ATE110713T1 - Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen. - Google Patents
Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen.Info
- Publication number
- ATE110713T1 ATE110713T1 AT90908860T AT90908860T ATE110713T1 AT E110713 T1 ATE110713 T1 AT E110713T1 AT 90908860 T AT90908860 T AT 90908860T AT 90908860 T AT90908860 T AT 90908860T AT E110713 T1 ATE110713 T1 AT E110713T1
- Authority
- AT
- Austria
- Prior art keywords
- antiartherosclerotic
- antihyperlipidemic
- urea compounds
- cholesterol
- thiourea
- Prior art date
Links
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title abstract 3
- 230000001315 anti-hyperlipaemic effect Effects 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 4
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical class NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 abstract 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000031891 intestinal absorption Effects 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/359,830 US5015644A (en) | 1987-06-02 | 1989-06-01 | Antihyperlipidemic and antiatherosclerotic urea and carbamate compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE110713T1 true ATE110713T1 (de) | 1994-09-15 |
Family
ID=23415467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90908860T ATE110713T1 (de) | 1989-06-01 | 1990-05-31 | Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5015644A (de) |
| EP (1) | EP0474733B1 (de) |
| JP (1) | JP2799242B2 (de) |
| AT (1) | ATE110713T1 (de) |
| AU (1) | AU5675990A (de) |
| CA (1) | CA2054209C (de) |
| DE (1) | DE69012116T2 (de) |
| DK (1) | DK0474733T3 (de) |
| IE (1) | IE64603B1 (de) |
| PT (1) | PT94231A (de) |
| WO (1) | WO1990015048A1 (de) |
| ZA (1) | ZA904231B (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
| IL100915A (en) * | 1991-02-19 | 1996-03-31 | Erba Carlo Spa | Disubstituted ureas and thioureas their preparation and pharmaceutical compositions containing them |
| FR2679555B1 (fr) * | 1991-07-25 | 1993-11-19 | Fabre Medicament Pierre | Nouveaux derives de l'uree, leur preparation et leur application en therapeutique. |
| EP0642498A1 (de) * | 1992-05-28 | 1995-03-15 | Pfizer Inc. | N-aryl und n-heteroaryl derivate als acat-hemmstoffe |
| AU672699B2 (en) * | 1993-06-30 | 1996-10-10 | Sankyo Company Limited | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
| US5362744A (en) * | 1993-11-22 | 1994-11-08 | Warner-Lambert Company | Tetrazole-substituted urea acat inhibitors |
| US5441984A (en) * | 1994-01-06 | 1995-08-15 | Eli Lilly And Company | Urea, thiourea and guanidine derivatives |
| US5461049A (en) * | 1994-05-27 | 1995-10-24 | Warner-Lambert Company | Amide tetrazole ACAT inhibitors |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| EP0742208A1 (de) * | 1995-05-05 | 1996-11-13 | Grelan Pharmaceutical Co., Ltd. | 2-Ureido-benzamid-Derivate |
| CA2253502A1 (en) * | 1996-05-06 | 1997-11-13 | Stephen Warren Kaldor | Anti-viral compounds |
| EP0811600A3 (de) * | 1996-05-06 | 1998-06-03 | Eli Lilly And Company | Antivirusverbindungen |
| US6156924A (en) * | 1996-05-06 | 2000-12-05 | Eli Lilly And Company | Anti-viral compounds |
| DE69704180T2 (de) | 1996-05-06 | 2001-08-30 | Eli Lilly And Co., Indianapolis | Antivirusverbindungen |
| US6127422A (en) * | 1996-05-06 | 2000-10-03 | Eli Lilly And Company | Anti-viral method |
| US6103923A (en) * | 1996-05-06 | 2000-08-15 | Eli Lilly And Company | Anti-viral compounds |
| EP0806408B1 (de) * | 1996-05-06 | 2000-12-13 | Eli Lilly And Company | Antivirusverbindungen |
| US6096917A (en) * | 1997-05-02 | 2000-08-01 | Eli Lilly And Company | Anti-viral compounds |
| WO1999031075A1 (en) * | 1997-12-16 | 1999-06-24 | Warner-Lambert Company | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
| US6605623B1 (en) | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| AU7353300A (en) | 1999-09-08 | 2001-04-10 | Guilford Pharmaceuticals Inc. | Non-peptidic cyclophilin binding compounds and their use |
| KR20020073574A (ko) | 2000-02-02 | 2002-09-27 | 워너-램버트 캄파니 | 피지선 장애 치료용 콜레스테롤 에스테르 및 왁스에스테르 합성 이중 억제제 |
