ATE119887T1 - Benzimidazolderivate, ihre herstellung und ihre verwendung. - Google Patents

Benzimidazolderivate, ihre herstellung und ihre verwendung.

Info

Publication number: ATE119887T1
Authority: AT; Austria
Prior art keywords: hydrogen; halogen; alkyl; independently; production
Prior art date: 1990-09-24

Application number

AT91116148T

Other languages

English (en)

Inventor

Soren-Peter Olesen

Frank Waetjen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-09-24

Filing date

1991-09-23

Publication date

1995-04-15

1991-09-23 Application filed by Neurosearch As filed Critical Neurosearch As

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE119887T1 publication Critical patent/ATE119887T1/de

Links

229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
150000001556 benzimidazoles Chemical class 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
241000124008 Mammalia Species 0.000 abstract 2
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
102000004257 Potassium Channel Human genes 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
108020001213 potassium channel Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Polyesters Or Polycarbonates (AREA)
Graft Or Block Polymers (AREA)

AT91116148T 1990-09-24 1991-09-23 Benzimidazolderivate, ihre herstellung und ihre verwendung. ATE119887T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US58690090A	1990-09-24	1990-09-24

Publications (1)

Publication Number	Publication Date
ATE119887T1 true ATE119887T1 (de)	1995-04-15

Family

ID=24347548

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91116148T ATE119887T1 (de)	1990-09-24	1991-09-23	Benzimidazolderivate, ihre herstellung und ihre verwendung.

Country Status (15)

