AR059646A1 - Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen - Google Patents

Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen

Info

Publication number
AR059646A1
AR059646A1 ARP070100806A ARP070100806A AR059646A1 AR 059646 A1 AR059646 A1 AR 059646A1 AR P070100806 A ARP070100806 A AR P070100806A AR P070100806 A ARP070100806 A AR P070100806A AR 059646 A1 AR059646 A1 AR 059646A1
Authority
AR
Argentina
Prior art keywords
amino acids
peptide
thr
leu
gly
Prior art date
Application number
ARP070100806A
Other languages
English (en)
Inventor
Fernandez Rolando Ed Rodriguez
La Nuez Veulens Ania De
Garcia Mario Pablo Estrada
Rodriguez Rebeca Martinez
Santiago Glay Chinea
Benitez Jose Fernando Reyes
Masso Julio Raul Fernandez
Del Barco Herrera Diana Garcia
Acosta Jorge Amador Berlanga
Lasa Alexis Musacchio
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40130780&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR059646(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Publication of AR059646A1 publication Critical patent/AR059646A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)

Abstract

Compuestos químicos peptídicos obtenidos por modelacion molecular in silico, y cuya estructura les permite efectuar las mismas funciones que los secretagogos peptídicos de la hormona de crecimiento. La presente comprende además las composiciones que contienen dichos compuestos y su uso en la preparacion de medicamentos, suplementos nutricionales, u otras formulaciones de uso humano o animal. Reivindicacion 1: Compuestos químicos de naturaleza peptídica, con ciclos internos y compuestas de aminoácidos con estereoquímica L, y sus variantes homologas, que son capaces de realizar funciones similares a las atribuidas a la ghrelina, des-acil ghrelina, y otros secretagogos de la hormona de crecimiento peptídicos, que se caracterizan por tener una estructura química definida por la secuencia aminoacídica siguiente que incluye una ciclacion por sus cadenas laterales o empleando cualquier agente químico, y que son seleccionados cumpliendo con las siguientes regularidades estructurales [Aa1...Aan]X1[Ab1...Abn]X2[Ac1...Acn]Ad n, donde Aa son L-aminoácidos seleccionados del conjunto de [Cys, Gly, Ser, His, Ala, Leu, Met o Thr], variando en combinaciones desde 1 hasta 4 residuos, Ab son L-aminoácidos, seleccionados del conjunto de [Pro, Ile, Ala, Phe, Trp, Lys, Asp, Asn, Glu, GIn, Gly, Leu, Met, Tyr o Thr], variando en combinaciones de 1 hasta 4 residuos, Ac son L-aminoácidos seleccionados del conjunto [Arg, Leu, Pro, Val, Thr, Glu, His, GIn, Asn, Asp, Trp, Tyr, Phe, Ser, Ala , Gly o lle], variando en combinaciones de 1 hasta 5 y Ad son L-aminoácidos, naturales o no, sin límite de numero, X1 y X2 son L-aminoácidos, naturales o no, con las cadenas laterales enlazadas covalentemente formando un ciclo interno, utilizando cualquier reaccion química para la union de forma directa o utilizando un compuesto de enlazamiento como puente.
ARP070100806A 2006-02-28 2007-02-27 Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen AR059646A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20060050A CU23558A1 (es) 2006-02-28 2006-02-28 Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento

Publications (1)

Publication Number Publication Date
AR059646A1 true AR059646A1 (es) 2008-04-16

Family

ID=40130780

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070100806A AR059646A1 (es) 2006-02-28 2007-02-27 Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen

Country Status (18)

Country Link
US (1) US8367620B2 (es)
EP (1) EP1997827B1 (es)
JP (1) JP5183496B2 (es)
KR (1) KR101409277B1 (es)
CN (1) CN101432294B (es)
AR (1) AR059646A1 (es)
AU (1) AU2007219569B2 (es)
BR (1) BRPI0708366A2 (es)
CA (1) CA2637593C (es)
CL (2) CL2007000528A1 (es)
CU (1) CU23558A1 (es)
ES (1) ES2441441T3 (es)
MX (1) MX2008011142A (es)
MY (1) MY184130A (es)
NO (1) NO20084118L (es)
RU (1) RU2416618C2 (es)
WO (1) WO2007098716A1 (es)
ZA (1) ZA200807162B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4831551B2 (ja) * 2008-11-06 2011-12-07 国立大学法人名古屋大学 非虚血性心筋障害に対する医薬
CU24473B1 (es) * 2016-11-01 2020-02-04 Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma Composición vacunal que comprende un péptido secretagogo de la hormona de crecimiento como adyuvante vacunal
RU2734835C1 (ru) * 2020-02-11 2020-10-23 Федеральное государственное бюджетное учреждение науки Лимнологический институт Сибирского отделение Российской академии наук (ЛИН СО РАН) Способ повышения жизнестойкости эмбрионов рыб в аквакультуре

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KR20080110763A (ko) 2008-12-19
JP2009528303A (ja) 2009-08-06
RU2416618C2 (ru) 2011-04-20
CA2637593C (en) 2015-04-14
MY184130A (en) 2021-03-19
AU2007219569A1 (en) 2007-09-07
JP5183496B2 (ja) 2013-04-17
ZA200807162B (en) 2009-06-24
BRPI0708366A2 (pt) 2011-05-24
WO2007098716A1 (es) 2007-09-07
CL2007000528A1 (es) 2008-01-18
US8367620B2 (en) 2013-02-05
EP1997827B1 (en) 2013-10-09
RU2008138569A (ru) 2010-04-10
MX2008011142A (es) 2008-09-08
CA2637593A1 (en) 2007-09-07
CL2016001648A1 (es) 2017-02-24
ES2441441T3 (es) 2014-02-04
CN101432294A (zh) 2009-05-13
WO2007098716A8 (es) 2008-12-18
AU2007219569B2 (en) 2012-03-15
KR101409277B1 (ko) 2014-06-24
NO20084118L (no) 2008-09-29
US20100055118A1 (en) 2010-03-04
CU23558A1 (es) 2010-07-20
EP1997827A1 (en) 2008-12-03

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