NO322304B1 - Anvendelse av leptin for fremstilling av et medikament for inhibering av human brystkarcinomcelleproliferering - Google Patents

Anvendelse av leptin for fremstilling av et medikament for inhibering av human brystkarcinomcelleproliferering Download PDF

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Publication number
NO322304B1
NO322304B1 NO19995267A NO995267A NO322304B1 NO 322304 B1 NO322304 B1 NO 322304B1 NO 19995267 A NO19995267 A NO 19995267A NO 995267 A NO995267 A NO 995267A NO 322304 B1 NO322304 B1 NO 322304B1
Authority
NO
Norway
Prior art keywords
leptin
insulin
cell proliferation
cells
receptor
Prior art date
Application number
NO19995267A
Other languages
English (en)
Norwegian (no)
Other versions
NO995267D0 (no
NO995267L (no
Inventor
Batya Cohen
Menachem Rubinstein
Dalit Barkan
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of NO995267D0 publication Critical patent/NO995267D0/no
Publication of NO995267L publication Critical patent/NO995267L/no
Publication of NO322304B1 publication Critical patent/NO322304B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NO19995267A 1997-04-29 1999-10-28 Anvendelse av leptin for fremstilling av et medikament for inhibering av human brystkarcinomcelleproliferering NO322304B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12073397A IL120733A0 (en) 1997-04-29 1997-04-29 Leptin as an inhibitor of cell proliferation
PCT/IL1998/000196 WO1998048831A1 (en) 1997-04-29 1998-04-26 Leptin as an inhibitor of tumor cell proliferation

Publications (3)

Publication Number Publication Date
NO995267D0 NO995267D0 (no) 1999-10-28
NO995267L NO995267L (no) 1999-12-28
NO322304B1 true NO322304B1 (no) 2006-09-11

Family

ID=11070075

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19995267A NO322304B1 (no) 1997-04-29 1999-10-28 Anvendelse av leptin for fremstilling av et medikament for inhibering av human brystkarcinomcelleproliferering

Country Status (25)

Country Link
US (1) US7109159B1 (cs)
EP (1) EP0981365B1 (cs)
JP (1) JP4330662B2 (cs)
KR (1) KR100507731B1 (cs)
CN (1) CN1168497C (cs)
AR (1) AR012626A1 (cs)
AT (1) ATE283702T1 (cs)
AU (1) AU742927B2 (cs)
BG (1) BG63490B1 (cs)
CA (1) CA2288238A1 (cs)
CZ (1) CZ299872B6 (cs)
DE (1) DE69827942T2 (cs)
EA (1) EA002353B1 (cs)
EE (1) EE04801B1 (cs)
ES (1) ES2232944T3 (cs)
HU (1) HUP0002427A3 (cs)
IL (2) IL120733A0 (cs)
NO (1) NO322304B1 (cs)
NZ (1) NZ500589A (cs)
PL (1) PL195275B1 (cs)
PT (1) PT981365E (cs)
SK (1) SK284848B6 (cs)
UA (1) UA66793C2 (cs)
WO (1) WO1998048831A1 (cs)
ZA (1) ZA983608B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777388B1 (en) 1998-08-21 2004-08-17 Clf Medical Technology Acceleration Program, Inc. Leptin-related peptides
US7208572B2 (en) 1998-08-21 2007-04-24 Albany Medical College Leptin-related peptides
US20050272652A1 (en) 1999-03-29 2005-12-08 Gault Victor A Peptide analogues of GIP for treatment of diabetes, insulin resistance and obesity
IL132312A0 (en) * 1999-09-05 2001-03-19 Yeda Res & Dev Use of leptin in inhibition of endothelial cell proliferation
US8076288B2 (en) 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
US20060094652A1 (en) 2004-02-11 2006-05-04 Levy Odile E Hybrid polypeptides with selectable properties
US7863240B2 (en) * 2004-10-08 2011-01-04 Enzo Therapeutics, Inc. Methods and uses of leptin in hepatocellular carcinoma
US8969291B2 (en) 2004-10-08 2015-03-03 Enzo Therapeutics, Inc. Methods for decreasing leptin levels or activity for treating inflammation
US8263545B2 (en) 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
BRPI0606992A2 (pt) 2005-02-11 2009-07-28 Amylin Pharmaceuticals Inc análogo e polipeptìdeos hìbridos de gip com propriedades selecionáveis
BRPI0614649A2 (pt) 2005-08-11 2011-04-12 Amylin Pharmaceuticals Inc polipeptìdeos hìbridos com propriedades selecionáveis
AU2006279680B2 (en) 2005-08-11 2012-12-06 Amylin Pharmaceuticals, Llc Hybrid polypeptides with selectable properties
US8227408B2 (en) * 2005-09-07 2012-07-24 Neurotez, Inc. Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties
NZ602170A (en) 2008-02-08 2014-03-28 Ambrx Inc Modified leptin polypeptides and their uses
JP5622720B2 (ja) * 2008-05-21 2014-11-12 ニューロテスインコーポレイテッド 神経原繊維変化に関連する進行性認知障害の治療方法
CA2742600A1 (en) * 2008-11-04 2010-05-14 Nikolaos Tezapsidis Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amlyoid beta
WO2010146059A2 (en) 2009-06-16 2010-12-23 F. Hoffmann-La Roche Ag Biomarkers for igf-1r inhibitor therapy
TW202417497A (zh) 2015-10-12 2024-05-01 美商再生元醫藥公司 活化瘦素受體的抗原結合蛋白
EA201991075A1 (ru) 2016-11-08 2019-10-31 Антигенсвязывающие белки, которые проявляют антагонизм в отношении лептинового рецептора
KR20200100089A (ko) 2017-12-18 2020-08-25 리제너론 파마슈티칼스 인코포레이티드 렙틴 수용체 및/또는 gp130에 결합하는 이중 특이적 항원 결합 분자 및 이의 사용 방법
LT3773713T (lt) 2018-04-06 2025-08-25 Regeneron Pharmaceuticals, Inc. Leptino receptoriaus agonistinis antikūnas, skirtas kaulų masės didinimui subjektui, kuriam pasireiškia medžiagų apykaitos sutrikimas arba hipoleptinemija
CN120629571B (zh) * 2025-06-13 2026-03-27 蚌埠医学院第一附属医院（蚌埠医学院附属肿瘤医院） Lepr基因或蛋白作为靶标在制备胆管细胞癌治疗产品中的用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL122718A0 (en) * 1995-06-30 1998-08-16 Lilly Co Eli Methods for treating diabetes
JPH11512296A (ja) * 1995-09-19 1999-10-26 イーライ・リリー・アンド・カンパニー 医療用タンパク質をコードしているｄｎａ
CA2244693A1 (en) * 1996-01-23 1997-07-31 Progenitor, Inc. Methods for using the obese gene and its gene product to stimulate hematopoietic development

Also Published As

Publication number Publication date
AU742927B2 (en) 2002-01-17
WO1998048831A1 (en) 1998-11-05
AR012626A1 (es) 2000-11-08
KR100507731B1 (ko) 2005-08-10
US7109159B1 (en) 2006-09-19
KR20010012080A (ko) 2001-02-15
BG63490B1 (bg) 2002-03-29
CZ384899A3 (cs) 2000-06-14
EA002353B1 (ru) 2002-04-25
DE69827942T2 (de) 2005-12-08
EA199900981A1 (ru) 2000-04-24
NO995267D0 (no) 1999-10-28
JP4330662B2 (ja) 2009-09-16
HK1028350A1 (en) 2001-02-16
BG103832A (en) 2000-10-31
CA2288238A1 (en) 1998-11-05
SK147199A3 (en) 2000-06-12
SK284848B6 (sk) 2006-01-05
AU7076298A (en) 1998-11-24
PT981365E (pt) 2005-03-31
CZ299872B6 (cs) 2008-12-17
PL195275B1 (pl) 2007-08-31
NO995267L (no) 1999-12-28
ATE283702T1 (de) 2004-12-15
ZA983608B (en) 1998-11-02
EE04801B1 (et) 2007-04-16
HUP0002427A2 (hu) 2000-12-28
UA66793C2 (uk) 2004-06-15
ES2232944T3 (es) 2005-06-01
NZ500589A (en) 2001-03-30
CN1261802A (zh) 2000-08-02
HUP0002427A3 (en) 2003-02-28
EP0981365A1 (en) 2000-03-01
IL120733A0 (en) 1997-08-14
DE69827942D1 (de) 2005-01-05
EE9900510A (et) 2000-06-15
EP0981365B1 (en) 2004-12-01
CN1168497C (zh) 2004-09-29
PL336582A1 (en) 2000-07-03
IL132633A (en) 2007-07-04
JP2001524968A (ja) 2001-12-04

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