AP904A - Antithrombotic Azacycloalkylalkanoyl peptides and pseudopeptides. - Google Patents
Antithrombotic Azacycloalkylalkanoyl peptides and pseudopeptides. Download PDFInfo
- Publication number
- AP904A AP904A APAP/P/1999/001452A AP9901452A AP904A AP 904 A AP904 A AP 904A AP 9901452 A AP9901452 A AP 9901452A AP 904 A AP904 A AP 904A
- Authority
- AP
- ARIPO
- Prior art keywords
- aspartyl
- butanoyl
- ethylglycyl
- compound
- acid
- Prior art date
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- 239000003146 anticoagulant agent Substances 0.000 title abstract description 6
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
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- 125000001151 peptidyl group Chemical group 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000009117 preventive therapy Methods 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- ZHNFLHYOFXQIOW-LPYZJUEESA-N quinine sulfate dihydrate Chemical compound [H+].[H+].O.O.[O-]S([O-])(=O)=O.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21.C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 ZHNFLHYOFXQIOW-LPYZJUEESA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 229910052705 radium Inorganic materials 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910052701 rubidium Inorganic materials 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 238000013391 scatchard analysis Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000005476 size effect Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 239000003634 thrombocyte concentrate Substances 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000004953 trihalomethyl group Chemical group 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
- 229940007718 zinc hydroxide Drugs 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
- ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/700,950 US5780590A (en) | 1993-10-15 | 1996-08-21 | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
| PCT/US1997/014578 WO1998017678A1 (en) | 1996-08-21 | 1997-08-15 | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AP9901452A0 AP9901452A0 (en) | 1999-03-31 |
| AP904A true AP904A (en) | 2000-11-24 |
Family
ID=24815484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| APAP/P/1999/001452A AP904A (en) | 1996-08-21 | 1997-08-15 | Antithrombotic Azacycloalkylalkanoyl peptides and pseudopeptides. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5780590A (no) |
| EP (1) | EP0929572A4 (no) |
| JP (1) | JP2001501965A (no) |
| KR (1) | KR20000035797A (no) |
| CN (1) | CN1231671A (no) |
| AP (1) | AP904A (no) |
| AU (1) | AU722112B2 (no) |
| BG (1) | BG103197A (no) |
| BR (1) | BR9711205A (no) |
| CA (1) | CA2263732A1 (no) |
| EA (1) | EA001391B1 (no) |
| HU (1) | HUP9903961A3 (no) |
| IL (1) | IL128556A0 (no) |
| NO (1) | NO990836L (no) |
| NZ (1) | NZ334059A (no) |
| OA (1) | OA10975A (no) |
| PL (1) | PL331713A1 (no) |
| SK (1) | SK14699A3 (no) |
| UA (1) | UA48252C2 (no) |
| WO (1) | WO1998017678A1 (no) |
| ZA (1) | ZA977511B (no) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6274705B1 (en) | 1996-05-02 | 2001-08-14 | Aventis Pharmaceuticals Products Inc. | Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides |
| PL331772A1 (en) * | 1996-08-21 | 1999-08-02 | Rhone Poulenc Rorer Pharma | Stable non-hygroscopic crystalline form of n-[n-n-(4-piperidin-4-yl)-n-ethylglycin] compounds |
| WO1999019294A1 (en) * | 1997-05-14 | 1999-04-22 | Aventis Pharmaceuticals Products Inc. Legal/Patents | Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides |
| CA2306823A1 (en) * | 1997-10-10 | 1999-04-22 | Aventis Pharmaceuticals Products Inc. | Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides |
| EP1155033A1 (en) * | 1998-12-30 | 2001-11-21 | Aventis Pharmaceuticals Products Inc. | Process for preparing a stable non-hygroscopic crystalline n-[n-[n-(piperdin-4-yl)butanoyl)-n-ethylglycyl]-(l)-aspartyl]-ss-cyclohexylalanine amide |
| US7200838B2 (en) * | 2000-12-20 | 2007-04-03 | National Instruments Corporation | System and method for automatically generating a graphical program in response to a state diagram |
| US7544681B2 (en) | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
| JP5284779B2 (ja) * | 2005-06-07 | 2013-09-11 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド | コンジュゲート化された向精神薬の新規な塩およびその調製方法 |
| CN101511388B (zh) | 2006-07-17 | 2012-10-24 | 特拉维夫大学拉莫特有限公司 | 含有精神药物或gaba激动剂和有机酸的缀合物以及它们在治疗疼痛和其它cns疾病中的用途 |
| WO2009101616A1 (en) | 2008-02-11 | 2009-08-20 | Ramot At Tel Aviv University Ltd. | Novel conjugates for treating neurodegenerative diseases and disorders |
| CA2782514A1 (en) | 2009-12-09 | 2011-06-16 | Biolinerx Ltd. | Methods of improving cognitive functions |
| EP2539857A4 (en) | 2010-02-24 | 2013-07-24 | Univ Ramot | CRYSTALLINE FORMS OF TRI MESYLATE SALT OF PERPHENAZINE GABA AND METHOD OF MANUFACTURING THEREOF |
| US8916610B2 (en) | 2010-09-22 | 2014-12-23 | Ramot At Tel-Aviv University Ltd. | Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821188A (en) * | 1972-06-14 | 1974-06-28 | American Home Prod | Proline and pyroglutamic acid containing tripeptides |
| GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
| US4683291A (en) * | 1985-10-28 | 1987-07-28 | Scripps Clinic And Research Foundation | Platelet binding inhibitors |
| FR2608160B1 (fr) * | 1986-12-15 | 1989-03-31 | Inst Nat Sante Rech Med | Nouveaux derives peptidiques et leur application notamment en therapeutique |
| US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
| US5037808A (en) * | 1988-07-20 | 1991-08-06 | Monsanto Co. | Indolyl platelet-aggregation inhibitors |
| US4992463A (en) * | 1988-07-20 | 1991-02-12 | Monsanto Company | Thienyl peptide mimetic compounds which are useful in inhibiting platelet aggregation |
| US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
| US5023233A (en) * | 1989-07-28 | 1991-06-11 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US4952562A (en) * | 1989-09-29 | 1990-08-28 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptides and pseudopeptides |
| WO1991004746A1 (en) * | 1989-09-29 | 1991-04-18 | Rhone-Poulenc Rorer International (Holdings) Inc. | Anti-thrombotic peptides and pseudopeptides |
| US5053392A (en) * | 1989-12-01 | 1991-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors |
| US5086069A (en) * | 1990-02-05 | 1992-02-04 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptide and pseudopeptide derivatives |
| CA2037153A1 (en) * | 1990-03-09 | 1991-09-10 | Leo Alig | Acetic acid derivatives |
| GB9007751D0 (en) * | 1990-04-05 | 1990-06-06 | Ciba Geigy Ag | Novel platelet-aggregation inhibitors |
| US5064814A (en) * | 1990-04-05 | 1991-11-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptide and pseudopeptide derivatives |
| IL99538A0 (en) * | 1990-09-27 | 1992-08-18 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
| IL99539A0 (en) * | 1990-09-27 | 1992-08-18 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical compositions containing them |
| MX9201416A (es) * | 1991-03-28 | 1992-10-01 | Rhone Poulenc Rorer Int | Peptidos y pseudopeptidos antitromboticos. |
| AU661659B2 (en) * | 1991-04-11 | 1995-08-03 | Rhone-Poulenc Rorer International (Holdings) Inc. | Anti-thrombotic peptide and pseudopeptide derivatives |
| DE69213546T2 (de) * | 1991-05-13 | 1997-02-27 | Fujisawa Pharmaceutical Co | Neue Peptid-Verbindungen und Verfahren zur Herstellung davon |
| CN1135717A (zh) * | 1993-10-15 | 1996-11-13 | 罗纳-布朗克·罗莱尔药物有限公司 | 抗血栓形成的氮杂环烷基链烷酰肽和假肽 |
-
1996
- 1996-08-21 US US08/700,950 patent/US5780590A/en not_active Expired - Lifetime
-
1997
- 1997-08-15 JP JP10519340A patent/JP2001501965A/ja not_active Ceased
- 1997-08-15 EP EP97938424A patent/EP0929572A4/en not_active Withdrawn
- 1997-08-15 NZ NZ334059A patent/NZ334059A/xx unknown
- 1997-08-15 KR KR1019997001363A patent/KR20000035797A/ko not_active Ceased
- 1997-08-15 HU HU9903961A patent/HUP9903961A3/hu unknown
- 1997-08-15 PL PL97331713A patent/PL331713A1/xx unknown
- 1997-08-15 WO PCT/US1997/014578 patent/WO1998017678A1/en not_active Ceased
- 1997-08-15 BR BR9711205A patent/BR9711205A/pt not_active Application Discontinuation
- 1997-08-15 CN CN97198164A patent/CN1231671A/zh active Pending
- 1997-08-15 AU AU40749/97A patent/AU722112B2/en not_active Ceased
- 1997-08-15 SK SK146-99A patent/SK14699A3/sk unknown
- 1997-08-15 UA UA99031553A patent/UA48252C2/uk unknown
- 1997-08-15 CA CA002263732A patent/CA2263732A1/en not_active Abandoned
- 1997-08-15 EA EA199900216A patent/EA001391B1/ru not_active IP Right Cessation
- 1997-08-15 AP APAP/P/1999/001452A patent/AP904A/en active
- 1997-08-15 IL IL12855697A patent/IL128556A0/xx unknown
- 1997-08-21 ZA ZA9707511A patent/ZA977511B/xx unknown
-
1999
- 1999-02-15 OA OA9900033A patent/OA10975A/en unknown
- 1999-02-22 BG BG103197A patent/BG103197A/xx unknown
- 1999-02-22 NO NO990836A patent/NO990836L/no unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5051405A (en) * | 1989-10-10 | 1991-09-24 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Anti-thrombotic peptides and pseudopeptides |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998017678A1 (en) | 1998-04-30 |
| KR20000035797A (ko) | 2000-06-26 |
| HUP9903961A3 (en) | 2000-12-28 |
| NO990836L (no) | 1999-04-20 |
| AU722112B2 (en) | 2000-07-20 |
| BG103197A (bg) | 2000-05-31 |
| OA10975A (en) | 2001-11-01 |
| ZA977511B (en) | 1998-03-03 |
| AU4074997A (en) | 1998-05-15 |
| BR9711205A (pt) | 1999-08-17 |
| EP0929572A1 (en) | 1999-07-21 |
| HUP9903961A2 (hu) | 2000-04-28 |
| JP2001501965A (ja) | 2001-02-13 |
| SK14699A3 (en) | 2000-11-07 |
| NZ334059A (en) | 2000-01-28 |
| PL331713A1 (en) | 1999-08-02 |
| CA2263732A1 (en) | 1998-04-30 |
| NO990836D0 (no) | 1999-02-22 |
| UA48252C2 (uk) | 2002-08-15 |
| CN1231671A (zh) | 1999-10-13 |
| US5780590A (en) | 1998-07-14 |
| AP9901452A0 (en) | 1999-03-31 |
| IL128556A0 (en) | 2000-01-31 |
| EA001391B1 (ru) | 2001-02-26 |
| EP0929572A4 (en) | 2001-09-12 |
| EA199900216A1 (ru) | 1999-08-26 |
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