AP3499A - Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors - Google Patents

Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors

Info

Publication number: AP3499A
Authority: AP; ARIPO
Prior art keywords: pyrazolospiroketone; acetyl; derivatives; coa carboxylase; carboxylase inhibitors
Prior art date: 2011-04-22

Application number

AP2013007129A

Other languages

English (en)

Other versions

AP2013007129A0 (en

Inventor

James Alfred Southers Jr

Robert Lee Dow

David Andrew Griffith

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-04-22

Filing date

2012-04-09

Publication date

2015-12-31

2012-04-09 Application filed by Pfizer filed Critical Pfizer

2013-09-30 Publication of AP2013007129A0 publication Critical patent/AP2013007129A0/xx

2015-12-31 Application granted granted Critical

2015-12-31 Publication of AP3499A publication Critical patent/AP3499A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Child & Adolescent Psychology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Enzymes And Modification Thereof (AREA)
Photographic Processing Devices Using Wet Methods (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Peptides Or Proteins (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AP2013007129A 2011-04-22 2012-04-09 Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors AP3499A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201161478240P	2011-04-22	2011-04-22
PCT/IB2012/051732 WO2012143813A1 (en)	2011-04-22	2012-04-09	Pyrazolospiroketone derivatives for use as acetyl - coa carboxylase inhibitors

Publications (2)

Publication Number	Publication Date
AP2013007129A0 AP2013007129A0 (en)	2013-09-30
AP3499A true AP3499A (en)	2015-12-31

Family

ID=46025823

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2013007129A AP3499A (en)	2011-04-22	2012-04-09	Pyrazolospiroketone derivatives for use as acetyl-coa carboxylase inhibitors

Country Status (43)

Country	Link
US (4)	US8802688B2 (es)
EP (1)	EP2699576B1 (es)
JP (1)	JP5657174B2 (es)
KR (1)	KR101567659B1 (es)
CN (2)	CN106117205B (es)
AP (1)	AP3499A (es)
AR (1)	AR086198A1 (es)
AU (1)	AU2012245996B2 (es)
CA (1)	CA2831380C (es)
CL (1)	CL2013002794A1 (es)
CO (1)	CO6801757A2 (es)
CR (1)	CR20130464A (es)
CU (1)	CU24164B1 (es)
CY (1)	CY1117122T1 (es)
DK (1)	DK2699576T3 (es)
DO (1)	DOP2013000243A (es)
EA (1)	EA022375B1 (es)
EC (1)	ECSP13013038A (es)
ES (1)	ES2561452T3 (es)
GE (1)	GEP20166474B (es)
GT (1)	GT201300258A (es)
HR (1)	HRP20151397T1 (es)
HU (1)	HUE028602T2 (es)
IL (1)	IL228949A (es)
MA (1)	MA35061B1 (es)
ME (1)	ME02312B (es)
MX (1)	MX348860B (es)
MY (1)	MY162167A (es)
NI (1)	NI201300111A (es)
NZ (1)	NZ616156A (es)
PE (1)	PE20141187A1 (es)
PH (1)	PH12013501941A1 (es)
PL (1)	PL2699576T3 (es)
PT (1)	PT2699576E (es)
PY (1)	PY1218709A (es)
RS (1)	RS54526B1 (es)
SG (1)	SG194142A1 (es)
SI (1)	SI2699576T1 (es)
TN (1)	TN2013000393A1 (es)
TW (1)	TWI464171B (es)
UA (1)	UA107753C2 (es)
UY (1)	UY34027A (es)
WO (1)	WO2012143813A1 (es)

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CN102491974B (zh) *	2011-12-12	2013-08-07	南京药石药物研发有限公司	1-（2-氟苄基）-1H-吡唑并[3，4-b]吡啶-3-甲脒盐酸盐的合成方法
KR102243637B1 (ko)	2013-03-14	2021-04-26	리커리엄 아이피 홀딩스, 엘엘씨	바이사이클릭 진통 화합물
HK1221662A1 (zh)	2013-05-10	2017-06-09	Gilead Apollo, Llc	Acc抑制剂和其用途
MX2015015422A (es)	2013-05-10	2016-06-21	Nimbus Apollo Inc	Inhibidores de acetil-coa carboxilasa (acc) y usos de los mismos.
CN105358152A (zh) *	2013-05-10	2016-02-24	尼普斯阿波罗有限公司	Acc抑制剂和其用途
BR112016004118A2 (pt)	2013-09-12	2017-10-17	Pfizer	uso de inibidores da acetil-coa carboxilase para tratamento de acne vulgar
JPWO2015056782A1 (ja)	2013-10-17	2017-03-09	塩野義製薬株式会社	新規アルキレン誘導体
EP3080072A4 (en) *	2013-12-12	2017-07-19	Kalyra Pharmaceuticals, inc.	Bicyclic alkyl compounds and synthesis
WO2015134710A1 (en) *	2014-03-07	2015-09-11	Kalyra Pharmaceuticals, Inc.	Propellane derivates and synthesis
CA2892342C (en)	2014-05-22	2016-11-01	Sylvain-Paul Morency	Tool and method for layer depalletizing
WO2016044331A1 (en)	2014-09-17	2016-03-24	Kalyra Pharmaceuticals, Inc.	Bicyclic compounds
HK1255689A1 (en) *	2015-12-31	2019-08-23	北京谷神生命健康科技有限公司	Triacetyl-3-hydroxyphenyladenosine and application in preparing pharmaceutical drug for preventing or treating non-alcoholic fatty liver disease
CN106580986B (zh) *	2016-11-28	2017-09-15	王保亮	一种治疗少弱精子症的药物组合物
MX389668B (es)	2017-05-15	2025-03-20	Recurium Ip Holdings Llc	Compuestos biciclo[1.1.1]pentilo sustituidos y uso de los mismos para el tratamiento del dolor y fiebre.
IL313710A (en)	2017-11-21	2024-08-01	Pfizer	Crystalline 2-amino-2-(hydroxymethyl)propane-1,3-diol salt of 4-(4-(1-isopropyl-7-oxo-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidine]-1'-carbonyl)-6-methoxypyridin-2-yl)benzoic acid
CN111574530B (zh) *	2020-04-21	2022-07-26	徐州医科大学	一种acc抑制剂及其医药用途
CN120457124A (zh) *	2022-12-30	2025-08-08	苏州浦合医药科技有限公司	Prmt5-mta抑制剂
CN121241054A (zh) *	2023-04-14	2025-12-30	北京双鹤润创科技有限公司	氮杂环羰基稠环衍生物及其用途
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2012
- 2012-04-09 RS RS20160026A patent/RS54526B1/sr unknown
- 2012-04-09 MY MYPI2013003372A patent/MY162167A/en unknown
- 2012-04-09 WO PCT/IB2012/051732 patent/WO2012143813A1/en not_active Ceased
- 2012-04-09 JP JP2014505745A patent/JP5657174B2/ja active Active
- 2012-04-09 PL PL12718387T patent/PL2699576T3/pl unknown
- 2012-04-09 SG SG2013075148A patent/SG194142A1/en unknown
- 2012-04-09 CN CN201610487378.8A patent/CN106117205B/zh not_active Expired - Fee Related
- 2012-04-09 GE GEAP201213267A patent/GEP20166474B/en unknown
- 2012-04-09 SI SI201230417T patent/SI2699576T1/sl unknown
- 2012-04-09 HR HRP20151397TT patent/HRP20151397T1/hr unknown
- 2012-04-09 AU AU2012245996A patent/AU2012245996B2/en not_active Ceased
- 2012-04-09 DK DK12718387.9T patent/DK2699576T3/en active
- 2012-04-09 ME MEP-2015-214A patent/ME02312B/me unknown
- 2012-04-09 CA CA2831380A patent/CA2831380C/en active Active
- 2012-04-09 PH PH1/2013/501941A patent/PH12013501941A1/en unknown
- 2012-04-09 CN CN201280019621.3A patent/CN103492388A/zh active Pending
- 2012-04-09 ES ES12718387.9T patent/ES2561452T3/es active Active
- 2012-04-09 EP EP12718387.9A patent/EP2699576B1/en active Active
- 2012-04-09 PT PT127183879T patent/PT2699576E/pt unknown
- 2012-04-09 AP AP2013007129A patent/AP3499A/xx active
- 2012-04-09 CU CU20130126A patent/CU24164B1/es active IP Right Grant
- 2012-04-09 HU HUE12718387A patent/HUE028602T2/hu unknown
- 2012-04-09 KR KR1020137030875A patent/KR101567659B1/ko not_active Expired - Fee Related
- 2012-04-09 EA EA201391288A patent/EA022375B1/ru not_active IP Right Cessation
- 2012-04-09 PE PE2013002387A patent/PE20141187A1/es not_active Application Discontinuation
- 2012-04-09 MA MA36357A patent/MA35061B1/fr unknown
- 2012-04-09 MX MX2013012313A patent/MX348860B/es active IP Right Grant
- 2012-04-09 NZ NZ616156A patent/NZ616156A/en not_active IP Right Cessation
- 2012-04-18 TW TW101113766A patent/TWI464171B/zh not_active IP Right Cessation
- 2012-04-19 UY UY0001034027A patent/UY34027A/es not_active Application Discontinuation
- 2012-04-20 PY PY201201218709A patent/PY1218709A/es unknown
- 2012-04-20 AR ARP120101364A patent/AR086198A1/es unknown
- 2012-04-21 US US13/452,839 patent/US8802688B2/en active Active
- 2012-09-04 UA UAA201311822A patent/UA107753C2/ru unknown
2013
- 2013-09-12 CR CR20130464A patent/CR20130464A/es unknown
- 2013-09-27 CL CL2013002794A patent/CL2013002794A1/es unknown
- 2013-09-27 TN TNP2013000393A patent/TN2013000393A1/fr unknown
- 2013-10-17 IL IL228949A patent/IL228949A/en active IP Right Grant
- 2013-10-18 NI NI201300111A patent/NI201300111A/es unknown
- 2013-10-18 GT GT201300258A patent/GT201300258A/es unknown
- 2013-10-21 DO DO2013000243A patent/DOP2013000243A/es unknown
- 2013-10-24 CO CO13252716A patent/CO6801757A2/es active IP Right Grant
- 2013-11-22 EC ECSP13013038 patent/ECSP13013038A/es unknown
2014
- 2014-07-08 US US14/325,420 patent/US20140323730A1/en not_active Abandoned
2015
- 2015-01-09 US US14/593,370 patent/US20150112068A1/en not_active Abandoned
- 2015-08-07 US US14/820,884 patent/US20150336958A1/en not_active Abandoned
2016
- 2016-01-14 CY CY20161100038T patent/CY1117122T1/el unknown

