ZA975197B - Intermediates for oligonucleotides. - Google Patents

Intermediates for oligonucleotides.

Info

Publication number: ZA975197B
Authority: ZA; South Africa
Prior art keywords: group; hydrogen; formula; nucleoside; nuc
Prior art date: 1996-06-13

Application number

ZA9705197A

Other languages

English (en)

Inventor

Stephen Paul Collingwood

Heinz Ernst Moser

Karl-Heinz Altmann

Mark Edward Douglas

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-13

Filing date

1997-06-12

Publication date

1997-12-15

1997-06-12 Application filed by Novartis Ag filed Critical Novartis Ag

1997-12-15 Publication of ZA975197B publication Critical patent/ZA975197B/xx

Links

108091034117 Oligonucleotide Proteins 0.000 title abstract 2
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
239000001257 hydrogen Substances 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
239000002777 nucleoside Substances 0.000 abstract 2
150000003833 nucleoside derivatives Chemical class 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

ZA9705197A 1996-06-13 1997-06-12 Intermediates for oligonucleotides. ZA975197B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9612600.8A GB9612600D0 (en)	1996-06-13	1996-06-13	Chemical compounds

Publications (1)

Publication Number	Publication Date
ZA975197B true ZA975197B (en)	1997-12-15

Family

ID=10795396

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9705197A ZA975197B (en)	1996-06-13	1997-06-12	Intermediates for oligonucleotides.

Country Status (12)

Country	Link
US (1)	US6329519B1 (de)
EP (1)	EP0906327B1 (de)
JP (1)	JP2000512288A (de)
CN (1)	CN1221423A (de)
AT (1)	ATE210675T1 (de)
AU (1)	AU2971997A (de)
BR (1)	BR9709791A (de)
CA (1)	CA2257453A1 (de)
DE (1)	DE69709098T2 (de)
GB (1)	GB9612600D0 (de)
WO (1)	WO1997047636A2 (de)
ZA (1)	ZA975197B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE44779E1 (en)	1997-03-07	2014-02-25	Santaris Pharma A/S	Bicyclonucleoside and oligonucleotide analogues
JP3756313B2 (ja) *	1997-03-07	2006-03-15	武今西	新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en)	1997-03-07	2004-08-03	Takeshi Imanishi	Bicyclonucleoside and oligonucleotide analogue
US7030230B2 (en)	2002-10-25	2006-04-18	Isis Pharmaceuticals, Inc.	Process of purifying phosphoramidites
EP2708541B1 (de)	2003-11-13	2015-01-28	Isis Pharmaceuticals, Inc.	5,6-Dihydroxy-Isoindol-Derivate als Linker für Oligomer-Festphasensynthese
US7427675B2 (en)	2004-08-23	2008-09-23	Isis Pharmaceuticals, Inc.	Compounds and methods for the characterization of oligonucleotides

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3307744A1 (de)	1983-03-04	1984-09-06	Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig	2'-desoxy-3'-phosphonylmethyl-nucleoside
JPH03503894A (ja) *	1988-03-25	1991-08-29	ユニバーシィティ　オブ　バージニア　アランミ　パテンツ　ファウンデイション	オリゴヌクレオチド　ｎ‐アルキルホスホラミデート
US5658731A (en) *	1990-04-09	1997-08-19	Europaisches Laboratorium Fur Molekularbiologie	2'-O-alkylnucleotides as well as polymers which contain such nucleotides
DE4037363A1 (de)	1990-04-09	1991-10-10	Europ Lab Molekularbiolog	2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten
US5386023A (en) *	1990-07-27	1995-01-31	Isis Pharmaceuticals	Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5378825A (en)	1990-07-27	1995-01-03	Isis Pharmaceuticals, Inc.	Backbone modified oligonucleotide analogs
GB9304618D0 (en)	1993-03-06	1993-04-21	Ciba Geigy Ag	Chemical compounds
GB9311682D0 (en)	1993-06-05	1993-07-21	Ciba Geigy Ag	Chemical compounds
GB9417746D0 (en) *	1994-09-03	1994-10-19	Ciba Geigy Ag	Chemical compounds

