CR10519A - Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos - Google Patents

Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos

Info

Publication number
CR10519A
CR10519A CR10519A CR10519A CR10519A CR 10519 A CR10519 A CR 10519A CR 10519 A CR10519 A CR 10519A CR 10519 A CR10519 A CR 10519A CR 10519 A CR10519 A CR 10519A
Authority
CR
Costa Rica
Prior art keywords
antibacterial agents
benzotiazinona
new derivatives
independently
caused
Prior art date
Application number
CR10519A
Other languages
English (en)
Inventor
Vadim A Makarov
Stewart T Cole
Ute Mollmann
Original Assignee
Leibniz Inst - Hki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leibniz Inst - Hki filed Critical Leibniz Inst - Hki
Publication of CR10519A publication Critical patent/CR10519A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nuevos derivados de benzotiazina de formula (I) y su uso como agentes antibacterianos en enfermedades infecciosas causadas por bacterias especialmente tuberculosis (TB) y lepra causadas por micobacterias, en la que R1 y R2 son independientemente uno del otro, NO2, CN, CONR7R8, COOR9, CHO, halogeno, NR7R8, SO2NR7R8, SR9, OCF3, mono-m du i trifluorometilo; R3 y R4 son, independientemente uno del otro.
CR10519A 2006-05-24 2008-12-17 Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos CR10519A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2006/004942 WO2007134625A1 (en) 2006-05-24 2006-05-24 New benzothiazinone derivatives and their use as antibacterial agents

Publications (1)

Publication Number Publication Date
CR10519A true CR10519A (es) 2009-04-14

Family

ID=37595033

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10519A CR10519A (es) 2006-05-24 2008-12-17 Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos

Country Status (24)

Country Link
US (2) US7863268B2 (es)
EP (1) EP2029583B1 (es)
JP (1) JP5068813B2 (es)
KR (1) KR101314999B1 (es)
CN (1) CN101472922B (es)
AP (1) AP2444A (es)
AT (1) ATE470667T1 (es)
AU (1) AU2006343832B2 (es)
BR (1) BRPI0621693B8 (es)
CA (1) CA2652841C (es)
CR (1) CR10519A (es)
CY (1) CY1110769T1 (es)
DE (1) DE602006014885D1 (es)
DK (1) DK2029583T3 (es)
EA (1) EA015910B1 (es)
ES (1) ES2345902T3 (es)
IL (1) IL195453A (es)
MX (1) MX2008014958A (es)
NZ (1) NZ573833A (es)
PL (1) PL2029583T3 (es)
PT (1) PT2029583E (es)
SI (1) SI2029583T1 (es)
TN (1) TNSN08474A1 (es)
WO (1) WO2007134625A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101314999B1 (ko) 2006-05-24 2013-10-04 라이브니츠 인스티튜트 포 내추럴 프로덕트 리서치 앤드 인펙션 바이올로지 이.브이. 한스-크뇔-인스티튜트 (에이치케이아이) 신규한 벤조티아지논 유도체 및 그의 항균제로서의 용도
EP2020406A1 (en) * 2007-07-16 2009-02-04 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection
WO2009100731A1 (en) 2008-02-13 2009-08-20 Universita' Degli Studi Di Pavia An effective new drug target for the treatment of tuberculosis
EP2380886A1 (en) 2010-04-23 2011-10-26 Vadim A. Makarov Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones
EP2640712B1 (en) * 2010-11-19 2018-07-11 Ecole Polytechnique Fédérale de Lausanne (EPFL) 2-piperazin-1-yl-4h-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections
EP2468746A1 (en) 2010-12-23 2012-06-27 The University of Queensland Benzothiazinone compounds and their use as anti-tuberculosis agents
US8486717B2 (en) 2011-01-18 2013-07-16 Symbolics, Llc Lateral flow assays using two dimensional features
CN102276598B (zh) * 2011-05-27 2014-11-05 四川大学 苯并噻嗪硫酮衍生物及其制备方法和用途
CN102367239B (zh) * 2011-07-20 2015-10-28 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途
EP2570413A1 (en) 2011-09-15 2013-03-20 The University Of Queensland Benzothiazinone derivatives as anti-tuberculosis agents
CN103508980B (zh) * 2012-06-14 2016-07-06 四川大学 苯并噻嗪-4-酮衍生物及其制备方法和用途
US9874556B2 (en) 2012-07-18 2018-01-23 Symbolics, Llc Lateral flow assays using two dimensional features
CN104211708B (zh) * 2013-05-29 2018-08-24 中国医学科学院药物研究所 苯并噁嗪酮衍生物及其作为抗菌剂的应用
WO2015038978A1 (en) 2013-09-13 2015-03-19 Symbolics, Llc Lateral flow assays using two dimensional test and control signal readout patterns
JP6412570B2 (ja) 2013-11-18 2018-10-24 グリロ‐ヴェルケ アーゲー アルカンおよび発煙硫酸からアルカンスルホン酸を製造するための新規な開始剤
DE102014012546A1 (de) * 2014-09-26 2016-03-31 Martin-Luther-Universität Halle-Wittenberg Antimykobakteriell wirksame Substanzen, Verfahren zu ihrer Herstellung und deren Verwendung
EP3072889A1 (en) * 2015-03-23 2016-09-28 Ecole Polytechnique Federale De Lausanne (Epfl) 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides
CN105622596B (zh) * 2016-02-19 2018-10-30 浙江司太立制药股份有限公司 含有烷氧亚胺基氮杂环片段的苯并噻嗪-4-酮类化合物及其制备方法
CN105669664B (zh) * 2016-02-19 2019-05-10 浙江司太立制药股份有限公司 含有碱性氮杂环片段的苯并噻嗪-4-酮类化合物及其制备方法
US11155542B2 (en) 2016-09-22 2021-10-26 University Of Notre Dame Du Lac Antimicrobial compounds, their use for the treatment of mammalian infections and a new metabolic mechanism
RU2663848C1 (ru) * 2018-03-23 2018-08-10 Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук (ИОС УрО РАН) 5-Фтор-2-(4-этоксикарбонилпиперазин-1-ил)-1,3-бензотиазин-4-он, обладающий противотуберкулезной активностью
CN111269197A (zh) * 2020-04-08 2020-06-12 苏州大学 苯并噻嗪酮化合物及其制备方法与作为抗结核药物的应用
CN113121521B (zh) * 2021-03-26 2022-11-04 苏州大学 6-位三氟甲基取代的苯并噻嗪酮衍生物及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470168A (en) * 1967-03-31 1969-09-30 American Home Prod 2-substituted-4h-1,3-benzothiazin-4-one derivatives
US3522247A (en) * 1967-11-07 1970-07-28 Pfizer & Co C 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators
GB8611617D0 (en) 1986-05-13 1986-06-18 Shell Int Research Fungicides
WO2000051992A1 (en) 1999-03-04 2000-09-08 E.I. Du Pont De Nemours And Company Fused bicyclic oxazinone and thiazinone fungicides
EP1312607A1 (en) 2001-11-17 2003-05-21 MEDAC GmbH Dithiocarbamate derivatives and their use as antibacterial agents
WO2004060881A1 (ja) 2002-12-05 2004-07-22 Takeda Pharmaceutical Company Limited １，３−ベンゾチアジノン誘導体、その製造法および用途
US20090093468A1 (en) 2004-03-26 2009-04-09 Patrizia Cali Peptide Deformylase Inhibitors
KR101314999B1 (ko) 2006-05-24 2013-10-04 라이브니츠 인스티튜트 포 내추럴 프로덕트 리서치 앤드 인펙션 바이올로지 이.브이. 한스-크뇔-인스티튜트 (에이치케이아이) 신규한 벤조티아지논 유도체 및 그의 항균제로서의 용도

Also Published As

Publication number Publication date
JP5068813B2 (ja) 2012-11-07
EA200870564A1 (ru) 2009-06-30
EP2029583B1 (en) 2010-06-09
IL195453A0 (en) 2009-08-03
KR20090029736A (ko) 2009-03-23
PL2029583T3 (pl) 2010-10-29
DK2029583T3 (da) 2010-09-27
AP2008004723A0 (en) 2008-12-31
JP2009537576A (ja) 2009-10-29
CA2652841A1 (en) 2007-11-29
US20110160193A1 (en) 2011-06-30
CN101472922A (zh) 2009-07-01
AU2006343832A1 (en) 2007-11-29
ES2345902T3 (es) 2010-10-05
KR101314999B1 (ko) 2013-10-04
US20090239851A1 (en) 2009-09-24
ATE470667T1 (de) 2010-06-15
NZ573833A (en) 2010-10-29
PT2029583E (pt) 2010-08-12
CN101472922B (zh) 2012-05-30
CA2652841C (en) 2015-01-27
AP2444A (en) 2012-08-31
TNSN08474A1 (en) 2010-04-14
US7863268B2 (en) 2011-01-04
CY1110769T1 (el) 2015-06-10
AU2006343832B2 (en) 2011-07-21
BRPI0621693A2 (pt) 2011-12-20
EP2029583A1 (en) 2009-03-04
BRPI0621693B1 (pt) 2020-11-17
MX2008014958A (es) 2009-04-15
BRPI0621693B8 (pt) 2021-05-25
IL195453A (en) 2013-01-31
DE602006014885D1 (de) 2010-07-22
WO2007134625A1 (en) 2007-11-29
EA015910B1 (ru) 2011-12-30
SI2029583T1 (sl) 2010-09-30

Similar Documents

Publication Publication Date Title
CR10519A (es) Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos
UY29041A1 (es) Derivados de amino-piperidina, su preparacion y su utilización en terapeutica
AR072016A1 (es) Derivados de isoxazol que funcionan como potenciadores de los receptores de glutamato
UY31071A1 (es) Derivados heterociclicos sustituidos y su uso farmaceutico y composiciones
UY28936A1 (es) Grupo de compuestos benzoil-amino-heterociclilo y composiciones farmaceuticas que los comprenden, utiles para tratamiento de enfermedades mediadas por glucoquinasa (gq)
CO6541645A2 (es) Compuestos de indol y su uso farmaceutico
UY31183A1 (es) Derivados de pirazinona y procesos para su preparación
UY32628A (es) Inhibidores de la replicación del virus de la inmunodeficiencia humana
ECSP12012292A (es) Ciertas amino-piridazinas, composicioines de las mismas y métodos de uso de los mismos
UY30481A1 (es) Isoxazolinas sustituidas, composiciones farmaccuticas que contienen a las mismas, metodos de preparacion y usos.
ATE477367T1 (de) Gewebeweichmachende dosierer und anwendungen
ECSP12012011A (es) Ciertas triazolopiridinas y triazolopirazinas, composiciones de estas y sus métodos de empleo
UY30350A1 (es) Inhibidores de la replicacion del virus de la inmunodeficiencia humana
CR20110230A (es) Inhibidores de las enzimas de proteina cinasa activadas por mitogeno p38
EA201070169A1 (ru) 2,3-дигидробензо[1,4]диоксин-2-илметиловые производные в качестве альфа2с антагонистов для применения в лечении заболеваний перифирической центральной нервной системы
ECSP088905A (es) Nuevos compuestos
ECSP088763A (es) Nuevas combinaciones terapéuticas para el tratamiento de la depresión
NI200900071A (es) Compuestos de pirozolina y su uso y composiciones farmacéuticas. pc 33496a.
CR11814A (es) Derivados de azacarbolinas, su preparacion y su utilizacion terapeutica
BRPI0713132B8 (pt) compostos derivados de cinamoil-piperazina, método de preparação dos referidos compostos, composições farmacêuticas, seus usos como antagonistas de par-i e produtos
ES2571998T3 (es) Composiciones y usos médicos de derivados del ajoeno
CL2009001804A1 (es) Uso de un copolimero de vinilamina-vinilformamida y un portador para preparar una composicion destinada a fortalecer las fibras queratinosas.
UY29198A1 (es) Derivados sustituidos de quinazolinona y derivados sustituidos de quinazolina-2, 4-diona, composiciones conteniéndolos, procedimientos de preparación y aplicaciones
ATE528290T1 (de) Spiroindolinon-derivate
MY157518A (en) Dibenzothiazepine derivatives and use thereof