ATE120335T1 - Verfahren zur lyophilisierung von zellen lyophilisierungsmedien und verfahren zur wiederherstellung von lyophilisierten zellen. - Google Patents

Verfahren zur lyophilisierung von zellen lyophilisierungsmedien und verfahren zur wiederherstellung von lyophilisierten zellen.

Info

Publication number
ATE120335T1
ATE120335T1 AT89308672T AT89308672T ATE120335T1 AT E120335 T1 ATE120335 T1 AT E120335T1 AT 89308672 T AT89308672 T AT 89308672T AT 89308672 T AT89308672 T AT 89308672T AT E120335 T1 ATE120335 T1 AT E120335T1
Authority
AT
Austria
Prior art keywords
cells
lyophilization
restoring
media
lyophilized
Prior art date
Application number
AT89308672T
Other languages
English (en)
Inventor
Raymond Paul Goodrich
Christine Marie Williams
Original Assignee
Cobe Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cobe Lab filed Critical Cobe Lab
Application granted granted Critical
Publication of ATE120335T1 publication Critical patent/ATE120335T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
AT89308672T 1988-08-26 1989-08-25 Verfahren zur lyophilisierung von zellen lyophilisierungsmedien und verfahren zur wiederherstellung von lyophilisierten zellen. ATE120335T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23758388A 1988-08-26 1988-08-26
US07/378,349 US5045446A (en) 1988-08-26 1989-07-11 Lyophilization of cells

Publications (1)

Publication Number Publication Date
ATE120335T1 true ATE120335T1 (de) 1995-04-15

Family

ID=26930824

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89308672T ATE120335T1 (de) 1988-08-26 1989-08-25 Verfahren zur lyophilisierung von zellen lyophilisierungsmedien und verfahren zur wiederherstellung von lyophilisierten zellen.

Country Status (7)

Country Link
US (3) US5045446A (de)
EP (2) EP0356257B1 (de)
JP (1) JP2809735B2 (de)
AT (1) ATE120335T1 (de)
CA (1) CA1327763C (de)
DE (1) DE68921945T2 (de)
IL (1) IL91413A0 (de)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL90188A0 (en) * 1988-05-18 1989-12-15 Cryopharm Corp Process and medium for the lyophilization of erythrocytes
US6007978A (en) * 1988-05-18 1999-12-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
US5153004A (en) * 1989-06-02 1992-10-06 Cryopharm Corporation Freezing and thawing of erythrocytes
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
US5178884A (en) * 1988-05-18 1993-01-12 Cryopharm Corporation Lyophilized and reconstituted red blood cell compositions
US5958670A (en) * 1988-05-18 1999-09-28 Cobe Laboratories, Inc. Method of freezing cells and cell-like materials
US5059518A (en) * 1988-10-20 1991-10-22 Coulter Corporation Stabilized lyophilized mammalian cells and method of making same
WO1991018504A1 (en) * 1990-05-25 1991-12-12 Cryopharm Corporation Process for lyophilizing cells, cell-like materials and platelets in a mixture of biocompatible amphipathic polymers
AU650045B2 (en) 1990-09-12 1994-06-09 Lifecell Corporation Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US8067149B2 (en) * 1990-09-12 2011-11-29 Lifecell Corporation Acellular dermal matrix and method of use thereof for grafting
IL104470A0 (en) * 1992-01-21 1993-05-13 Cryopharm Corp Process for freezing cells and cell like materials and compositions prepared thereby
DK0679088T3 (da) * 1992-09-29 2002-10-28 Inhale Therapeutic Syst Pulmonal levering af aktive fragmenter af parathyreoideaea hormon
DE69535897D1 (de) 1994-03-07 2009-01-22 Nektar Therapeutics Verfahren und Zusammensetzung für die pulmonale Darreichung von Insulin
US20030113273A1 (en) * 1996-06-17 2003-06-19 Patton John S. Methods and compositions for pulmonary delivery of insulin
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof
US6586006B2 (en) 1994-08-04 2003-07-01 Elan Drug Delivery Limited Solid delivery systems for controlled release of molecules incorporated therein and methods of making same
US6290991B1 (en) * 1994-12-02 2001-09-18 Quandrant Holdings Cambridge Limited Solid dose delivery vehicle and methods of making same
CZ88697A3 (en) 1994-09-22 1997-09-17 Quadrant Holdings Cambridge Composition used for re-hydration and nourishment in the course of athletic outputs and processes for preparing thereof
US20050158699A1 (en) * 1995-06-07 2005-07-21 Kadkade Prakash G. Cryopreservation of plant cells
US5965438A (en) * 1995-06-07 1999-10-12 Phyton, Inc. Cryopreservation of plant cells
US6964771B1 (en) * 1995-06-07 2005-11-15 Elan Drug Delivery Limited Method for stably incorporating substances within dry, foamed glass matrices
US5690963A (en) * 1995-06-30 1997-11-25 The United States Of America As Represented By The Secretary Of The Navy Freeze dried red blood cells
US5736313A (en) * 1995-10-20 1998-04-07 The United States Of America As Represented By The Secretary Of The Navy Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing
US6274369B1 (en) * 1996-02-02 2001-08-14 Invitrogen Corporation Method capable of increasing competency of bacterial cell transformation
US5958455A (en) * 1996-02-09 1999-09-28 Quadrant Holdings Cambridge Ltd Oral solid dosage forms, methods of making same and compositions thereof
US5762961A (en) * 1996-02-09 1998-06-09 Quadrant Holdings Cambridge Ltd. Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof
FR2746109B1 (fr) * 1996-03-12 1998-04-17 Rhone Poulenc Rorer Sa Milieu pour la conservation de materiel biologique
US5891692A (en) * 1996-03-29 1999-04-06 Life Technologies, Inc. Method for increasing the viability and transformation ability of bacteria during or after storage at low temperatures
US6632648B1 (en) * 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
US6509146B1 (en) 1996-05-29 2003-01-21 Universal Preservation Technologies, Inc. Scalable long-term shelf preservation of sensitive biological solutions and suspensions
US6060233A (en) * 1996-06-14 2000-05-09 Biostore New Zealand, Ltd Methods for the lyophilization of platelets, platelet membranes or erythrocytes
US6040132A (en) * 1996-06-14 2000-03-21 Biostore New Zealand, Ltd. Methods for the lyophilization of living biological materials
US5750330A (en) * 1996-06-19 1998-05-12 Litron Laboratories Method and composition for lyophilizing red blood cells
JP3989574B2 (ja) * 1996-07-11 2007-10-10 ネオ製薬工業株式会社 歯牙保存液
US6468782B1 (en) 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
ATE230923T1 (de) 1997-02-07 2003-02-15 Elan Drug Delivery Ltd Verfahren und zusammensetzungen zur herstellung getrockneter, lagerungsstabiler blutplättchen
EP1005529B1 (de) 1997-02-12 2005-04-27 Invitrogen Corporation Verfahren zur trocknung von kompetenten zellen
DE19707508C2 (de) * 1997-02-25 2000-05-31 Hemofarm Vrsac Verfahren zur Isolierung von Hämoglobin und die Verwendung des so isolierten Hämoglobins
US6071745A (en) * 1997-06-27 2000-06-06 Bio-Rad Laboratories Method and formulation for lyophilizing cultured human cells to preserve RNA and DNA contained in cells for use in molecular biology experiments
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US5955257A (en) * 1997-10-21 1999-09-21 Regents Of The University Of Minnesota Infusible grade short-term cell storage medium for mononuclear cells
GB2330516A (en) * 1997-10-22 1999-04-28 Elizabeth Acton Cryopreservation of cell suspensions
US5972592A (en) * 1997-12-29 1999-10-26 Cornell Research Foundation, Inc. Increasing reproductive efficiency of bull semen using fucose or a compound with a fucose moiety
CA2332986C (en) * 1998-05-26 2009-09-08 Lifecell Corporation Cryopreservation of human red blood cells
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6127177A (en) * 1998-09-11 2000-10-03 Massachusetts Institute Of Technology Controlled reversible poration for preservation of biological materials
US6508983B1 (en) 1999-07-19 2003-01-21 Cobe Cardiovascular Exchanger apparatus and method of manufacture
US7112576B1 (en) 1999-12-10 2006-09-26 Regents Of The University Of Minnesota Compositions and methods for cryopreservation of peripheral blood lymphocytes
AU2594001A (en) * 1999-12-21 2001-07-03 Bioenergy Inc. Compositions for the storage of platelets
EP1255439A4 (de) * 2000-02-10 2007-01-03 Univ California Therapeutische plättchen und verfahren
US6770478B2 (en) 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
PT1280520E (pt) 2000-05-10 2014-12-16 Novartis Ag Pós à base de fosfolípidos para administração de fármacos
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US6653062B1 (en) * 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
AU2002248178A1 (en) * 2000-12-15 2002-08-12 Stratagene Mutant cells with enhanced resistance to desiccation
AU2002331847A1 (en) * 2001-09-14 2003-04-01 Invitrogen Corporation Composition for stabilizing biological materials
TWI324518B (en) 2001-12-19 2010-05-11 Nektar Therapeutics Pulmonary delivery of aminoglycosides
US20050031596A1 (en) * 2003-08-06 2005-02-10 Crowe John H. Cells and method for preserving cells
AU2003268033A1 (en) * 2002-07-26 2004-02-16 The General Hospital Corporation Systems and methods for cell preservation
