ES2176252T3 - Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. - Google Patents

Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos.

Info

Publication number
ES2176252T3
ES2176252T3 ES94924713T ES94924713T ES2176252T3 ES 2176252 T3 ES2176252 T3 ES 2176252T3 ES 94924713 T ES94924713 T ES 94924713T ES 94924713 T ES94924713 T ES 94924713T ES 2176252 T3 ES2176252 T3 ES 2176252T3
Authority
ES
Spain
Prior art keywords
alcoxi
rent
replaced
hydrogen
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94924713T
Other languages
English (en)
Inventor
Hermann Amschler
Dieter Flockerzi
Beate Gutterer
Armin Hatzelmann
Christian Schudt
Rolf Beume
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4223466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2176252(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Application granted granted Critical
Publication of ES2176252T3 publication Critical patent/ES2176252T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I), DONDE UNO DE LOS SUSTITUYENTE R1 O R2 SIGNIFICA HIDROGENO, 1 - 6C - ALCOXI, 3 - 7C -CICLOALCOXI, 3 - 7C - CICLOALQUILMETOXI, BENCILOXI O 1 - 4C - ALCOXI SUSTITUIDO COMPLETA O PARCIALMENTE POR FLUOR, Y 1 - 4C - ALCOXI SUSTITUIDO DE FORMA COMPLETA O PARCIALMENTE POR FLUOR, Y R3 SIGNIFICA FENILO, PIRIDILO, FENILO SUSTITUIDO POR R31, R32 Y R33 O PIRIDILO SUSTITUIDO POR R34, R35, R36 Y R37, DONDE R31, ES HIDROXI, HALOGENO, CIANO, CARBOXILO, TRIFLUORMETILO, 1 - 4C ALQUILO, 1 - 4C - ALCOXI, 1 - 4C - ALCOXICARBONILO, 1 - 4C ALQUILCARBONILO, 1 - 4C - ALQUILCARBONILOXI, AMINO, MONO O DI 1 4C - ALQUILAMINO O 1 - 4C - ALQUILCARBONILAMINO, R32, ES HIDROGENO, HIDROXI, HALOGENO, AMINO, TRIFLUOR METILO, 1 - 4C ALQUILO O 1 - 4C - ALCOXI, R33 ES HIDROGENO, HALOGENO, 1 - 4C ALQUILO O 1 - 4C - ALCOXI, R34 ES HIDROXI, HALOGENO, CIANO, CARBOXILO, 1 - 4C - ALQUILO, 1 - 4C - ALCOXI, 1 - 4C ALCOXICARBONILO O AMINO, R35 ES HIDROGENO, HALOGENO, AMINO O 1 4C - ALQUILO, R36 ES HIDROGENO OHALOGENO, Y R37 ES HIDROGENO O HALOGENO, SIENDO NUEVOS PRODUCTOS TERAPEUTICOS ACTIVOS BRONQUIALES.
ES94924713T 1993-07-02 1994-07-02 Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos. Expired - Lifetime ES2176252T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH199693 1993-07-02

Publications (1)

Publication Number Publication Date
ES2176252T3 true ES2176252T3 (es) 2002-12-01

Family

ID=4223466

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94924713T Expired - Lifetime ES2176252T3 (es) 1993-07-02 1994-07-02 Benzamidas sustituidas con fluoro-alcoxi y su utilizacion como agentes inhibidores de fosfodiesterasas de nucleotidos ciclicos.

Country Status (27)

Country Link
US (1) US5712298A (es)
EP (1) EP0706513B1 (es)
JP (1) JP3093271B2 (es)
KR (1) KR100331255B1 (es)
CN (1) CN1046939C (es)
AT (1) ATE217612T1 (es)
AU (1) AU687087B2 (es)
CA (1) CA2165192C (es)
CY (2) CY2389B1 (es)
CZ (1) CZ290266B6 (es)
DE (2) DE59410119D1 (es)
DK (1) DK0706513T3 (es)
ES (1) ES2176252T3 (es)
FI (1) FI112864B (es)
FR (1) FR10C0052I2 (es)
HU (1) HU220041B (es)
LU (1) LU91709I2 (es)
LV (1) LV13074B (es)
NO (2) NO305598B1 (es)
NZ (1) NZ271316A (es)
PL (1) PL178314B1 (es)
PT (1) PT706513E (es)
RU (1) RU2137754C1 (es)
SG (1) SG143011A1 (es)
SI (1) SI0706513T1 (es)
SK (1) SK283263B6 (es)
WO (1) WO1995001338A1 (es)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7951397B2 (en) 2002-02-20 2011-05-31 Nycomed Gmbh Oral dosage form containing a PDE 4 inhibitor as an active ingredient and polyvinylpyrrolidon as excipient
US8536206B2 (en) 2003-03-08 2013-09-17 Takeda Gmbh Process for the preparation of roflumilast
US8663694B2 (en) 2005-03-16 2014-03-04 Takeda Gmbh Taste masked dosage form containing roflumilast

Families Citing this family (200)

* Cited by examiner, † Cited by third party
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US6096768A (en) * 1992-01-28 2000-08-01 Rhone-Poulenc Rorer Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group
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US5958926A (en) 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
WO1998019672A1 (en) * 1996-11-01 1998-05-14 Nitromed Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
USRE37234E1 (en) * 1996-11-01 2001-06-19 Nitromed, Inc. Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses
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