ZA989559B - Process for the recycle of a waste product of diltiazem synthesis - Google Patents
Process for the recycle of a waste product of diltiazem synthesisInfo
- Publication number
- ZA989559B ZA989559B ZA989559A ZA989559A ZA989559B ZA 989559 B ZA989559 B ZA 989559B ZA 989559 A ZA989559 A ZA 989559A ZA 989559 A ZA989559 A ZA 989559A ZA 989559 B ZA989559 B ZA 989559B
- Authority
- ZA
- South Africa
- Prior art keywords
- recycle
- waste product
- diltiazem
- synthesis
- diltiazem synthesis
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 title abstract 2
- 229960004166 diltiazem Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000002699 waste material Substances 0.000 title 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Compounds Of Unknown Constitution (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT97MI002374A IT1295376B1 (it) | 1997-10-22 | 1997-10-22 | Processo per il riciclo di un sottoprodotto della sintesi del diltiazem |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA989559B true ZA989559B (en) | 1999-04-22 |
Family
ID=11378079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA989559A ZA989559B (en) | 1997-10-22 | 1998-10-20 | Process for the recycle of a waste product of diltiazem synthesis |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6114523A (fr) |
| EP (1) | EP1025080B1 (fr) |
| JP (1) | JP2001520219A (fr) |
| KR (1) | KR20010031267A (fr) |
| CN (1) | CN1121383C (fr) |
| AT (1) | ATE230724T1 (fr) |
| AU (1) | AU743612B2 (fr) |
| CA (1) | CA2304371A1 (fr) |
| DE (1) | DE69810653T2 (fr) |
| ES (1) | ES2189263T3 (fr) |
| HU (1) | HU225099B1 (fr) |
| IL (1) | IL134534A0 (fr) |
| IT (1) | IT1295376B1 (fr) |
| PL (1) | PL194251B1 (fr) |
| SK (1) | SK284417B6 (fr) |
| WO (1) | WO1999020603A1 (fr) |
| ZA (1) | ZA989559B (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7408084B2 (en) * | 2002-06-11 | 2008-08-05 | Kaneka Corporation | Process for producing optically active β-amino alcohol |
| CN103755663B (zh) * | 2014-01-26 | 2016-02-24 | 武汉工程大学 | 地尔硫卓中间体副产物L-cis-内酰胺的回收工艺 |
| CN110284181A (zh) * | 2019-08-07 | 2019-09-27 | 山东新华制药股份有限公司 | 地尔硫卓ab异构体的单晶制备方法 |
| CN112279820B (zh) * | 2020-12-18 | 2021-04-02 | 苏州开元民生科技股份有限公司 | 2-(4-甲氧苯基)-3-羟基-2,3-二氢-1,5-苯并硫氮杂卓酮的制备方法 |
| CN118684635B (zh) * | 2024-08-22 | 2024-11-05 | 苏州开元民生科技股份有限公司 | 一种地尔硫卓手性中间体的制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1236467A (en) * | 1967-10-28 | 1971-06-23 | Tanabe Seiyaku Co | Benzothiazepine derivatives |
| EP0059335B1 (fr) * | 1981-02-27 | 1985-05-15 | Tanabe Seiyaku Co., Ltd. | Procédé pour la préparation des esters de l'acide thréo-hydroxy-2 (méthoxy-4 phényl)-3 (nitro-2 phénylthio)-3 propionique |
| SE449611B (sv) * | 1982-07-09 | 1987-05-11 | Tanabe Seiyaku Co | Sett att framstella 1,5-bensotiazepinderivat |
| IT1152721B (it) * | 1982-10-15 | 1987-01-07 | Luso Farmaco Inst | Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico |
| IT1230057B (it) * | 1989-04-13 | 1991-09-27 | Zambon Spa | Processo di risoluzione di intermedi utili per la preparazione di 1,5-benzotiazepine |
| JPH0798813B2 (ja) * | 1989-04-28 | 1995-10-25 | 田辺製薬株式会社 | １，５―ベンゾチアゼピン誘導体の製法 |
| IT1232306B (it) * | 1989-07-27 | 1992-01-28 | Zambon Spa | Processo di risoluzione di intermedi utili per la preparazione del diltiazem |
| IT1237526B (it) * | 1989-12-06 | 1993-06-08 | Zambon Spa | Processo di preparazione di un intermedio per il diltiazem |
| JPH085869B2 (ja) * | 1990-03-08 | 1996-01-24 | 田辺製薬株式会社 | １，５−ベンゾチアゼピン誘導体の製法 |
| NL9000763A (nl) * | 1990-03-31 | 1991-10-16 | Stamicarbon | Werkwijze voor het bereiden van 1,5-benzothiazepine-derivaten. |
| IT1249318B (it) * | 1991-05-23 | 1995-02-22 | Zambon Spa | Processo per la preparazione di benzotiazepine per ciclizzazione con acidi fosfonici |
| FI93741C (fi) * | 1993-03-24 | 1995-05-26 | Orion Yhtymae Oy | Menetelmä optisesti puhtaitten (2S,3S)- ja (2R,3R)-threo-alkyyli-2-hydroksi-3-(4-metoksifenyyli)-3-(2-X-fenyylitio)propionaattien tai vastaavien asyloitujen yhdisteiden valmistamiseksi |
| JPH07108982A (ja) * | 1993-10-13 | 1995-04-25 | Nippon Shokubai Co Ltd | 浮き桟橋 |
-
1997
- 1997-10-22 IT IT97MI002374A patent/IT1295376B1/it active IP Right Grant
-
1998
- 1998-10-12 ES ES98954403T patent/ES2189263T3/es not_active Expired - Lifetime
- 1998-10-12 AT AT98954403T patent/ATE230724T1/de active
- 1998-10-12 PL PL98339054A patent/PL194251B1/pl not_active IP Right Cessation
- 1998-10-12 WO PCT/EP1998/006467 patent/WO1999020603A1/fr not_active Ceased
- 1998-10-12 SK SK560-2000A patent/SK284417B6/sk unknown
- 1998-10-12 CN CN98809527A patent/CN1121383C/zh not_active Expired - Fee Related
- 1998-10-12 HU HU0100997A patent/HU225099B1/hu not_active IP Right Cessation
- 1998-10-12 CA CA002304371A patent/CA2304371A1/fr not_active Abandoned
- 1998-10-12 AU AU11531/99A patent/AU743612B2/en not_active Ceased
- 1998-10-12 DE DE69810653T patent/DE69810653T2/de not_active Expired - Lifetime
- 1998-10-12 JP JP2000516945A patent/JP2001520219A/ja active Pending
- 1998-10-12 IL IL13453498A patent/IL134534A0/xx not_active IP Right Cessation
- 1998-10-12 EP EP98954403A patent/EP1025080B1/fr not_active Expired - Lifetime
- 1998-10-12 KR KR1020007004254A patent/KR20010031267A/ko not_active Ceased
- 1998-10-20 ZA ZA989559A patent/ZA989559B/xx unknown
- 1998-10-21 US US09/176,189 patent/US6114523A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL194251B1 (pl) | 2007-05-31 |
| SK284417B6 (sk) | 2005-03-04 |
| AU743612B2 (en) | 2002-01-31 |
| CA2304371A1 (fr) | 1999-04-29 |
| ES2189263T3 (es) | 2003-07-01 |
| IT1295376B1 (it) | 1999-05-12 |
| DE69810653D1 (de) | 2003-02-13 |
| WO1999020603A1 (fr) | 1999-04-29 |
| ITMI972374A1 (it) | 1999-04-22 |
| DE69810653T2 (de) | 2003-11-13 |
| KR20010031267A (ko) | 2001-04-16 |
| SK5602000A3 (en) | 2000-09-12 |
| JP2001520219A (ja) | 2001-10-30 |
| PL339054A1 (en) | 2000-12-04 |
| HUP0100997A2 (hu) | 2001-08-28 |
| HU225099B1 (en) | 2006-06-28 |
| IL134534A0 (en) | 2001-04-30 |
| EP1025080A1 (fr) | 2000-08-09 |
| CN1271340A (zh) | 2000-10-25 |
| EP1025080B1 (fr) | 2003-01-08 |
| US6114523A (en) | 2000-09-05 |
| ATE230724T1 (de) | 2003-01-15 |
| AU1153199A (en) | 1999-05-10 |
| HUP0100997A3 (en) | 2002-11-28 |
| CN1121383C (zh) | 2003-09-17 |
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