ZA986475B - Thermodynamically stable modification of 1-(4-carbazoly loxy)3-[2-)2-methoxyphenoxy)ethylamino]-2-propanole, and pharmaceutical compositions containing it. - Google Patents

Thermodynamically stable modification of 1-(4-carbazoly loxy)3-[2-)2-methoxyphenoxy)ethylamino]-2-propanole, and pharmaceutical compositions containing it.

Info

Publication number: ZA986475B
Authority: ZA; South Africa
Prior art keywords: carbazoly; propanole; loxy; methoxyphenoxy; ethylamino
Prior art date: 1997-07-22

Application number

ZA9806475A

Other languages

English (en)

Inventor

Erhard Reinholz

Peter Beyer

Original Assignee

Roche Diagnostics Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-22

Filing date

1998-07-21

Publication date

2000-01-21

1998-07-21 Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh

2000-01-21 Publication of ZA986475B publication Critical patent/ZA986475B/xx

Links

125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 title 1
230000004048 modification Effects 0.000 title 1
238000012986 modification Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

ZA9806475A 1997-07-22 1998-07-21 Thermodynamically stable modification of 1-(4-carbazoly loxy)3-[2-)2-methoxyphenoxy)ethylamino]-2-propanole, and pharmaceutical compositions containing it. ZA986475B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97112491A EP0893440A1 (en)	1997-07-22	1997-07-22	Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it

Publications (1)

Publication Number	Publication Date
ZA986475B true ZA986475B (en)	2000-01-21

Family

ID=8227094

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9806475A ZA986475B (en)	1997-07-22	1998-07-21	Thermodynamically stable modification of 1-(4-carbazoly loxy)3-[2-)2-methoxyphenoxy)ethylamino]-2-propanole, and pharmaceutical compositions containing it.

Country Status (31)

Country	Link
EP (2)	EP0893440A1 (cs)
JP (1)	JP2001510824A (cs)
KR (1)	KR100336229B1 (cs)
CN (1)	CN1125047C (cs)
AR (1)	AR015133A1 (cs)
AT (1)	ATE236123T1 (cs)
AU (1)	AU740453B2 (cs)
BR (1)	BR9810776A (cs)
CA (1)	CA2296637C (cs)
CZ (1)	CZ296947B6 (cs)
DE (1)	DE69812964T2 (cs)
DK (1)	DK1000027T3 (cs)
ES (1)	ES2195366T3 (cs)
HR (1)	HRP980406A2 (cs)
HU (1)	HUP0003198A3 (cs)
IL (1)	IL133677A (cs)
MA (1)	MA26523A1 (cs)
MY (1)	MY117734A (cs)
NO (1)	NO313588B1 (cs)
NZ (1)	NZ502136A (cs)
PE (1)	PE96999A1 (cs)
PL (1)	PL191602B1 (cs)
PT (1)	PT1000027E (cs)
RU (1)	RU2202542C2 (cs)
SI (1)	SI1000027T1 (cs)
TR (1)	TR200000148T2 (cs)
TW (1)	TW505631B (cs)
UY (1)	UY25108A1 (cs)
WO (1)	WO1999005105A1 (cs)
YU (1)	YU2200A (cs)
ZA (1)	ZA986475B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001074356A1 (en) *	2000-04-03	2001-10-11	F. Hoffmann-La Roche Ag	Concentrated solutions of carvedilol
CA2413702A1 (en)	2000-06-28	2002-01-03	Teva Pharmaceuticals Industries Ltd.	Carvedilol
EP1655285A1 (en) *	2000-06-28	2006-05-10	Teva Pharmaceutical Industries Ltd.	Method for preparation of a crystalline form of carvedilol (form II)
WO2003005970A2 (en) *	2001-07-13	2003-01-23	Smithkline Beecham Corporation	Carvedilol polymorph
US20050019399A1 (en)	2001-09-21	2005-01-27	Gina Fischer	Controlled release solid dispersions
PL370412A1 (en) *	2001-09-28	2005-05-30	F.Hoffmann-La Roche Ag	Pseudopolymorphic forms of carvedilol
US6710184B2 (en) *	2002-01-15	2004-03-23	Teva Pharmaceutical Industries Ltd.	Crystalline solids of carvedilol and processes for their preparation
JP2006500320A (ja) *	2002-04-30	2006-01-05	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	カルベジロール一クエン酸塩一水和物
CA2492084A1 (en) *	2002-06-27	2004-01-08	Sb Pharmco Puerto Rico Inc.	Carvedilol hydobromide
BR0312102A (pt)	2002-06-27	2007-05-29	Sb Pharmco Inc	sais de fosfato de carvedilol e/ou seus solvatos, composições correspondentes, e/ou métodos de tratamento
WO2004041252A1 (en) *	2002-11-08	2004-05-21	Egalet A/S	Controlled release carvedilol compositions
US8877241B2 (en)	2003-03-26	2014-11-04	Egalet Ltd.	Morphine controlled release system
WO2004094378A1 (en) *	2003-04-21	2004-11-04	Matrix Laboratories Ltd	Process for the preparation of carvedilol form-ii
SI21616A (sl) *	2003-09-02	2005-04-30	Krka, Tovarna Zdravil, D.D., Novo Mesto	Nove kristalne oblike karvedilola
JP2007512372A (ja) *	2003-11-25	2007-05-17	エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド	カルベジロール塩、対応する組成物、送達および／または治療方法
CA2589699A1 (en) *	2004-12-09	2006-06-15	Zach System S.P.A.	Process for the preparation of carvedilol and its enantiomers
EP1781611A1 (en) *	2005-06-09	2007-05-09	Teva Pharmaceutical Industries Ltd.	Crystalline forms of carvedilol and processes for their preparation
WO2008002683A2 (en)	2006-06-28	2008-01-03	Teva Pharmaceutical Industries Ltd.	Polymorphous forms of carvedilol phosphate
RU2366653C2 (ru) *	2006-07-03	2009-09-10	Ооо "Нанокриохимия"	Способ получения рентгеноаморфной модификации карведилола
US20080249317A1 (en) *	2007-04-04	2008-10-09	Apotex Inc.	Novel amorphous form of carvedilol phosphate and processes for the preparation thereof
US8821928B2 (en)	2007-06-04	2014-09-02	Egalet Ltd.	Controlled release pharmaceutical compositions for prolonged effect
NZ594207A (en)	2009-02-06	2013-03-28	Egalet Ltd	Immediate release composition resistant to abuse by intake of alcohol
AU2010265213B2 (en)	2009-06-24	2012-08-23	Egalet Ltd.	Controlled release formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2815926A1 (de) *	1978-04-13	1979-10-18	Boehringer Mannheim Gmbh	Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE2805404A1 (de) *	1978-02-09	1979-08-16	Merck Patent Gmbh	1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung
DE3319027A1 (de) *	1983-05-26	1984-11-29	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten

1997
- 1997-07-22 EP EP97112491A patent/EP0893440A1/en not_active Withdrawn
1998
- 1998-07-15 MY MYPI98003245A patent/MY117734A/en unknown
- 1998-07-15 PE PE1998000626A patent/PE96999A1/es not_active Application Discontinuation
- 1998-07-18 AU AU86319/98A patent/AU740453B2/en not_active Ceased
- 1998-07-18 ES ES98937576T patent/ES2195366T3/es not_active Expired - Lifetime
- 1998-07-18 JP JP2000504104A patent/JP2001510824A/ja active Pending
- 1998-07-18 WO PCT/EP1998/004475 patent/WO1999005105A1/en not_active Ceased
- 1998-07-18 TR TR2000/00148T patent/TR200000148T2/xx unknown
- 1998-07-18 AT AT98937576T patent/ATE236123T1/de not_active IP Right Cessation
- 1998-07-18 CZ CZ20000221A patent/CZ296947B6/cs not_active IP Right Cessation
- 1998-07-18 SI SI9830442T patent/SI1000027T1/xx unknown
- 1998-07-18 CN CN98807436A patent/CN1125047C/zh not_active Expired - Fee Related
- 1998-07-18 NZ NZ502136A patent/NZ502136A/en unknown
- 1998-07-18 PL PL338432A patent/PL191602B1/pl unknown
- 1998-07-18 YU YU2200A patent/YU2200A/sh unknown
- 1998-07-18 CA CA002296637A patent/CA2296637C/en not_active Expired - Fee Related
- 1998-07-18 DK DK98937576T patent/DK1000027T3/da active
- 1998-07-18 TW TW087111738A patent/TW505631B/zh not_active IP Right Cessation
- 1998-07-18 IL IL13367798A patent/IL133677A/en not_active IP Right Cessation
- 1998-07-18 KR KR1020007000667A patent/KR100336229B1/ko not_active Expired - Fee Related
- 1998-07-18 RU RU2000103033/04A patent/RU2202542C2/ru not_active IP Right Cessation
- 1998-07-18 HU HU0003198A patent/HUP0003198A3/hu unknown
- 1998-07-18 BR BR9810776-3A patent/BR9810776A/pt not_active Application Discontinuation
- 1998-07-18 DE DE69812964T patent/DE69812964T2/de not_active Expired - Fee Related
- 1998-07-18 EP EP98937576A patent/EP1000027B1/en not_active Expired - Lifetime
- 1998-07-18 PT PT98937576T patent/PT1000027E/pt unknown
- 1998-07-20 MA MA25178A patent/MA26523A1/fr unknown
- 1998-07-21 AR ARP980103547A patent/AR015133A1/es unknown
- 1998-07-21 ZA ZA9806475A patent/ZA986475B/xx unknown
- 1998-07-22 UY UY25108A patent/UY25108A1/es not_active IP Right Cessation
- 1998-07-22 HR HR97112491.2A patent/HRP980406A2/hr not_active Application Discontinuation
2000
- 2000-01-21 NO NO20000301A patent/NO313588B1/no unknown

Also Published As

Publication number	Publication date
HUP0003198A3 (en)	2002-10-28
KR100336229B1 (ko)	2002-05-09
CN1264366A (zh)	2000-08-23
TR200000148T2 (tr)	2000-07-21
HRP980406A2 (en)	1999-04-30
DK1000027T3 (da)	2003-07-21
NO20000301L (no)	2000-01-21
EP0893440A1 (en)	1999-01-27
NZ502136A (en)	2002-05-31
SI1000027T1 (en)	2003-10-31
DE69812964D1 (de)	2003-05-08
YU2200A (sh)	2002-03-18
PL338432A1 (en)	2000-11-06
PT1000027E (pt)	2003-07-31
WO1999005105A1 (en)	1999-02-04
JP2001510824A (ja)	2001-08-07
MY117734A (en)	2004-07-31
CA2296637A1 (en)	1999-02-04
IL133677A0 (en)	2001-04-30
AR015133A1 (es)	2001-04-18
CZ2000221A3 (cs)	2000-05-17
DE69812964T2 (de)	2004-03-04
UY25108A1 (es)	2000-12-29
AU740453B2 (en)	2001-11-01
AU8631998A (en)	1999-02-16
HUP0003198A2 (en)	2001-03-28
PE96999A1 (es)	1999-10-12
RU2202542C2 (ru)	2003-04-20
EP1000027A1 (en)	2000-05-17
NO20000301D0 (no)	2000-01-21
TW505631B (en)	2002-10-11
CN1125047C (zh)	2003-10-22
KR20010022097A (ko)	2001-03-15
CZ296947B6 (cs)	2006-08-16
IL133677A (en)	2004-06-01
EP1000027B1 (en)	2003-04-02
ATE236123T1 (de)	2003-04-15
CA2296637C (en)	2005-11-15
ES2195366T3 (es)	2003-12-01
PL191602B1 (pl)	2006-06-30
NO313588B1 (no)	2002-10-28
HK1029339A1 (en)	2001-03-30
MA26523A1 (fr)	2004-12-20
BR9810776A (pt)	2000-09-19

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