ATE174033T1 - Avermectin-derivate - Google Patents

Avermectin-derivate

Info

Publication number: ATE174033T1
Authority: AT; Austria
Prior art keywords: avermectin derivatives; substituted; ketoximes; derivatives; compounds
Prior art date: 1989-07-31

Application number

AT90308409T

Other languages

English (en)

Inventor

Bruce O Linn

Helmut Mrozik

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-07-31

Filing date

1990-07-31

Publication date

1998-12-15

1990-07-31 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE174033T1 publication Critical patent/ATE174033T1/de

Links

RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract 4
150000001875 compounds Chemical class 0.000 abstract 2
230000000895 acaricidal effect Effects 0.000 abstract 1
125000004442 acylamino group Chemical group 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
230000000507 anthelmentic effect Effects 0.000 abstract 1
239000003096 antiparasitic agent Substances 0.000 abstract 1
229940125687 antiparasitic agent Drugs 0.000 abstract 1
125000000043 benzamido group Chemical group [H]N([*])C(=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
239000003153 chemical reaction reagent Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000000749 insecticidal effect Effects 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Tropical Medicine & Parasitology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

AT90308409T 1989-07-31 1990-07-31 Avermectin-derivate ATE174033T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/387,207 US5023241A (en)	1989-07-31	1989-07-31	Avermectin derivatives

Publications (1)

Publication Number	Publication Date
ATE174033T1 true ATE174033T1 (de)	1998-12-15

Family

ID=23528933

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90308409T ATE174033T1 (de)	1989-07-31	1990-07-31	Avermectin-derivate

Country Status (10)

Country	Link
US (1)	US5023241A (de)
EP (1)	EP0411897B1 (de)
JP (1)	JPH0826059B2 (de)
AT (1)	ATE174033T1 (de)
AU (1)	AU630992B2 (de)
CA (1)	CA2022113A1 (de)
DE (1)	DE69032797T2 (de)
IE (1)	IE902752A1 (de)
NZ (1)	NZ234685A (de)
ZA (1)	ZA905996B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69310539T2 (de) *	1992-11-20	1998-01-15	British Tech Group	Bildrekonstruktion
GB9300883D0 (en) *	1993-01-18	1993-03-10	Pfizer Ltd	Antiparasitic agents
US5411946A (en) *	1993-02-24	1995-05-02	Merck & Co., Inc.	Avermectin derivatives
US5420260A (en) *	1993-09-29	1995-05-30	Merck & Co., Inc.	Process for 4"-epi-acetylamino-4"-deoxy-5-oximinoavermectin B1
US5362862A (en) *	1993-09-29	1994-11-08	Merck & Co., Inc.	Process for 4"-EPI-acetylamino-4"-deoxy-5-oximinoavermectin-B1
CZ287404B6 (en) *	1993-10-05	2000-11-15	Pfizer	Process for preparing doramectin
US5535503A (en) *	1993-12-03	1996-07-16	Globe Products Inc.	Stator lead wire connection method and apparatus
US5981500A (en) *	1994-01-12	1999-11-09	Pfizer Inc.	Antiparasitic agents related to the milbemycins and avermectins
US5578581A (en) *	1994-04-26	1996-11-26	Merck & Co., Inc.	Active avermectin analogue
CR6574A (es) *	2001-02-27	2004-10-28	Syngenta Participations Ag	Sales de avermectinas substituidas en la posicion 4 con propiedades plaguicidas
EG23124A (en) *	2001-02-27	2004-04-28	Syngenta Participations Ag	Avermectins substituted in the 4-position having pesticidal properties
AR036486A1 (es) *	2001-08-28	2004-09-15	Syngenta Participations Ag	Derivados 4"-desoxi-4"-(s)-amino avermectina, composicion plaguicida, procedimiento para la preparacion de esa composicion, metodo para controlar plagas, y uso de estos derivados para preparar una composicion
TW200407330A (en)	2002-05-07	2004-05-16	Syngenta Participations Ag	4"-Deoxy-4"-(S)-amido avermectin derivatives
GB0302308D0 (en) *	2003-01-31	2003-03-05	Syngenta Participations Ag	Avermectin and avermectin monosaccharide derivatives substituted in the 4"- or 4'-position having pesticidal properties
GB0302309D0 (en) *	2003-01-31	2003-03-05	Syngenta Participations Ag	Avermectin monosaccharide derivatives substituted in the 4 -position having pesticidal properties
GB0302310D0 (en)	2003-01-31	2003-03-05	Syngenta Participations Ag	Avermectin- and avermectin monosaccharide derivatives substituted in the 4"- or 4' - positionhaving pesticidal properties
GB0302548D0 (en) *	2003-02-04	2003-03-12	Syngenta Participations Ag	Avermectins substituted in the 4"- and 4' -positions having pesticidal properties
GB0320176D0 (en) *	2003-08-28	2003-10-01	Syngenta Participations Ag	Avermectins and avermectin monosaccharides substitued in the 4'-and 4"-positionhaving pesticidal properties
EP1632498A1 (de) *	2004-09-03	2006-03-08	Syngenta Participations AG	Derivate von Avermectin, Avermectin Monosaccharid und Avermectin Aglycon
DE102007007750A1 (de) *	2006-08-17	2008-02-21	Bayer Cropscience Ag	Avermectinderivate
TWI457347B (zh)	2008-12-04	2014-10-21	Merial Ltd	二聚合的阿佛菌素（ａｖｅｒｍｅｃｔｉｎ）及密倍脈心（ｍｉｌｂｅｍｙｃｉｎ）衍生物
US8980896B2 (en)	2009-12-17	2015-03-17	Merial, Inc.	Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
MX379693B (es)	2011-12-02	2025-03-11	Merial Ltd	Formulaciones de moxidectina inyectables de larga acción y formas de cristal de moxidectina novedosas.
CN103396465B (zh) *	2013-07-19	2016-01-20	中国农业科学院植物保护研究所	一种阿维菌素烟碱二效价化合物及其制备和应用
CN113150053B (zh) *	2020-01-22	2024-10-01	华东理工大学	偶氮苯类阿维菌素衍生物及其制备方法和应用
CN117720589B (zh) *	2023-09-07	2026-08-11	常州齐晖药业有限公司	一种依普菌素的制备方法
WO2025176869A1 (fr) *	2024-02-21	2025-08-28	Mayan Pharma	Nouveaux dérivés urées de macrolides amphotères et solubilisation d'antibiotiques amphotères par des dérivés urées de glucides

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE434277B (sv) *	1976-04-19	1984-07-16	Merck & Co Inc	Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4199569A (en) *	1977-10-03	1980-04-22	Merck & Co., Inc.	Selective hydrogenation products of C-076 compounds and derivatives thereof
US4206205A (en) *	1977-10-03	1980-06-03	Merck & Co., Inc.	Monosaccharide and aglycone derivatives of C-076
US4427663A (en) *	1982-03-16	1984-01-24	Merck & Co., Inc.	4"-Keto-and 4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof
US4579864A (en) *	1984-06-11	1986-04-01	Merck & Co., Inc.	Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
ES8800986A1 (es) *	1985-07-27	1987-12-01	Pfizer	Un procedimiento para la produccion de un nuevo derivado de avermectina
US4831016A (en) *	1986-10-31	1989-05-16	Merck & Co., Inc.	Reduced avermectin derivatives
IN167980B (de) *	1987-01-23	1991-01-19	Pfizer
US4806527A (en) *	1987-03-16	1989-02-21	Merck & Co., Inc.	Avermectin derivatives
US4874749A (en) *	1987-07-31	1989-10-17	Merck & Co., Inc.	4"-Deoxy-4-N-methylamino avermectin Bla/Blb
US4873224A (en) *	1988-05-23	1989-10-10	Merck & Co., Inc.	Avermectin derivatives

1989
- 1989-07-31 US US07/387,207 patent/US5023241A/en not_active Expired - Fee Related
1990
- 1990-07-27 CA CA002022113A patent/CA2022113A1/en not_active Abandoned
- 1990-07-27 NZ NZ234685A patent/NZ234685A/en unknown
- 1990-07-30 AU AU59988/90A patent/AU630992B2/en not_active Ceased
- 1990-07-30 IE IE275290A patent/IE902752A1/en unknown
- 1990-07-31 AT AT90308409T patent/ATE174033T1/de not_active IP Right Cessation
- 1990-07-31 ZA ZA905996A patent/ZA905996B/xx unknown
- 1990-07-31 DE DE69032797T patent/DE69032797T2/de not_active Expired - Fee Related
- 1990-07-31 EP EP90308409A patent/EP0411897B1/de not_active Expired - Lifetime
- 1990-07-31 JP JP2203791A patent/JPH0826059B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5023241A (en)	1991-06-11
JPH0826059B2 (ja)	1996-03-13
CA2022113A1 (en)	1991-02-01
EP0411897A3 (en)	1991-10-16
EP0411897A2 (de)	1991-02-06
EP0411897B1 (de)	1998-12-02
JPH03141291A (ja)	1991-06-17
NZ234685A (en)	1992-11-25
DE69032797T2 (de)	1999-07-01
AU630992B2 (en)	1992-11-12
IE902752A1 (en)	1991-02-27
ZA905996B (en)	1991-05-29
AU5998890A (en)	1991-01-31
DE69032797D1 (de)	1999-01-14

Legal Events

Date	Code	Title	Description
1999-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69032797D1 (de)	1999-01-14	Avermectin-Derivate
ATE76875T1 (de)	1992-06-15	Pentasaccharide.
ATE162796T1 (de)	1998-02-15	4-a-substutierte avermectinderivate
GB2087880B (en)	1985-05-01	7-oxo-4-thia-1-azabicyclo(3,2,0)-heptane and 7-oxo-4-thia-1-azabicyclo(3,2,0)hept-2-ene derivatives
BR9006233A (pt)	1991-09-24	Derivados de fenil-2-oxazolina e de fenil-2-tiazolina 2-substituidos,processo para sua producao,inseticida e/ou acaricida que os contem e processo para controlar insetos
NO892696D0 (no)	1989-06-28	Tiokromanestere av fenoler og tereftalater med retinoidliknende aktivitet.
PT975635E (pt)	2003-09-30	Trifluorometilalquilamino-triazolopirimidinas fungicidas
ES2077071T3 (es)	1995-11-16	Derivados de quinolin-3-carboxamida.
ITMI912025A1 (it)	1993-01-23	Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
DK656488D0 (da)	1988-11-24	Praeparat med langvarig frigivelse indeholdende 1,4-dihydropyridinforbindelser
KR890009962A (ko)	1989-08-05	매뉴마이신 유도체, 이의 제조방법 및 용도
DK592688A (da)	1989-04-27	Benz(thi)amidderivater, deres fremstilling og anvendelse som fungicider
ITMI931012A1 (it)	1994-11-18	Composti spiro-piranici dotati di caratteristiche fotocromatiche
ATE124691T1 (de)	1995-07-15	Antitumor- und antibiotikum-substanz, ihre herstellung und verwendungen.
DK525588A (da)	1989-03-24	Saccharidderivater
ES2067780T3 (es)	1995-04-01	2'-desoxi-2'-metilidenocitidina dihidrato, metodos para su produccion y composiciones.
ATE87926T1 (de)	1993-04-15	Ethylierte avermectine.
EP0285671A4 (de)	1989-06-14	Pyridin-derivate
YU49171B (sh)	2004-05-12	Intermedijeri u sintezi doramektina i postupak za njihovu sintezu
JPS5653654A (en)	1981-05-13	Preparation of novel aniline derivative
RU1807052C (ru)	1993-04-07	1,10-Фенантролинаты 4-нитрофенил-4 @ -пиридилметанидов натри или кали , обладающие индикаторными свойствами по отношению к воде или протонным органическим растворител м с интервалом перехода окраски от синей к бесцветной при рК @ 29
JPS6445360A (en)	1989-02-17	1-benzyl-4-hydroxy-2-pyrrolidone derivative and production thereof
SU1626617A1 (ru)	1999-08-10	Производные хлораля, обладающие фунгицидными свойствами
SE8802932D0 (sv)	1988-08-18	Nya 9-antrylalkylforeningar, forfarande for framstellning derav samt anvendning derav
GR3006580T3 (de)	1993-06-30