DK106586D0 - Cyklopenta(d)pyrimidinderivater samt deres fremstilling og anvendelse - Google Patents

Cyklopenta(d)pyrimidinderivater samt deres fremstilling og anvendelse

Info

Publication number: DK106586D0
Authority: DK; Denmark
Prior art keywords: sup; cyclopenta; preparation; pyrimidine derivatives; hydrogen
Prior art date: 1985-03-07

Application number

DK106586A

Other languages

English (en)

Other versions

DK165109C (da

DK165109B (da

DK106586A (da

Inventor

Nobuyoshi Iwata

Isao Nakayama

Kanichi Nakamura

Tomio Kimura

Takashi Kobayashi

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-07

Filing date

1986-03-07

Publication date

1986-03-07

1986-03-07 Application filed by Sankyo Co filed Critical Sankyo Co

1986-03-07 Publication of DK106586D0 publication Critical patent/DK106586D0/da

1986-09-08 Publication of DK106586A publication Critical patent/DK106586A/da

1992-10-12 Publication of DK165109B publication Critical patent/DK165109B/da

1993-03-01 Application granted granted Critical

1993-03-01 Publication of DK165109C publication Critical patent/DK165109C/da

Links

LTFBFZBWUKWXID-UHFFFAOYSA-N 1h-cyclopenta[d]pyrimidine Chemical class N1=CNC2=CC=CC2=C1 LTFBFZBWUKWXID-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
208000020401 Depressive disease Diseases 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000001430 anti-depressive effect Effects 0.000 abstract 1
239000000935 antidepressant agent Substances 0.000 abstract 1
229940005513 antidepressants Drugs 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
201000003102 mental depression Diseases 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Public Health (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Dental Preparations (AREA)
Saccharide Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Luminescent Compositions (AREA)
Soil Working Implements (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Eyeglasses (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK106586A 1985-03-07 1986-03-07 4-anilino-cyklopentaoedaapyrimidinderivater samt farmaceutiske midler indeholdende saadanne DK165109C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP4362685		1985-03-07
JP4362685		1985-03-07

Publications (4)

Publication Number	Publication Date
DK106586D0 true DK106586D0 (da)	1986-03-07
DK106586A DK106586A (da)	1986-09-08
DK165109B DK165109B (da)	1992-10-12
DK165109C DK165109C (da)	1993-03-01

Family

ID=12669058

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK106586A DK165109C (da)	1985-03-07	1986-03-07	4-anilino-cyklopentaoedaapyrimidinderivater samt farmaceutiske midler indeholdende saadanne

Country Status (14)

Country	Link
US (1)	US4749704A (da)
EP (1)	EP0194161B1 (da)
JP (1)	JPS6270A (da)
KR (1)	KR890003839B1 (da)
AT (1)	ATE106077T1 (da)
AU (1)	AU580391B2 (da)
CA (1)	CA1273632A (da)
DE (1)	DE3689848T2 (da)
DK (1)	DK165109C (da)
ES (3)	ES8704905A1 (da)
FI (1)	FI88717C (da)
IE (1)	IE64504B1 (da)
NO (1)	NO168767C (da)
ZA (1)	ZA861708B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5037980A (en) *	1988-04-18	1991-08-06	American Cyanamid Company	Phenyl imidazo[1,2-a]pyrimidines
US5877178A (en) *	1991-04-08	1999-03-02	Duquesne University Of The Holy Ghost	Pyrimidine derivatives and methods of making and using these derivatives
US5234936A (en) *	1991-10-24	1993-08-10	American Home Products Corporation	Pyrimidocycloalkanes as a ii antagonists
JP2007501821A (ja) *	2003-08-12	2007-02-01	エフ．ホフマン−ラ　ロシュ　アーゲー	Ｃｆｒアンタゴニストとしてのテトラヒドロキナゾリン誘導体
US7568556B2 (en)	2005-10-26	2009-08-04	Mitsubishi Electric Corporation	Elevator group management control device
ATE532789T1 (de)	2006-07-06	2011-11-15	Array Biopharma Inc	Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
US8063050B2 (en)	2006-07-06	2011-11-22	Array Biopharma Inc.	Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
EP2049500B1 (en)	2006-07-06	2011-09-07	Array Biopharma, Inc.	Cyclopenta [d] pyrimidines as akt protein kinase inhibitors
US8329701B2 (en)	2006-07-06	2012-12-11	Array Biopharma Inc.	Dihydrofuro pyrimidines as AKT protein kinase inhibitors
WO2008021456A2 (en) *	2006-08-16	2008-02-21	Cytovia, Inc.	N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof
US9409886B2 (en)	2007-07-05	2016-08-09	Array Biopharma Inc.	Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101918373B (zh)	2007-07-05	2013-06-05	阵列生物制药公司	作为akt蛋白激酶抑制剂的嘧啶基环戊烷
CN103396409B (zh)	2007-07-05	2015-03-11	阵列生物制药公司	作为akt蛋白激酶抑制剂的嘧啶基环戊烷
US8846683B2 (en)	2007-07-05	2014-09-30	Array Biopharma, Inc.	Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
NZ586346A (en)	2008-01-09	2012-02-24	Array Biopharma Inc	Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8853216B2 (en)	2008-01-09	2014-10-07	Array Biopharma, Inc.	Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
DE112009002588B4 (de)	2008-10-20	2019-08-14	Mitsubishi Electric Corporation	Aufzuggruppenverwaltungssystem
KR102021157B1 (ko)	2011-04-01	2019-09-11	제넨테크, 인크.	Ａｋｔ 억제제 화합물 및 아비라테론의 조합물, 및 사용 방법
TR201815685T4 (tr)	2011-04-01	2018-11-21	Genentech Inc	Kanser tedavisi için akt ve mek inhibe edici bileşiklerin kombinasyonları.
GB201121127D0 (en)	2011-12-08	2012-01-18	Dow Corning	Treatment of filler with silane
CN111303053B (zh) *	2020-03-16	2023-01-17	中国海洋大学	环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3470182A (en) *	1967-02-09	1969-09-30	Sandoz Ag	4-amino-substituted quinazolines
US3980650A (en) *	1972-05-05	1976-09-14	N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia	4-Amino-pyrimidine derivatives
US3915976A (en) *	1972-09-01	1975-10-28	Sandoz Ag	Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines
PH20344A (en) *	1981-01-29	1986-12-04	Sankyo Co	Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them
JPS57203072A (en) *	1981-06-05	1982-12-13	Sankyo Co Ltd	4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