Country	Link
EP (1)	EP0477819B1 (de)
JP (1)	JP3203017B2 (de)
KR (1)	KR100195770B1 (de)
AT (1)	ATE119887T1 (de)
AU (1)	AU635440B2 (de)
CA (1)	CA2052041C (de)
DE (1)	DE69108156T2 (de)
DK (1)	DK0477819T3 (de)
ES (1)	ES2072504T3 (de)
FI (1)	FI103408B1 (de)
IE (1)	IE67133B1 (de)
NO (1)	NO180795C (de)
NZ (1)	NZ239540A (de)
PT (1)	PT99032B (de)
ZA (1)	ZA916805B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0520200B1 (de) *	1991-06-24	1998-02-18	Neurosearch A/S	Imidazol-Verbindungen, Verfahren zu ihrer Herstellung und ihre Anwendung
US5158969A (en) *	1991-08-21	1992-10-27	Neurosearch A/S	Indole derivatives as potassium channel blockers
US5232899A (en) *	1992-06-08	1993-08-03	Imperial Chemical Industries Plc	Benzoxazolinones and their use as herbicides
WO1994011355A1 (fr) *	1992-11-19	1994-05-26	Dainippon Pharmaceutical Co., Ltd.	Derive de 3,4-dihydro-1(2-hydroxyphenyl)-2(1h)-quinoxalinone et compose associe
DK154092D0 (da) *	1992-12-23	1992-12-23	Neurosearch As	Imidazolforbindelser, deres fremstilling og anvendelse
DK28893D0 (da) *	1993-03-15	1993-03-15	Neurosearch As	Benzimidazole derivater, deres fremstilling og anvendelse
DK41193D0 (da) *	1993-04-07	1993-04-07	Neurosearch As	Ionkanalaabnere
US5637470A (en) *	1994-05-13	1997-06-10	Merck & Co., Inc.	Screening array using cells expressing recombinant α and β subunits of the mammalian large-conductance (maxi-K) potassium channel
FR2722190B1 (fr) *	1994-07-05	1996-10-04	Sanofi Sa	Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
US5565483A (en) *	1995-06-07	1996-10-15	Bristol-Myers Squibb Company	3-substituted oxindole derivatives as potassium channel modulators
TW504504B (en) *	1996-11-26	2002-10-01	Bristol Myers Squibb Co	4-aryl-3-hydroxyquinolin-2-one derivatives as ion channel modulators
US5893085A (en) *	1997-06-10	1999-04-06	Phillips; Ronald W.	Dynamic fuzzy logic process for identifying objects in three-dimensional data
WO1999009983A1 (en) *	1997-08-28	1999-03-04	Bristol-Myers Squibb Company	4-aryl-3-aminoquinoline-2-one derivatives as potassium channel modulators
BR9915744A (pt) *	1998-12-04	2001-08-21	Bristol Myers Squibb Co	Derivados 4-arilquinolin-2-ona 3-substituìdos como moduladores do canal de potássio
AU760250B2 (en) *	1998-12-04	2003-05-08	Neurosearch A/S	New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents
WO2004002962A1 (en) *	2002-06-26	2004-01-08	Poseidon Pharmaceuticals A/S	Novel benzimidazol-2-one derivatives and their use
WO2004064835A1 (en) *	2003-01-17	2004-08-05	Neurosearch A/S	Use of ion channel modulating agents for treating pain
ES2222831B2 (es) *	2003-07-30	2006-02-16	Laboratorios Del Dr. Esteve, S.A.	Combinacion de principio activo que comprende un compuesto 2,5-dihidroxibencenosulfonico y un modulador de los canales de k+.
AR050084A1 (es) *	2004-07-27	2006-09-27	Novartis Ag	Derivados de bencimidazolona como inhibidores de hsp90
JP5313883B2 (ja) *	2007-04-18	2013-10-09	キッセイ薬品工業株式会社	含窒素縮合環誘導体、それを含有する医薬組成物及びその医薬用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH460028A (de) *	1965-01-22	1968-07-31	Wander Ag Dr A	Verfahren zur Herstellung von Benzimidazolonderivaten
FR1561830A (de) *	1968-05-08	1969-03-28
GB1408408A (en) *	1971-11-24	1975-10-01	Beecham Group Ltd	Benzimidazole derivatives
GB1476949A (en) *	1974-11-20	1977-06-16	Wyeth John & Brother Ltd	Imidazo-1,2-a-benzimidazole and pyrimido-1,2-a-benzimidazole derivatives their preparation and their pharmaceutical compositions
CH622009A5 (de) *	1976-06-11	1981-03-13	Ciba Geigy Ag
DE3042481A1 (de) *	1980-11-11	1982-06-16	A. Nattermann & Cie GmbH, 5000 Köln	(omega)-(2-oxo-benzazolinyl)-alkansaeure-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
CA1327579C (en) *	1986-02-03	1994-03-08	Frans Eduard Janssens	Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines

1991
- 1991-08-26 NZ NZ239540A patent/NZ239540A/en not_active IP Right Cessation
- 1991-08-28 ZA ZA916805A patent/ZA916805B/xx unknown
- 1991-08-28 AU AU82767/91A patent/AU635440B2/en not_active Ceased
- 1991-09-11 IE IE319791A patent/IE67133B1/en not_active IP Right Cessation
- 1991-09-11 FI FI914275A patent/FI103408B1/fi not_active IP Right Cessation
- 1991-09-20 JP JP24194691A patent/JP3203017B2/ja not_active Expired - Fee Related
- 1991-09-20 KR KR1019910016522A patent/KR100195770B1/ko not_active Expired - Fee Related
- 1991-09-23 DE DE69108156T patent/DE69108156T2/de not_active Expired - Fee Related
- 1991-09-23 DK DK91116148.7T patent/DK0477819T3/da active
- 1991-09-23 NO NO913728A patent/NO180795C/no unknown
- 1991-09-23 AT AT91116148T patent/ATE119887T1/de not_active IP Right Cessation
- 1991-09-23 ES ES91116148T patent/ES2072504T3/es not_active Expired - Lifetime
- 1991-09-23 EP EP91116148A patent/EP0477819B1/de not_active Expired - Lifetime
- 1991-09-23 CA CA002052041A patent/CA2052041C/en not_active Expired - Fee Related
- 1991-09-24 PT PT99032A patent/PT99032B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3203017B2 (ja)	2001-08-27
NZ239540A (en)	1993-11-25
FI103408B (fi)	1999-06-30
ES2072504T3 (es)	1995-07-16
ZA916805B (en)	1992-05-27
DE69108156T2 (de)	1995-07-06
IE913197A1 (en)	1992-02-25
PT99032A (pt)	1993-11-30
NO913728L (no)	1992-03-25
AU635440B2 (en)	1993-03-18
FI914275A0 (fi)	1991-09-11
NO180795C (no)	1997-06-25
KR100195770B1 (ko)	1999-06-15
PT99032B (pt)	1999-02-26
FI103408B1 (fi)	1999-06-30
NO180795B (no)	1997-03-17
FI914275L (fi)	1992-03-25
IE67133B1 (en)	1996-03-06
NO913728D0 (no)	1991-09-23
EP0477819A2 (de)	1992-04-01
CA2052041C (en)	2002-08-20
AU8276791A (en)	1992-03-26
EP0477819A3 (en)	1992-05-20
KR920006327A (ko)	1992-04-27
EP0477819B1 (de)	1995-03-15
CA2052041A1 (en)	1992-03-25
DE69108156D1 (de)	1995-04-20
DK0477819T3 (da)	1995-07-17
JPH04305568A (ja)	1992-10-28

Legal Events

Date	Code	Title	Description
2009-06-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69108156D1 (de)	1995-04-20	Benzimidazolderivate, ihre Herstellung und ihre Verwendung.
ATE117295T1 (de)	1995-02-15	4-oxochinolin-3-carbonsäure-derivate, ihre herstellung und ihre verwendung.
ATE216360T1 (de)	2002-05-15	Sulfinsäurederivate und deren herstellung und verwendung
NO972304L (no)	1997-11-24	Vitamin D3-analoger
ATE181552T1 (de)	1999-07-15	Isatinoximderivate, ihre herstellung und anwendung
DE59001281D1 (de)	1993-06-03	Oxidierte diphenylheteroalkane, ihre herstellung und verwendung.
ATE79257T1 (de)	1992-08-15	Verwendung von tetrahydrobenz(c,d>indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
DE69831559T2 (de)	2006-06-14	Substituierte (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8yl)phenyl derivate, deren herstellung und deren verwendung in der behandlung von entzündungen und immunkrankheiten
DE69903053D1 (de)	2002-10-24	Diaminocyclobuten-3,4-dionderivate, deren herstellung und deren verwendung
ATE125795T1 (de)	1995-08-15	Isatinderivate, ihre herstellung und verwendung.
DE69414017D1 (de)	1998-11-26	Benzimidazolderivate, ihre Herstellung und Verwendung
ATE22289T1 (de)	1986-10-15	N-(3-trifluormethylphenyl)-n'-propargylpiperazi , seine herstellung und verwendung.
DE69426581D1 (de)	2001-02-22	Isatinoxim-Derivate, ihre Herstellung und Verwendung
ATE17485T1 (de)	1986-02-15	3,7a-diazacyclohepta(j,k)fluorenderivate, ihre herstellung und ihre therapeutische verwendung.
DE3770713D1 (de)	1991-07-18	8-phenylthiotetrahydrochinolin-derivate und ihre salze, ihre herstellung, verwendung als arzneimittel und zusammensetzungen davon.
ATE6361T1 (de)	1984-03-15	N-sulfenylierte harnstoffe, verfahren zu ihrer herstellung, diese enthaltende fungizide mittel und ihre verwendung.
ATE155479T1 (de)	1997-08-15	Neue cytarabin-derivate, ihre herstellung und verwendung
DE69014239D1 (de)	1995-01-05	Phenylglycidamide, verwendbar in der Herstellung von alpha-Hydroxy-beta-sulfido-arylpropionsäure-Derivaten.