CU20130126A7 - Inhibidores sustituidos de acetil-coa carboxilasa - Google Patents

Inhibidores sustituidos de acetil-coa carboxilasa

Info

Publication number
CU20130126A7
CU20130126A7 CUP2013000126A CU20130126A CU20130126A7 CU 20130126 A7 CU20130126 A7 CU 20130126A7 CU P2013000126 A CUP2013000126 A CU P2013000126A CU 20130126 A CU20130126 A CU 20130126A CU 20130126 A7 CU20130126 A7 CU 20130126A7
Authority
CU
Cuba
Prior art keywords
coa
carboxilasa
acetil
inhibitors
replaced
Prior art date
Application number
CUP2013000126A
Other languages
English (en)
Other versions
CU24164B1 (es
Inventor
Robert Lee Dow
David Andrew Griffith
Jr James Alfred Southers
David James Edmonds
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20130126A7 publication Critical patent/CU20130126A7/es
Publication of CU24164B1 publication Critical patent/CU24164B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Photographic Processing Devices Using Wet Methods (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención proporciona un compuesto de Fórmula (I) (Espacio para Fórmula) o una sal del mismo aceptable desde el punto de vista farmacéutico; donde G es (Espacio para Fórmula) R1, R2 y R3 son como se describe en la presente; composiciones farmacéuticas del mismo; y el uso del mismo en el tratamiento de enfermedades, afecciones o trastornos modulados por la inhibición de una enzima(s) acetil- CoA carboxilasa en un animal.
CU20130126A 2011-04-22 2012-04-09 Inhibidores sustituidos de acetil-coa carboxilasa CU24164B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161478240P 2011-04-22 2011-04-22
PCT/IB2012/051732 WO2012143813A1 (en) 2011-04-22 2012-04-09 Pyrazolospiroketone derivatives for use as acetyl - coa carboxylase inhibitors

Publications (2)

Publication Number Publication Date
CU20130126A7 true CU20130126A7 (es) 2014-01-29
CU24164B1 CU24164B1 (es) 2016-03-31

Family

ID=46025823

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20130126A CU24164B1 (es) 2011-04-22 2012-04-09 Inhibidores sustituidos de acetil-coa carboxilasa

Country Status (43)

Country Link
US (4) US8802688B2 (es)
EP (1) EP2699576B1 (es)
JP (1) JP5657174B2 (es)
KR (1) KR101567659B1 (es)
CN (2) CN106117205B (es)
AP (1) AP3499A (es)
AR (1) AR086198A1 (es)
AU (1) AU2012245996B2 (es)
CA (1) CA2831380C (es)
CL (1) CL2013002794A1 (es)
CO (1) CO6801757A2 (es)
CR (1) CR20130464A (es)
CU (1) CU24164B1 (es)
CY (1) CY1117122T1 (es)
DK (1) DK2699576T3 (es)
DO (1) DOP2013000243A (es)
EA (1) EA022375B1 (es)
EC (1) ECSP13013038A (es)
ES (1) ES2561452T3 (es)
GE (1) GEP20166474B (es)
GT (1) GT201300258A (es)
HR (1) HRP20151397T1 (es)
HU (1) HUE028602T2 (es)
IL (1) IL228949A (es)
MA (1) MA35061B1 (es)
ME (1) ME02312B (es)
MX (1) MX348860B (es)
MY (1) MY162167A (es)
NI (1) NI201300111A (es)
NZ (1) NZ616156A (es)
PE (1) PE20141187A1 (es)
PH (1) PH12013501941A1 (es)
PL (1) PL2699576T3 (es)
PT (1) PT2699576E (es)
PY (1) PY1218709A (es)
RS (1) RS54526B1 (es)
SG (1) SG194142A1 (es)
SI (1) SI2699576T1 (es)
TN (1) TN2013000393A1 (es)
TW (1) TWI464171B (es)
UA (1) UA107753C2 (es)
UY (1) UY34027A (es)
WO (1) WO2012143813A1 (es)

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CN111574530B (zh) * 2020-04-21 2022-07-26 徐州医科大学 一种acc抑制剂及其医药用途
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Also Published As

Publication number Publication date
ECSP13013038A (es) 2014-01-31
PL2699576T3 (pl) 2016-05-31
US8802688B2 (en) 2014-08-12
UA107753C2 (xx) 2015-02-10
CR20130464A (es) 2013-10-16
MX348860B (es) 2017-06-30
KR101567659B1 (ko) 2015-11-09
MY162167A (en) 2017-05-31
EP2699576A1 (en) 2014-02-26
CN103492388A (zh) 2014-01-01
DOP2013000243A (es) 2013-12-31
CY1117122T1 (el) 2017-04-05
AP3499A (en) 2015-12-31
PH12013501941A1 (en) 2021-06-23
PT2699576E (pt) 2016-03-09
RS54526B1 (sr) 2016-06-30
PE20141187A1 (es) 2014-09-18
HRP20151397T1 (hr) 2016-01-15
GEP20166474B (en) 2016-05-10
HUE028602T2 (hu) 2016-12-28
TWI464171B (zh) 2014-12-11
CN106117205B (zh) 2018-09-21
IL228949A (en) 2016-11-30
SI2699576T1 (sl) 2016-02-29
SG194142A1 (en) 2013-11-29
CU24164B1 (es) 2016-03-31
ES2561452T3 (es) 2016-02-26
AP2013007129A0 (en) 2013-09-30
CN106117205A (zh) 2016-11-16
UY34027A (es) 2013-04-05
JP2014515755A (ja) 2014-07-03
IL228949A0 (en) 2013-12-31
NZ616156A (en) 2014-08-29
MA35061B1 (fr) 2014-04-03
NI201300111A (es) 2014-02-12
US20140323730A1 (en) 2014-10-30
CO6801757A2 (es) 2013-11-29
AU2012245996A1 (en) 2013-10-03
CL2013002794A1 (es) 2013-12-27
US20150336958A1 (en) 2015-11-26
JP5657174B2 (ja) 2015-01-21
TN2013000393A1 (fr) 2015-01-20
PY1218709A (es) 2016-01-01
GT201300258A (es) 2015-06-02
EP2699576B1 (en) 2015-12-09
US20150112068A1 (en) 2015-04-23
EA201391288A1 (ru) 2014-04-30
KR20140015511A (ko) 2014-02-06
TW201305162A (zh) 2013-02-01
MX2013012313A (es) 2014-01-31
DK2699576T3 (en) 2016-02-15
AR086198A1 (es) 2013-11-27
US20120270893A1 (en) 2012-10-25
WO2012143813A1 (en) 2012-10-26
CA2831380C (en) 2016-04-05
AU2012245996B2 (en) 2016-09-01
ME02312B (me) 2016-06-20
EA022375B1 (ru) 2015-12-30
CA2831380A1 (en) 2012-10-26

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