| US6175034B1 (en) | 2000-04-10 | 2001-01-16 | Eli Lilly And Company | Anti-viral compounds |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| MXPA03006666A (es) | 2001-01-25 | 2004-05-31 | Guilford Pharm Inc | Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso. |
| US20040072903A1 (en) * | 2001-05-08 | 2004-04-15 | Auerbach Bruce Jeffrey | Carboxyalkylether-acat inhibitors combinations |
| US7173151B2 (en) * | 2003-02-27 | 2007-02-06 | Sanofi-Aventisdeutschand Gmbh | Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals |
| NZ549721A (en) | 2004-03-05 | 2010-08-27 | Univ Pennsylvania | Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects |
| EP1976513B1 (de) * | 2006-01-06 | 2016-08-24 | Sunovion Pharmaceuticals Inc. | Cycloalkylamine als monoamin-wiederaufnahmehemmer |
| EP2066329B1 (de) | 2006-09-15 | 2017-09-06 | Reviva Pharmaceuticals, Inc. | Synthese, verwendung und zusammensetzungen von cyclobutylmethylaminen |
| CL2007002958A1 (es) * | 2006-10-12 | 2008-05-09 | Epix Delaware Inc | Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr |
| US20080161279A1 (en) * | 2006-12-21 | 2008-07-03 | Wisler Gerald L | Methods of Treating Obesity |
| KR20100102646A (ko) | 2007-12-11 | 2010-09-24 | 가부시키가이샤 사이토파스파인더 | 카르복스아미드 화합물 및 케모카인 수용체 길항제로서의 이의 용도 |
| WO2010039801A2 (en) | 2008-10-02 | 2010-04-08 | The J. David Gladstone Institutes | Methods of treating hepatitis c virus infection |
| WO2012003501A2 (en) | 2010-07-02 | 2012-01-05 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives |
| IN2014DN08604A (de) | 2012-03-22 | 2015-05-22 | Univ Michigan | |
| WO2015117147A1 (en) | 2014-02-03 | 2015-08-06 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents |
| US9394236B2 (en) | 2014-02-03 | 2016-07-19 | Quadriga Biosciences, Inc. | β-substituted γ-amino acids and analogs as chemotherapeutic agents |
| AU2015320358B2 (en) | 2014-09-26 | 2020-05-14 | Millendo Therapeutics, Inc. | Solid drug form of N-(2,6-bis(1-methylethyl)phenyl)-N'-((1-(4-(dimethylamino)phenyl)cyclopentyl) methyl)urea hydrochloride and compositions, methods and kits related thereto |
| US20160287565A1 (en) | 2015-04-06 | 2016-10-06 | Millendo Therapeutics, Inc. | Combination therapy for treating disorders associated with excess cortisol production |
| CA2994404C (en) | 2015-08-03 | 2020-12-08 | Quadriga Biosciences, Inc. | Beta-substituted beta-amino acids and analogs as chemotherapeutic agents and uses thereof |
| EP4188372A1 (de) | 2020-07-29 | 2023-06-07 | Amryt Pharmaceuticals Inc. | Lomitapid zur verwendung in verfahren zur behandlung von hyperlipidämie und hypercholesterinämie bei pädiatrischen patienten |
| CN112441941B (zh) * | 2020-12-03 | 2022-08-02 | 浙江荣耀生物科技股份有限公司 | 一种1-(4-氨基苯基)环戊基甲腈的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3852343A (en) * | 1970-07-22 | 1974-12-03 | Labofina Sa | A process for the production of benzene carboxylic acids from ethyl substituted benzens |
| EP0049538A3 (de) * | 1979-07-14 | 1982-10-13 | Bayer Ag | Verwendung von Thioharnstoffderivaten als Arzneimittel bei der Behandlung von Fettstoffwechselstörungen |
| DE2945530A1 (de) * | 1979-11-10 | 1981-06-04 | Chemische Werke Hüls AG, 4370 Marl | Harnstoffe mit cyclischen substituenten, ihre herstellung und verwendung als herbizide |
| GB2080808B (en) * | 1980-01-25 | 1984-01-04 | Reanal Finomvegyszergyar | Process for the preparation of n-aryl-n-(mono- or disubstituted)-urea derivatives |
| US4387105A (en) * | 1982-01-26 | 1983-06-07 | American Cyanamid Company | Methods of treating atherosclerosis with dialkylureas and dialkylthioureas |
| US4623662A (en) * | 1985-05-23 | 1986-11-18 | American Cyanamid Company | Antiatherosclerotic ureas and thioureas |
| US4397868A (en) * | 1982-01-26 | 1983-08-09 | American Cyanamid Company | Method of treating atherosclerosis with trisubstituted ureas |
| IE61716B1 (en) * | 1987-06-02 | 1994-11-30 | Warner Lambert Co | Antihyperlipidemic and antiatherosclerotic urea compounds |
-
1989
- 1989-06-01 US US07/359,830 patent/US5015644A/en not_active Expired - Lifetime
-
1990
- 1990-05-31 EP EP90908860A patent/EP0474733B1/de not_active Expired - Lifetime
