CR10519A - Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos - Google Patents

Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos

Info

Publication number
CR10519A
CR10519A CR10519A CR10519A CR10519A CR 10519 A CR10519 A CR 10519A CR 10519 A CR10519 A CR 10519A CR 10519 A CR10519 A CR 10519A CR 10519 A CR10519 A CR 10519A
Authority
CR
Costa Rica
Prior art keywords
antibacterial agents
benzotiazinona
new derivatives
independently
caused
Prior art date
Application number
CR10519A
Other languages
English (en)
Inventor
Vadim A Makarov
Stewart T Cole
Ute Mollmann
Original Assignee
Leibniz Inst - Hki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leibniz Inst - Hki filed Critical Leibniz Inst - Hki
Publication of CR10519A publication Critical patent/CR10519A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nuevos derivados de benzotiazina de formula (I) y su uso como agentes antibacterianos en enfermedades infecciosas causadas por bacterias especialmente tuberculosis (TB) y lepra causadas por micobacterias, en la que R1 y R2 son independientemente uno del otro, NO2, CN, CONR7R8, COOR9, CHO, halogeno, NR7R8, SO2NR7R8, SR9, OCF3, mono-m du i trifluorometilo; R3 y R4 son, independientemente uno del otro.
CR10519A 2006-05-24 2008-12-17 Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos CR10519A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2006/004942 WO2007134625A1 (en) 2006-05-24 2006-05-24 New benzothiazinone derivatives and their use as antibacterial agents

Publications (1)

Publication Number Publication Date
CR10519A true CR10519A (es) 2009-04-14

Family

ID=37595033

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10519A CR10519A (es) 2006-05-24 2008-12-17 Nuevos derivados de benzotiazinona y su uso como agentes antibacterianos

Country Status (24)

Country Link
US (2) US7863268B2 (es)
EP (1) EP2029583B1 (es)
JP (1) JP5068813B2 (es)
KR (1) KR101314999B1 (es)
CN (1) CN101472922B (es)
AP (1) AP2444A (es)
AT (1) ATE470667T1 (es)
AU (1) AU2006343832B2 (es)
BR (1) BRPI0621693B8 (es)
CA (1) CA2652841C (es)
CR (1) CR10519A (es)
CY (1) CY1110769T1 (es)
DE (1) DE602006014885D1 (es)
DK (1) DK2029583T3 (es)
EA (1) EA015910B1 (es)
ES (1) ES2345902T3 (es)
IL (1) IL195453A (es)
MX (1) MX2008014958A (es)
NZ (1) NZ573833A (es)
PL (1) PL2029583T3 (es)
PT (1) PT2029583E (es)
SI (1) SI2029583T1 (es)
TN (1) TNSN08474A1 (es)
WO (1) WO2007134625A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0621693B8 (pt) 2006-05-24 2021-05-25 Leibniz Insititute For Natural Product Res And Infection Biology E V Hans Knoell Institut Hki compostos derivados de benzotiazinona, composição farmacêutica, e seu uso como agentes antibacterianos
EP2020406A1 (en) * 2007-07-16 2009-02-04 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection
ES2434116T3 (es) 2008-02-13 2013-12-13 Sentinel Ch S.P.A. Una nueva y eficaz diana farmacológica para el tratamiento de la tuberculosis
EP2380886A1 (en) 2010-04-23 2011-10-26 Vadim A. Makarov Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones
JP6061346B2 (ja) * 2010-11-19 2017-01-18 エコール ポリテクニーク フェデラル ドゥ ローザンヌ （イーピーエフエル） ２−ピペラジン−１−イル−４ｈ−１，３−ベンゾチアジン−４−オン誘導体、および哺乳類の感染症治療へのその使用
EP2468746A1 (en) 2010-12-23 2012-06-27 The University of Queensland Benzothiazinone compounds and their use as anti-tuberculosis agents
US8486717B2 (en) 2011-01-18 2013-07-16 Symbolics, Llc Lateral flow assays using two dimensional features
CN102276598B (zh) * 2011-05-27 2014-11-05 四川大学 苯并噻嗪硫酮衍生物及其制备方法和用途
CN102367239B (zh) * 2011-07-20 2015-10-28 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途
EP2570413A1 (en) 2011-09-15 2013-03-20 The University Of Queensland Benzothiazinone derivatives as anti-tuberculosis agents
CN103508980B (zh) * 2012-06-14 2016-07-06 四川大学 苯并噻嗪-4-酮衍生物及其制备方法和用途
US9874556B2 (en) 2012-07-18 2018-01-23 Symbolics, Llc Lateral flow assays using two dimensional features
CN104211708B (zh) * 2013-05-29 2018-08-24 中国医学科学院药物研究所 苯并噁嗪酮衍生物及其作为抗菌剂的应用
CN108051590B (zh) 2013-09-13 2020-12-11 Symbolics有限责任公司 运用二维试验和对照信号读出模式的侧向层析检测
MY179376A (en) 2013-11-18 2020-11-05 Basf Se Novel initiator for preparing alkanesulfonic acids from alkane and oleum
DE102014012546A1 (de) * 2014-09-26 2016-03-31 Martin-Luther-Universität Halle-Wittenberg Antimykobakteriell wirksame Substanzen, Verfahren zu ihrer Herstellung und deren Verwendung
EP3072889A1 (en) * 2015-03-23 2016-09-28 Ecole Polytechnique Federale De Lausanne (Epfl) 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides
CN105622596B (zh) * 2016-02-19 2018-10-30 浙江司太立制药股份有限公司 含有烷氧亚胺基氮杂环片段的苯并噻嗪-4-酮类化合物及其制备方法
CN105669664B (zh) * 2016-02-19 2019-05-10 浙江司太立制药股份有限公司 含有碱性氮杂环片段的苯并噻嗪-4-酮类化合物及其制备方法
EP3515920B1 (en) * 2016-09-22 2021-08-25 Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. -Hans-Knöll-Institut- (HKI) New antimicrobial compounds, their use for the treatment of mammalian infections and a new metabolic mechanism
RU2663848C1 (ru) * 2018-03-23 2018-08-10 Федеральное государственное бюджетное учреждение науки Институт органического синтеза им. И.Я. Постовского Уральского отделения Российской академии наук (ИОС УрО РАН) 5-Фтор-2-(4-этоксикарбонилпиперазин-1-ил)-1,3-бензотиазин-4-он, обладающий противотуберкулезной активностью
CN111269197A (zh) * 2020-04-08 2020-06-12 苏州大学 苯并噻嗪酮化合物及其制备方法与作为抗结核药物的应用
CN113121521B (zh) * 2021-03-26 2022-11-04 苏州大学 6-位三氟甲基取代的苯并噻嗪酮衍生物及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3470168A (en) * 1967-03-31 1969-09-30 American Home Prod 2-substituted-4h-1,3-benzothiazin-4-one derivatives
US3522247A (en) * 1967-11-07 1970-07-28 Pfizer & Co C 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators
GB8611617D0 (en) 1986-05-13 1986-06-18 Shell Int Research Fungicides
AU3704400A (en) 1999-03-04 2000-09-21 E.I. Du Pont De Nemours And Company Fused bicyclic oxazinone and thiazinone fungicides
EP1312607A1 (en) 2001-11-17 2003-05-21 MEDAC GmbH Dithiocarbamate derivatives and their use as antibacterial agents
WO2004060881A1 (ja) 2002-12-05 2004-07-22 Takeda Pharmaceutical Company Limited １，３−ベンゾチアジノン誘導体、その製造法および用途
US20090093468A1 (en) * 2004-03-26 2009-04-09 Patrizia Cali Peptide Deformylase Inhibitors
BRPI0621693B8 (pt) 2006-05-24 2021-05-25 Leibniz Insititute For Natural Product Res And Infection Biology E V Hans Knoell Institut Hki compostos derivados de benzotiazinona, composição farmacêutica, e seu uso como agentes antibacterianos

Also Published As

Publication number Publication date
AU2006343832A1 (en) 2007-11-29
PT2029583E (pt) 2010-08-12
KR101314999B1 (ko) 2013-10-04
JP5068813B2 (ja) 2012-11-07
BRPI0621693A2 (pt) 2011-12-20
ATE470667T1 (de) 2010-06-15
MX2008014958A (es) 2009-04-15
WO2007134625A1 (en) 2007-11-29
ES2345902T3 (es) 2010-10-05
NZ573833A (en) 2010-10-29
KR20090029736A (ko) 2009-03-23
US20110160193A1 (en) 2011-06-30
EP2029583A1 (en) 2009-03-04
CA2652841C (en) 2015-01-27
US7863268B2 (en) 2011-01-04
CA2652841A1 (en) 2007-11-29
AU2006343832B2 (en) 2011-07-21
IL195453A (en) 2013-01-31
DE602006014885D1 (de) 2010-07-22
AP2444A (en) 2012-08-31
EA015910B1 (ru) 2011-12-30
CN101472922A (zh) 2009-07-01
EP2029583B1 (en) 2010-06-09
DK2029583T3 (da) 2010-09-27
BRPI0621693B8 (pt) 2021-05-25
TNSN08474A1 (en) 2010-04-14
BRPI0621693B1 (pt) 2020-11-17
CY1110769T1 (el) 2015-06-10
EA200870564A1 (ru) 2009-06-30
SI2029583T1 (sl) 2010-09-30
PL2029583T3 (pl) 2010-10-29
CN101472922B (zh) 2012-05-30
US20090239851A1 (en) 2009-09-24
JP2009537576A (ja) 2009-10-29
AP2008004723A0 (en) 2008-12-31
IL195453A0 (en) 2009-08-03

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