AP1374A - Aerosolizable particles resistant to hygroscopic growth. - Google Patents

Aerosolizable particles resistant to hygroscopic growth. Download PDF

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Publication number
AP1374A
AP1374A APAP/P/2001/002093A AP2001002093A AP1374A AP 1374 A AP1374 A AP 1374A AP 2001002093 A AP2001002093 A AP 2001002093A AP 1374 A AP1374 A AP 1374A
Authority
AP
ARIPO
Prior art keywords
particles
active agent
hygroscopic
growth inhibitor
hygroscopic growth
Prior art date
Application number
APAP/P/2001/002093A
Other languages
English (en)
Other versions
AP2001002093A0 (en
Inventor
Andrew Clark
Mei-Chang Kuo
Cecily Lalor
Barry John Aldous
Original Assignee
Inhale Therapeutic Syst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhale Therapeutic Syst filed Critical Inhale Therapeutic Syst
Publication of AP2001002093A0 publication Critical patent/AP2001002093A0/xx
Application granted granted Critical
Publication of AP1374A publication Critical patent/AP1374A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
APAP/P/2001/002093A 1998-09-14 1999-09-13 Aerosolizable particles resistant to hygroscopic growth. AP1374A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10016398P 1998-09-14 1998-09-14
PCT/US1999/021109 WO2000015262A1 (en) 1998-09-14 1999-09-13 Dry powder active agent pulmonary delivery

Publications (2)

Publication Number Publication Date
AP2001002093A0 AP2001002093A0 (en) 2001-03-31
AP1374A true AP1374A (en) 2005-02-28

Family

ID=22278404

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/2001/002093A AP1374A (en) 1998-09-14 1999-09-13 Aerosolizable particles resistant to hygroscopic growth.

Country Status (44)

Country Link
EP (1) EP1117442A1 (is)
JP (1) JP2002524535A (is)
KR (1) KR20010075063A (is)
CN (1) CN1317977A (is)
AP (1) AP1374A (is)
AR (1) AR022090A1 (is)
AU (1) AU753014B2 (is)
BG (1) BG105430A (is)
BR (1) BR9913722A (is)
CA (1) CA2343920A1 (is)
CO (1) CO5130023A1 (is)
CZ (1) CZ2001829A3 (is)
DZ (1) DZ2892A1 (is)
EA (1) EA003476B1 (is)
EE (1) EE200100151A (is)
GE (1) GEP20043257B (is)
GT (1) GT199900156A (is)
HK (1) HK1042231A1 (is)
HN (1) HN1999000159A (is)
HR (1) HRP20010189A2 (is)
HU (1) HUP0103837A3 (is)
ID (1) ID28845A (is)
IL (2) IL141562A0 (is)
IS (1) IS5878A (is)
LT (1) LT4897B (is)
LV (1) LV12658B (is)
MA (1) MA25590A1 (is)
MY (1) MY129282A (is)
NO (1) NO20011251L (is)
NZ (1) NZ510168A (is)
OA (1) OA11781A (is)
PA (1) PA8481901A1 (is)
PE (1) PE20001061A1 (is)
PL (1) PL195574B1 (is)
SA (1) SA99200718B1 (is)
SK (1) SK3442001A3 (is)
TN (1) TNSN99173A1 (is)
TR (1) TR200101182T2 (is)
TW (1) TWI226248B (is)
UA (1) UA76085C2 (is)
UY (1) UY25711A1 (is)
WO (1) WO2000015262A1 (is)
YU (1) YU24201A (is)
ZA (1) ZA200101995B (is)

Families Citing this family (33)

