ZA9610769 A ZA 9610769A ZA 9610769 B ZA9610769 B ZA 9610769B
Authority
ZA
South Africa
Prior art keywords
carnitine
alkanoyl
combination
fatty acid
polyunsaturated fatty
Prior art date
Application number
ZA9610769A
Other languages
English (en)
Inventor
Menotti Calvani
Claudio Cavazza
Original Assignee
Sigma Tau Ind Farmaceuti
Sandz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti, Sandz Ltd filed Critical Sigma Tau Ind Farmaceuti
Publication of ZA9610769B publication Critical patent/ZA9610769B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
ZA9610769A 1995-12-21 1996-12-20 Pharmaceutical composition comprising l-carnitine or an alkanoyl l-carnitine in combination with a polyunsaturated fatty acid ZA9610769B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95RM000835A IT1277953B1 (it) 1995-12-21 1995-12-21 Composizione farmaceutica contenente l-carnitina o una alcanoil l- carnitina e un acido poliinsaturo della serie 3-omega utile per

Publications (1)

Publication Number Publication Date
ZA9610769B true ZA9610769B (en) 1997-07-09

Family

ID=11403724

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9610769A ZA9610769B (en) 1995-12-21 1996-12-20 Pharmaceutical composition comprising l-carnitine or an alkanoyl l-carnitine in combination with a polyunsaturated fatty acid

Country Status (13)

Country Link
US (1) US5753703A (da)
EP (1) EP0780124B1 (da)
JP (1) JPH09176005A (da)
KR (1) KR970032853A (da)
AT (1) ATE210977T1 (da)
CA (1) CA2191645C (da)
DE (1) DE69618158T2 (da)
DK (1) DK0780124T3 (da)
ES (1) ES2169197T3 (da)
IT (1) IT1277953B1 (da)
PT (1) PT780124E (da)
TW (1) TW522013B (da)
ZA (1) ZA9610769B (da)

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US6482585B2 (en) * 1997-04-16 2002-11-19 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Storage and maintenance of blood products including red blood cells and platelets
US5863940A (en) 1997-12-01 1999-01-26 Sigma-Tau Healthscience S.P.A. Medicament and therapeutical method for treating idiopathic asthenozoospermia
US6090848A (en) * 1997-12-01 2000-07-18 Sigma-Tau Healthscience S.P.A. Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
US20020002154A1 (en) * 1998-02-11 2002-01-03 Pol-Henri Guivarc'h Method and composition for treatment of inflammatory conditions
DK0951909T4 (da) 1998-03-19 2011-01-24 Sigma Tau Ind Farmaceuti Kombinationspræparat omfattende en L-carnitin eller en alkanoyl-L-carnitin, en glycosaminoglycan og/eller bestanddel deraf
IT1299161B1 (it) * 1998-04-17 2000-02-29 Sigma Tau Healthscience Spa Composizione comprendente l-carnitina o un'alcanoil l-carnitina e nadh e/o nadph
IT1302125B1 (it) * 1998-08-03 2000-07-31 Sigma Tau Healthscience Spa Composizione ad attivita' antiossidante ed antiproliferativacomprendente una carnitina ed un carotenoide
IT1308613B1 (it) 1999-02-17 2002-01-09 Pharmacia & Upjohn Spa Acidi grassi essenziali nella prevenzione di eventi cardiovascolari.
IT1305308B1 (it) * 1999-03-26 2001-05-04 Biosint S P A Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione
IT1317008B1 (it) * 2000-04-04 2003-05-26 Sigma Tau Healthscience Spa Integratore alimentare energizzante sulla muscolatura scheletrica eprotettivo sull'apparato cardiovascolare.
US8252309B2 (en) * 2000-04-04 2012-08-28 Sigma-Tau Industrie Farmaceutiche Riunite Spa Dietary supplement energy-providing to skeletal muscles
US7226916B1 (en) * 2000-05-08 2007-06-05 N.V. Nutricia Preparation for the prevention and/or treatment of vascular disorders
US7208180B2 (en) * 2000-05-08 2007-04-24 N.V. Nutricia Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith
ITMI20010129A1 (it) 2001-01-25 2002-07-25 Pharmacia & Upjohn Spa Acidi grassi essenziali nella terapia di insufficienza cardiaca e scompenso cardiaco
WO2003009854A1 (en) * 2001-07-20 2003-02-06 Lonza Ag Lipid lowering composition comprising carnitine and phytosterol
ITMI20012384A1 (it) * 2001-11-12 2003-05-12 Quatex Nv Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori
ES2208131B1 (es) * 2002-03-27 2005-09-01 Volker Bartz Metodo para la fabricacion de un medicamento reductor de niveles de lipidos en sangre para la administracion oral.
DE20214827U1 (de) 2002-09-25 2003-02-20 Bartz, Volker, 35440 Linden Leistungsförderer für Sportler zur oralen Einnahme
WO2004091603A1 (fr) * 2003-04-07 2004-10-28 Clinigenetics Utilisation d’un ester de dha pour le traitement des malades cardiovasculaires
EP1466597A1 (en) * 2003-04-07 2004-10-13 Clinigenetics Use of dha esters to control or prevent cardiovascular diseases
US8173618B2 (en) * 2003-07-25 2012-05-08 University Of Massachusetts Formulations for reducing neuronal degeneration
US20050232911A1 (en) * 2004-04-19 2005-10-20 Schreiber Brian D Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid
RS52735B (sr) * 2005-07-08 2013-08-30 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Primena kombinacije koja sadrži l-karnitin ili alkanoil l-karnitin, benzokvinon rastvorljiv u mastima i omega-3-polinezasićenu masnu kiselinu za pripremu dodataka ishrani ili leka za lečenje oboljenja rožnjače
EP2777701A1 (en) * 2006-05-31 2014-09-17 Mochida Pharmaceutical Co., Ltd. Composition for preventing the occurrence of a cardiovascular event in multiple risk patient comprising the ethyl ester of all-cis-5,8,11,14,17-icosapentaenoic acid
JPWO2008093848A1 (ja) * 2007-02-02 2010-05-20 サンスター株式会社 ホスファチジルコリンを含有する炎症マーカー低減組成物
US8597640B2 (en) * 2007-10-31 2013-12-03 University Of Massachusetts Lowell Over-the-counter vitamin/nutriceutical formulation that provides neuroprotection and maintains or improves cognitive performance in alzheimer's disease and normal aging
EP2323647B1 (en) 2008-08-07 2014-09-10 SPA SOCIETA' PRODOTTI ANTIBIOTICI S.p.A. Long-term treatment of symptomatic heart failure
BRPI0921679A2 (pt) * 2008-11-11 2016-02-16 Sigma Tau Ind Farmaceuti composto útil para tratar celulite
AU2009315314B2 (en) * 2008-11-14 2013-04-18 Bomi P. Framroze A method of lowering circulating oxidized low density lipoprotein-beta-2-glycoprotein 1 complex for treatment of atherosclerosclerosis
EP2384192B1 (en) * 2009-01-05 2017-10-25 Calanus AS Biological oil composition, formulations comprising the oil composition, and use thereof to prevent or treat cardiovascular disease
US8993625B2 (en) 2009-03-11 2015-03-31 Stable Solutions Llc Method of mitigating adverse drug events using omega-3 fatty acids as a parenteral therapeutic drug vehicle
US9034389B2 (en) 2009-03-11 2015-05-19 Stable Solutions Llc Omega-3 enriched fish oil-in-water parenteral nutrition emulsions
US20110071090A1 (en) * 2009-03-11 2011-03-24 Stable Solutions Llc Method of mitigating adverse drug events using omega-3-fatty acids as a parenteral therapeutic drug vehicle
DK2440065T3 (da) * 2009-06-12 2018-12-10 Calanus As Copepodoliesammensætning, formuleringer, der omfatter oliesammensætningen, og anvendelse deraf til reduktion af ophobning af visceralt fedt, forbedring af glucosetolerance og forebyggelse eller behandling af fedmerelaterede sygdomme og forstyrrelser
US20110015154A1 (en) * 2009-07-20 2011-01-20 Kellermann Gottfried H Supporting acetylcholine function
US20110098265A1 (en) * 2009-10-28 2011-04-28 Neuroscience, Inc. Methods for reducing cravings and impulses associated with addictive and compulsive behaviors
CA2834173A1 (en) 2011-05-03 2012-11-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Composition useful for the treatment of lipid metabolism disorders
CN107028926A (zh) * 2011-08-26 2017-08-11 国立大学法人大阪大学 糖尿病性心血管并发症的预防/治疗剂
GB201223370D0 (en) * 2012-12-24 2013-02-06 Univ Tartu Method of treatment using lactobacillus fermentum ME-3
US10130603B2 (en) 2013-11-05 2018-11-20 Colgate-Palmolive Company Methods and compositions for improving kidney function
CA3073802A1 (en) * 2017-08-23 2019-02-28 Gavish-Galilee Bio Applications Ltd. Compositions and methods for treating atherosclerotic cardiovascular disease

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JPS56115736A (en) * 1980-02-19 1981-09-11 Kagakuhin Kensa Kyokai Separation and purification of eicosapentaenoic acid and docosahexaenoic acid
DE3026368A1 (de) * 1980-07-11 1982-02-18 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Naehrloesung fuer die vollstaendige parenterale ernaehrung und fuer gesteigerte energieproduktion
DE3785667T2 (de) * 1986-09-17 1994-07-21 Clintec Nutrition Co Zusatznahrung bzw. therapie für personen mit risiko oder in behandlung für arteriosklerotische vaskuläre, kardiovaskuläre und/oder thrombotische erkrankungen.
US4918104A (en) * 1987-06-16 1990-04-17 Weiss Howard S Method and composition for increasing the concentration of omega-3 polyunsaturated fatty acids in poultry and poultry eggs and poultry and eggs resulting therefrom
DE3726299A1 (de) * 1987-06-26 1989-02-23 Dietl Hans Fettemulsion zur intravenoesen anwendung
JP2839276B2 (ja) * 1989-01-23 1998-12-16 日本分光工業株式会社 超臨界流体抽出・分離方法及び装置
US4968719A (en) * 1989-04-03 1990-11-06 Sigma Tau, Industrie Farmaceutiche Riunite Spa Method for treating vascular disease
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DE4012894C2 (de) * 1990-04-23 1998-11-12 Werner Dr Gielsdorf Pharmazeutisches Mittel zur Behandlung von Störungen des Fettstoffwechsels
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Also Published As

Publication number Publication date
ITRM950835A1 (it) 1997-06-21
DE69618158D1 (de) 2002-01-31
PT780124E (pt) 2002-06-28
IT1277953B1 (it) 1997-11-12
DE69618158T2 (de) 2002-07-18
TW522013B (en) 2003-03-01
KR970032853A (ko) 1997-07-22
ITRM950835A0 (da) 1995-12-21
ATE210977T1 (de) 2002-01-15
JPH09176005A (ja) 1997-07-08
EP0780124B1 (en) 2001-12-19
ES2169197T3 (es) 2002-07-01
US5753703A (en) 1998-05-19
DK0780124T3 (da) 2002-04-15
EP0780124A1 (en) 1997-06-25
CA2191645C (en) 2007-07-31
CA2191645A1 (en) 1997-06-22

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