AP2444A - New benzothiazinone derivatives and their use as antibacterial agents - Google Patents

New benzothiazinone derivatives and their use as antibacterial agents

Info

Publication number
AP2444A
AP2444A AP2008004723A AP2008004723A AP2444A AP 2444 A AP2444 A AP 2444A AP 2008004723 A AP2008004723 A AP 2008004723A AP 2008004723 A AP2008004723 A AP 2008004723A AP 2444 A AP2444 A AP 2444A
Authority
AP
ARIPO
Prior art keywords
antibacterial agents
new
benzothiazinone derivatives
derivatives
new benzothiazinone
Prior art date
Application number
AP2008004723A
Other languages
English (en)
Other versions
AP2008004723A0 (en
Inventor
Vadim A Makarov
Stewart T Cole
Ute Mollmann
Original Assignee
Leibniz Inst For Natural Product Res Andinfection Biology Ev Hans Knoll Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leibniz Inst For Natural Product Res Andinfection Biology Ev Hans Knoll Inst filed Critical Leibniz Inst For Natural Product Res Andinfection Biology Ev Hans Knoll Inst
Publication of AP2008004723A0 publication Critical patent/AP2008004723A0/xx
Application granted granted Critical
Publication of AP2444A publication Critical patent/AP2444A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AP2008004723A 2006-05-24 2006-05-24 New benzothiazinone derivatives and their use as antibacterial agents AP2444A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2006/004942 WO2007134625A1 (en) 2006-05-24 2006-05-24 New benzothiazinone derivatives and their use as antibacterial agents

Publications (2)

Publication Number Publication Date
AP2008004723A0 AP2008004723A0 (en) 2008-12-31
AP2444A true AP2444A (en) 2012-08-31

Family

ID=37595033

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2008004723A AP2444A (en) 2006-05-24 2006-05-24 New benzothiazinone derivatives and their use as antibacterial agents

Country Status (24)

Country Link
US (2) US7863268B2 (xx)
EP (1) EP2029583B1 (xx)
JP (1) JP5068813B2 (xx)
KR (1) KR101314999B1 (xx)
CN (1) CN101472922B (xx)
AP (1) AP2444A (xx)
AT (1) ATE470667T1 (xx)
AU (1) AU2006343832B2 (xx)
BR (1) BRPI0621693B8 (xx)
CA (1) CA2652841C (xx)
CR (1) CR10519A (xx)
CY (1) CY1110769T1 (xx)
DE (1) DE602006014885D1 (xx)
DK (1) DK2029583T3 (xx)
EA (1) EA015910B1 (xx)
ES (1) ES2345902T3 (xx)
IL (1) IL195453A (xx)
MX (1) MX2008014958A (xx)
NZ (1) NZ573833A (xx)
PL (1) PL2029583T3 (xx)
PT (1) PT2029583E (xx)
SI (1) SI2029583T1 (xx)
TN (1) TNSN08474A1 (xx)
WO (1) WO2007134625A1 (xx)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5068813B2 (ja) 2006-05-24 2012-11-07 ライブニッツ インスティトゥート フォー ナチュラル プロダクト リサーチ アンド インフェクション バイオロジー エー．ファウ． ハンス−クネル−インスティトゥート（ハーカーイー） 新規なベンゾチアジノン誘導体、及び抗菌剤としてのその使用
EP2020406A1 (en) * 2007-07-16 2009-02-04 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection
RU2474621C2 (ru) * 2008-02-13 2013-02-10 Сентинель Сх С.П.А. Новая эффективная лекарственная мишень для лечения туберкулеза
EP2380886A1 (en) 2010-04-23 2011-10-26 Vadim A. Makarov Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones
AU2011330742B2 (en) 2010-11-19 2016-10-13 Ecole Polytechnique Federale De Lausanne (Epfl) 2-piperazin-1-yl-4H-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections
EP2468746A1 (en) 2010-12-23 2012-06-27 The University of Queensland Benzothiazinone compounds and their use as anti-tuberculosis agents
US8486717B2 (en) 2011-01-18 2013-07-16 Symbolics, Llc Lateral flow assays using two dimensional features
CN102276598B (zh) * 2011-05-27 2014-11-05 四川大学 苯并噻嗪硫酮衍生物及其制备方法和用途
CN102367239B (zh) * 2011-07-20 2015-10-28 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途
EP2570413A1 (en) 2011-09-15 2013-03-20 The University Of Queensland Benzothiazinone derivatives as anti-tuberculosis agents
CN103508980B (zh) * 2012-06-14 2016-07-06 四川大学 苯并噻嗪-4-酮衍生物及其制备方法和用途
US9874556B2 (en) 2012-07-18 2018-01-23 Symbolics, Llc Lateral flow assays using two dimensional features
CN104211708B (zh) * 2013-05-29 2018-08-24 中国医学科学院药物研究所 苯并噁嗪酮衍生物及其作为抗菌剂的应用
EP3044592B1 (en) 2013-09-13 2019-07-17 Symbolics, LLC Lateral flow assays using two dimensional test and control signal readout patterns
MY179376A (en) 2013-11-18 2020-11-05 Basf Se Novel initiator for preparing alkanesulfonic acids from alkane and oleum
DE102014012546A1 (de) * 2014-09-26 2016-03-31 Martin-Luther-Universität Halle-Wittenberg Antimykobakteriell wirksame Substanzen, Verfahren zu ihrer Herstellung und deren Verwendung
EP3072889A1 (en) 2015-03-23 2016-09-28 Ecole Polytechnique Federale De Lausanne (Epfl) 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides
CN105669664B (zh) * 2016-02-19 2019-05-10 浙江司太立制药股份有限公司 含有碱性氮杂环片段的苯并噻嗪-4-酮类化合物及其制备方法
CN105622596B (zh) * 2016-02-19 2018-10-30 浙江司太立制药股份有限公司 含有烷氧亚胺基氮杂环片段的苯并噻嗪-4-酮类化合物及其制备方法
RU2752568C2 (ru) * 2016-09-22 2021-07-29 Ляйбниц-Институт Фюр Натурштофф-Форшунг Унд Инфекционсбиологи Е.Ф. Ханс-Кнёлль Институт (Хки) Новые антимикробные соединения, их применение для лечения инфекций млекопитающих и новый метаболический механизм
RU2663848C1 (ru) * 2018-03-23 2018-08-10 Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук (ИОС УрО РАН) 5-Фтор-2-(4-этоксикарбонилпиперазин-1-ил)-1,3-бензотиазин-4-он, обладающий противотуберкулезной активностью
CN111269197A (zh) * 2020-04-08 2020-06-12 苏州大学 苯并噻嗪酮化合物及其制备方法与作为抗结核药物的应用
CN113121521B (zh) * 2021-03-26 2022-11-04 苏州大学 6-位三氟甲基取代的苯并噻嗪酮衍生物及其制备方法与应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3522247A (en) * 1967-11-07 1970-07-28 Pfizer & Co C 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators
WO2005092872A1 (en) * 2004-03-26 2005-10-06 Arpida A/S Peptide deformylase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470168A (en) * 1967-03-31 1969-09-30 American Home Prod 2-substituted-4h-1,3-benzothiazin-4-one derivatives
GB8611617D0 (en) 1986-05-13 1986-06-18 Shell Int Research Fungicides
AU3704400A (en) 1999-03-04 2000-09-21 E.I. Du Pont De Nemours And Company Fused bicyclic oxazinone and thiazinone fungicides
EP1312607A1 (en) 2001-11-17 2003-05-21 MEDAC GmbH Dithiocarbamate derivatives and their use as antibacterial agents
AU2003289176A1 (en) 2002-12-05 2004-07-29 Takeda Pharmaceutical Company Limited 1,3-benzothiazinone derivatives, process for producing the same and use thereof
JP5068813B2 (ja) 2006-05-24 2012-11-07 ライブニッツ インスティトゥート フォー ナチュラル プロダクト リサーチ アンド インフェクション バイオロジー エー．ファウ． ハンス−クネル−インスティトゥート（ハーカーイー） 新規なベンゾチアジノン誘導体、及び抗菌剤としてのその使用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3522247A (en) * 1967-11-07 1970-07-28 Pfizer & Co C 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators
WO2005092872A1 (en) * 2004-03-26 2005-10-06 Arpida A/S Peptide deformylase inhibitors

Also Published As

Publication number Publication date
AU2006343832A1 (en) 2007-11-29
JP2009537576A (ja) 2009-10-29
JP5068813B2 (ja) 2012-11-07
CY1110769T1 (el) 2015-06-10
ES2345902T3 (es) 2010-10-05
ATE470667T1 (de) 2010-06-15
AU2006343832B2 (en) 2011-07-21
PL2029583T3 (pl) 2010-10-29
SI2029583T1 (sl) 2010-09-30
CA2652841C (en) 2015-01-27
TNSN08474A1 (en) 2010-04-14
PT2029583E (pt) 2010-08-12
BRPI0621693B8 (pt) 2021-05-25
BRPI0621693B1 (pt) 2020-11-17
CN101472922B (zh) 2012-05-30
IL195453A (en) 2013-01-31
WO2007134625A1 (en) 2007-11-29
MX2008014958A (es) 2009-04-15
CA2652841A1 (en) 2007-11-29
NZ573833A (en) 2010-10-29
US20090239851A1 (en) 2009-09-24
DE602006014885D1 (de) 2010-07-22
CN101472922A (zh) 2009-07-01
EA200870564A1 (ru) 2009-06-30
US20110160193A1 (en) 2011-06-30
BRPI0621693A2 (pt) 2011-12-20
DK2029583T3 (da) 2010-09-27
AP2008004723A0 (en) 2008-12-31
EP2029583A1 (en) 2009-03-04
EP2029583B1 (en) 2010-06-09
KR20090029736A (ko) 2009-03-23
KR101314999B1 (ko) 2013-10-04
US7863268B2 (en) 2011-01-04
IL195453A0 (en) 2009-08-03
EA015910B1 (ru) 2011-12-30
CR10519A (es) 2009-04-14

Similar Documents

Publication Publication Date Title
IL195453A0 (en) New benzothiazinone derivatives and their use as antibacterial agents
TWI561237B (en) Substituted dihydropyrazolones and their use
GB0612428D0 (en) Antibacterial agents
IL184844A0 (en) ??-cyclodextrin derivatives as antibacterial agents
IL187904A0 (en) Quinoline derivatives as antibacterial agents
PL2853293T3 (pl) Związki tioniny i ich zastosowanie
EP2007377A4 (en) ANTIBACTERIAL ACTIVE SUBSTANCES
ZA200807809B (en) Substituted chromanol derivatives and their use
IL194880A0 (en) Aminothiazole derivatives and their uses as antibacterial agents
AP2654A (en) Quinoline derivatives as antibacterial agents
ZA200808035B (en) Antibacterial agents
GB0611115D0 (en) Compounds and their use
PT1898909T (pt) Derivados de quinolina como agentes antibacterianos
AP2483A (en) Quinoline derivatives as antibacterial agents
PL1898914T3 (pl) Pochodne chinoliny jako środki przeciwbakteryjne
AP2733A (en) Quinoline derivatives as antibacterial agents
GB0619611D0 (en) Compounds and their use
ZA200810642B (en) New benzothiazinone derivatives and their use as antibacterial agents
HK1143137A (en) 3-spiropyrimidinetrione-quinoline derivatives and their use as antibacterial agents
HU0600122D0 (en) New compounds and their use
HK1139131A (en) 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents
GB0623070D0 (en) Antibacterial agents
GB0610888D0 (en) Compounds and their use
GB0619609D0 (en) Compounds and their use
GB0619610D0 (en) Compounds and their use