- 1990-05-31 DE DE69012116T patent/DE69012116T2/de not_active Expired - Fee Related
- 1990-05-31 AT AT90908860T patent/ATE110713T1/de not_active IP Right Cessation
- 1990-05-31 WO PCT/US1990/003055 patent/WO1990015048A1/en not_active Ceased
- 1990-05-31 AU AU56759/90A patent/AU5675990A/en not_active Abandoned
- 1990-05-31 CA CA002054209A patent/CA2054209C/en not_active Expired - Fee Related
- 1990-05-31 JP JP2508304A patent/JP2799242B2/ja not_active Expired - Fee Related
- 1990-05-31 DK DK90908860.1T patent/DK0474733T3/da active
- 1990-06-01 ZA ZA904231A patent/ZA904231B/xx unknown
- 1990-06-01 PT PT94231A patent/PT94231A/pt not_active Application Discontinuation
- 1990-06-01 IE IE198390A patent/IE64603B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0474733T3 (da) | 1994-11-21 |
| IE64603B1 (en) | 1995-08-23 |
| DE69012116T2 (de) | 1994-12-22 |
| ZA904231B (en) | 1992-02-26 |
| AU5675990A (en) | 1991-01-07 |
| WO1990015048A1 (en) | 1990-12-13 |
| EP0474733A1 (de) | 1992-03-18 |
| IE901983A1 (en) | 1991-01-02 |
| PT94231A (pt) | 1991-02-08 |
| IE901983L (en) | 1990-12-01 |
| JP2799242B2 (ja) | 1998-09-17 |
| US5015644A (en) | 1991-05-14 |
| JPH04505617A (ja) | 1992-10-01 |
| CA2054209A1 (en) | 1990-12-02 |
| EP0474733B1 (de) | 1994-08-31 |
| CA2054209C (en) | 2002-01-15 |
| DE69012116D1 (de) | 1994-10-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69012116D1 (de) | Antihyperlipidemische und antiartherosklerotische harnstoffverbindungen. | |
| ATE90340T1 (de) | Antihyperlipidemische und antiatherosclerotische verbindungen und zusammensetzungen. | |
| IE881380L (en) | Antiatherosclerotic ureas | |
| ES2060682T3 (es) | N-((fenil(2,6-disubstituido))-n'-aril)ureas como agentes antihipercolesterolemicos y antiateroscleroticos. | |
| BR8703425A (pt) | Conjunto para o amortecimento de vibracoes | |
| BR8806948A (pt) | Conjunto para o amortecimento de vibracoes | |
| DK249389D0 (da) | 2-acylamino-benzothiazol-forbindelser og deres anvendelse til fremstilling af laegemidler til behandling af tumorer | |
| FI880796A0 (fi) | Maettade fettsyreamider som inhibitorer av acyl-coa:kolesterol-acyltransferaser. | |
| ES2056992T3 (es) | N-((fenil(2,6-disubstituido))-n'-diarilalquil)ureas como agentes antihiperlipidemicos y antiateroscleroticos. | |
| IT8821542A0 (it) | Composti attivi come inibitori della biosintesi del colesterolo. | |
| ES2037768T3 (es) | Procedimiento para preparar n-(fenil(2,6-disustituido))-ureas y carbamatos inhibidores de acil-coa: colesterol acil-transferasa. | |
| ATE158288T1 (de) | Antiatherosklerotische und antithrombotische 1- benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on- derivate | |
| FR2599246B1 (fr) | Orthese dynamique du genou. | |
| FI915093A0 (fi) | Sackarinderivat anvaendbara som inhibitorer foer proteolytiskt enzym och deras framstaellning. | |
| DK158972C (da) | Farmaceutiske formuleringer indeholdende benzothiophenderivater | |
| BR8904423A (pt) | Catalisador e processo para o tratamento de gas contendo compostos de enxofre | |
| IT9021645A0 (it) | Procedimento per il trattamento di torbide di raffineria | |
| PT99435A (pt) | Processo para a preparacao de derivados de amino-sulfonil-ureia e de composicoes farmaceuticas que os contem | |
| DE3780506D1 (de) | Reinigung des einkettigen und zweikettigen gewebeplasminogenaktivators. | |
| SE8603847D0 (sv) | Forfarande for fastsettning av fest- eller upphengningsdon jemte don for forfarandets genomforande | |
| DK0386487T3 (da) | N-(Substitueret aryl)-N-(substitueret alkoxy)-urinstoffer og -thiourinstoffer som antihypercholesterolæmiske og antiatherosclerotiske midler | |
| NO883063L (no) | Fremgangsmaate, anordning og sett for maaling av vevplasminogenaktivator-aktivitet. | |
| FI844645L (fi) | 1,7-difenyl-3-metylaza-7-cyan-8 -metyl-nonan foer anvaendning vid bekaempning av sjukdomar. | |
| FI901668A0 (fi) | Menetelmä plasmiiniaktiivisuuden määrittämiseksi | |
| FI903473A7 (fi) | Menetelmä uusien, typpeä ja rikkiä sisältävien heterosyklisten yhdisteiden valmistamiseksi |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |