ATE106077T1 - Zyklopenta(d>pyrimidinderivate, ihre herstellung und verwendung. - Google Patents

Zyklopenta(d>pyrimidinderivate, ihre herstellung und verwendung.

Info

Publication number: ATE106077T1
Authority: AT; Austria
Prior art keywords: sup; cyclopenta; production; hydrogen; pyrimide
Prior art date: 1985-03-07

Application number

AT86301660T

Other languages

English (en)

Inventor

Nobuyoshi Biol Res Lab S Iwata

Hiromachi

Isao Biol Res Lab San Nakayama

Kanichi An-Met Res La Nakamura

Tomio Ube Res Lab Kimura

Takashi Ube Res Lab Kobayashi

Original Assignee

Sankyo Co

Ube Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-07

Filing date

1986-03-07

Publication date

1994-06-15

1986-03-07 Application filed by Sankyo Co, Ube Industries filed Critical Sankyo Co

1994-06-15 Application granted granted Critical

1994-06-15 Publication of ATE106077T1 publication Critical patent/ATE106077T1/de

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
208000020401 Depressive disease Diseases 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
201000003102 mental depression Diseases 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Dental Preparations (AREA)
Hydrogenated Pyridines (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Soil Working Implements (AREA)
Luminescent Compositions (AREA)
Eyeglasses (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT86301660T 1985-03-07 1986-03-07 Zyklopenta(d>pyrimidinderivate, ihre herstellung und verwendung. ATE106077T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4362685		1985-03-07

Publications (1)

Publication Number	Publication Date
ATE106077T1 true ATE106077T1 (de)	1994-06-15

Family

ID=12669058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86301660T ATE106077T1 (de)	1985-03-07	1986-03-07	Zyklopenta(d>pyrimidinderivate, ihre herstellung und verwendung.

Country Status (14)

Country	Link
US (1)	US4749704A (de)
EP (1)	EP0194161B1 (de)
JP (1)	JPS6270A (de)
KR (1)	KR890003839B1 (de)
AT (1)	ATE106077T1 (de)
AU (1)	AU580391B2 (de)
CA (1)	CA1273632A (de)
DE (1)	DE3689848T2 (de)
DK (1)	DK165109C (de)
ES (3)	ES8704905A1 (de)
FI (1)	FI88717C (de)
IE (1)	IE64504B1 (de)
NO (1)	NO168767C (de)
ZA (1)	ZA861708B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5037980A (en) *	1988-04-18	1991-08-06	American Cyanamid Company	Phenyl imidazo[1,2-a]pyrimidines
US5877178A (en) *	1991-04-08	1999-03-02	Duquesne University Of The Holy Ghost	Pyrimidine derivatives and methods of making and using these derivatives
US5234936A (en) *	1991-10-24	1993-08-10	American Home Products Corporation	Pyrimidocycloalkanes as a ii antagonists
CA2534785A1 (en) *	2003-08-12	2005-02-17	Robin Douglas Clark	Tetrahydroquinazoline derivatives as cfr antagonists
JPWO2007049342A1 (ja)	2005-10-26	2009-04-30	三菱電機株式会社	エレベーター群管理制御装置
CA2656618C (en)	2006-07-06	2014-08-26	Array Biopharma Inc.	Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8063050B2 (en)	2006-07-06	2011-11-22	Array Biopharma Inc.	Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2054418B1 (de)	2006-07-06	2011-11-09	Array Biopharma Inc.	Dihydrothienopyrimidine als akt-proteinkinase-inhibitoren
DE602007011628D1 (de)	2006-07-06	2011-02-10	Array Biopharma Inc	Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
WO2008021456A2 (en) *	2006-08-16	2008-02-21	Cytovia, Inc.	N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US8846683B2 (en)	2007-07-05	2014-09-30	Array Biopharma, Inc.	Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en)	2007-07-05	2016-08-09	Array Biopharma Inc.	Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
ES2533557T3 (es)	2007-07-05	2015-04-13	Array Biopharma, Inc.	Pirimidil ciclopentanos como inhibidores de proteína cinasa AKT
AR067413A1 (es)	2007-07-05	2009-10-07	Genentech Inc	Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer
MX2010007546A (es)	2008-01-09	2010-09-30	Array Biopharma Inc	Pirimidil ciclopentanos hidroxilados en forma de inhibidores de akt proteína quinasa.
WO2009089459A1 (en)	2008-01-09	2009-07-16	Array Biopharma Inc.	Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
JP5230749B2 (ja)	2008-10-20	2013-07-10	三菱電機株式会社	エレベーター群管理装置
CN103841975A (zh)	2011-04-01	2014-06-04	基因泰克公司	Akt抑制剂化合物和厄洛替尼的组合以及使用方法
CN103841976A (zh)	2011-04-01	2014-06-04	基因泰克公司	Akt和mek抑制剂化合物的组合及其使用方法
GB201121127D0 (en)	2011-12-08	2012-01-18	Dow Corning	Treatment of filler with silane
CN111303053B (zh) *	2020-03-16	2023-01-17	中国海洋大学	环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3470182A (en) *	1967-02-09	1969-09-30	Sandoz Ag	4-amino-substituted quinazolines
US3980650A (en) *	1972-05-05	1976-09-14	N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia	4-Amino-pyrimidine derivatives
US3915976A (en) *	1972-09-01	1975-10-28	Sandoz Ag	Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines
PH20344A (en) *	1981-01-29	1986-12-04	Sankyo Co	Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them
JPS57203072A (en) *	1981-06-05	1982-12-13	Sankyo Co Ltd	4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

1986
- 1986-03-06 US US06/837,079 patent/US4749704A/en not_active Expired - Lifetime
- 1986-03-06 JP JP61049238A patent/JPS6270A/ja not_active Withdrawn
- 1986-03-07 CA CA000503571A patent/CA1273632A/en not_active Expired - Lifetime
- 1986-03-07 KR KR1019860001624A patent/KR890003839B1/ko not_active Expired
- 1986-03-07 EP EP86301660A patent/EP0194161B1/de not_active Expired - Lifetime
- 1986-03-07 DK DK106586A patent/DK165109C/da not_active IP Right Cessation
- 1986-03-07 FI FI860969A patent/FI88717C/fi not_active IP Right Cessation
- 1986-03-07 AT AT86301660T patent/ATE106077T1/de not_active IP Right Cessation
- 1986-03-07 DE DE3689848T patent/DE3689848T2/de not_active Expired - Fee Related
- 1986-03-07 IE IE59786A patent/IE64504B1/en not_active IP Right Cessation
- 1986-03-07 AU AU54481/86A patent/AU580391B2/en not_active Ceased
- 1986-03-07 NO NO860852A patent/NO168767C/no unknown
- 1986-03-07 ZA ZA861708A patent/ZA861708B/xx unknown
- 1986-03-07 ES ES552796A patent/ES8704905A1/es not_active Expired
- 1986-11-14 ES ES557198A patent/ES8801221A1/es not_active Expired
- 1986-11-14 ES ES557199A patent/ES8801222A1/es not_active Expired

Also Published As

Publication number	Publication date
DK165109B (da)	1992-10-12
DK106586D0 (da)	1986-03-07
ES8704905A1 (es)	1987-04-16
FI860969A0 (fi)	1986-03-07
ES557198A0 (es)	1988-01-01
FI88717B (fi)	1993-03-15
IE64504B1 (en)	1995-08-09
FI88717C (fi)	1993-06-28
KR890003839B1 (ko)	1989-10-05
EP0194161A3 (en)	1987-09-02
FI860969L (fi)	1986-09-08
JPS6270A (ja)	1987-01-06
AU5448186A (en)	1986-09-11
CA1273632A (en)	1990-09-04
NO168767C (no)	1992-04-01
DE3689848T2 (de)	1995-01-12
DK106586A (da)	1986-09-08
NO168767B (no)	1991-12-23
EP0194161B1 (de)	1994-05-25
EP0194161A2 (de)	1986-09-10
US4749704A (en)	1988-06-07
NO860852L (no)	1986-09-08
DK165109C (da)	1993-03-01
HK1005450A1 (en)	1999-01-08
ES8801222A1 (es)	1988-01-01
ES557199A0 (es)	1988-01-01
KR860007221A (ko)	1986-10-08
ES8801221A1 (es)	1988-01-01
IE860597L (en)	1986-09-07
DE3689848D1 (de)	1994-06-30
ZA861708B (en)	1986-11-26
ES552796A0 (es)	1987-04-16
AU580391B2 (en)	1989-01-12

Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2001-12-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE106077T1 (de)	1994-06-15	Zyklopenta(d>pyrimidinderivate, ihre herstellung und verwendung.
ATE90092T1 (de)	1993-06-15	Thiazolidinon-derivate, ihre herstellung und ihre verwendung.
EP0192060B1 (de)	1991-09-18	Heterocyclische Verbindungen
DE69534975D1 (de)	2006-06-08	Verwendung von noribogain derivaten zur behandlung von chemischer abhängigkeit bei säugern
ATE27162T1 (de)	1987-05-15	C-076-verbindungen, deren herstellung und eine zuechtung fuer ihre herstellung.
DE68920796D1 (de)	1995-03-09	Chinolinderivate, ihre Herstellung und Verwendung.
IE872588L (en)	1988-03-27	Compounds
LV10422A (lv)	1995-02-20	Jaunie fluor-naftacendioni to glikozetie atvasinajumi un vinu razosanas panemiens
ATE121395T1 (de)	1995-05-15	Cumarinderivate, ihre herstellung und ihre verwendung zur behandlung von zerebrovaskulären störungen.
MY102270A (en)	1992-05-15	New furanuronic acid derivatives, process their production and their use.
FI870460A0 (fi)	1987-02-03	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 5-substituerade oktahydroindolizinderivat och vid foerfarandet anvaendbara mellanprodukter.
DK7286A (da)	1986-07-10	Octahydroindoliziner
JO1676B1 (en)	1992-08-09	Extra compounds indinol II
ATE46156T1 (de)	1989-09-15	1,3-benzoxathiol-derivate, deren verwendung und deren herstellung.
EP0432841A3 (en)	1992-01-29	Spiro-indoline-oxazine compounds with photochromatic and photosensitizing characteristics and the process for their preparation
DE3561512D1 (de)	1988-03-03	Diphenylmethylimine derivatives
ATE100809T1 (de)	1994-02-15	Benzo(b>phenanthrolinderivate, ihre herstellung und ihre therapeutische verwendung.
AR246321A1 (es)	1994-07-29	Nuevos colorantes y procedimiento para su obtencion.
IE45258L (en)	1977-08-09	Tetrahydronaphthalenes
ATE15184T1 (de)	1985-09-15	Fluorphenoxybenzylester, ihre herstellung und ihre verwendung als schaedlingsbekaempfungsmittel.
TH3130A (th)	1986-03-03	อนุพันธ์ของเฟนิลควินโนลีน