1996
- 1996-06-13 GB GBGB9612600.8A patent/GB9612600D0/en active Pending
1997
- 1997-06-03 WO PCT/GB1997/001490 patent/WO1997047636A2/en not_active Ceased
- 1997-06-03 AT AT97924155T patent/ATE210675T1/de active
- 1997-06-03 EP EP97924155A patent/EP0906327B1/de not_active Expired - Lifetime
- 1997-06-03 JP JP10501337A patent/JP2000512288A/ja active Pending
- 1997-06-03 DE DE69709098T patent/DE69709098T2/de not_active Expired - Lifetime
- 1997-06-03 CN CN97195452A patent/CN1221423A/zh active Pending
- 1997-06-03 CA CA002257453A patent/CA2257453A1/en not_active Abandoned
- 1997-06-03 AU AU29719/97A patent/AU2971997A/en not_active Abandoned
- 1997-06-03 BR BR9709791A patent/BR9709791A/pt not_active Application Discontinuation
- 1997-06-03 US US09/202,294 patent/US6329519B1/en not_active Expired - Lifetime
- 1997-06-12 ZA ZA9705197A patent/ZA975197B/xx unknown

Also Published As

Publication number	Publication date
JP2000512288A (ja)	2000-09-19
GB9612600D0 (en)	1996-08-21
EP0906327A2 (de)	1999-04-07
US6329519B1 (en)	2001-12-11
WO1997047636A3 (en)	1998-02-12
CA2257453A1 (en)	1997-12-18
BR9709791A (pt)	1999-08-10
CN1221423A (zh)	1999-06-30
DE69709098T2 (de)	2002-09-05
EP0906327B1 (de)	2001-12-12
WO1997047636A2 (en)	1997-12-18
ATE210675T1 (de)	2001-12-15
DE69709098D1 (de)	2002-01-24
AU2971997A (en)	1998-01-07

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IL117848A0 (en)	1996-08-04	Novel compounds a process for their production and pharmacetical compositions containing same
PT915866E (pt)	2002-07-31	Processo aperfeicoado para a sintese de esteres protegidos do acido (s)-3,4-di-hidroxibutirico
DE69327438D1 (de)	2000-02-03	Therapeutische Mittel für die Parkinsonsche Krankheit
GB2346879A (en)	2000-08-23	Preparation of 3-substituted adenines and imidazo pyridines
NZ298296A (en)	1999-11-29	Imidazo[4,5-c]quinoline amines; medicaments to induce interferon biosynthesis
ATE266013T1 (de)	2004-05-15	1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4)
HUP9902576A1 (hu)	1999-12-28	Új eritromicinszármazékok, eljárás előállításukra és alkalmazásuk gyógyászati készítményekben
PT918776E (pt)	2004-07-30	Sintese total de acilfulvenos antitumorais
EP0714900A3 (de)	1996-07-31	Alkylhydrogenchlorsilane, Verfahren zu deren Herstellung und deren Verwendung
MY138051A (en)	2009-04-30	Compounds and processes
ZA975197B (en)	1997-12-15	Intermediates for oligonucleotides.
DE69028610D1 (de)	1996-10-24	Chirale 1,5-diiodo-2-methoxy oder benzyloxy Zwischenprodukte
MY101618A (en)	1991-12-17	Intermediates for the production of epipodophyloxin and related compounds and processes for the preparation and use thereof
MY132057A (en)	2007-09-28	Quinoxalinones, a process for their preparation and their use
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ES8707716A1 (es)	1987-08-16	Procedimiento para la obtencion de 1-aril-4-nitropirazoles
ZA974886B (en)	1997-12-08	Novel dibenzo-oxazepine and -dioxepine derivatives.
SE8501988D0 (sv)	1985-04-24	Iminothiazolidine derivatives
GB9906328D0 (en)	1999-05-12	2-Substituted RNA preparation
YU71400A (sh)	2003-04-30	Poboljšani postupak za pripremanje farmaceutski dragocenih derivata norbenzomorfana
ID19038A (id)	1998-06-04	Turunan feniletanolaminotetralinkarboksamida
DE69711506D1 (de)	2002-05-08	Methylsulfomycin 1, Verfahren zu dessen Herstellung und Verwendung
YU37902A (sh)	2005-07-19	Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3- benzazocini i njihova primena kao lekova
EP1007511A4 (de)	2001-07-11	Herstellung von beta-mehtylcarbapenem-zwischenprodukten
TH22634A (th)	1996-12-27	" เบนซอกซาโซลิล และเบนโซไธอะโซลิลออกซาโซลิดิโนน "