ZA983608B - Leptin as an inhibitor of tumor cell proliferation - Google Patents

Leptin as an inhibitor of tumor cell proliferation

Info

Publication number: ZA983608B
Authority: ZA; South Africa
Prior art keywords: leptin; inhibitor; cell proliferation; tumor cell; tumor
Prior art date: 1997-04-29

Application number

ZA983608A

Other languages

English (en)

Inventor

Dalit Barkan

Batya Cohen

Menachem Rubinstein

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-29

Filing date

1998-04-29

Publication date

1998-11-02

1998-04-29 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

1998-11-02 Publication of ZA983608B publication Critical patent/ZA983608B/xx

Links

102000016267 Leptin Human genes 0.000 title 1
108010092277 Leptin Proteins 0.000 title 1
230000004663 cell proliferation Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 title 1
229940039781 leptin Drugs 0.000 title 1
210000004881 tumor cell Anatomy 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Genetics & Genomics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA983608A 1997-04-29 1998-04-29 Leptin as an inhibitor of tumor cell proliferation ZA983608B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL12073397A IL120733A0 (en)	1997-04-29	1997-04-29	Leptin as an inhibitor of cell proliferation

Publications (1)

Publication Number	Publication Date
ZA983608B true ZA983608B (en)	1998-11-02

Family

ID=11070075

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA983608A ZA983608B (en)	1997-04-29	1998-04-29	Leptin as an inhibitor of tumor cell proliferation

Country Status (25)

Country	Link
US (1)	US7109159B1 (cs)
EP (1)	EP0981365B1 (cs)
JP (1)	JP4330662B2 (cs)
KR (1)	KR100507731B1 (cs)
CN (1)	CN1168497C (cs)
AR (1)	AR012626A1 (cs)
AT (1)	ATE283702T1 (cs)
AU (1)	AU742927B2 (cs)
BG (1)	BG63490B1 (cs)
CA (1)	CA2288238A1 (cs)
CZ (1)	CZ299872B6 (cs)
DE (1)	DE69827942T2 (cs)
EA (1)	EA002353B1 (cs)
EE (1)	EE04801B1 (cs)
ES (1)	ES2232944T3 (cs)
HU (1)	HUP0002427A3 (cs)
IL (2)	IL120733A0 (cs)
NO (1)	NO322304B1 (cs)
NZ (1)	NZ500589A (cs)
PL (1)	PL195275B1 (cs)
PT (1)	PT981365E (cs)
SK (1)	SK284848B6 (cs)
UA (1)	UA66793C2 (cs)
WO (1)	WO1998048831A1 (cs)
ZA (1)	ZA983608B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6777388B1 (en)	1998-08-21	2004-08-17	Clf Medical Technology Acceleration Program, Inc.	Leptin-related peptides
US7208572B2 (en)	1998-08-21	2007-04-24	Albany Medical College	Leptin-related peptides
US20050272652A1 (en)	1999-03-29	2005-12-08	Gault Victor A	Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
IL132312A0 (en) *	1999-09-05	2001-03-19	Yeda Res & Dev	Use of leptin in inhibition of endothelial cell proliferation
US8076288B2 (en)	2004-02-11	2011-12-13	Amylin Pharmaceuticals, Inc.	Hybrid polypeptides having glucose lowering activity
US20060094652A1 (en)	2004-02-11	2006-05-04	Levy Odile E	Hybrid polypeptides with selectable properties
US7863240B2 (en) *	2004-10-08	2011-01-04	Enzo Therapeutics, Inc.	Methods and uses of leptin in hepatocellular carcinoma
US8969291B2 (en)	2004-10-08	2015-03-03	Enzo Therapeutics, Inc.	Methods for decreasing leptin levels or activity for treating inflammation
US8263545B2 (en)	2005-02-11	2012-09-11	Amylin Pharmaceuticals, Inc.	GIP analog and hybrid polypeptides with selectable properties
BRPI0606992A2 (pt)	2005-02-11	2009-07-28	Amylin Pharmaceuticals Inc	análogo e polipeptìdeos hìbridos de gip com propriedades selecionáveis
BRPI0614649A2 (pt)	2005-08-11	2011-04-12	Amylin Pharmaceuticals Inc	polipeptìdeos hìbridos com propriedades selecionáveis
AU2006279680B2 (en)	2005-08-11	2012-12-06	Amylin Pharmaceuticals, Llc	Hybrid polypeptides with selectable properties
US8227408B2 (en) *	2005-09-07	2012-07-24	Neurotez, Inc.	Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
US8497240B2 (en)	2006-08-17	2013-07-30	Amylin Pharmaceuticals, Llc	DPP-IV resistant GIP hybrid polypeptides with selectable properties
NZ602170A (en)	2008-02-08	2014-03-28	Ambrx Inc	Modified leptin polypeptides and their uses
JP5622720B2 (ja) *	2008-05-21	2014-11-12	ニューロテスインコーポレイテッド	神経原繊維変化に関連する進行性認知障害の治療方法
CA2742600A1 (en) *	2008-11-04	2010-05-14	Nikolaos Tezapsidis	Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta
WO2010146059A2 (en)	2009-06-16	2010-12-23	F. Hoffmann-La Roche Ag	Biomarkers for igf-1r inhibitor therapy
TW202417497A (zh)	2015-10-12	2024-05-01	美商再生元醫藥公司	活化瘦素受體的抗原結合蛋白
EA201991075A1 (ru)	2016-11-08	2019-10-31		Антигенсвязывающие белки, которые проявляют антагонизм в отношении лептинового рецептора
KR20200100089A (ko)	2017-12-18	2020-08-25	리제너론 파마슈티칼스 인코포레이티드	렙틴 수용체 및/또는 gp130에 결합하는 이중 특이적 항원 결합 분자 및 이의 사용 방법
LT3773713T (lt)	2018-04-06	2025-08-25	Regeneron Pharmaceuticals, Inc.	Leptino receptoriaus agonistinis antikūnas, skirtas kaulų masės didinimui subjektui, kuriam pasireiškia medžiagų apykaitos sutrikimas arba hipoleptinemija
CN120629571B (zh) *	2025-06-13	2026-03-27	蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院）	Lepr基因或蛋白作为靶标在制备胆管细胞癌治疗产品中的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL122718A0 (en) *	1995-06-30	1998-08-16	Lilly Co Eli	Methods for treating diabetes
JPH11512296A (ja) *	1995-09-19	1999-10-26	イーライ・リリー・アンド・カンパニー	医療用タンパク質をコードしているｄｎａ
CA2244693A1 (en) *	1996-01-23	1997-07-31	Progenitor, Inc.	Methods for using the obese gene and its gene product to stimulate hematopoietic development

