ATE104146T1 - Zubereitung mit verzoegerter freigabe eines hydrochlorids eines basischen arzneistoffs. - Google Patents
Zubereitung mit verzoegerter freigabe eines hydrochlorids eines basischen arzneistoffs.Info
- Publication number
- ATE104146T1 ATE104146T1 AT90311748T AT90311748T ATE104146T1 AT E104146 T1 ATE104146 T1 AT E104146T1 AT 90311748 T AT90311748 T AT 90311748T AT 90311748 T AT90311748 T AT 90311748T AT E104146 T1 ATE104146 T1 AT E104146T1
- Authority
- AT
- Austria
- Prior art keywords
- hydrochloride
- delayed
- release preparation
- basic drug
- preparation
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229950010731 arotinolol Drugs 0.000 abstract 1
- BHIAIPWSVYSKJS-UHFFFAOYSA-N arotinolol Chemical compound S1C(SCC(O)CNC(C)(C)C)=NC(C=2SC(=CC=2)C(N)=O)=C1 BHIAIPWSVYSKJS-UHFFFAOYSA-N 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
- 229920000447 polyanionic polymer Polymers 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1280579A JPH03145418A (ja) | 1989-10-27 | 1989-10-27 | 塩基性薬物塩酸塩の徐放性製剤 |
| EP90311748A EP0425298B1 (de) | 1989-10-27 | 1990-10-26 | Zubereitung mit verzögerter Freigabe eines Hydrochlorids eines basischen Arzneistoffs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE104146T1 true ATE104146T1 (de) | 1994-04-15 |
Family
ID=17627005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90311748T ATE104146T1 (de) | 1989-10-27 | 1990-10-26 | Zubereitung mit verzoegerter freigabe eines hydrochlorids eines basischen arzneistoffs. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5234691A (de) |
| EP (1) | EP0425298B1 (de) |
| JP (1) | JPH03145418A (de) |
| KR (1) | KR910007517A (de) |
| AT (1) | ATE104146T1 (de) |
| CA (1) | CA2028633A1 (de) |
| DE (1) | DE69008107T2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5085866A (en) * | 1988-12-02 | 1992-02-04 | Southern Research Institute | Method of producing zero-order controlled-released devices |
| US5492700A (en) * | 1991-11-26 | 1996-02-20 | Warner-Lambert Company | Process and composition for the development of controlled release gemfibrozil dosage form |
| DE19504831A1 (de) * | 1995-02-14 | 1996-09-05 | Basf Ag | Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose |
| DE19842753A1 (de) | 1998-09-18 | 2000-03-23 | Bayer Ag | Agitationsunabhängige pharmazeutische Retardzubereitungen und Verfahren zu ihrer Herstellung |
| ES2162746B1 (es) * | 1999-10-21 | 2003-02-16 | Lipotec Sa | Microcapsulas para la estabilizacion de productos cosmeticos, farmaceuticos o de alimentacion. |
| GB0025208D0 (en) * | 2000-10-13 | 2000-11-29 | Euro Celtique Sa | Delayed release pharmaceutical formulations |
| US20030175342A1 (en) * | 2002-03-14 | 2003-09-18 | Karl Kolter | Coated pharmaceutical single-unit delayed-release forms, based on polyvinyl acetate |
| US7037521B2 (en) * | 2003-03-28 | 2006-05-02 | Bausch & Lomb Incorporated | Using a laser for cutting a hole in a capsule for controlled drug delivery |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| JP5849947B2 (ja) | 2010-03-29 | 2016-02-03 | アステラス製薬株式会社 | 放出制御医薬組成物 |
| CN111513192A (zh) * | 2020-05-19 | 2020-08-11 | 北京中联华康科技有限公司 | 一种酯化半胱胺盐酸盐稳定型粉末及其制备方法与应用 |
| CN116172968A (zh) * | 2022-12-30 | 2023-05-30 | 山东中健康桥制药有限公司 | 一种盐酸阿罗洛尔制剂及其制备方法 |
| CN117064861B (zh) * | 2023-09-28 | 2025-04-08 | 石家庄格瑞药业有限公司 | 一种阿罗洛尔缓释片及其制备方法 |
| CN117100721B (zh) * | 2023-10-07 | 2025-01-28 | 石家庄格瑞药业有限公司 | 一种阿罗洛尔缓释微丸胶囊及其制备方法 |
| US12097189B1 (en) | 2024-02-09 | 2024-09-24 | Astellas Pharma Inc. | Pharmaceutical composition for modified release |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3458622A (en) * | 1967-04-07 | 1969-07-29 | Squibb & Sons Inc | Controlled release tablet |
| US3909444A (en) * | 1971-08-05 | 1975-09-30 | Ncr Co | Microcapsule |
| GB1468172A (en) * | 1973-03-28 | 1977-03-23 | Benzon As Alfred | Oral drug preparations |
| ZA765931B (en) * | 1975-10-10 | 1977-09-28 | Squibb & Sons Inc | Controlled release tablet |
| GB1561204A (en) * | 1977-06-01 | 1980-02-13 | Ici Ltd | Sustained release pharmaceutical composition |
| CA1125698A (en) * | 1978-03-09 | 1982-06-15 | Masaru Yoshida | Process for preparing a polymer composition |
| DD146547A5 (de) * | 1978-07-15 | 1981-02-18 | Boehringer Sohn Ingelheim | Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen |
| FR2470599A1 (fr) * | 1979-12-07 | 1981-06-12 | Panoz Donald | Perfectionnements apportes aux procedes de preparation de formes galeniques a action retard et a liberation programmee et formes galeniques de medicaments ainsi obtenus |
| US4449983A (en) * | 1982-03-22 | 1984-05-22 | Alza Corporation | Simultaneous delivery of two drugs from unit delivery device |
| JPS6113683A (ja) * | 1984-06-28 | 1986-01-21 | Oki Electric Ind Co Ltd | 半導体レ−ザ及びその製造方法 |
| DE3681348D1 (de) * | 1985-06-11 | 1991-10-17 | Teijin Ltd | Oral-arzneizubereitung mit retardwirkung. |
| US4904649A (en) * | 1986-05-23 | 1990-02-27 | New England Medical Center Hospitals, Inc. | Method and solution for treating glaucoma |
| US4798725A (en) * | 1986-06-16 | 1989-01-17 | Norwich Eaton Pharmaceuticals, Inc. | Sustained release capsule |
| JPS6353966A (ja) * | 1986-08-22 | 1988-03-08 | Fuji Xerox Co Ltd | 読出し専用メモリ及びその製造方法 |
| FR2624732B1 (fr) * | 1987-12-21 | 1991-02-15 | Synthelabo | Formulation pharmaceutique a liberation prolongee |
-
1989
- 1989-10-27 JP JP1280579A patent/JPH03145418A/ja active Pending
-
1990
- 1990-10-26 US US07/603,484 patent/US5234691A/en not_active Expired - Fee Related
- 1990-10-26 DE DE69008107T patent/DE69008107T2/de not_active Expired - Fee Related
- 1990-10-26 AT AT90311748T patent/ATE104146T1/de not_active IP Right Cessation
- 1990-10-26 EP EP90311748A patent/EP0425298B1/de not_active Expired - Lifetime
- 1990-10-26 CA CA002028633A patent/CA2028633A1/en not_active Abandoned
- 1990-10-27 KR KR1019900017296A patent/KR910007517A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03145418A (ja) | 1991-06-20 |
| CA2028633A1 (en) | 1991-04-28 |
| DE69008107T2 (de) | 1994-08-04 |
| US5234691A (en) | 1993-08-10 |
| DE69008107D1 (de) | 1994-05-19 |
| KR910007517A (ko) | 1991-05-30 |
| EP0425298B1 (de) | 1994-04-13 |
| EP0425298A2 (de) | 1991-05-02 |
| EP0425298A3 (en) | 1991-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |