ATE114658T1 - Piperaziniocephalosporine. - Google Patents

Piperaziniocephalosporine.

Info

Publication number
ATE114658T1
ATE114658T1 AT90116330T AT90116330T ATE114658T1 AT E114658 T1 ATE114658 T1 AT E114658T1 AT 90116330 T AT90116330 T AT 90116330T AT 90116330 T AT90116330 T AT 90116330T AT E114658 T1 ATE114658 T1 AT E114658T1
Authority
AT
Austria
Prior art keywords
alkyl
same
antibacterial
hydroxyarylpiperaziniocephalosporins
cephalosporins
Prior art date
Application number
AT90116330T
Other languages
English (en)
Inventor
Hiroshi Onoue
Toshiro Konoike
Hiroyuki Ishitobi
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE114658T1 publication Critical patent/ATE114658T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT90116330T 1989-09-07 1990-08-26 Piperaziniocephalosporine. ATE114658T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP23263189 1989-09-07

Publications (1)

Publication Number Publication Date
ATE114658T1 true ATE114658T1 (de) 1994-12-15

Family

ID=16942341

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90116330T ATE114658T1 (de) 1989-09-07 1990-08-26 Piperaziniocephalosporine.

Country Status (7)

Country Link
US (1) US5143910A (de)
EP (1) EP0416410B1 (de)
JP (1) JP2969283B2 (de)
KR (1) KR0158452B1 (de)
AT (1) ATE114658T1 (de)
DE (1) DE69014490T2 (de)
DK (1) DK0416410T3 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0492277A3 (en) * 1990-12-20 1992-10-14 F. Hoffmann-La Roche Ag Cephalosporin derivatives
EP0550775A1 (de) * 1992-01-07 1993-07-14 F. Hoffmann-La Roche Ag Cephalosporinderivate
JP3081773B2 (ja) * 1995-03-31 2000-08-28 株式会社資生堂 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤
JP4189043B2 (ja) * 1996-09-30 2008-12-03 株式会社資生堂 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤
US6479495B1 (en) 1997-09-29 2002-11-12 Aventis Pharmaceuticals Inc. Aminoalkylphenol derivatives and related compounds
KR20010040254A (ko) * 1997-09-29 2001-05-15 스티븐 엘. 네스빗 아미노알킬페놀 유도체 및 관련 화합물
JP2007501254A (ja) * 2003-08-05 2007-01-25 サマリタン，ファーマスーティカルス，インク． アセチルコリンエステラーゼ阻害特性を有する、シグマ‐１受容体配位子
US20060247248A1 (en) * 2003-08-05 2006-11-02 Vassilios Papadopoulos Sigma-1 receptor ligand with acetylcholinesterase
US20090053137A1 (en) * 2006-03-15 2009-02-26 Moore Dennis A Chelating Conjugates Having a Substituted Aromatic Moiety and Derivatives Thereof
CA2702257C (en) 2007-10-09 2016-07-12 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
EA019520B1 (ru) 2008-10-31 2014-04-30 Сионоги Энд Ко., Лтд. Цефалоспорины, содержащие катехольную группу
AU2011236933A1 (en) 2010-04-05 2013-05-02 Shionogi & Co., Ltd. Cephem compound having catechol group
CN102918047A (zh) * 2010-04-05 2013-02-06 盐野义制药株式会社 具有假儿茶酚基团的头孢烯类化合物
JP5852562B2 (ja) * 2010-04-28 2016-02-03 塩野義製薬株式会社 新規なセフェム誘導体
KR20140039202A (ko) 2011-04-28 2014-04-01 시오노기세야쿠 가부시키가이샤 카테콜 또는 의사 카테콜 구조를 갖는 신규 세펨 화합물
MX2013012820A (es) 2011-05-02 2014-02-10 Zoetis Llc Cefalosporinas novedosas utiles como agentes antibacteriales.
WO2013002215A1 (ja) 2011-06-27 2013-01-03 塩野義製薬株式会社 ピリジニウム基を有するセフェム化合物
WO2013051597A1 (ja) 2011-10-04 2013-04-11 塩野義製薬株式会社 カテコール基を有するセフェム誘導体
WO2014069649A1 (en) 2012-10-29 2014-05-08 Shionogi & Co., Ltd. Processes for production of intermediates for 2-alkyl cephem compounds
UY35103A (es) 2012-10-29 2014-05-30 Glaxo Group Ltd Compuestos de cefem 2-sustituidos
KR20220061163A (ko) 2019-09-06 2022-05-12 나브리바 테라퓨틱스 게엠베하 사이드로포어 세팔로스포린 접합체 및 이의 용도
EP4095141A4 (de) 2020-01-22 2023-06-28 Shanghai Senhui Medicine Co., Ltd. Antibakterielle cephalosporin-verbindung und pharmazeutische anwendung davon
EP4279491A4 (de) 2021-01-12 2024-07-24 Shanghai Senhui Medicine Co., Ltd. Antibakterielle cephalosporinverbindung und herstellungsverfahren dafür
CN121127245A (zh) 2023-06-01 2025-12-12 江苏恒瑞医药股份有限公司 一种包含头孢类抗菌化合物的药物组合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5285187A (en) * 1976-01-08 1977-07-15 Shionogi & Co Ltd Antibacterials against pseudomonas aeruginosa
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
JPS6117589A (ja) * 1984-07-03 1986-01-25 Meiji Seika Kaisha Ltd 新規セフアロスポリン誘導体及びその製造法
KR920004820B1 (ko) * 1984-02-23 1992-06-18 메이지제과 주식회사 새로운 세팔로스포린 유도체의 제조방법
US4880795A (en) * 1984-05-22 1989-11-14 Bayer Aktiengesellschaft Cephalosporins
IL77458A (en) * 1985-01-14 1990-07-26 Eisai Co Ltd Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor
ZA86405B (en) * 1985-01-31 1986-09-24 Yamanouchi Pharma Co Ltd Cephalosporin compounds and slats thereof,and their production
DE3506159A1 (de) * 1985-02-22 1986-08-28 Bayer Ag, 5090 Leverkusen Neue cephalosporine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
JPS6230786A (ja) * 1985-04-11 1987-02-09 Eisai Co Ltd ３−（キヌクリジニオ）メチル−３−セフエム誘導体
JPS625961A (ja) * 1985-07-01 1987-01-12 Meiji Seika Kaisha Ltd 酸性基を有するピリドチオン類化合物および該化合物より誘導される新規なセフアロスポリン誘導体
DE3541095A1 (de) * 1985-11-21 1987-05-27 Bayer Ag Neue cephalosporine, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel
JPS62209082A (ja) * 1986-03-11 1987-09-14 Banyu Pharmaceut Co Ltd セフアロスポリン誘導体
DE3775798D1 (de) * 1986-03-19 1992-02-20 Banyu Pharma Co Ltd Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.
US4782155A (en) * 1986-03-19 1988-11-01 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents
US4814328A (en) * 1986-03-19 1989-03-21 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, and antibacterial agents
EP0272827A3 (de) * 1986-12-23 1990-02-07 ZENECA Pharma S.A. 3-Heterocyclethiomethyl-cephalosporine
DE3711343A1 (de) * 1987-04-03 1988-10-20 Bayer Ag Cephalosporinderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
PH25965A (en) * 1988-06-06 1992-01-13 Fujisawa Pharmaceutical Co New cephem compounds which have antimicrobial activities

Also Published As

Publication number Publication date
EP0416410A1 (de) 1991-03-13
EP0416410B1 (de) 1994-11-30
US5143910A (en) 1992-09-01
DE69014490D1 (de) 1995-01-12
KR910006303A (ko) 1991-04-29
DE69014490T2 (de) 1995-04-20
KR0158452B1 (ko) 1998-12-01
DK0416410T3 (da) 1995-05-15
JP2969283B2 (ja) 1999-11-02
JPH03173893A (ja) 1991-07-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee