OA10975A - Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides - Google Patents

Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides Download PDF

Info

Publication number: OA10975A
Authority: OA; OAPI
Prior art keywords: compound; acid; butanoyl; aspartyl; mixture
Prior art date: 1996-08-21

Application number

OA9900033A

Other languages

English (en)

Inventor

Scott I Klein

Bruce F Molino

Mark Czekaj

Charles J Gardner

Original Assignee

Rhone Poulenc Rorer Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-08-21

Filing date

1999-02-15

Publication date

2001-11-01

1999-02-15 Application filed by Rhone Poulenc Rorer Pharma filed Critical Rhone Poulenc Rorer Pharma

2001-11-01 Publication of OA10975A publication Critical patent/OA10975A/en

Links

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VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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125000001325 propanoyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 1
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NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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125000003107 substituted aryl group Chemical group 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
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HOWHQWFXSLOJEF-MGZLOUMQSA-N systemin Chemical compound NCCCC[C@H](N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)OC(=O)[C@@H]1CCCN1C(=O)[C@H]1N(C(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2N(CCC2)C(=O)[C@H]2N(CCC2)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)N)C(C)C)CCC1 HOWHQWFXSLOJEF-MGZLOUMQSA-N 0.000 description 1
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230000001732 thrombotic effect Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
238000012546 transfer Methods 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
125000004953 trihalomethyl group Chemical group 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
229940038773 trisodium citrate Drugs 0.000 description 1
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
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210000003462 vein Anatomy 0.000 description 1
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UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
229940007718 zinc hydroxide Drugs 0.000 description 1
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ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical compound OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

OA9900033A 1996-08-21 1999-02-15 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides OA10975A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/700,950 US5780590A (en)	1993-10-15	1996-08-21	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Publications (1)

Publication Number	Publication Date
OA10975A true OA10975A (en)	2001-11-01

Family

ID=24815484

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA9900033A OA10975A (en)	1996-08-21	1999-02-15	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides

Country Status (21)