1986
- 1986-03-06 US US06/837,079 patent/US4749704A/en not_active Expired - Lifetime
- 1986-03-06 JP JP61049238A patent/JPS6270A/ja not_active Withdrawn
- 1986-03-07 AT AT86301660T patent/ATE106077T1/de not_active IP Right Cessation
- 1986-03-07 AU AU54481/86A patent/AU580391B2/en not_active Ceased
- 1986-03-07 ZA ZA861708A patent/ZA861708B/xx unknown
- 1986-03-07 NO NO860852A patent/NO168767C/no unknown
- 1986-03-07 DE DE3689848T patent/DE3689848T2/de not_active Expired - Fee Related
- 1986-03-07 CA CA000503571A patent/CA1273632A/en not_active Expired - Lifetime
- 1986-03-07 IE IE59786A patent/IE64504B1/en not_active IP Right Cessation
- 1986-03-07 DK DK106586A patent/DK165109C/da not_active IP Right Cessation
- 1986-03-07 ES ES552796A patent/ES8704905A1/es not_active Expired
- 1986-03-07 KR KR1019860001624A patent/KR890003839B1/ko not_active Expired
- 1986-03-07 FI FI860969A patent/FI88717C/fi not_active IP Right Cessation
- 1986-03-07 EP EP86301660A patent/EP0194161B1/en not_active Expired - Lifetime
- 1986-11-14 ES ES557198A patent/ES8801221A1/es not_active Expired
- 1986-11-14 ES ES557199A patent/ES8801222A1/es not_active Expired

Also Published As

Publication number	Publication date
NO168767C (no)	1992-04-01
DK165109C (da)	1993-03-01
DK165109B (da)	1992-10-12
DE3689848T2 (de)	1995-01-12
DK106586A (da)	1986-09-08
ES557199A0 (es)	1988-01-01
KR860007221A (ko)	1986-10-08
HK1005450A1 (en)	1999-01-08
JPS6270A (ja)	1987-01-06
ES8704905A1 (es)	1987-04-16
NO860852L (no)	1986-09-08
EP0194161A3 (en)	1987-09-02
KR890003839B1 (ko)	1989-10-05
AU580391B2 (en)	1989-01-12
IE860597L (en)	1986-09-07
FI860969A0 (fi)	1986-03-07
DE3689848D1 (de)	1994-06-30
NO168767B (no)	1991-12-23
ES557198A0 (es)	1988-01-01
CA1273632A (en)	1990-09-04
FI88717B (fi)	1993-03-15
AU5448186A (en)	1986-09-11
ZA861708B (en)	1986-11-26
IE64504B1 (en)	1995-08-09
ES8801222A1 (es)	1988-01-01
ATE106077T1 (de)	1994-06-15
EP0194161A2 (en)	1986-09-10
ES8801221A1 (es)	1988-01-01
FI88717C (fi)	1993-06-28
EP0194161B1 (en)	1994-05-25
US4749704A (en)	1988-06-07
ES552796A0 (es)	1987-04-16
FI860969L (fi)	1986-09-08

Legal Events

Date	Code	Title	Description
2001-10-29	PBP	Patent lapsed

Publication	Publication Date	Title
DK106586A (da)	1986-09-08	Cyklopenta(d)pyrimidinderivater samt deres fremstilling og anvendelse
DK51986D0 (da)	1986-02-03	Heterocycliske forbindelser, deres fremstilling og anvendelse som insecticide midler
ZA86262B (en)	1986-08-27	Therapeutic agents
ES2016464A6 (es)	1990-11-01	Procedimiento para preparar derivados de 2', 5' -oligoadenilato.
FI870460A0 (fi)	1987-02-03	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 5-substituerade oktahydroindolizinderivat och vid foerfarandet anvaendbara mellanprodukter.
DK7286D0 (da)	1986-01-08	Octahydroindoliziner
DE3572814D1 (en)	1989-10-12	1, 3-benzoxathiole derivatives, their use and their preparation
DE3561512D1 (de)	1988-03-03	Diphenylmethylimine derivatives
ATE144900T1 (de)	1996-11-15	Verwendung von xanthinderivaten gegen magengeschwüre