AR044005A1 - Compuestos biciclicos, procedimiento para su preparacion, su uso para preparar un medicamento y composiciones farmaceuticas que los comprenden - Google Patents

Compuestos biciclicos, procedimiento para su preparacion, su uso para preparar un medicamento y composiciones farmaceuticas que los comprenden

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Publication number
AR044005A1
AR044005A1 ARP040101187A ARP040101187A AR044005A1 AR 044005 A1 AR044005 A1 AR 044005A1 AR P040101187 A ARP040101187 A AR P040101187A AR P040101187 A ARP040101187 A AR P040101187A AR 044005 A1 AR044005 A1 AR 044005A1
Authority
AR
Argentina
Prior art keywords
alkyl
halo
nr3r4
cyano
alkoxy
Prior art date
Application number
ARP040101187A
Other languages
English (en)
Original Assignee
Neurocrine Biosciences Inc
Sb Pharmco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc, Sb Pharmco Inc filed Critical Neurocrine Biosciences Inc
Publication of AR044005A1 publication Critical patent/AR044005A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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Abstract

Compuestos bicíclicos de fórmula (1) que incluye estereoisómeros, profármacos y sales o solvatos farmacéuticamente aceptables de los dichos compuestos, en la cual: la línea de trazos representa un doble enlace; R es arilo o heteroarilo, cada uno de los cuales puede estar sustituido con 1 a 4 grupos J seleccionados de: halógeno, alquilo C1-6, alcoxi C1-6, halo alquilo (C1-6), alquenilo C2-6, alquinilo C2-6, halo alcoxi (C1-6), -C(O)R2, nitro, hidroxi, -NR3R4, ciano o un grupo Z; R1 es hidrógeno, cicloalquilo C3-7, alquilo C1-6, alcoxi C1-6, tioalquilo C1-6, alquenilo C2-6, alquinilo C2-6, halo alquilo (C1-6), halo alcoxi (C1-6), halógeno, NR3R4 o ciano; R2 es un alquilo C1-4, -OR3 o -NR3R4; R3 es hidrógeno o alquilo C1-6; R4 es hidrógeno o alquilo C1-6; R5 es un alquilo C1-6, halo alquilo C1-6, alcoxi C1-6, halo alcoxi (C1-6), cicloalquilo C3-7, hidroxi, halógeno, nitro, ciano, -NR3R4; -C(O)R2; R6 es un alquilo C1-6, halo alquilo C1-6, alcoxi C1-6, halo alcoxi (C1-6), cicloalquilo C3-7, hidroxi, halógeno, nitro, ciano, -NR3R4; -C(O)R2; R7 es hidrógeno, alquilo C1-6, halógeno o halo alquilo (C1-6); R8 es hidrógeno, cicloalquilo C3-7, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, NR3R4 o ciano; R9 es hidrógeno, cicloalquilo C3-7, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, NR3R4 o ciano; R10 es hidrógeno, cicloalquilo C3-7, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, NR3R4 o ciano; R11 es hidrógeno, cicloalquilo C3-7, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, NR3R4 o ciano; R12 es R3 o -C(O)R2; D es CR8R9 o es CR8 cuando forma un doble enlace con G; G es CR10R11 o es CR10 cuando forma un doble enlace con D o es CR10 cuando forma un doble enlace con X cuando X es carbono; X es carbono o nitrógeno; Y es nitrógeno o -CR7; W es un anillo de 4-8 miembros que puede estar saturado o que puede contener uno o tres dobles enlaces, y en el cual: un átomo de carbono es reemplazado con un carbonilo o S(O)m; y C1-4 pueden estar opcionalmente reemplazados con oxígeno, nitrógeno o NR12, S(O)m, carbonilo, y dicho anillo puede estar adicionalmente sustituido con 1 a 8 grupos R6; Z es un heterociclo de 5-6 miembros, que puede estar sustituido con 1 a 8 grupos R5 o un anillo fenilo que puede estar sustituido con 1 a 4 grupos R5; m es un número entero de 0 a 2. Procedimientos para su preparación, composiciones farmacéuticas que los contienen y a su uso en el tratamiento de trastornos intermediados por el factor liberador de corticotropina (CRF) tales como depresión, ansiedad, IBS (enfermedad de intestino irritable) e IBD (enfermedad inflamatoria del intestino).
ARP040101187A 2003-04-09 2004-04-07 Compuestos biciclicos, procedimiento para su preparacion, su uso para preparar un medicamento y composiciones farmaceuticas que los comprenden AR044005A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0308208.8A GB0308208D0 (en) 2003-04-09 2003-04-09 Chemical compounds
US48532203P 2003-07-07 2003-07-07

Publications (1)

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AR044005A1 true AR044005A1 (es) 2005-08-24

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ARP040101187A AR044005A1 (es) 2003-04-09 2004-04-07 Compuestos biciclicos, procedimiento para su preparacion, su uso para preparar un medicamento y composiciones farmaceuticas que los comprenden

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US7427630B2 (en) 2008-09-23
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