AT510866A3 - Stabiles pharmazeutisches kombinationspräparat - Google Patents

Stabiles pharmazeutisches kombinationspräparat Download PDF

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Publication number
AT510866A3
AT510866A3 ATA9359/2009A AT93592009A AT510866A3 AT 510866 A3 AT510866 A3 AT 510866A3 AT 93592009 A AT93592009 A AT 93592009A AT 510866 A3 AT510866 A3 AT 510866A3
Authority
AT
Austria
Prior art keywords
pharmaceutical combination
combination preparation
stable pharmaceutical
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
ATA9359/2009A
Other languages
English (en)
Other versions
AT510866A2 (de
Original Assignee
Egis Gyogyszergyar Nyilvanosan Muködö Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan Muködö Reszvenytarsasag filed Critical Egis Gyogyszergyar Nyilvanosan Muködö Reszvenytarsasag
Priority to ATGM8014/2015U priority Critical patent/AT14769U1/de
Publication of AT510866A2 publication Critical patent/AT510866A2/de
Publication of AT510866A3 publication Critical patent/AT510866A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Packages (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Stabile, feste pharmazeutische Zusammensetzung enthaltendAmlodipin oder pharmazeutisch annehmbare Salze davon undBisoprolol oder pharmazeutisch annehmbare Salze davon sowiepharmazeutisch annehmbare Hilfsstoffe, verpackt in einerfeuchtigkeitsbeständigen Verpackung, und die weiters wenigerals 0,5% der Verbindung gemäß Formel (3), bezogen auf dasGewicht der Wirkstoffe, umfasst.
ATA9359/2009A 2008-09-30 2009-09-30 Stabiles pharmazeutisches kombinationspräparat AT510866A3 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ATGM8014/2015U AT14769U1 (de) 2008-09-30 2009-09-30 Stabiles pharmazeutisches Kombinationspräparat

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP0800591A HU230877B1 (hu) 2008-09-30 2008-09-30 Stabil kombinációs gyógyszerkészítmény
PCT/HU2009/000085 WO2010038091A2 (en) 2008-09-30 2009-09-30 Stable combination pharmaceutical composition

Publications (2)

Publication Number Publication Date
AT510866A2 AT510866A2 (de) 2012-07-15
AT510866A3 true AT510866A3 (de) 2014-06-15

Family

ID=89988527

Family Applications (2)

Application Number Title Priority Date Filing Date
ATGM8014/2015U AT14769U1 (de) 2008-09-30 2009-09-30 Stabiles pharmazeutisches Kombinationspräparat
ATA9359/2009A AT510866A3 (de) 2008-09-30 2009-09-30 Stabiles pharmazeutisches kombinationspräparat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ATGM8014/2015U AT14769U1 (de) 2008-09-30 2009-09-30 Stabiles pharmazeutisches Kombinationspräparat

Country Status (31)

Country Link
EP (2) EP2344141B1 (de)
KR (1) KR101772619B1 (de)
CN (1) CN102164585B (de)
AT (2) AT14769U1 (de)
BG (1) BG66274B1 (de)
CH (1) CH702345B1 (de)
CY (1) CY1122084T1 (de)
CZ (2) CZ30825U1 (de)
DE (1) DE202009019152U1 (de)
DK (1) DK2344141T3 (de)
EA (2) EA038392B1 (de)
EE (1) EE05723B1 (de)
ES (2) ES2739900T3 (de)
GE (1) GEP20135859B (de)
HR (3) HRP20191373T1 (de)
HU (3) HU230877B1 (de)
LT (3) LT2344141T (de)
ME (1) ME03774B (de)
MX (2) MX2011003407A (de)
MY (1) MY175270A (de)
PL (3) PL394605A1 (de)
PT (3) PT2010038091Y (de)
RO (1) RO127490B1 (de)
RS (3) RS60784B1 (de)
RU (2) RU2549437C2 (de)
SG (1) SG194392A1 (de)
SI (2) SI2344141T1 (de)
SK (2) SK7997Y1 (de)
SM (1) SMT201900434T1 (de)
UA (1) UA101407C2 (de)
WO (1) WO2010038091A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU230877B1 (hu) 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stabil kombinációs gyógyszerkészítmény
CN101766611B (zh) * 2010-02-09 2011-10-12 施慧达药业集团(吉林)有限公司 一种左旋氨氯地平或其可药用盐和β受体阻滞剂的药物组合物及其应用
BR112014020184B1 (pt) 2012-02-17 2021-11-30 Egis Gyógyszergyár Zrt Preparação farmacêutica que contém anlodipina e ra-mipril
SMT202400092T1 (it) * 2013-06-13 2024-05-14 Akebia Therapeutics Inc Composizioni e metodi per il trattamento dell'anemia
HUP1300496A2 (hu) 2013-08-16 2015-03-02 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Stabil kombinációs gyógyszerkészítmény
FR3027803B1 (fr) * 2014-11-05 2018-02-09 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant et un inhibiteur de l'enzyme de conversion
PH12018502155B1 (en) 2016-04-20 2024-03-27 Servier Lab Pharmaceutical composition comprising a beta blocker, a converting enzyme inhibitor and an antihypertensive or an nsaid
IL319228A (en) 2022-09-07 2025-04-01 Lasse Kinast Immediate-release oral pharmaceutical dosage form of amlodipine with increased API quantity
CN116687926B (zh) * 2023-07-27 2023-12-12 石家庄四药有限公司 一种比索洛尔氨氯地平复方片剂及其制备方法
EP4710920A1 (de) 2024-09-16 2026-03-18 Adamed Pharma S.A. Pharmazeutische zusammensetzung enthaltend eine kombination aus amlodipin, ramipril und rosuvastatin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005099699A1 (en) * 2004-04-07 2005-10-27 Sepracor Inc. Combination of (s)-amlodipine and a beta-blocker, and methods for reducing hypertension
IN224215B (de) * 2004-08-05 2009-02-06

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU221810B1 (hu) * 1997-08-12 2003-01-28 EGIS Gyógyszergyár Rt. Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
CA2433181C (en) 2000-12-29 2005-11-22 Pfizer Limited Amlodipine hemifumarate
AT5874U1 (de) * 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
AU2001100431A4 (en) * 2001-10-03 2001-11-01 Pfizer Limited Pharmaceutical compositions comprising amlodipine maleate
WO2003032954A1 (en) 2001-10-17 2003-04-24 Dr. Reddy's Laboratories Ltd. Stabilized pharmaceutical formulations containing amlodipine maleate
WO2004075825A2 (en) * 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Dosage forms of amlodipine and processes for their preparation
WO2005051350A2 (en) * 2003-10-28 2005-06-09 Torrent Pharmaceuticals Limited Water dispersible tablet
WO2006059217A1 (en) * 2004-12-01 2006-06-08 Ranbaxy Laboratories Limited Stable solid dosage forms of amlodipine besylate and processes for their preparation
CZ2005141A3 (cs) * 2005-03-07 2006-04-12 Lunaria, Spol. S. R. O. Lécivý prípravek na bázi amlodipin-besilátu se zvýsenou stabilitou
IES20070122A2 (en) * 2006-12-05 2008-05-28 Michael Hilary Burke A process for the preparation of an orally administered unit dose tablet
HU230877B1 (hu) 2008-09-30 2018-11-29 EGIS Gyógyszergyár NyR Stabil kombinációs gyógyszerkészítmény

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005099699A1 (en) * 2004-04-07 2005-10-27 Sepracor Inc. Combination of (s)-amlodipine and a beta-blocker, and methods for reducing hypertension
IN224215B (de) * 2004-08-05 2009-02-06

Also Published As

Publication number Publication date
HRP20110162A2 (hr) 2011-06-30
RU2014139476A (ru) 2015-06-20
CN102164585B (zh) 2016-04-27
HRP20110162B1 (hr) 2019-09-20
PL2344141T3 (pl) 2019-10-31
RU2011112047A (ru) 2012-11-10
GEP20135859B (en) 2013-06-25
EE05723B1 (et) 2014-10-15
DK2344141T3 (da) 2019-08-05
PL2359815T3 (pl) 2020-11-30
MX2011003407A (es) 2011-06-20
HUP0800591A2 (en) 2010-10-28
EA026238B1 (ru) 2017-03-31
EA038392B1 (ru) 2021-08-20
HK1155976A1 (zh) 2012-06-01
RS20110136A1 (sr) 2012-08-31
AT510866A2 (de) 2012-07-15
PT2010038091Y (pt) 2020-02-10
RO127490B1 (ro) 2022-01-28
SI2344141T1 (sl) 2019-09-30
ES2385988B2 (es) 2013-12-11
BG66274B1 (bg) 2012-12-28
EA201100430A1 (ru) 2011-10-31
EP2344141A2 (de) 2011-07-20
ES2739900T3 (es) 2020-02-04
ES2385988A1 (es) 2012-08-06
EA026238B9 (ru) 2017-05-31
SMT201900434T1 (it) 2019-09-09
RS59201B1 (sr) 2019-10-31
EE201100029A (et) 2011-06-15
RU2687282C2 (ru) 2019-05-13
LT2011012A (lt) 2011-10-25
SI2359815T1 (sl) 2020-10-30
SK288593B6 (sk) 2018-09-03
WO2010038091A9 (en) 2011-04-07
MX382264B (es) 2025-03-11
WO2010038091A2 (en) 2010-04-08
RS60686B1 (sr) 2020-09-30
EP2359815B1 (de) 2020-01-08
SK7997Y1 (sk) 2018-02-05
LT2359815T (lt) 2020-04-27
PT2359815T (pt) 2020-04-16
CN102164585A (zh) 2011-08-24
PT2344141T (pt) 2019-08-06
CZ308237B6 (cs) 2020-03-18
CY1122084T1 (el) 2020-11-25
PL394605A1 (pl) 2011-09-26
HRP20200614T1 (hr) 2020-10-02
RO127490A2 (ro) 2012-06-29
HUE049948T2 (hu) 2020-11-30
HU230877B1 (hu) 2018-11-29
HUE045326T2 (hu) 2019-12-30
SK72017U1 (sk) 2017-08-02
RS60784B1 (sr) 2020-10-30
EA201691869A1 (ru) 2017-04-28
HU0800591D0 (en) 2008-11-28
RU2549437C2 (ru) 2015-04-27
AT14769U1 (de) 2016-05-15
ME03774B (de) 2021-04-20
CZ30825U1 (cs) 2017-07-11
EP2344141B1 (de) 2019-05-01
EP2359815A1 (de) 2011-08-24
CZ2011252A3 (cs) 2011-07-07
MY175270A (en) 2020-06-17
SG194392A1 (en) 2013-11-29
BG110927A (bg) 2011-09-30
UA101407C2 (ru) 2013-03-25
HRP20191373T1 (hr) 2019-11-01
DE202009019152U1 (de) 2017-03-06
CH702345B1 (de) 2014-05-15
KR20110063563A (ko) 2011-06-10
HRP20110162A8 (hr) 2019-03-22
WO2010038091A3 (en) 2010-09-23
LT2344141T (lt) 2019-08-26
LT5815B (lt) 2012-02-27
KR101772619B1 (ko) 2017-08-29
SK50232011A3 (sk) 2011-08-04

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Effective date: 20160515