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US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
ATE555773T1 (de) 1999-06-09 2012-05-15 Sievers Robert E Überkritische fluidgestützte verneblung und blasen trochnen
US6475468B2 (en) * 2001-02-15 2002-11-05 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
CA2446904A1 (en) * 2001-05-24 2003-04-03 Alexza Pharmaceuticals, Inc. Delivery of drug esters through an inhalation route
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
WO2003043585A2 (en) 2001-11-20 2003-05-30 Advanced Inhalation Research, Inc. Improved particulate compositions for pulmonary delivery
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
EP1487774B1 (en) 2002-02-25 2018-09-19 Diffusion Pharmaceuticals LLC Bipolar trans carotenoid salts and their uses
AU2003232081B2 (en) * 2002-07-03 2009-02-05 Brandeis University Central airway administration for systemic delivery of therapeutics
ES2280835T3 (es) * 2002-12-19 2007-09-16 Pharmacia Corporation Formulacion no higroscopica que comprende un farmaco higroscopico.
DE10338403A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierung, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyrindinyl)-piperazin, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
HUE058227T2 (hu) * 2004-04-23 2022-07-28 Cydex Pharmaceuticals Inc DPI készítmény, amely szulfoalkil-éter-ciklodextrint tartalmaz
NZ561664A (en) * 2005-02-24 2011-02-25 Diffusion Pharmaceuticals Llc Trans carotenoids, their synthesis, formulation and uses
CA2602007A1 (en) * 2005-03-09 2006-09-14 Ono Pharmaceutical Co., Ltd. Particle and preparation containing the particle
MX348982B (es) 2005-10-26 2017-07-06 Cydex Pharmaceuticals Inc Composiciones de eter sulfoalquilico-ciclodextrina y metodos de preparacion de las mismas.
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
US20080035143A1 (en) * 2006-08-14 2008-02-14 Sievers Robert E Human-powered dry powder inhaler and dry powder inhaler compositions
KR20090081407A (ko) * 2006-10-25 2009-07-28 다이닛본 스미토모 세이야꾸 가부시끼가이샤 고결 방지 과립상 제제
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
CN101687757A (zh) 2007-04-13 2010-03-31 扩散药品有限公司 双极性反式类胡萝卜素作为预治疗及其在周围血管疾病的治疗中的应用
US12370352B2 (en) 2007-06-28 2025-07-29 Cydex Pharmaceuticals, Inc. Nasal and ophthalmic delivery of aqueous corticosteroid solutions
AU2008319225B2 (en) 2007-10-31 2016-09-29 Diffusion Pharmaceuticals Llc A new class of therapeutics that enhance small molecule diffusion
DK2432502T3 (en) 2009-05-20 2018-03-12 Aeras STABLE, SPRAY DRIED, IMMUNOGENE, VIRUS COMPOSITIONS
EP2445339B1 (en) 2009-06-22 2019-08-07 Diffusion Pharmaceuticals LLC Diffusion enhancing compound and its use with a thrombolytic
JP2013527231A (ja) 2010-06-02 2013-06-27 ディフュージョン・ファーマシューティカルズ・エルエルシー 双極性トランスカロテノイドの経口製剤
RU2650636C2 (ru) * 2012-05-03 2018-04-16 Янссен Сайенсиз Айрлэнд Юси Составы на основе полиинозиновой-полицитидиловой кислоты (poly(i:с)) для лечения инфекций верхних дыхательных путей
BR112015010601B1 (pt) * 2012-11-09 2022-07-19 Civitas Therapeutics, Inc. Composição farmacêutica e uso da composição
US20180043585A9 (en) * 2013-09-20 2018-02-15 Virginia Commonwealth University Delivery of particles using hygroscopic excipients
CA2965759C (en) 2014-10-31 2023-12-12 Glaxosmithkline Intellectual Property Development Limited Powdered polypeptides with decreased disulfide impurities comprising divalent cationic materials
CN109152839A (zh) 2016-03-24 2019-01-04 扩散药品有限公司 双极性反式类胡萝卜素连同化疗和放射治疗在治疗癌症中的用途
US20220378727A1 (en) * 2021-05-14 2022-12-01 The University Of Hong Kong Dry powder formulations of tamibarotene for pulmonary and intranasal delivery

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
EP0611567A1 (en) * 1992-06-12 1994-08-24 Teijin Limited Ultrafine powder for inhalation and production thereof
WO1996019197A1 (en) * 1994-12-22 1996-06-27 Astra Aktiebolag Aerosol formulations of peptides and proteins
WO1998031346A1 (en) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation of particles for inhalation
WO1999038493A1 (en) * 1998-01-30 1999-08-05 Rtp Pharma Inc. Microparticle inhalation formulations

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
EP0611567A1 (en) * 1992-06-12 1994-08-24 Teijin Limited Ultrafine powder for inhalation and production thereof
WO1996019197A1 (en) * 1994-12-22 1996-06-27 Astra Aktiebolag Aerosol formulations of peptides and proteins
WO1998031346A1 (en) * 1997-01-16 1998-07-23 Massachusetts Institute Of Technology Preparation of particles for inhalation
WO1999038493A1 (en) * 1998-01-30 1999-08-05 Rtp Pharma Inc. Microparticle inhalation formulations

Also Published As

Publication number Publication date
HRP20010189A2 (en) 2005-04-30
NO20011251L (no) 2001-04-17
ID28845A (id) 2001-07-05
SK3442001A3 (en) 2001-11-06
EA003476B1 (ru) 2003-06-26
CA2343920A1 (en) 2000-03-23
IS5878A (is) 2001-03-05
CN1317977A (zh) 2001-10-17
TR200101182T2 (tr) 2001-09-21
GT199900156A (es) 2001-03-07
EA200100300A1 (ru) 2001-10-22
LT4897B (lt) 2002-02-25
PE20001061A1 (es) 2000-10-08
EP1117442A1 (en) 2001-07-25
NZ510168A (en) 2003-09-26
MA25590A1 (fr) 2002-12-31
KR20010075063A (ko) 2001-08-09
SA99200718B1 (ar) 2006-11-04
PA8481901A1 (es) 2002-04-25
BG105430A (en) 2001-12-29
PL195574B1 (pl) 2007-10-31
CO5130023A1 (es) 2002-02-27
EE200100151A (et) 2002-06-17
TNSN99173A1 (fr) 2005-11-10
JP2002524535A (ja) 2002-08-06
BR9913722A (pt) 2001-05-29
WO2000015262A1 (en) 2000-03-23
HN1999000159A (es) 1999-11-11
UA76085C2 (en) 2006-07-17
NO20011251D0 (no) 2001-03-13
AR022090A1 (es) 2002-09-04
OA11781A (en) 2005-07-26
IL141562A (en) 2007-07-24
ZA200101995B (en) 2002-03-11
YU24201A (sh) 2003-08-29
AP2001002093A0 (en) 2001-03-31
HUP0103837A3 (en) 2002-11-28
AU753014B2 (en) 2002-10-03
GEP20043257B (en) 2004-06-25
PL346768A1 (en) 2002-02-25
MY129282A (en) 2007-03-30
TWI226248B (en) 2005-01-11
IL141562A0 (en) 2002-03-10
HK1042231A1 (zh) 2002-08-09
CZ2001829A3 (cs) 2001-09-12
LT2001021A (en) 2001-11-26
LV12658A (lv) 2001-05-20
AU6039799A (en) 2000-04-03
DZ2892A1 (fr) 2003-12-15
LV12658B (lv) 2001-09-20
HUP0103837A2 (hu) 2002-05-29
UY25711A1 (es) 1999-11-17

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