US7270946B2 (en) * 2002-10-04 2007-09-18 Organ Recovery Systems, Inc. Method for treatment of cellular materials with sugars prior to preservation
GB0230152D0 (en) * 2002-12-24 2003-02-05 Sinvent As Product
US20050095320A1 (en) * 2003-10-29 2005-05-05 Richard Botteri [An Isotonic Sports Drink for Female Athletes Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Nutrition During Execise and Competition]
US20050100636A1 (en) * 2003-11-10 2005-05-12 Megan Botteri [A Low-Calorie Sports Drink For Physically Active Women That is Fortified with Iron, Calcium and Essential Vitamins for Use in Rehydration and Replacing Electrolytes Lost During Periods of Physical Activity]
ES2668551T3 (es) 2005-09-26 2018-05-18 Lifecell Corporation Composición seca de plaquetas
KR20080103637A (ko) * 2007-05-25 2008-11-28 주식회사 알앤엘바이오 지방유래 줄기세포를 함유하는 사지말단부 허혈성 질환의세포치료용 조성물
CA2753291C (en) * 2009-02-23 2017-08-15 Cell & Tissue Systems, Inc. Method for ice-free cryopreservation of tissue
CN102753975B (zh) * 2010-02-19 2015-05-20 卡帝拉药物有限公司 基本上保留免疫原性的被杀死细胞的药物组合物
US20180042850A1 (en) * 2010-02-19 2018-02-15 Cadila Pharmaceuticals Ltd. Pharmaceutical Composition of Killed Cells with Substantially Retained Immunogenicity
US20130230494A1 (en) * 2010-05-25 2013-09-05 The Research Foundation Of State University Of New York Cellular Preparations For Wound Management
US20130008191A1 (en) * 2011-07-07 2013-01-10 Suchak Naresh J Methods for freezing and thawing proteins
MX2015006491A (es) 2012-11-23 2015-12-03 Seres Health Inc Composiciones bacterianas sinergicas y metodos de produccion y uso de las mismas.
EP2951283A4 (de) 2013-02-04 2017-01-25 Seres Therapeutics, Inc. Zusammensetzungen und verfahren
MX369877B (es) 2013-02-04 2019-11-25 Seres Therapeutics Inc Composiciones y metodos.
JP2016519664A (ja) 2013-03-15 2016-07-07 セレス セラピューティクス インコーポレイテッド ネットワークを基にした微生物組成物及び方法
MX367109B (es) 2013-11-25 2019-08-05 Seres Therapeutics Inc Composiciones bacterianas sinergicas y sus metodos de produccion y usos.
US9956282B2 (en) 2013-12-16 2018-05-01 Seres Therapeutics, Inc. Bacterial compositions and methods of use thereof for treatment of immune system disorders
WO2015191599A2 (en) 2014-06-09 2015-12-17 Terumo Bct, Inc. Lyophilization
WO2016086071A1 (en) * 2014-11-24 2016-06-02 Nueou, Inc. Spectrally encoded consumable spectrometer apparatus and methods
US20180362921A1 (en) * 2015-12-14 2018-12-20 Groupe Santé Devonian Inc. Extraction and process for active thylakoid membranes
WO2018017843A1 (en) 2016-07-22 2018-01-25 Tissue Testing Technologies Llc Enhancement of cell cryopreservation with glycolipids
US11246308B2 (en) 2016-12-20 2022-02-15 Tissue Testing Technologies Llc Ice-free preservation of large volume tissue samples for viable, functional tissue banking
BR112020002992A2 (pt) 2017-08-14 2020-08-18 Seres Therapeutics, Inc. composições e métodos para tratamento de doença colestática
WO2019074886A1 (en) 2017-10-09 2019-04-18 Terumo Bct Biotechnologies, Llc LYOPHILIZATION CONTAINER AND METHOD OF USE
JP2021501185A (ja) 2017-10-30 2021-01-14 セレス セラピューティクス インコーポレイテッド 抗生物質耐性を処置するための組成物及び方法
US11609042B2 (en) 2019-03-14 2023-03-21 Terumo Bct Biotechnologies, Llc Multi-part lyophilization container and method of use
BR112022007399A2 (pt) 2019-11-07 2022-07-05 Tissue Testing Tech Llc Vitrificação sem gelo e nanoaquecimento de grandes amostras de tecido
US20220354108A1 (en) 2021-05-04 2022-11-10 Tissue Testing Technologies Llc Preservation methods using trehalose with other cryoprotectants being absent from the cryopreservation protocol
EP4358717A1 (de) * 2021-06-25 2024-05-01 Lonza Ltd. Verfahren zur kryoprotektion und lyoprotektion von zellen

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR654692A (fr) * 1928-01-04 1929-04-09 Assemblage pour poutres et colonnes ou piliers métalliques
US2786014A (en) * 1952-09-10 1957-03-19 James L Tullis Platelet preservation
US2875588A (en) * 1953-06-11 1959-03-03 Ohio Commw Eng Co Preservation of red blood cells
US3079919A (en) * 1958-11-10 1963-03-05 Baxter Laboratories Inc Parenteral solution equipment and method
US3228838A (en) * 1959-04-23 1966-01-11 Union Carbide Corp Preservation of biological substances
US3080725A (en) * 1960-08-11 1963-03-12 Union Carbide Corp Method and apparatus for controlled rate cooling and warming of biological substances
US3158283A (en) * 1961-04-24 1964-11-24 Union Carbide Corp Corrugated contained for the low temperature preservation of biological substances
US3344167A (en) * 1962-03-19 1967-09-26 Exxon Research Engineering Co Difluoraminoalkyl nitrates
US3303662A (en) * 1963-03-01 1967-02-14 Union Carbide Corp Process for cell preservation
BE643051A (de) * 1963-05-31 1964-05-15
US3347745A (en) * 1963-12-06 1967-10-17 Union Carbide Corp Process for freezing erythrocytes
FR1413976A (fr) * 1964-08-31 1965-10-15 Récipient souple en matière plastique, notamment pour sérum
US3344617A (en) * 1965-02-25 1967-10-03 Union Carbide Corp Apparatus for the preservation of biological substances
NL6509726A (de) * 1965-07-28 1967-01-30
NL126572C (de) * 1966-03-24
GB1244344A (en) * 1967-11-13 1971-08-25 Abbott Lab Hemagglutination testing procedure employing stabilized and potentiated erythrocytes and a method for their preparation
DE2025718C3 (de) * 1967-11-13 1979-06-13 Abbott Laboratories, Chicago, Ill. (V.St.A.) Verfahren zum Stabilisieren von lyophillsierten Erythrozyten
US3758382A (en) * 1968-07-26 1973-09-11 Us Navy Ve agent process of freezing blood using a hydroxyalkyl starch as cryoprotecti
US3554256A (en) * 1968-11-08 1971-01-12 Dave Champman Goldsmith & Yama Flexible intravenous container
US3677022A (en) * 1969-07-24 1972-07-18 Redeco Method for extending the useful storage period of biological substances such as blood
CA928215A (en) * 1969-08-08 1973-06-12 M. Brake Jon Process for the cryogenic preservation of blood and erythrocytes and products produced thereby
US3915794A (en) * 1973-02-09 1975-10-28 Rit Rech Ind Therapeut Stabilizing compositions for cell-free viruses and cell-free virus preparations containing them
DE2310964A1 (de) * 1973-03-02 1974-09-05 Schering Ag Antigen- bzw. antigen-proteinkonjugatbeschichtete erythrocytenpraeparation
FR2284842A1 (fr) * 1974-09-11 1976-04-09 Nestle Sa Perfectionnement apporte la lyophilisation des produits solides, liquides ou pateux
DE2532183C3 (de) * 1975-07-18 1982-03-04 Behringwerke Ag, 3550 Marburg Polyionische isotonische Salzlösung zur Konservierung von Erythrozyten oder zur Perfusion und zur Konservierung von zur Transplantion bestimmter Organen
CA1055932A (en) * 1975-10-22 1979-06-05 Hematech Inc. Blood substitute based on hemoglobin
US4018911A (en) * 1975-11-10 1977-04-19 The United States Of America As Represented By The Secretary Of The Navy Method for large volume freezing and thawing of packed erythrocytes
DE2551208C3 (de) * 1975-11-14 1981-05-27 Behringwerke Ag, 3550 Marburg Verfahren zur Herstellung einer stabilen Erythrozyten-Präparation
US4059967A (en) * 1976-02-19 1977-11-29 The Community Blood Council Of Greater New York, Inc. Process for freezing blood platelets
US4132594A (en) * 1976-06-28 1979-01-02 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Gas diffusion liquid storage bag and method of use for storing blood
US4131200A (en) * 1976-07-06 1978-12-26 Union Carbide Corporation Thermoplastic blood bag
SU686732A1 (ru) * 1977-05-05 1979-09-25 Владивостокский государственный медицинский институт Способ получени комплемента
US4112070A (en) * 1977-06-08 1978-09-05 Research Corporation Blood preservation system
US4320111A (en) * 1977-06-14 1982-03-16 American Home Products Corporation Immunologic compositions methods of preparation and use
DE2820603A1 (de) * 1978-05-11 1979-11-15 Gersonde Klaus Prof Dr Modifizierte intakte erythrozyten und sie enthaltendes blut bzw. blutkonserven
US4278198A (en) * 1977-11-17 1981-07-14 Baxter Travenol Laboratories, Inc. Flexible collapsible container with a stiffening member
US4243687A (en) * 1979-01-10 1981-01-06 Leo Kline Freeze-dried natural sour dough starter
CA1138704A (en) * 1979-03-02 1983-01-04 Unilever Limited Composite ice confections and processes for preparing them
DE2929278A1 (de) * 1979-07-19 1981-01-29 Forschungsgesellschaft Fuer Bi Verfahren zum eingefrieren von zellsuspensionen
US4267269A (en) * 1980-02-05 1981-05-12 Baxter Travenol Laboratories, Inc. Red cell storage solution
DE3007913A1 (de) * 1980-03-01 1981-09-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Verfahren zum einfrieren von biologischem zellmaterial unter benutzung von frierschutzmitteln, die vor dem einsatz des zellmaterials nicht ausgewaschen werden muessen
SU959786A1 (ru) * 1980-04-17 1982-09-23 Московский технологический институт мясной и молочной промышленности Способ консервировани цельной крови
JPS577419A (en) * 1980-06-17 1982-01-14 Toshiba Kagaku Kogyo Kk Erythrocyte storing solution
SU932438A1 (ru) * 1980-07-31 1982-05-30 Московский Ордена Трудового Красного Знамени Физико-Технический Институт Перестраиваемый отрезающий оптический фильтр
US4521975A (en) * 1981-05-04 1985-06-11 Marquest Medical Products, Inc. Lyophilizing and forming biologicals having a predetermined unit dosage
JPS589688A (ja) * 1981-07-06 1983-01-20 Toyobo Co Ltd 安定な酵素組成物
JPS58131566A (ja) * 1982-04-28 1983-08-05 Green Cross Corp:The 赤血球凍結乾燥物
DE3225408A1 (de) * 1982-07-07 1984-01-12 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Waessrige loesung zum suspendieren und lagern von zellen, insbesondere erythrozyten
FR2542617B2 (fr) * 1982-07-09 1986-06-06 Rgl Transfusion Sanguine Centr Solution protectrice pour la conservation de cellules fonctionnelles
US4639513A (en) * 1984-02-02 1987-01-27 Cuno Inc. Intravenously injectable immunoglobulin G (IGG) and method for producing same
US4883459A (en) * 1983-07-29 1989-11-28 Reynaldo Calderon Retrograde perfusion
US4865871A (en) * 1983-08-23 1989-09-12 Board Of Regents The University Of Texas System Method for cryopreparing biological tissue
US4585735A (en) * 1984-07-19 1986-04-29 American National Red Cross Prolonged storage of red blood cells
US5084377A (en) * 1984-09-19 1992-01-28 Larry Rowan Cryogenic suspension method
FR2581289A1 (fr) * 1985-05-06 1986-11-07 Rgl Transfusion Sanguine Centr Solution synthetique pour la conservation prolongee de concentres erythrocytaires
GB8604983D0 (en) * 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
JPH0827283B2 (ja) * 1986-03-10 1996-03-21 財団法人化学及血清療法研究所 免疫凝集反応用組成物
US4806343A (en) * 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
US4731330A (en) * 1986-07-01 1988-03-15 Biotrack, Inc. Whole blood control sample
JPS63106562A (ja) * 1986-10-23 1988-05-11 Green Cross Corp:The 逆受身赤血球凝集反応用試薬
US4764463A (en) * 1986-10-30 1988-08-16 The University Of Tennessee Research Corporation Platelet cyropreservation
US4963362A (en) * 1987-08-07 1990-10-16 Regents Of The University Of Minnesota Freeze-dried liposome mixture containing cyclosporin
US4980277A (en) * 1987-10-16 1990-12-25 Cultor Ltd. Cryoprotectant solution and method
US5192553A (en) * 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
JPH0769585B2 (ja) * 1987-12-14 1995-07-31 富士写真フイルム株式会社 写真用ハロゲン化銀乳剤の製造方法
US5045446A (en) * 1988-08-26 1991-09-03 Cryopharm Corporation Lyophilization of cells
IL90188A0 (en) * 1988-05-18 1989-12-15 Cryopharm Corp Process and medium for the lyophilization of erythrocytes
US5153004A (en) * 1989-06-02 1992-10-06 Cryopharm Corporation Freezing and thawing of erythrocytes
US5043261A (en) * 1989-04-10 1991-08-27 Cryopharm Corporation Lyophilized and reconstituted red blood cell and hemosome compositions
US5171661A (en) * 1988-05-18 1992-12-15 Cryopharm Corporation Medium for lyophilization of erythrocytes
US5178884A (en) * 1988-05-18 1993-01-12 Cryopharm Corporation Lyophilized and reconstituted red blood cell compositions
US5213814A (en) * 1989-04-10 1993-05-25 Cryopharm Corporation Lyophilized and reconstituted blood platelet compositions
FI80172C (fi) * 1988-05-25 1990-04-10 Nokia Mobile Phones Ltd Fm-mellanfrekvenskrets.
US4900780A (en) * 1988-05-25 1990-02-13 Masonic Medical Research Laboratory Acellular resuscitative fluid
DE3817906A1 (de) * 1988-05-26 1989-11-30 Boehringer Mannheim Gmbh Verfahren und behaeltnis zum gefriertrocknen unter sterilen bedingungen
EP0356258A3 (de) * 1988-08-26 1990-06-06 Cryopharm Corporation Gefriertrocknungsmethode für rote Blutkörperchen und Mittel dafür
US4874690A (en) * 1988-08-26 1989-10-17 Cryopharm Corporation Lyophilization of red blood cells
US5059518A (en) * 1988-10-20 1991-10-22 Coulter Corporation Stabilized lyophilized mammalian cells and method of making same
US5030560A (en) * 1988-11-04 1991-07-09 Immucor, Inc. Method for drying mammalian cells for use in solid phase immunoassays and articles incorporating same
US4983515A (en) * 1989-02-16 1991-01-08 E. I. Du Pont De Nemours And Company Labeled cryopreserved cells for use as targets in cytotoxicity assays
GB8903593D0 (en) * 1989-02-16 1989-04-05 Pafra Ltd Storage of materials
US5118792A (en) * 1989-05-10 1992-06-02 Dna Plant Technology Corporation Ice crystal growth suppression polypeptides and method of making
GB8920007D0 (en) * 1989-09-05 1989-10-18 Devilbiss Co Spraygun
US4973327A (en) * 1989-11-01 1990-11-27 Cryopharm Blood bag for lyophilization
WO1991016060A1 (en) * 1990-04-16 1991-10-31 Cryopharm Corporation Method of inactivation of viral and bacterial blood contaminants
WO1991018504A1 (en) * 1990-05-25 1991-12-12 Cryopharm Corporation Process for lyophilizing cells, cell-like materials and platelets in a mixture of biocompatible amphipathic polymers
US5145770A (en) * 1990-06-04 1992-09-08 Biosurface Technology, Inc. Cryopreservation of cultured epithelial sheets
AU650045B2 (en) * 1990-09-12 1994-06-09 Lifecell Corporation Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions
JPH05506457A (ja) * 1991-02-15 1993-09-22 クライアファーム コーポレイション 非哺乳類の有核細胞と血液物質の混合物の凍結乾燥及び再構成法
US5242792A (en) * 1991-02-25 1993-09-07 The United States Of America As Represented By The Secretary Of The Navy Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides

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EP0356257A2 (de) 1990-02-28
DE68921945D1 (de) 1995-05-04
JP2809735B2 (ja) 1998-10-15
IL91413A0 (en) 1990-04-29
CA1327763C (en) 1994-03-15
EP0356257B1 (de) 1995-03-29
US5045446A (en) 1991-09-03
JPH02186981A (ja) 1990-07-23
EP0508496A1 (de) 1992-10-14
US5648206A (en) 1997-07-15
US5425951A (en) 1995-06-20
DE68921945T2 (de) 1995-08-03
EP0356257A3 (en) 1990-07-25

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