ATE107964T1 - Aktivierte rnase l als markierung für virus- infektionen. - Google Patents
Aktivierte rnase l als markierung für virus- infektionen.Info
- Publication number
- ATE107964T1 ATE107964T1 AT88301819T AT88301819T ATE107964T1 AT E107964 T1 ATE107964 T1 AT E107964T1 AT 88301819 T AT88301819 T AT 88301819T AT 88301819 T AT88301819 T AT 88301819T AT E107964 T1 ATE107964 T1 AT E107964T1
- Authority
- AT
- Austria
- Prior art keywords
- pathway
- rnase
- aids
- biochemical
- inhibitor
- Prior art date
Links
- 230000009385 viral infection Effects 0.000 title 1
- 108010000834 2-5A-dependent ribonuclease Proteins 0.000 abstract 3
- 102100027962 2-5A-dependent ribonuclease Human genes 0.000 abstract 3
- 239000003112 inhibitor Substances 0.000 abstract 3
- 230000007257 malfunction Effects 0.000 abstract 3
- 230000037361 pathway Effects 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 2
- 241000700605 Viruses Species 0.000 abstract 2
- SIIZPVYVXNXXQG-KGXOGWRBSA-N [(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-4-[[(3s,4r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methyl [(2r,4r,5r)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(phosphonooxymethyl)oxolan-3-yl] hydrogen phosphate Polymers C1=NC2=C(N)N=CN=C2N1[C@@H]1O[C@H](COP(O)(=O)OC2[C@@H](O[C@H](COP(O)(O)=O)[C@H]2O)N2C3=NC=NC(N)=C3N=C2)[C@@H](O)[C@H]1OP(O)(=O)OCC([C@@H](O)[C@H]1O)OC1N1C(N=CN=C2N)=C2N=C1 SIIZPVYVXNXXQG-KGXOGWRBSA-N 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000008238 biochemical pathway Effects 0.000 abstract 1
- 230000002032 cellular defenses Effects 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000037041 intracellular level Effects 0.000 abstract 1
- 230000000750 progressive effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
- G01N2333/922—Ribonucleases (RNAses); Deoxyribonucleases (DNAses)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2137287A | 1987-03-03 | 1987-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE107964T1 true ATE107964T1 (de) | 1994-07-15 |
Family
ID=21803819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88301819T ATE107964T1 (de) | 1987-03-03 | 1988-03-02 | Aktivierte rnase l als markierung für virus- infektionen. |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0285263B1 (de) |
| JP (1) | JPH0675520B2 (de) |
| KR (1) | KR880011593A (de) |
| AT (1) | ATE107964T1 (de) |
| AU (1) | AU618525B2 (de) |
| CA (1) | CA1337278C (de) |
| DE (1) | DE3850428T2 (de) |
| DK (1) | DK112888A (de) |
| ES (1) | ES2058252T3 (de) |
| FI (1) | FI880959A7 (de) |
| IE (1) | IE66831B1 (de) |
| IL (1) | IL85576A0 (de) |
| MX (1) | MX173802B (de) |
| NO (1) | NO880934L (de) |
| NZ (1) | NZ223721A (de) |
| OA (1) | OA08720A (de) |
| PH (1) | PH30882A (de) |
| PT (1) | PT86878B (de) |
| RU (1) | RU2049336C1 (de) |
| ZA (1) | ZA881471B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0306347B1 (de) * | 1987-09-04 | 1995-05-10 | Hem Pharmaceuticals Corp. | Diagnose von Mangelzuständen doppelsträngiger RNS |
| US5593973A (en) * | 1987-09-04 | 1997-01-14 | Hemispherx Biopharma Inc. | Treatment of viral hepatitis with mismatched dsRNA |
| AU724056B2 (en) * | 1987-09-04 | 2000-09-14 | Hem Research, Inc. | Diagnosis and treatment of double stranded deficiency states |
| DE68914201T2 (de) * | 1988-07-07 | 1994-07-14 | Hem Pharma Corp | Diagnose und Behandlung chronischer Ermüdungserscheinungen. |
| US5985565A (en) * | 1996-10-09 | 1999-11-16 | Temple University-Of The Commonwealth System Of Higher Education | Chronic fatigue syndrome diagnosis |
| US6207366B1 (en) | 1999-04-14 | 2001-03-27 | Temple University- Of The Commonwealth System Of Higher Education | Chronic fatigue syndrome diagnosis |
| US6080554A (en) * | 1999-04-27 | 2000-06-27 | R.E.D. Laboratories, N.V. | Methods and compositions for use in characterizing multiple sclerosis disease activity in a subject |
| RU2202110C1 (ru) * | 2001-07-26 | 2003-04-10 | Научно-исследовательский испытательный центр (медико-биологической защиты) Государственного научно-исследовательского испытательного института военной медицины МО РФ | Способ определения активности и функционального состояния синтетазы оксида азота |
| WO2017193051A1 (en) * | 2016-05-06 | 2017-11-09 | The Trustees Of Princeton University | Methods of monitoring rnase l activity |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0113162B1 (de) * | 1982-09-16 | 1989-07-19 | Hem Research, Inc. | Wucherungshemmende Wirkung von ds-Ribonucleinsäuren auf Tumorzellen |
| CA1326450C (en) * | 1985-08-26 | 1994-01-25 | William A. Carter | Modulation of aids virus-related events by double stranded rnas (dsrnas) |
-
1988
- 1988-02-24 PH PH36550A patent/PH30882A/en unknown
- 1988-02-29 CA CA000560052A patent/CA1337278C/en not_active Expired - Fee Related
- 1988-02-29 IL IL85576A patent/IL85576A0/xx unknown
- 1988-03-02 NZ NZ223721A patent/NZ223721A/xx unknown
- 1988-03-02 ZA ZA881471A patent/ZA881471B/xx unknown
- 1988-03-02 AU AU12563/88A patent/AU618525B2/en not_active Ceased
- 1988-03-02 PT PT86878A patent/PT86878B/pt not_active IP Right Cessation
- 1988-03-02 FI FI880959A patent/FI880959A7/fi not_active Application Discontinuation
- 1988-03-02 AT AT88301819T patent/ATE107964T1/de not_active IP Right Cessation
- 1988-03-02 DK DK112888A patent/DK112888A/da not_active Application Discontinuation
- 1988-03-02 IE IE58788A patent/IE66831B1/en not_active IP Right Cessation
- 1988-03-02 EP EP88301819A patent/EP0285263B1/de not_active Expired - Lifetime
- 1988-03-02 DE DE3850428T patent/DE3850428T2/de not_active Expired - Fee Related
- 1988-03-02 ES ES88301819T patent/ES2058252T3/es not_active Expired - Lifetime
- 1988-03-02 JP JP63047656A patent/JPH0675520B2/ja not_active Expired - Fee Related
- 1988-03-02 NO NO880934A patent/NO880934L/no unknown
- 1988-03-03 OA OA59294A patent/OA08720A/xx unknown
- 1988-03-03 MX MX1063188A patent/MX173802B/es unknown
- 1988-03-03 KR KR1019880002188A patent/KR880011593A/ko not_active Ceased
- 1988-03-03 RU SU884355468A patent/RU2049336C1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| OA08720A (en) | 1989-03-31 |
| PT86878B (pt) | 1992-05-29 |
| IE880587L (en) | 1988-09-03 |
| FI880959A0 (fi) | 1988-03-02 |
| ZA881471B (en) | 1988-12-28 |
| DE3850428T2 (de) | 1994-11-24 |
| IL85576A0 (en) | 1988-08-31 |
| AU1256388A (en) | 1988-09-01 |
| FI880959A7 (fi) | 1988-09-04 |
| KR880011593A (ko) | 1988-10-29 |
| MX173802B (es) | 1994-03-29 |
| DE3850428D1 (de) | 1994-08-04 |
| JPH0675520B2 (ja) | 1994-09-28 |
| RU2049336C1 (ru) | 1995-11-27 |
| JPS63309200A (ja) | 1988-12-16 |
| PT86878A (pt) | 1988-04-01 |
| NO880934L (no) | 1988-09-05 |
| NO880934D0 (no) | 1988-03-02 |
| AU618525B2 (en) | 1992-01-02 |
| EP0285263B1 (de) | 1994-06-29 |
| CA1337278C (en) | 1995-10-10 |
| ES2058252T3 (es) | 1994-11-01 |
| DK112888D0 (da) | 1988-03-02 |
| IE66831B1 (en) | 1996-02-07 |
| PH30882A (en) | 1997-12-23 |
| DK112888A (da) | 1988-09-04 |
| EP0285263A2 (de) | 1988-10-05 |
| EP0285263A3 (en) | 1990-04-18 |
| NZ223721A (en) | 1991-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |