ATE112573T1 - Inhibin und dessen reinigung. - Google Patents

Inhibin und dessen reinigung.

Info

Publication number: ATE112573T1
Authority: AT; Austria
Prior art keywords: leu; pro; cys; phe; gly
Prior art date: 1985-07-18

Application number

AT86904699T

Other languages

English (en)

Inventor

Nicholas Chai-Kwan Ling

Shao-Yao Ying

Fred Stephen Esch

Roger Charles Louis Guillemin

Original Assignee

Salk Inst For Biological Studi

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-18

Filing date

1986-07-17

Publication date

1994-10-15

1986-07-17 Application filed by Salk Inst For Biological Studi filed Critical Salk Inst For Biological Studi

1994-10-15 Application granted granted Critical

1994-10-15 Publication of ATE112573T1 publication Critical patent/ATE112573T1/de

Links

239000000893 inhibin Substances 0.000 title abstract 2
ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 title abstract 2
238000000746 purification Methods 0.000 title 1
108090000623 proteins and genes Proteins 0.000 abstract 3
102000004169 proteins and genes Human genes 0.000 abstract 3
230000006334 disulfide bridging Effects 0.000 abstract 2
102000002746 Inhibins Human genes 0.000 abstract 1
108010004250 Inhibins Proteins 0.000 abstract 1
239000012506 Sephacryl® Substances 0.000 abstract 1
229920002684 Sepharose Polymers 0.000 abstract 1
238000001042 affinity chromatography Methods 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
210000001733 follicular fluid Anatomy 0.000 abstract 1
238000002523 gelfiltration Methods 0.000 abstract 1
238000004264 monolayer culture Methods 0.000 abstract 1
230000001817 pituitary effect Effects 0.000 abstract 1
238000004007 reversed phase HPLC Methods 0.000 abstract 1
230000028327 secretion Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Detergent Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT86904699T 1985-07-18 1986-07-17 Inhibin und dessen reinigung. ATE112573T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US75686685A	1985-07-18	1985-07-18
US06/784,436 US4740587A (en)	1985-07-18	1985-10-03	Inhibin and method of purifying same

Publications (1)

Publication Number	Publication Date
ATE112573T1 true ATE112573T1 (de)	1994-10-15

Family

ID=27116303

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT86904699T ATE112573T1 (de)	1985-07-18	1986-07-17	Inhibin und dessen reinigung.

Country Status (7)

Country	Link
US (1)	US4740587A (de)
EP (1)	EP0232326B1 (de)
JP (1)	JPH07108916B2 (de)
AT (1)	ATE112573T1 (de)
AU (1)	AU605105B2 (de)
DE (1)	DE3650088T2 (de)
WO (1)	WO1987000528A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1341617C (en) *	1984-06-08	2011-06-28	Henry George Burger	Inhibin isolated from ovarian follicular fluid
AU610821B2 (en) *	1985-04-18	1991-05-30	Inhibin Pty Limited	Recombinant inhibin
KR940004077B1 (ko)	1985-04-18	1994-05-11	바이오테크놀로지 오스트레일리아 프로프라이어터리 리밋티드	재조합 인히빈
JPH0637520B2 (ja) *	1985-07-03	1994-05-18	味の素株式会社	ポリペプチド
US5089396A (en) *	1985-10-03	1992-02-18	Genentech, Inc.	Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
ZA867569B (en) *	1985-10-03	1988-06-29	Genentech Inc	Nucleic acid encoding the alpha or beta chains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5047336A (en) *	1985-10-30	1991-09-10	Biogen, Inc.	DNA sequences, recombinant DNA molecules and processes for producing mullerian inhibiting substance-like polypeptides
US5427780A (en) *	1985-10-30	1995-06-27	Biogen, Inc.	Composition comprising Mullerian inhibiting substance-like polypeptides
US4864019A (en) *	1985-11-08	1989-09-05	The Salk Institute For Biological Studies	Antibodies to inhibin and conjugates produced therefrom
AU599373B2 (en) *	1986-03-13	1990-07-19	Biotechnology Australia Proprietary Limited	Method of assay of inhibin
US5015729A (en) *	1986-06-24	1991-05-14	The Salk Institute For Biological Studies	Ovine inhibin
US6150328A (en)	1986-07-01	2000-11-21	Genetics Institute, Inc.	BMP products
JP2653125B2 (ja) *	1988-09-22	1997-09-10	味の素株式会社	血糖低下剤
US5200395A (en) *	1988-10-18	1993-04-06	Ajinomoto Company, Inc.	Pharmaceutical composition of BUF-5 for treating anemia
US4997815A (en) *	1988-11-01	1991-03-05	Children's Hospital Medical Center Of Northern California	Method for augmenting fetal hemoglobin by treatment with activin and/or inhibin
US5942220A (en) *	1990-03-16	1999-08-24	Chiron Corporation	Inhibitor of cytokine activity and applications thereof
WO1994026892A1 (en) *	1993-05-12	1994-11-24	Genetics Institute, Inc.	Bmp-11 compositions
US6291206B1 (en)	1993-09-17	2001-09-18	Genetics Institute, Inc.	BMP receptor proteins
AU689184B2 (en)	1993-12-07	1998-03-26	Genetics Institute, Llc	BMP-12, BMP-13 and tendon-inducing compositions thereof
US5658876A (en) *	1994-04-28	1997-08-19	The General Hospital Corporation	Activin antagonists as novel contraceptives
JPH07238097A (ja) *	1994-09-07	1995-09-12	Masao Igarashi	インヒビンを抗原とするＩｇＧ抗体
US6727224B1 (en)	1999-02-01	2004-04-27	Genetics Institute, Llc.	Methods and compositions for healing and repair of articular cartilage
DK1223990T3 (da)	1999-10-15	2004-11-29	Inst Genetics Llc	Formuleringer af hyaluronsyre til tilförsel af osteogene proteiner
TW200526779A (en)	2001-02-08	2005-08-16	Wyeth Corp	Modified and stabilized GDF propeptides and uses thereof
US7226587B2 (en)	2001-06-01	2007-06-05	Wyeth	Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en)	2001-06-08	2006-12-01	Wyeth Corp	Calcium phosphate delivery vehicles for osteoinductive proteins
CA2490409A1 (en)	2002-06-28	2004-01-08	Centocor, Inc.	Mammalian ch1 deleted mimetibodies, compositions, methods and uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0730114B2 (ja) *	1985-04-03	1995-04-05	正雄五十嵐	インヒビン
AU610821B2 (en) *	1985-04-18	1991-05-30	Inhibin Pty Limited	Recombinant inhibin
AU5903986A (en) *	1985-04-18	1986-11-05	Biotechnology Australia Proprietary Limited	Recombinant inhibin
NZ217727A (en) *	1985-10-03	1990-05-28	Genentech Inc	Nucleic acid encoding alpha or b chain of inhibin, its production and compositions containing it

1985
- 1985-10-03 US US06/784,436 patent/US4740587A/en not_active Expired - Lifetime
1986
- 1986-07-17 DE DE3650088T patent/DE3650088T2/de not_active Expired - Lifetime
- 1986-07-17 JP JP61504032A patent/JPH07108916B2/ja not_active Expired - Lifetime
- 1986-07-17 AU AU61498/86A patent/AU605105B2/en not_active Expired
- 1986-07-17 EP EP86904699A patent/EP0232326B1/de not_active Expired - Lifetime
- 1986-07-17 AT AT86904699T patent/ATE112573T1/de not_active IP Right Cessation
- 1986-07-17 WO PCT/US1986/001505 patent/WO1987000528A1/en not_active Ceased

Also Published As

Publication number	Publication date
EP0232326A4 (de)	1988-06-14
AU605105B2 (en)	1991-01-10
US4740587A (en)	1988-04-26
DE3650088D1 (de)	1994-11-10
DE3650088T2 (de)	1995-01-26
WO1987000528A1 (en)	1987-01-29
AU6149886A (en)	1987-02-10
EP0232326B1 (de)	1994-10-05
JPH07108916B2 (ja)	1995-11-22
JPS63500309A (ja)	1988-02-04
EP0232326A1 (de)	1987-08-19

Legal Events

Date	Code	Title	Description
1995-04-15	UEP	Publication of translation of european patent specification
2006-10-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE112573T1 (de)	1994-10-15	Inhibin und dessen reinigung.
ATE113654T1 (de)	1994-11-15	Follistatin und verfahren zur reinigung desselben.
Parkhouse et al.	1981	Characterization of surface antigens of Trichinella spiralis infective larvae
DE3852054D1 (de)	1994-12-15	Monoklonale Antikörper gegen Glycolipid-Antigene und ihre Verwendung.
DE69033942D1 (de)	2002-05-08	Gliederstruktur für Gehroboter mit Beinen
EP0939121A3 (de)	1999-11-24	TFN-bindende Proteine
ATE125362T1 (de)	1995-08-15	Monoklonale antikörper gegen glykosyliertes albumin, hybride zellinien, die diese antikörper produzieren, sowie deren verwendung.
DK60586D0 (da)	1986-02-07	Inhibin isoleret fra ovariefollikelvaeske og fremgangsmaade til isolering og rensning af inhibin
IE780912L (en)	1978-11-07	A glycoprotain and process for the production thereof
DE3877753D1 (de)	1993-03-04	Transformierender wachstumsfaktor-beta.
IL94039A0 (en)	1991-01-31	Antibodies to anti-cytotoxic proteins
SE8202012L (sv)	1982-10-01	Humaninterferon-beslektade peptider, antigener, antikroppar och forfarande for framstellning derav
ATE47155T1 (de)	1989-10-15	Monoklonaler antikoerper.
AU2275588A (en)	1989-04-20	Agents and procedures for provoking an immune response to gnrh and immuno sterilizing mammals
DE69018442D1 (de)	1995-05-11	Glied mit zapfen für laderverbindungen und ähnliche.
AU567747B2 (en)	1987-12-03	Early detection of mammalian pregnancy
ES8505406A1 (es)	1985-06-01	Procedimiento de obtener y aislar hibridomas secretores de anticuerpos, procedimiento de obtener anticuerpos y metodo de obtener polipeptidos
IE832452L (en)	1984-04-20	Lymphocyte growth factor
DE3887750D1 (de)	1994-03-24	Selektive entfernung von immunkomplexen.
EP0109434A4 (de)	1986-09-23	In vitro diagnoseverfahren unter verwendung von monoklonalen antikörpern gegen konnektive gewebeproteine.
CA2010256A1 (en)	1990-08-17	Protein anti-cancer agent
ATE76877T1 (de)	1992-06-15	Hapten-protein-konjugate und ihre verwendung.
Glant	1982	Concanavalin A-binding link protein in the proteoglycan aggregate of hyaline cartilage
SE8904007D0 (sv)	1989-11-28	Monoklona antikroppar och diagnostiseringsmetod
FI882019L (fi)	1988-11-03	Monoklonaalisia vasta-aineita intaktin prokollageenipeptidin (tyyppi III) ja prokollageenin (tyyppi III) selektiivistä, immunologista määritystä varten kehonnesteistä