AR033295A1 - Compuestos biciclicos de pirimidina, proceso para su obtencion, uso de los mismos para la preparacion de una composicion farmaceutica y dicha composicion farmaceutica - Google Patents

Compuestos biciclicos de pirimidina, proceso para su obtencion, uso de los mismos para la preparacion de una composicion farmaceutica y dicha composicion farmaceutica

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Publication number
AR033295A1
AR033295A1 ARP020101597A ARP020101597A AR033295A1 AR 033295 A1 AR033295 A1 AR 033295A1 AR P020101597 A ARP020101597 A AR P020101597A AR P020101597 A ARP020101597 A AR P020101597A AR 033295 A1 AR033295 A1 AR 033295A1
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AR
Argentina
Prior art keywords
substituted
alkyl
groups
group
haloalkyl
Prior art date
Application number
ARP020101597A
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English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from GB0110567A external-priority patent/GB0110567D0/en
Priority claimed from GB0110570A external-priority patent/GB0110570D0/en
Priority claimed from GB0110569A external-priority patent/GB0110569D0/en
Priority claimed from GB0117420A external-priority patent/GB0117420D0/en
Priority claimed from GB0117399A external-priority patent/GB0117399D0/en
Priority claimed from GB0117401A external-priority patent/GB0117401D0/en
Priority claimed from GB0203201A external-priority patent/GB0203201D0/en
Priority claimed from GB0206834A external-priority patent/GB0206834D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR033295A1 publication Critical patent/AR033295A1/es

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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Abstract

Compuestos bicíclicos de pirimidina de la formula (1) que incluyen sus estereoisomeros, profármacos y sales o solvatos farmacéuticamente aceptables, donde: R es arilo o heteroarilo, cada uno de los cuales puede estar sustituido con 1 a 4 grupos seleccionados entre: halogeno, alquilo C1-6, alcoxi C1-6, haloalquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalcoxi C1-6; -COR4, nitro, -NR9R10, ciano, y un grupo R5; R1 es hidrogeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, haloalquilo C1-6, haloalcoxi C1-6, halogeno, NR9R10 o ciano; R2 es hidrogeno, cicloalquilo C3-7, o un grupo R6; R3 tiene el mismo significado que R2, pero R2 y R3 no pueden ser simultáneamente hidrogeno, o R2 y R3 junto con el N forman un heterociclo saturado o insaturado, que puede estar sustituido con 1 a 3 grupos R7; o R2 y R3 junto con el N forman un grupo heteroarilo de 5-10 miembros, en el que el grupo heteroarilo de 5 miembros contiene al menos un heteroátomo seleccionado entre oxígeno, azufre o nitrogeno y el grupo heteroarilo de 6-10 miembros contiene de 1 a 3 átomos de nitrogeno y donde dicho heteroarilo de 5-10 miembros puede estar sustituido con 1 a 3 grupos R7; R4 es un alquilo C1-4, -OR9 o ûNR9R10; R5 es un heterociclo de 5-6 miembros, que puede ser saturado o puede contener de uno a tres dobles enlaces, y que puede estar sustituido con 1 o más grupos R8; R6 es un alquilo C1-6 que puede estar sustituido con uno o más grupos seleccionados entre: cicloalquilo C3-7, alcoxi C1-6, haloalcoxi C1-6, hidroxi, haloalquilo C1-6; R7 es un grupo R5, un grupo R6, cicloalquilo C3-7, alcoxi C1-6, hidroxi, halogeno, nitro, ciano, C(O)NR9R10 fenilo que puede estar sustituido con 1 a 4 grupos R8; R8 es alquilo C1-6, haloalquilo C1-2, halogeno, nitro, alcoxi C1-6 o ciano; R9 es hidrogeno o alquilo C1-6; R10 independientemente de R9, tiene los mismos significados; X es carbono o nitrogeno; n es 1 o 2. Procedimientos para su obtencion, composiciones farmacéuticas que los contienen y su uso para preparar dichas composiciones farmacéuticas de utilidad en el tratamiento de las enfermedades mediadas por el factor liberador de corticotropina (CRF), como depresion, ansiedad, IBS (síndrome del intestino irritable) y la IBD (enfermedad inflamatoria del intestino.
ARP020101597A 2001-04-30 2002-04-30 Compuestos biciclicos de pirimidina, proceso para su obtencion, uso de los mismos para la preparacion de una composicion farmaceutica y dicha composicion farmaceutica AR033295A1 (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB0110567A GB0110567D0 (en) 2001-04-30 2001-04-30 Chemical compounds
GB0110570A GB0110570D0 (en) 2001-04-30 2001-04-30 Chemical compounds
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