AP3050A - New Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions comprising them - Google Patents

New Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions comprising them

Info

Publication number: AP3050A
Authority: AP; ARIPO
Prior art keywords: preparation; new; pharmaceutical compositions; benzothiadiazepine; compounds
Prior art date: 2009-03-20

Application number

AP2011005935A

Other languages

English (en)

Other versions

AP2011005935A0 (en

Inventor

Alexis Cordi

Patrice Desos

Pierre Lestage

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-20

Filing date

2010-03-18

Publication date

2014-11-30

2010-03-18 Application filed by Servier Lab filed Critical Servier Lab

2011-10-31 Publication of AP2011005935A0 publication Critical patent/AP2011005935A0/xx

2014-11-30 Application granted granted Critical

2014-11-30 Publication of AP3050A publication Critical patent/AP3050A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/36—Seven-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AP2011005935A 2009-03-20 2010-03-18 New Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions comprising them AP3050A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0901300A FR2943342B1 (fr)	2009-03-20	2009-03-20	Nouveaux derives de benzothiadiazepines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
PCT/FR2010/000227 WO2010106249A1 (fr)	2009-03-20	2010-03-18	Derives de benzothiadiazepines en tant que modulateures des recepteurs ampa et nmda

Publications (2)

Publication Number	Publication Date
AP2011005935A0 AP2011005935A0 (en)	2011-10-31
AP3050A true AP3050A (en)	2014-11-30

Family

ID=40863576

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2011005935A AP3050A (en)	2009-03-20	2010-03-18	New Benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions comprising them

Country Status (44)

Country	Link
US (1)	US8236790B2 (ar)
EP (1)	EP2246339B1 (ar)
JP (1)	JP5437473B2 (ar)
KR (1)	KR101431504B1 (ar)
CN (1)	CN102361860B (ar)
AP (1)	AP3050A (ar)
AR (1)	AR075892A1 (ar)
AT (1)	ATE513822T1 (ar)
AU (1)	AU2010200815B2 (ar)
BR (1)	BRPI1009200A2 (ar)
CA (1)	CA2696705C (ar)
CL (1)	CL2011002287A1 (ar)
CO (1)	CO6361956A2 (ar)
CR (1)	CR20110484A (ar)
CU (1)	CU24030B1 (ar)
CY (1)	CY1111807T1 (ar)
DK (1)	DK2246339T3 (ar)
EA (1)	EA020259B1 (ar)
EC (1)	ECSP11011340A (ar)
ES (1)	ES2368691T3 (ar)
FR (1)	FR2943342B1 (ar)
GE (1)	GEP20135862B (ar)
HN (1)	HN2011002458A (ar)
HR (1)	HRP20110626T1 (ar)
IL (1)	IL215016A (ar)
JO (1)	JO2780B1 (ar)
MA (1)	MA33131B1 (ar)
MX (1)	MX2011009638A (ar)
MY (1)	MY154001A (ar)
NI (1)	NI201100169A (ar)
NZ (1)	NZ595082A (ar)
PE (1)	PE20120113A1 (ar)
PL (1)	PL2246339T3 (ar)
PT (1)	PT2246339E (ar)
RS (1)	RS51919B (ar)
SA (1)	SA110310217B1 (ar)
SG (1)	SG174274A1 (ar)
SI (1)	SI2246339T1 (ar)
TN (1)	TN2011000469A1 (ar)
TW (1)	TWI388326B (ar)
UA (1)	UA100477C2 (ar)
UY (1)	UY32475A (ar)
WO (1)	WO2010106249A1 (ar)
ZA (1)	ZA201001905B (ar)

Families Citing this family (22)

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Publication number	Priority date	Publication date	Assignee	Title
PT2464645T (pt) *	2009-07-27	2017-10-11	Gilead Sciences Inc	Compostos heterocíclicos fusionados como moduladores do canal de iões
WO2012003392A1 (en)	2010-07-02	2012-01-05	Gilead Sciences, Inc.	Fused heterocyclic compounds as ion channel modulators
SI2603513T1 (sl)	2010-08-10	2020-07-31	Takeda Pharmaceutical Company Limited	Heterociklična spojina in njena uporaba kot pozitivni alosterični modulator receptorja AMPA
ES2586931T3 (es)	2010-11-04	2016-10-19	Albireo Ab	Inhibidores de IBAT para el tratamiento de enfermedades hepáticas
AU2012253653A1 (en)	2011-05-10	2013-05-02	Gilead Sciences, Inc.	Fused heterocyclic compounds as sodium channel modulators
NO3175985T3 (ar)	2011-07-01	2018-04-28
TWI622583B (zh) *	2011-07-01	2018-05-01	基利科學股份有限公司	作為離子通道調節劑之稠合雜環化合物
AU2015224425B2 (en) *	2011-07-01	2017-02-09	Gilead Sciences, Inc.	Fused benzoxazepinones as ion channel modulators
US9493484B2 (en)	2012-02-08	2016-11-15	Takeda Pharmaceutical Company Limited	Heterocyclic compound and use thereof
US11801226B2 (en)	2018-06-20	2023-10-31	Albireo Ab	Pharmaceutical formulation of odevixibat
RS63899B1 (sr)	2019-02-06	2023-02-28	Albireo Ab	Benzotiadiazepinska jedinjenja i njihova upotreba kao modulatora žučnih kiselina
PL4031552T3 (pl)	2019-09-16	2025-03-17	Takeda Pharmaceutical Company Limited	Pochodne azolowo-skondensowanych pirydazyn-3(2h)-onów
BR112022010505A2 (pt)	2019-12-04	2022-09-06	Albireo Ab	Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar
CN111548325A (zh) *	2020-05-16	2020-08-18	西安都创医药科技有限公司	一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111518055A (zh) *	2020-05-16	2020-08-11	西安都创医药科技有限公司	一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111620838A (zh) *	2020-05-16	2020-09-04	西安都创医药科技有限公司	一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111574475B (zh) *	2020-06-03	2022-09-20	西安都创医药科技有限公司	卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
AU2021379076A1 (en)	2020-11-12	2023-06-08	Albireo Ab	Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
AU2021390172A1 (en)	2020-12-04	2023-06-22	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
CN115368363B (zh) *	2021-05-17	2024-02-20	中山大学	一种手性或消旋的嘧啶并二氮杂环庚酮类化合物及其制备方法和应用
TW202313579A (zh)	2021-06-03	2023-04-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
CN121175293A (zh) *	2023-05-25	2025-12-19	正大天晴药业集团股份有限公司	一种苯并噻二氮卓化合物及其用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993021170A1 (fr) *	1992-04-15	1993-10-28	Rhone-Poulenc Rorer S.A.	Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant
WO1999041246A1 (en) *	1998-02-11	1999-08-19	Du Pont Pharmaceuticals Company	Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
EP1655030A1 (fr) *	2004-11-03	2006-05-10	Les Laboratoires Servier	Derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (5)

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CA2320354A1 (en)	1998-02-18	1999-08-26	Neurosearch A/S	Novel compounds and their use as positive ampa receptor modulators
US6156746A (en) *	1998-08-25	2000-12-05	Bristol-Myers Squibb Company	1,2,5-benzothiadiazepine-1,1-dioxides with n-2 imidazolylalkyl substituents
GB0209467D0 (en) *	2002-04-25	2002-06-05	Astrazeneca Ab	Chemical compounds
DE10300973A1 (de) *	2003-01-14	2004-07-22	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Carbonsäuren und deren Ester, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2879201B1 (fr) *	2004-12-10	2007-02-16	Servier Lab	Nouveaux derives de benzothiazine et benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

2009
- 2009-03-20 FR FR0901300A patent/FR2943342B1/fr not_active Expired - Fee Related
2010
- 2010-03-02 JO JO201077A patent/JO2780B1/ar active
- 2010-03-03 AU AU2010200815A patent/AU2010200815B2/en not_active Ceased
- 2010-03-04 UY UY0001032475A patent/UY32475A/es unknown
- 2010-03-11 TW TW099107121A patent/TWI388326B/zh not_active IP Right Cessation
- 2010-03-17 SA SA110310217A patent/SA110310217B1/ar unknown
- 2010-03-17 CA CA2696705A patent/CA2696705C/fr not_active Expired - Fee Related
- 2010-03-17 ZA ZA2010/01905A patent/ZA201001905B/en unknown
- 2010-03-18 ES ES10290141T patent/ES2368691T3/es active Active
- 2010-03-18 MA MA34178A patent/MA33131B1/fr unknown
- 2010-03-18 BR BRPI1009200A patent/BRPI1009200A2/pt not_active IP Right Cessation
- 2010-03-18 WO PCT/FR2010/000227 patent/WO2010106249A1/fr not_active Ceased
- 2010-03-18 SI SI201030006T patent/SI2246339T1/sl unknown
- 2010-03-18 NZ NZ595082A patent/NZ595082A/en not_active IP Right Cessation
- 2010-03-18 KR KR1020117024772A patent/KR101431504B1/ko not_active Expired - Fee Related
- 2010-03-18 SG SG2011064367A patent/SG174274A1/en unknown
- 2010-03-18 PE PE2011001589A patent/PE20120113A1/es not_active Application Discontinuation
- 2010-03-18 JP JP2012500288A patent/JP5437473B2/ja not_active Expired - Fee Related
- 2010-03-18 CN CN201080012931.3A patent/CN102361860B/zh not_active Expired - Fee Related
- 2010-03-18 DK DK10290141.0T patent/DK2246339T3/da active
- 2010-03-18 GE GEAP201012414A patent/GEP20135862B/en unknown
- 2010-03-18 MY MYPI2011004188A patent/MY154001A/en unknown
- 2010-03-18 AT AT10290141T patent/ATE513822T1/de active
- 2010-03-18 PL PL10290141T patent/PL2246339T3/pl unknown
- 2010-03-18 UA UAA201112094A patent/UA100477C2/uk unknown
- 2010-03-18 AP AP2011005935A patent/AP3050A/xx active
- 2010-03-18 EA EA201101334A patent/EA020259B1/ru not_active IP Right Cessation
- 2010-03-18 MX MX2011009638A patent/MX2011009638A/es active IP Right Grant
- 2010-03-18 PT PT10290141T patent/PT2246339E/pt unknown
- 2010-03-18 EP EP10290141A patent/EP2246339B1/fr active Active
- 2010-03-18 RS RS20110385A patent/RS51919B/sr unknown
- 2010-03-19 US US12/661,598 patent/US8236790B2/en not_active Expired - Fee Related
- 2010-03-19 AR ARP100100881A patent/AR075892A1/es unknown
2011
- 2011-08-31 HR HR20110626T patent/HRP20110626T1/hr unknown
- 2011-09-07 IL IL215016A patent/IL215016A/en not_active IP Right Cessation
- 2011-09-07 CU CU2011000169A patent/CU24030B1/es active IP Right Grant
- 2011-09-08 CY CY20111100869T patent/CY1111807T1/el unknown
- 2011-09-12 CR CR20110484A patent/CR20110484A/es unknown
- 2011-09-13 NI NI201100169A patent/NI201100169A/es unknown
- 2011-09-15 CL CL2011002287A patent/CL2011002287A1/es unknown
- 2011-09-19 TN TN2011000469A patent/TN2011000469A1/fr unknown
- 2011-09-19 CO CO11121546A patent/CO6361956A2/es active IP Right Grant
- 2011-09-19 EC EC2011011340A patent/ECSP11011340A/es unknown
- 2011-09-20 HN HN2011002458A patent/HN2011002458A/es unknown

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993021170A1 (fr) *	1992-04-15	1993-10-28	Rhone-Poulenc Rorer S.A.	Derives d'acide 3,4-dihydro-2h-1,2,4-benzothiadiazine 1,1-dioxyde-3-carboxylique, leur preparation et les medicaments les contenant
WO1999041246A1 (en) *	1998-02-11	1999-08-19	Du Pont Pharmaceuticals Company	Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors
EP1655030A1 (fr) *	2004-11-03	2006-05-10	Les Laboratoires Servier	Derives de benzothiadiazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number	Publication date
TWI388326B (zh)	2013-03-11
MX2011009638A (es)	2011-09-28
CU20110169A7 (es)	2012-02-15
SI2246339T1 (sl)	2011-09-30
MA33131B1 (fr)	2012-03-01
ECSP11011340A (es)	2011-10-31
ATE513822T1 (de)	2011-07-15
TN2011000469A1 (fr)	2013-03-27
FR2943342B1 (fr)	2011-03-04
GEP20135862B (en)	2013-06-25
CO6361956A2 (es)	2012-01-20
AU2010200815A1 (en)	2010-10-07
US20100240635A1 (en)	2010-09-23
IL215016A (en)	2013-08-29
HRP20110626T1 (hr)	2011-10-31
CU24030B1 (es)	2014-10-02
FR2943342A1 (fr)	2010-09-24
KR20110128209A (ko)	2011-11-28
SG174274A1 (en)	2011-10-28
IL215016A0 (en)	2011-11-30
CN102361860A (zh)	2012-02-22
JP5437473B2 (ja)	2014-03-12
MY154001A (en)	2015-04-30
JP2012520858A (ja)	2012-09-10
TW201036615A (en)	2010-10-16
EP2246339B1 (fr)	2011-06-22
RS51919B (sr)	2012-02-29
CA2696705C (fr)	2013-02-12
JO2780B1 (ar)	2014-03-15
AP2011005935A0 (en)	2011-10-31
ZA201001905B (en)	2010-11-24
EA020259B1 (ru)	2014-09-30
SA110310217B1 (ar)	2013-06-15
CN102361860B (zh)	2014-09-10
US8236790B2 (en)	2012-08-07
CR20110484A (es)	2011-10-24
NZ595082A (en)	2013-12-20
HK1167404A1 (en)	2012-11-30
NI201100169A (es)	2012-01-11
CL2011002287A1 (es)	2012-02-03
AU2010200815B2 (en)	2015-05-07
EA201101334A1 (ru)	2012-04-30
UY32475A (es)	2010-09-30
HN2011002458A (es)	2014-05-19
DK2246339T3 (da)	2011-10-10
CY1111807T1 (el)	2015-10-07
EP2246339A1 (fr)	2010-11-03
PT2246339E (pt)	2011-08-01
PL2246339T3 (pl)	2011-11-30
PE20120113A1 (es)	2012-02-24
KR101431504B1 (ko)	2014-08-20
ES2368691T3 (es)	2011-11-21
WO2010106249A1 (fr)	2010-09-23
UA100477C2 (uk)	2012-12-25
AR075892A1 (es)	2011-05-04
BRPI1009200A2 (pt)	2017-06-13
CA2696705A1 (fr)	2010-09-20

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IL215016A0 (en)	2011-11-30	New benzothiadiazepine compounds, a process for their preparation and pharmaceutical compositions containing them
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IL218044A (en)	2017-02-28	(Trihalophenyl – Methyl) –1) –Halophenyl –– 2Imidazolyl – Ethyl (–Sites, process for their preparation and pharmaceutical preparations containing them
PL2504331T3 (pl)	2015-04-30	Związek, jego nowe formy, zawierające je kompozycje farmaceutyczne i sposoby otrzymywania oraz zastosowanie
IL213105A (en)	2015-09-24	Compounds, their preparation process, pharmaceutical preparations containing them and their use in the preparation of drugs
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