Country	Link
US (1)	US5780590A (no)
EP (1)	EP0929572A4 (no)
JP (1)	JP2001501965A (no)
KR (1)	KR20000035797A (no)
CN (1)	CN1231671A (no)
AP (1)	AP904A (no)
AU (1)	AU722112B2 (no)
BG (1)	BG103197A (no)
BR (1)	BR9711205A (no)
CA (1)	CA2263732A1 (no)
EA (1)	EA001391B1 (no)
HU (1)	HUP9903961A3 (no)
IL (1)	IL128556A0 (no)
NO (1)	NO990836L (no)
NZ (1)	NZ334059A (no)
OA (1)	OA10975A (no)
PL (1)	PL331713A1 (no)
SK (1)	SK14699A3 (no)
UA (1)	UA48252C2 (no)
WO (1)	WO1998017678A1 (no)
ZA (1)	ZA977511B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6274705B1 (en)	1996-05-02	2001-08-14	Aventis Pharmaceuticals Products Inc.	Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides
JP4008499B2 (ja) *	1996-08-21	2007-11-14	アヴェンティスファーマシューティカルズインコーポレイテッド	Ｎ―［ｎ―ｎ―（４―（ピペリジン―４―イル）ブタノイル）―ｎ―エチルグリシル］化合物の安定な非吸湿性結晶形
WO1999019294A1 (en) *	1997-05-14	1999-04-22	Aventis Pharmaceuticals Products Inc. Legal/Patents	Process for the preparation of azacycloalkylalkanoyl pseudotetrapeptides
JP2001519411A (ja) *	1997-10-10	2001-10-23	アヴェンティスファーマシューティカルズプロダクツインコーポレイテッド	アザシクロアルキルアルカノイルプソイドテトラぺプチドの調製方法
AU2844800A (en) *	1998-12-30	2000-07-24	Aventis Pharmaceuticals Products Inc.	Process for preparing a stable non-hygroscopic crystalline n-(n-(n- piperdin- 4-yl)butanoyl)- n.ethylglycyl)- (l)-aspartyl) -ss-cyclohexylalanine amide
US7200838B2 (en) *	2000-12-20	2007-04-03	National Instruments Corporation	System and method for automatically generating a graphical program in response to a state diagram
US7544681B2 (en)	2001-09-27	2009-06-09	Ramot At Tel Aviv University Ltd.	Conjugated psychotropic drugs and uses thereof
MX2007015511A (es) *	2005-06-07	2008-03-06	Univ Ramot	Sales novedosas de farmacos sicotropicos conjugados y procesos para prepararlas.
EP2051735B1 (en)	2006-07-17	2012-08-29	Ramot, at Tel Aviv University Ltd.	Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use treating pain and other cns disorders
WO2009101616A1 (en)	2008-02-11	2009-08-20	Ramot At Tel Aviv University Ltd.	Novel conjugates for treating neurodegenerative diseases and disorders
US8975251B2 (en)	2009-12-09	2015-03-10	Bar-Ilan University	Methods of improving cognitive functions
JP2013520488A (ja)	2010-02-24	2013-06-06	ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド	ペルフェナジン−ｇａｂａのトリメシラート塩の結晶性形態物及びその製法方法
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1996
- 1996-08-21 US US08/700,950 patent/US5780590A/en not_active Expired - Lifetime
1997
- 1997-08-15 EP EP97938424A patent/EP0929572A4/en not_active Withdrawn
- 1997-08-15 NZ NZ334059A patent/NZ334059A/xx unknown
- 1997-08-15 JP JP10519340A patent/JP2001501965A/ja not_active Ceased
- 1997-08-15 IL IL12855697A patent/IL128556A0/xx unknown
- 1997-08-15 AU AU40749/97A patent/AU722112B2/en not_active Ceased
- 1997-08-15 CA CA002263732A patent/CA2263732A1/en not_active Abandoned
- 1997-08-15 UA UA99031553A patent/UA48252C2/uk unknown
- 1997-08-15 CN CN97198164A patent/CN1231671A/zh active Pending
- 1997-08-15 HU HU9903961A patent/HUP9903961A3/hu unknown
- 1997-08-15 BR BR9711205A patent/BR9711205A/pt not_active Application Discontinuation
- 1997-08-15 KR KR1019997001363A patent/KR20000035797A/ko not_active Ceased
- 1997-08-15 EA EA199900216A patent/EA001391B1/ru not_active IP Right Cessation
- 1997-08-15 PL PL97331713A patent/PL331713A1/xx unknown
- 1997-08-15 WO PCT/US1997/014578 patent/WO1998017678A1/en not_active Ceased
- 1997-08-15 AP APAP/P/1999/001452A patent/AP904A/en active
- 1997-08-15 SK SK146-99A patent/SK14699A3/sk unknown
- 1997-08-21 ZA ZA9707511A patent/ZA977511B/xx unknown
1999
- 1999-02-15 OA OA9900033A patent/OA10975A/en unknown
- 1999-02-22 NO NO990836A patent/NO990836L/no unknown
- 1999-02-22 BG BG103197A patent/BG103197A/xx unknown

Also Published As

Publication number	Publication date
US5780590A (en)	1998-07-14
KR20000035797A (ko)	2000-06-26
AU4074997A (en)	1998-05-15
NO990836L (no)	1999-04-20
EA001391B1 (ru)	2001-02-26
EP0929572A1 (en)	1999-07-21
AU722112B2 (en)	2000-07-20
WO1998017678A1 (en)	1998-04-30
CA2263732A1 (en)	1998-04-30
NO990836D0 (no)	1999-02-22
AP9901452A0 (en)	1999-03-31
UA48252C2 (uk)	2002-08-15
EA199900216A1 (ru)	1999-08-26
JP2001501965A (ja)	2001-02-13
AP904A (en)	2000-11-24
IL128556A0 (en)	2000-01-31
ZA977511B (en)	1998-03-03
HUP9903961A2 (hu)	2000-04-28
PL331713A1 (en)	1999-08-02
BR9711205A (pt)	1999-08-17
EP0929572A4 (en)	2001-09-12
SK14699A3 (en)	2000-11-07
CN1231671A (zh)	1999-10-13
BG103197A (bg)	2000-05-31
NZ334059A (en)	2000-01-28
HUP9903961A3 (en)	2000-12-28

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