AP1374A - Aerosolizable particles resistant to hygroscopic growth. - Google Patents

Aerosolizable particles resistant to hygroscopic growth. Download PDF

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Publication number
AP1374A
AP1374A APAP/P/2001/002093A AP2001002093A AP1374A AP 1374 A AP1374 A AP 1374A AP 2001002093 A AP2001002093 A AP 2001002093A AP 1374 A AP1374 A AP 1374A
Authority
AP
ARIPO
Prior art keywords
particles
active agent
hygroscopic
growth inhibitor
hygroscopic growth
Prior art date
Application number
APAP/P/2001/002093A
Other languages
English (en)
Other versions
AP2001002093A0 (en
Inventor
Andrew Clark
Mei-Chang Kuo
Cecily Lalor
Barry John Aldous
Original Assignee
Inhale Therapeutic Syst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhale Therapeutic Syst filed Critical Inhale Therapeutic Syst
Publication of AP2001002093A0 publication Critical patent/AP2001002093A0/xx
Application granted granted Critical
Publication of AP1374A publication Critical patent/AP1374A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
APAP/P/2001/002093A 1998-09-14 1999-09-13 Aerosolizable particles resistant to hygroscopic growth. AP1374A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10016398P 1998-09-14 1998-09-14
PCT/US1999/021109 WO2000015262A1 (en) 1998-09-14 1999-09-13 Dry powder active agent pulmonary delivery

Publications (2)

Publication Number Publication Date
AP2001002093A0 AP2001002093A0 (en) 2001-03-31
AP1374A true AP1374A (en) 2005-02-28

Family

ID=22278404

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2001/002093A AP1374A (en) 1998-09-14 1999-09-13 Aerosolizable particles resistant to hygroscopic growth.

Country Status (44)

Country Link
EP (1) EP1117442A1 (is)
JP (1) JP2002524535A (is)
KR (1) KR20010075063A (is)
CN (1) CN1317977A (is)
AP (1) AP1374A (is)
AR (1) AR022090A1 (is)
AU (1) AU753014B2 (is)
BG (1) BG105430A (is)
BR (1) BR9913722A (is)
CA (1) CA2343920A1 (is)
CO (1) CO5130023A1 (is)
CZ (1) CZ2001829A3 (is)
DZ (1) DZ2892A1 (is)
EA (1) EA003476B1 (is)
EE (1) EE200100151A (is)
GE (1) GEP20043257B (is)
GT (1) GT199900156A (is)
HK (1) HK1042231A1 (is)
HN (1) HN1999000159A (is)
HR (1) HRP20010189A2 (is)
HU (1) HUP0103837A3 (is)
ID (1) ID28845A (is)
IL (2) IL141562A0 (is)
IS (1) IS5878A (is)
LT (1) LT4897B (is)
LV (1) LV12658B (is)
MA (1) MA25590A1 (is)
MY (1) MY129282A (is)
NO (1) NO20011251L (is)
NZ (1) NZ510168A (is)
OA (1) OA11781A (is)
PA (1) PA8481901A1 (is)
PE (1) PE20001061A1 (is)
PL (1) PL195574B1 (is)
SA (1) SA99200718B1 (is)
SK (1) SK3442001A3 (is)
TN (1) TNSN99173A1 (is)
TR (1) TR200101182T2 (is)
TW (1) TWI226248B (is)
UA (1) UA76085C2 (is)
UY (1) UY25711A1 (is)
WO (1) WO2000015262A1 (is)
YU (1) YU24201A (is)
ZA (1) ZA200101995B (is)

Families Citing this family (33)

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US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
HK1049621A1 (zh) 1999-06-09 2003-05-23 罗伯特‧E‧希弗斯 超临界流体辅助的喷雾和鼓泡乾燥
US6475468B2 (en) * 2001-02-15 2002-11-05 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
CA2446904A1 (en) * 2001-05-24 2003-04-03 Alexza Pharmaceuticals, Inc. Delivery of drug esters through an inhalation route
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
CA2465675C (en) 2001-11-20 2008-06-10 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
WO2003072734A2 (en) 2002-02-25 2003-09-04 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
CA2491129A1 (en) * 2002-07-03 2004-01-15 Brigham And Women's Hospital, Inc. Central airway administration for systemic delivery of therapeutics
JP2006513238A (ja) * 2002-12-19 2006-04-20 ファルマシア・コーポレーション 吸湿性薬物を含む非‐吸湿性製剤
DE10338403A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierung, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyrindinyl)-piperazin, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
BRPI0510119A (pt) 2004-04-23 2007-09-25 Cydex Inc formulação para dpi contendo sulfoaquil éter de ciclodextrina
UA95903C2 (ru) * 2005-02-24 2011-09-26 Дифьюжен Фармасьютикалз Ллк Транс-каротиноиды, их синтез, лекарственная форма и применение
KR20070110418A (ko) * 2005-03-09 2007-11-16 오노 야꾸힝 고교 가부시키가이샤 입자 및 그 입자를 함유하는 제제
SI2952197T1 (sl) 2005-10-26 2017-09-29 Cydex Pharmaceuticals, Inc. Sestavki sulfoalkil eter ciklodekstrina in metode priprave le-tega
US20100269819A1 (en) * 2006-08-14 2010-10-28 Sievers Robert E Human Powered Dry Powder Inhaler and Dry Powder Inhaler Compositions
CN101541311B (zh) * 2006-10-25 2013-01-23 大日本住友制药株式会社 不易结块的颗粒制剂
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
EP3483140A1 (en) 2007-04-13 2019-05-15 Diffusion Pharmaceuticals LLC Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
US12370352B2 (en) 2007-06-28 2025-07-29 Cydex Pharmaceuticals, Inc. Nasal and ophthalmic delivery of aqueous corticosteroid solutions
EA201070544A1 (ru) 2007-10-31 2010-12-30 Диффьюжн Фармасьютикалз Ллс Новый класс терапевтических веществ, усиливающих диффузию низкомолекулярных соединений
ES2661215T3 (es) * 2009-05-20 2018-03-28 Aeras Composiciones víricas; inmunógenas; secadas por pulverización; estables
KR101875843B1 (ko) 2009-06-22 2018-07-06 디퓨젼 파마슈티컬즈 엘엘씨 확산 촉진 화합물 및 그 화합물 단독 또는 혈전 용해제와 합쳐진 화합물의 용도
CN105287473A (zh) 2010-06-02 2016-02-03 扩散药品有限公司 包含双极性反式类胡萝卜素的组合物及其应用
SG11201406208QA (en) 2012-05-03 2014-11-27 Janssen Sciences Ireland Uc Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections
BR112015010601B1 (pt) * 2012-11-09 2022-07-19 Civitas Therapeutics, Inc. Composição farmacêutica e uso da composição
US20180043585A9 (en) * 2013-09-20 2018-02-15 Virginia Commonwealth University Delivery of particles using hygroscopic excipients
AU2015338717B2 (en) 2014-10-31 2018-12-20 Glaxosmithkline Intellectual Property Development Limited Powder formulation
WO2017165667A1 (en) 2016-03-24 2017-09-28 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
US20220378727A1 (en) * 2021-05-14 2022-12-01 The University Of Hong Kong Dry powder formulations of tamibarotene for pulmonary and intranasal delivery
EP4493276A4 (en) * 2022-03-18 2025-03-05 Pulmocures Ilac Egitim Danismanlik A.S. DOSAGE FORMS OF ACTIVE AGENTS AGAINST VIRAL DISEASES IN DRY POWDER INHALATOR DEVICES FOR SYMPTOMS DUE TO COVID-19 AND OTHER VIRAL LUNG DISEASES

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
EP0611567A1 (en) * 1992-06-12 1994-08-24 Teijin Limited Ultrafine powder for inhalation and production thereof
WO1996019197A1 (en) * 1994-12-22 1996-06-27 Astra Aktiebolag Aerosol formulations of peptides and proteins
WO1998031346A1 (en) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation of particles for inhalation
WO1999038493A1 (en) * 1998-01-30 1999-08-05 Rtp Pharma Inc. Microparticle inhalation formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
EP0611567A1 (en) * 1992-06-12 1994-08-24 Teijin Limited Ultrafine powder for inhalation and production thereof
WO1996019197A1 (en) * 1994-12-22 1996-06-27 Astra Aktiebolag Aerosol formulations of peptides and proteins
WO1998031346A1 (en) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation of particles for inhalation
WO1999038493A1 (en) * 1998-01-30 1999-08-05 Rtp Pharma Inc. Microparticle inhalation formulations

Also Published As

Publication number Publication date
JP2002524535A (ja) 2002-08-06
MA25590A1 (fr) 2002-12-31
WO2000015262A1 (en) 2000-03-23
YU24201A (sh) 2003-08-29
PE20001061A1 (es) 2000-10-08
MY129282A (en) 2007-03-30
IL141562A (en) 2007-07-24
CA2343920A1 (en) 2000-03-23
CN1317977A (zh) 2001-10-17
ID28845A (id) 2001-07-05
HRP20010189A2 (en) 2005-04-30
CZ2001829A3 (cs) 2001-09-12
CO5130023A1 (es) 2002-02-27
PL195574B1 (pl) 2007-10-31
LT4897B (lt) 2002-02-25
PA8481901A1 (es) 2002-04-25
LT2001021A (en) 2001-11-26
OA11781A (en) 2005-07-26
BG105430A (en) 2001-12-29
HUP0103837A2 (hu) 2002-05-29
HK1042231A1 (zh) 2002-08-09
NZ510168A (en) 2003-09-26
ZA200101995B (en) 2002-03-11
AU753014B2 (en) 2002-10-03
TNSN99173A1 (fr) 2005-11-10
EE200100151A (et) 2002-06-17
LV12658B (lv) 2001-09-20
LV12658A (lv) 2001-05-20
EP1117442A1 (en) 2001-07-25
UA76085C2 (en) 2006-07-17
GT199900156A (es) 2001-03-07
SA99200718B1 (ar) 2006-11-04
PL346768A1 (en) 2002-02-25
GEP20043257B (en) 2004-06-25
AP2001002093A0 (en) 2001-03-31
TWI226248B (en) 2005-01-11
DZ2892A1 (fr) 2003-12-15
UY25711A1 (es) 1999-11-17
NO20011251L (no) 2001-04-17
AR022090A1 (es) 2002-09-04
TR200101182T2 (tr) 2001-09-21
HUP0103837A3 (en) 2002-11-28
IL141562A0 (en) 2002-03-10
NO20011251D0 (no) 2001-03-13
IS5878A (is) 2001-03-05
EA003476B1 (ru) 2003-06-26
HN1999000159A (es) 1999-11-11
BR9913722A (pt) 2001-05-29
KR20010075063A (ko) 2001-08-09
EA200100300A1 (ru) 2001-10-22
AU6039799A (en) 2000-04-03
SK3442001A3 (en) 2001-11-06

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