1997
- 1997-04-29 IL IL12073397A patent/IL120733A0/xx unknown
1998
- 1998-04-26 PT PT98917580T patent/PT981365E/pt unknown
- 1998-04-26 SK SK1471-99A patent/SK284848B6/sk not_active IP Right Cessation
- 1998-04-26 EA EA199900981A patent/EA002353B1/ru not_active IP Right Cessation
- 1998-04-26 WO PCT/IL1998/000196 patent/WO1998048831A1/en not_active Ceased
- 1998-04-26 JP JP54678798A patent/JP4330662B2/ja not_active Expired - Fee Related
- 1998-04-26 UA UA99116415A patent/UA66793C2/uk unknown
- 1998-04-26 ES ES98917580T patent/ES2232944T3/es not_active Expired - Lifetime
- 1998-04-26 PL PL98336582A patent/PL195275B1/pl not_active IP Right Cessation
- 1998-04-26 AU AU70762/98A patent/AU742927B2/en not_active Ceased
- 1998-04-26 HU HU0002427A patent/HUP0002427A3/hu unknown
- 1998-04-26 CZ CZ0384899A patent/CZ299872B6/cs not_active IP Right Cessation
- 1998-04-26 CN CNB988066920A patent/CN1168497C/zh not_active Expired - Fee Related
- 1998-04-26 EP EP98917580A patent/EP0981365B1/en not_active Expired - Lifetime
- 1998-04-26 US US09/403,897 patent/US7109159B1/en not_active Expired - Fee Related
- 1998-04-26 NZ NZ500589A patent/NZ500589A/xx not_active IP Right Cessation
- 1998-04-26 KR KR10-1999-7009705A patent/KR100507731B1/ko not_active Expired - Fee Related
- 1998-04-26 EE EEP199900510A patent/EE04801B1/xx not_active IP Right Cessation
- 1998-04-26 AT AT98917580T patent/ATE283702T1/de active
- 1998-04-26 DE DE69827942T patent/DE69827942T2/de not_active Expired - Lifetime
- 1998-04-26 CA CA002288238A patent/CA2288238A1/en not_active Abandoned
- 1998-04-29 ZA ZA983608A patent/ZA983608B/xx unknown
- 1998-04-29 AR ARP980102003A patent/AR012626A1/es unknown
1999
- 1999-10-25 BG BG103832A patent/BG63490B1/bg unknown
- 1999-10-28 NO NO19995267A patent/NO322304B1/no not_active IP Right Cessation
- 1999-10-28 IL IL132633A patent/IL132633A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU742927B2 (en)	2002-01-17
WO1998048831A1 (en)	1998-11-05
AR012626A1 (es)	2000-11-08
KR100507731B1 (ko)	2005-08-10
US7109159B1 (en)	2006-09-19
KR20010012080A (ko)	2001-02-15
BG63490B1 (bg)	2002-03-29
CZ384899A3 (cs)	2000-06-14
EA002353B1 (ru)	2002-04-25
DE69827942T2 (de)	2005-12-08
EA199900981A1 (ru)	2000-04-24
NO995267D0 (no)	1999-10-28
JP4330662B2 (ja)	2009-09-16
HK1028350A1 (en)	2001-02-16
NO322304B1 (no)	2006-09-11
BG103832A (en)	2000-10-31
CA2288238A1 (en)	1998-11-05
SK147199A3 (en)	2000-06-12
SK284848B6 (sk)	2006-01-05
AU7076298A (en)	1998-11-24
PT981365E (pt)	2005-03-31
CZ299872B6 (cs)	2008-12-17
PL195275B1 (pl)	2007-08-31
NO995267L (no)	1999-12-28
ATE283702T1 (de)	2004-12-15
EE04801B1 (et)	2007-04-16
HUP0002427A2 (hu)	2000-12-28
UA66793C2 (uk)	2004-06-15
ES2232944T3 (es)	2005-06-01
NZ500589A (en)	2001-03-30
CN1261802A (zh)	2000-08-02
HUP0002427A3 (en)	2003-02-28
EP0981365A1 (en)	2000-03-01
IL120733A0 (en)	1997-08-14
DE69827942D1 (de)	2005-01-05
EE9900510A (et)	2000-06-15
EP0981365B1 (en)	2004-12-01
CN1168497C (zh)	2004-09-29
PL336582A1 (en)	2000-07-03
IL132633A (en)	2007-07-04
JP2001524968A (ja)	2001-12-04

Publication	Publication Date	Title
IL120733A0 (en)	1997-08-14	Leptin as an inhibitor of cell proliferation
EP0934404A4 (en)	2002-08-07	INHIBITION OF CELL PROLIFERATION
PL331254A1 (en)	1999-07-05	Phosphonianic inhibitors of matrix metaloproteases
EP0971723A4 (en)	2001-10-24	COMPOSITIONS AND METHODS FOR INHIBITING CELL PROLIFERATION
PL334846A1 (en)	2000-03-27	Sulphamidic inhibitors of metaloproteases
EG24027A (en)	2008-03-26	Pyrrolotriazine inhibitors of kinases
PL328048A1 (en)	1999-03-01	Method of obtaining compositions of ethylenic polymers
PL339738A1 (en)	2001-01-02	Novel lactamic inhibitors of metaloproteinases
AU1536799A (en)	1999-06-16	Bishydroxyureas as inhibitors of the 5-lipoxygenase
AU4296397A (en)	1998-02-20	Substituted bisindolylmaleimides for the inhibition of cell proliferation
HUP0101258A3 (en)	2002-08-28	Substituted bisindolymaleimides for the inhibition of cell proliferation
PL337331A1 (en)	2000-08-14	Cyanoguanidines as cell proliferation inhibitors
AU9312598A (en)	1999-03-29	Inhibitors of collagen assembly
PL337091A1 (en)	2000-07-31	Cyanoguanidines as inhibitors of cell proliferation
AU5333298A (en)	1998-07-31	Compositions and methods for tumour therapy
PL337031A1 (en)	2000-07-31	Cyanoguanidines as inhibitors of cell proliferation
AU3459497A (en)	1998-02-09	Cancer cell proliferation inhibitors
IL132633A0 (en)	2001-03-19	Leptin as an inhibitor of tumor cell proliferation
SI0981365T1 (en)	2005-04-30	Leptin as an inhibitor of tumor cell proliferation
AU2001290241A1 (en)	2002-04-02	Tumor cell proliferation inhibitors
AU8492598A (en)	1999-02-10	Methods and compositions for tumor reduction
PL336896A1 (en)	2000-07-17	Cyanoamidines as inhibitors of cell proliferation
AU5778698A (en)	1999-02-16	Reduction of restenosis
AUPO851597A0 (en)	1997-09-04	Treatment of prostate cancer
AU2086597A (en)	1997-09-22	Inhibition of proliferation of cells