AR008376A1 - Un compuesto que posee actividad como inhibidor de trombina, un proceso para llevar a cabo la produccion de dicho compuesto y una composicionfarmaceutica que lo contiene. - Google Patents

Un compuesto que posee actividad como inhibidor de trombina, un proceso para llevar a cabo la produccion de dicho compuesto y una composicionfarmaceutica que lo contiene.

Info

Publication number
AR008376A1
AR008376A1 ARP970102270A ARP970102270A AR008376A1 AR 008376 A1 AR008376 A1 AR 008376A1 AR P970102270 A ARP970102270 A AR P970102270A AR P970102270 A ARP970102270 A AR P970102270A AR 008376 A1 AR008376 A1 AR 008376A1
Authority
AR
Argentina
Prior art keywords
compound
activity
production
pharmaceutical composition
carry out
Prior art date
Application number
ARP970102270A
Other languages
English (en)
Original Assignee
Novarits Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novarits Ag filed Critical Novarits Ag
Publication of AR008376A1 publication Critical patent/AR008376A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto de la formula general I: donde Y es un grupo amino primario o secundario; R2 es el residuo de un aminoácido natural o sintético; R3 eshidrogeno o una cadena alquilo C1-C8 que puede estar sustituída por hidroxi o halogeno y; X es (CH2)n donde n es 1, 2 o 3 es CH2N o representa una cadenacerrada de fenilo fundida que, de manera opcional, se encuentra sustituída por uno o más grupos metoxi o bien una sal del mismo.
ARP970102270A 1996-06-01 1997-05-28 Un compuesto que posee actividad como inhibidor de trombina, un proceso para llevar a cabo la produccion de dicho compuesto y una composicionfarmaceutica que lo contiene. AR008376A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9611461.6A GB9611461D0 (en) 1996-06-01 1996-06-01 New compounds

Publications (1)

Publication Number Publication Date
AR008376A1 true AR008376A1 (es) 2000-01-19

Family

ID=10794610

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970102270A AR008376A1 (es) 1996-06-01 1997-05-28 Un compuesto que posee actividad como inhibidor de trombina, un proceso para llevar a cabo la produccion de dicho compuesto y una composicionfarmaceutica que lo contiene.

Country Status (8)

Country Link
AR (1) AR008376A1 (es)
AU (1) AU2908197A (es)
CO (1) CO4940504A1 (es)
GB (1) GB9611461D0 (es)
ID (1) ID16990A (es)
PE (1) PE69498A1 (es)
WO (1) WO1997046553A1 (es)
ZA (1) ZA974779B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040007672A (ko) * 2001-06-12 2004-01-24 에스케이 주식회사 신규한 페닐알킬디아민 및 아미드 유사체
AU2002331064B2 (en) * 2001-08-10 2007-08-23 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
US8859814B2 (en) * 2008-05-22 2014-10-14 Boehringer Ingelheim International Gmbh Alpha-substituted N-sulfonyl gylcine amides antagonists of CCR10, compositions containing the same and methods for using them
WO2012068106A2 (en) 2010-11-15 2012-05-24 Exelixis, Inc. Benzoxazepines as inhibitors of pi3k/mtor and methods of their use and manufacture
EP2643316A2 (en) 2010-11-24 2013-10-02 Exelixis, Inc. Benzoxazepines as inhibitors of p13k/mtor and methods of their use and manufacture
CN112679448B (zh) * 2020-12-31 2022-08-19 苏州昊帆生物股份有限公司 N-(2-氨基乙基)吗啉的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH31294A (en) * 1992-02-13 1998-07-06 Thomae Gmbh Dr K Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and process for preparing them.
JPH08504194A (ja) * 1992-12-01 1996-05-07 メルク エンド カンパニー インコーポレーテッド フィブリノーゲンレセプターアンタゴニスト
FR2727413B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Derives de 5-(1h-imidazol-4-yl)-1-oxo-2-(phenylsulfonamino)- pentylpiperidine, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
WO1997046553A1 (en) 1997-12-11
GB9611461D0 (en) 1996-08-07
ID16990A (id) 1997-11-27
AU2908197A (en) 1998-01-05
ZA974779B (en) 1997-12-01
PE69498A1 (es) 1998-11-27
CO4940504A1 (es) 2000-07-24

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