Patent Citations (1)

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WO2012042433A1 (en) *	2010-09-30	2012-04-05	Pfizer Inc.	N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS

Non-Patent Citations (1)

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Title
SCOTT W. BAGLEY ET AL.: "Synthesis of 7-Oxo-dihydrospiro[indazole-5,4'-piperidine] Acetyl-CoA Carboxylase Inhibitors", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 77, no. 3, 3 February 2012 (2012-02-03), pages 1497-1506, XP55030451 *

Also Published As

Publication number	Publication date
ECSP13013038A (es)	2014-01-31
PL2699576T3 (pl)	2016-05-31
US8802688B2 (en)	2014-08-12
UA107753C2 (xx)	2015-02-10
CR20130464A (es)	2013-10-16
MX348860B (es)	2017-06-30
KR101567659B1 (ko)	2015-11-09
MY162167A (en)	2017-05-31
EP2699576A1 (en)	2014-02-26
CN103492388A (zh)	2014-01-01
DOP2013000243A (es)	2013-12-31
CY1117122T1 (el)	2017-04-05
PH12013501941A1 (en)	2021-06-23
PT2699576E (pt)	2016-03-09
RS54526B1 (sr)	2016-06-30
PE20141187A1 (es)	2014-09-18
HRP20151397T1 (hr)	2016-01-15
GEP20166474B (en)	2016-05-10
HUE028602T2 (hu)	2016-12-28
TWI464171B (zh)	2014-12-11
CN106117205B (zh)	2018-09-21
IL228949A (en)	2016-11-30
SI2699576T1 (sl)	2016-02-29
SG194142A1 (en)	2013-11-29
CU24164B1 (es)	2016-03-31
ES2561452T3 (es)	2016-02-26
AP2013007129A0 (en)	2013-09-30
CN106117205A (zh)	2016-11-16
UY34027A (es)	2013-04-05
JP2014515755A (ja)	2014-07-03
IL228949A0 (en)	2013-12-31
NZ616156A (en)	2014-08-29
CU20130126A7 (es)	2014-01-29
MA35061B1 (fr)	2014-04-03
NI201300111A (es)	2014-02-12
US20140323730A1 (en)	2014-10-30
CO6801757A2 (es)	2013-11-29
AU2012245996A1 (en)	2013-10-03
CL2013002794A1 (es)	2013-12-27
US20150336958A1 (en)	2015-11-26
JP5657174B2 (ja)	2015-01-21
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GT201300258A (es)	2015-06-02
EP2699576B1 (en)	2015-12-09
US20150112068A1 (en)	2015-04-23
EA201391288A1 (ru)	2014-04-30
KR20140015511A (ko)	2014-02-06
TW201305162A (zh)	2013-02-01
MX2013012313A (es)	2014-01-31
DK2699576T3 (en)	2016-02-15
AR086198A1 (es)	2013-11-27
US20120270893A1 (en)	2012-10-25
WO2012143813A1 (en)	2012-10-26
CA2831380C (en)	2016-04-05
AU2012245996B2 (en)	2016-09-01
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